BR9905832A - Formulações de clorohexidina, sais de clorohexidina, soluções contendo estes sais e seu uso - Google Patents
Formulações de clorohexidina, sais de clorohexidina, soluções contendo estes sais e seu usoInfo
- Publication number
- BR9905832A BR9905832A BR9905832-4A BR9905832A BR9905832A BR 9905832 A BR9905832 A BR 9905832A BR 9905832 A BR9905832 A BR 9905832A BR 9905832 A BR9905832 A BR 9905832A
- Authority
- BR
- Brazil
- Prior art keywords
- salts
- chlorhexidine
- formulations
- lactone
- solutions containing
- Prior art date
Links
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 title abstract 6
- 239000000203 mixture Substances 0.000 title abstract 5
- 150000003839 salts Chemical class 0.000 title abstract 4
- 229960003260 chlorhexidine Drugs 0.000 title abstract 3
- 238000009472 formulation Methods 0.000 title abstract 3
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 150000007513 acids Chemical class 0.000 abstract 2
- 239000000645 desinfectant Substances 0.000 abstract 2
- 239000000243 solution Chemical class 0.000 abstract 2
- UOQHWNPVNXSDDO-UHFFFAOYSA-N 3-bromoimidazo[1,2-a]pyridine-6-carbonitrile Chemical compound C1=CC(C#N)=CN2C(Br)=CN=C21 UOQHWNPVNXSDDO-UHFFFAOYSA-N 0.000 abstract 1
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 abstract 1
- PHOQVHQSTUBQQK-SQOUGZDYSA-N D-glucono-1,5-lactone Chemical compound OC[C@H]1OC(=O)[C@H](O)[C@@H](O)[C@@H]1O PHOQVHQSTUBQQK-SQOUGZDYSA-N 0.000 abstract 1
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 abstract 1
- IAJILQKETJEXLJ-RSJOWCBRSA-N aldehydo-D-galacturonic acid Chemical compound O=C[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)C(O)=O IAJILQKETJEXLJ-RSJOWCBRSA-N 0.000 abstract 1
- 150000001450 anions Chemical class 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- AEMOLEFTQBMNLQ-UHFFFAOYSA-N beta-D-galactopyranuronic acid Natural products OC1OC(C(O)=O)C(O)C(O)C1O AEMOLEFTQBMNLQ-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 235000012208 gluconic acid Nutrition 0.000 abstract 1
- 239000000174 gluconic acid Substances 0.000 abstract 1
- 229950006191 gluconic acid Drugs 0.000 abstract 1
- 235000012209 glucono delta-lactone Nutrition 0.000 abstract 1
- 229960003681 gluconolactone Drugs 0.000 abstract 1
- 229940099563 lactobionic acid Drugs 0.000 abstract 1
- 150000002596 lactones Chemical class 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dermatology (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cosmetics (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicinal Preparation (AREA)
Abstract
Patente de Invenção:<B>"FORMULAçõES DE CLOROHEXIDINA, SAIS DE CLOROHEXIDINA, SOLUçõES CONTENDO ESTES SAIS E SEU USO"<D>. A invenção fornece misturas em pó de base de clorohexidina com ácidos de açúcares ou lactonas dos mesmos selecionados do grupo que consiste de ácido glucónico ou gluconolactona, ácido lactobiónico (I), D-galactono- -lactona (II), L-manono- -lactona (III), D-(-)-gulono- -lactona (IV), ácido D-(+)-galacturónico (V) e <244>-D-heptaglucono-y-lactona (VI). As formulações são caracterizadas por uma extraordinária estabilidade ao armazenamento. Também são fornecidos novos sais de clorohexidina com ânions de ácidos de açúcares, baseados nos compostos de (I) a (VI) e soluções aquosas destes. As formulações, soluções e sais puros são usadas como desinfetantes e no preparo de desinfetantes.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19857151A DE19857151A1 (de) | 1998-12-11 | 1998-12-11 | Chlorhexidin-Formulierungen, neue Chlorhexidinsalze, sie enthaltende Lösungen und deren Verwendung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9905832A true BR9905832A (pt) | 2000-08-29 |
Family
ID=7890710
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9905832-4A BR9905832A (pt) | 1998-12-11 | 1999-12-13 | Formulações de clorohexidina, sais de clorohexidina, soluções contendo estes sais e seu uso |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6500466B2 (pt) |
| EP (1) | EP1018337B1 (pt) |
| JP (1) | JP2000178189A (pt) |
| AU (1) | AU751521B2 (pt) |
| BR (1) | BR9905832A (pt) |
| CA (1) | CA2292226C (pt) |
| DE (2) | DE19857151A1 (pt) |
| DK (1) | DK1018337T3 (pt) |
| ES (1) | ES2192014T3 (pt) |
| IL (1) | IL133395A (pt) |
| PL (1) | PL200514B1 (pt) |
| ZA (1) | ZA997575B (pt) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10052322A1 (de) | 2000-10-21 | 2002-05-02 | Degussa | Wasserlösliche chlorhexidinhaltige Zusammensetzungen und deren Verwendung |
| GB0211576D0 (en) * | 2002-05-21 | 2002-06-26 | Cheetham J K | A novel formula for modification of chemical compounds on flavour solubility and stability |
| US7074459B2 (en) * | 2003-05-23 | 2006-07-11 | Stockel Richard F | Method for preserving wood |
| US20050114266A1 (en) * | 2003-11-26 | 2005-05-26 | Lingan Satkunanathan | System and method for managing licenses using interactive wizards |
| JP2009545783A (ja) * | 2006-07-31 | 2009-12-24 | 株式会社東芝 | 不揮発性メモリシステム、及びそのデータ読み出し/書き込み制御方法 |
| WO2010080936A2 (en) | 2009-01-07 | 2010-07-15 | Entrotech, Inc. | Chlorhexidine-containing antimicrobial laminates |
| EP2501676A2 (en) * | 2009-11-18 | 2012-09-26 | Medichem, S.A. | A di(4-chloro-phenyldiguanido) derivative which is free of potential genotoxicity and a process for reducing the residual amount of p-chloroaniline in said di(4-chloro-phenyldiguanido) derivative |
| US9346981B2 (en) * | 2011-01-21 | 2016-05-24 | Avery Dennison Corporation | Chlorhexidine gluconate containing solvent adhesive |
| EP2710085B1 (en) | 2011-05-16 | 2018-09-26 | Avery Dennison Corporation | Adhesive containing microparticles |
| JP6433436B2 (ja) | 2013-02-07 | 2018-12-05 | エーブリー デニソン コーポレイション | 改善された性質を有する抗菌性接着剤 |
| WO2014151355A1 (en) | 2013-03-15 | 2014-09-25 | Avery Dennison Corporation | Transparent cover dressing application system and inclusion of label strip |
| US11039615B2 (en) | 2014-04-18 | 2021-06-22 | Entrotech Life Sciences, Inc. | Methods of processing chlorhexidine-containing polymerizable compositions and antimicrobial articles formed thereby |
| JP6338435B2 (ja) * | 2014-04-25 | 2018-06-06 | 日本ゼトック株式会社 | 皮膚外用剤 |
| EP3789014A1 (en) | 2014-06-05 | 2021-03-10 | Avery Dennison Corporation | Articles with active agent concentrated at the substrate contacting surface and related methods |
| RU2696259C2 (ru) * | 2017-10-23 | 2019-08-01 | Общество С Ограниченной Ответственностью "Сан Системз" | Солюбилизация хлоргексидина основания, антисептическая и дезинфицирующая композиции |
| DE102019000322A1 (de) | 2019-01-14 | 2020-07-16 | Beuth Hochschule Für Technik Berlin | Polymerzusammensetzung mit antiseptischen Eigenschaften und Verfahren zur Herstellung |
| DE102019000321A1 (de) | 2019-01-14 | 2020-07-16 | Beuth Hochschule Für Technik Berlin | Orale Polymerzusammensetzung mit verzögerter Freisetzung |
| US20240197938A1 (en) * | 2021-01-04 | 2024-06-20 | Harcros Chemicals, Inc. | Antimicrobial compounds based on glucoheptonic acids and their salts |
| CN114391550B (zh) * | 2022-01-06 | 2022-11-22 | 江南大学 | 一种水溶性氯己定类抗菌剂及其制备方法和应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5726612A (en) * | 1980-07-24 | 1982-02-12 | Lion Corp | Preparation of oral composition |
| GB8427499D0 (en) * | 1984-10-31 | 1984-12-05 | Stafford Miller Ltd | Oral hygiene products |
| JPS61130210A (ja) * | 1984-11-28 | 1986-06-18 | Sunstar Inc | クロルヘキシジンを安定に配合したパスタ |
| FR2579979B1 (pt) * | 1985-04-05 | 1987-06-26 | Pf Cosmetique | |
| US5389677B1 (en) * | 1986-12-23 | 1997-07-15 | Tristrata Inc | Method of treating wrinkles using glycalic acid |
| US6051609A (en) * | 1997-09-09 | 2000-04-18 | Tristrata Technology, Inc. | Additives enhancing the effect of therapeutic agents |
| SE465905B (sv) * | 1989-03-15 | 1991-11-18 | Gunnar Roella | Tandvaardsmedel som innehaaller ett acetat- eller glukonatsalt av en antimikrobiell bisbiguanid |
| JP3305108B2 (ja) * | 1994-03-30 | 2002-07-22 | サンスター株式会社 | 歯磨組成物 |
| JPH09301858A (ja) * | 1996-05-13 | 1997-11-25 | Senju Pharmaceut Co Ltd | グルコン酸クロルヘキシジン安定化水性薬剤 |
| FR2752731B1 (fr) * | 1996-08-28 | 2001-04-27 | Pioch Michel | Composition utile notamment en chirurgie dentaire |
| US5877212A (en) * | 1997-04-16 | 1999-03-02 | Yu; Ruey J. | Molecular complex and control-release of alpha hydroxyacids |
-
1998
- 1998-12-11 DE DE19857151A patent/DE19857151A1/de not_active Withdrawn
-
1999
- 1999-11-25 ES ES99123468T patent/ES2192014T3/es not_active Expired - Lifetime
- 1999-11-25 EP EP99123468A patent/EP1018337B1/de not_active Expired - Lifetime
- 1999-11-25 DE DE59904218T patent/DE59904218D1/de not_active Expired - Lifetime
- 1999-11-25 DK DK99123468T patent/DK1018337T3/da active
- 1999-12-09 IL IL13339599A patent/IL133395A/en not_active IP Right Cessation
- 1999-12-09 ZA ZA9907575A patent/ZA997575B/xx unknown
- 1999-12-10 CA CA002292226A patent/CA2292226C/en not_active Expired - Fee Related
- 1999-12-10 PL PL337107A patent/PL200514B1/pl unknown
- 1999-12-10 JP JP11352069A patent/JP2000178189A/ja not_active Ceased
- 1999-12-10 AU AU64454/99A patent/AU751521B2/en not_active Ceased
- 1999-12-13 BR BR9905832-4A patent/BR9905832A/pt not_active Application Discontinuation
- 1999-12-13 US US09/458,717 patent/US6500466B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1018337A3 (de) | 2001-01-03 |
| IL133395A0 (en) | 2001-04-30 |
| DK1018337T3 (da) | 2003-05-05 |
| DE19857151A1 (de) | 2000-06-15 |
| JP2000178189A (ja) | 2000-06-27 |
| PL200514B1 (pl) | 2009-01-30 |
| US20020018814A1 (en) | 2002-02-14 |
| ZA997575B (en) | 2000-06-12 |
| CA2292226C (en) | 2009-02-10 |
| CA2292226A1 (en) | 2000-06-11 |
| IL133395A (en) | 2004-06-20 |
| AU6445499A (en) | 2000-06-15 |
| EP1018337A2 (de) | 2000-07-12 |
| AU751521B2 (en) | 2002-08-22 |
| PL337107A1 (en) | 2000-06-19 |
| US6500466B2 (en) | 2002-12-31 |
| EP1018337B1 (de) | 2003-02-05 |
| DE59904218D1 (de) | 2003-03-13 |
| ES2192014T3 (es) | 2003-09-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA10 | Dismissal: dismissal - article 33 of industrial property law | ||
| B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |