BR9902585A - A new process for the synthesis of aza-sugars with biological activity - Google Patents
A new process for the synthesis of aza-sugars with biological activityInfo
- Publication number
- BR9902585A BR9902585A BR9902585-0A BR9902585A BR9902585A BR 9902585 A BR9902585 A BR 9902585A BR 9902585 A BR9902585 A BR 9902585A BR 9902585 A BR9902585 A BR 9902585A
- Authority
- BR
- Brazil
- Prior art keywords
- sugars
- aza
- synthesis
- biological activity
- new process
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 4
- 238000003786 synthesis reaction Methods 0.000 title abstract 4
- 230000004071 biological effect Effects 0.000 title abstract 3
- 239000000126 substance Substances 0.000 abstract 2
- IBAQFPQHRJAVAV-ULAWRXDQSA-N Miglitol Chemical compound OCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO IBAQFPQHRJAVAV-ULAWRXDQSA-N 0.000 abstract 1
- 230000036436 anti-hiv Effects 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000002672 hepatitis B Diseases 0.000 abstract 1
- 230000004060 metabolic process Effects 0.000 abstract 1
- 229960001110 miglitol Drugs 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Patente de Invenção: <B>UM NOVO PROCESSO DE SìNTESE DE AZA-AçúCARES COM ATIVIDADE BIOLóGICA<D>. Trata-se de um trabalho que demonstra a preparação de aza-açúcares com as seguintes formulas estruturais: Esta invenção refere-se a um novo processo de síntese da 1-deoxinojirimmicina (<B>1<D>), N-butil-1-deoxinojirimicina (<B>16<D>), miglitol (<B>54<D>) e derivados. As substâncias desta invenção tem os seguintes tipos de atividades biológicas: anti-HIV, anti-diabetes, anti-hepatite B e contra doenças do metabolismo. O processo de preparação de aza-açúcares descrito nesta invenção quando comparado com os descritos anteriormente na literatura química, apresenta as seguintes vantagens: melhor rendimento global, baixo custo dos reagentes, número reduzido de etapas de síntese com fácil reprodução dos resultados experimentais.Invention Patent: <B> A NEW SYNTHESIS PROCESS OF AZA-SUGARS WITH BIOLOGICAL ACTIVITY <D>. This is a work that demonstrates the preparation of aza-sugars with the following structural formulas: This invention relates to a new process for the synthesis of 1-deoxinojirimmicin (<B> 1 <D>), N-butyl-1 -deoxinojirimicin (<B> 16 <D>), miglitol (<B> 54 <D>) and derivatives. The substances of this invention have the following types of biological activities: anti-HIV, anti-diabetes, anti-hepatitis B and against diseases of metabolism. The process of preparing aza-sugars described in this invention when compared to those previously described in the chemical literature, has the following advantages: better overall yield, low cost of reagents, reduced number of synthesis steps with easy reproduction of experimental results.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BR9902585-0A BR9902585A (en) | 1999-02-11 | 1999-02-11 | A new process for the synthesis of aza-sugars with biological activity |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BR9902585-0A BR9902585A (en) | 1999-02-11 | 1999-02-11 | A new process for the synthesis of aza-sugars with biological activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9902585A true BR9902585A (en) | 2000-09-26 |
Family
ID=4072742
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9902585-0A BR9902585A (en) | 1999-02-11 | 1999-02-11 | A new process for the synthesis of aza-sugars with biological activity |
Country Status (1)
| Country | Link |
|---|---|
| BR (1) | BR9902585A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005039578A3 (en) * | 2003-10-29 | 2005-09-29 | Az Univ Amsterdam | Use of a deoxynojirimycin derivative or a pharmaceutically salt thereof |
| US7528153B2 (en) | 2003-10-29 | 2009-05-05 | Genzyme Corporation | Deoxynojirimycin analogues and their uses as glucosylceramidase inhibitors |
| US7612093B2 (en) | 1997-02-14 | 2009-11-03 | United Therapeutics Corporation | Compositions of treating hepatitis virus infections with N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds in combination therapy |
-
1999
- 1999-02-11 BR BR9902585-0A patent/BR9902585A/en not_active Application Discontinuation
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7612093B2 (en) | 1997-02-14 | 2009-11-03 | United Therapeutics Corporation | Compositions of treating hepatitis virus infections with N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds in combination therapy |
| WO2005039578A3 (en) * | 2003-10-29 | 2005-09-29 | Az Univ Amsterdam | Use of a deoxynojirimycin derivative or a pharmaceutically salt thereof |
| US7528153B2 (en) | 2003-10-29 | 2009-05-05 | Genzyme Corporation | Deoxynojirimycin analogues and their uses as glucosylceramidase inhibitors |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA10 | Dismissal: dismissal - article 33 of industrial property law | ||
| B11N | Dismissal: publication cancelled [chapter 11.14 patent gazette] | ||
| B25C | Requirement related to requested transfer of rights | ||
| B25A | Requested transfer of rights approved |
Owner name: UNIVERSIDADE FEDERAL DO RIO DE JANEIRO - UFRJ (BR/ Free format text: TRANSFERIDO DE: CLAUDIO CERQUEIRA LOPES E ROSANGELA SABATTINI CAPELLA LOPES |
|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: DE ACORDO COM O ART. 37, INDEFIRO O PRESENTE PEDIDO, UMA VEZ QUE: - NAO ATENDE AO REQUISITO DE NOVIDADE, DE ACORDO COM O ART. 8O C/C ART. 11 DA LPI - NAO E CONSIDERADO INVENCAO, DE ACORDO COM O ART. 10 VIII DA LPI |
|
| B12B | Appeal against refusal [chapter 12.2 patent gazette] |