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BR9901551A - Processo para preparação de ácido 13-cis-retinóico. - Google Patents

Processo para preparação de ácido 13-cis-retinóico.

Info

Publication number
BR9901551A
BR9901551A BR9901551-0A BR9901551A BR9901551A BR 9901551 A BR9901551 A BR 9901551A BR 9901551 A BR9901551 A BR 9901551A BR 9901551 A BR9901551 A BR 9901551A
Authority
BR
Brazil
Prior art keywords
cis
retinoic acid
preparing
vinyl
ionol
Prior art date
Application number
BR9901551-0A
Other languages
English (en)
Other versions
BR9901551B1 (pt
Inventor
Angelo Magnone Grato
Original Assignee
Lab Mag Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lab Mag Spa filed Critical Lab Mag Spa
Publication of BR9901551A publication Critical patent/BR9901551A/pt
Publication of BR9901551B1 publication Critical patent/BR9901551B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/20—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by carboxyl groups or halides, anhydrides, or (thio)esters thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/09—Geometrical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrane Compounds (AREA)

Abstract

Patente de Invenção: <B>"PROCESSO PARA PREPARAçãO DE áCIDO 13-CIS-RETINóICO"<D>. Processo para síntese de ácido 13-cis-retinóico com alta pureza e estabilidade, sem uso de metais pesados em qualquer etapa, partindo de vinil-beta-ionol preparado de ionona e halogenetos de vinil magnésio.
BRPI9901551-0A 1998-05-19 1999-05-19 processo para preparação de ácido 13-cis -retinóico. BR9901551B1 (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT98MI001093A IT1299582B1 (it) 1998-05-19 1998-05-19 Procedimento per la preparazione dell'acido 13-cis-retinoico

Publications (2)

Publication Number Publication Date
BR9901551A true BR9901551A (pt) 2000-05-30
BR9901551B1 BR9901551B1 (pt) 2010-10-19

Family

ID=11380052

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI9901551-0A BR9901551B1 (pt) 1998-05-19 1999-05-19 processo para preparação de ácido 13-cis -retinóico.

Country Status (16)

Country Link
US (1) US6177579B1 (pt)
EP (1) EP0959069B1 (pt)
JP (1) JP4418048B2 (pt)
AT (1) ATE226190T1 (pt)
BR (1) BR9901551B1 (pt)
CA (1) CA2272439C (pt)
DE (1) DE69903498T2 (pt)
DK (1) DK0959069T3 (pt)
ES (1) ES2185263T3 (pt)
HU (1) HU229518B1 (pt)
IN (1) IN188476B (pt)
IT (1) IT1299582B1 (pt)
NO (1) NO317759B1 (pt)
PL (1) PL192958B1 (pt)
SG (1) SG80628A1 (pt)
ZA (1) ZA993395B (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7763748B2 (en) * 2007-02-20 2010-07-27 Ipca Laboratories Limited Process for preparation of highly pure isotretinoin
CN104447459A (zh) * 2014-11-28 2015-03-25 重庆华邦制药有限公司 异维a酸的新晶型及其制备方法与应用
CN111454141A (zh) * 2020-04-26 2020-07-28 上海新华联制药有限公司 一种异维a酸缩合物及其制备方法和应用
CN116283495B (zh) * 2021-12-01 2024-12-03 万华化学集团股份有限公司 一种乙烯基-β-紫罗兰醇的制备方法
CN116462621B (zh) * 2023-02-20 2025-05-27 湖北恒安芙林药业股份有限公司 一种维a酸的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3200231A1 (de) 1982-01-07 1983-07-21 Basf Ag, 6700 Ludwigshafen (alpha)-pyrone und verfahren zur herstellung von polyencarbonsaeuren
DE4313089A1 (de) 1993-04-22 1994-10-27 Basf Ag Verfahren zur Herstellung von 13-(Z)-Retinsäure
IT1289528B1 (it) 1996-12-27 1998-10-15 Lab Mag Spa Procedimento per la preparazione dell'acido 13,cis-retinoico

Also Published As

Publication number Publication date
EP0959069B1 (en) 2002-10-16
ZA993395B (en) 1999-11-18
US6177579B1 (en) 2001-01-23
HU229518B1 (hu) 2014-01-28
HUP9901651A2 (hu) 1999-12-28
ATE226190T1 (de) 2002-11-15
SG80628A1 (en) 2001-05-22
JP2000034275A (ja) 2000-02-02
DE69903498T2 (de) 2003-02-27
CA2272439A1 (en) 1999-11-19
DE69903498D1 (de) 2002-11-21
PL192958B1 (pl) 2006-12-29
HU9901651D0 (en) 1999-07-28
PL333200A1 (en) 1999-11-22
NO992396D0 (no) 1999-05-19
ITMI981093A1 (it) 1999-11-19
JP4418048B2 (ja) 2010-02-17
ES2185263T3 (es) 2003-04-16
CA2272439C (en) 2010-05-11
NO317759B1 (no) 2004-12-13
NO992396L (no) 1999-11-22
HUP9901651A3 (en) 2000-06-28
EP0959069A1 (en) 1999-11-24
BR9901551B1 (pt) 2010-10-19
IT1299582B1 (it) 2000-03-16
DK0959069T3 (da) 2003-02-24
IN188476B (pt) 2002-09-28

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Legal Events

Date Code Title Description
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: ALTERADA DA INT.CL C07C 51/00, C07C 403/20, A61P 17/10

Ipc: C07C 51/00 (2009.01), C07C 403/20 (2009.01), A61P

B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 19/10/2010, OBSERVADAS AS CONDICOES LEGAIS.

B25G Requested change of headquarter approved
B25A Requested transfer of rights approved
B25D Requested change of name of applicant approved
B25A Requested transfer of rights approved
B25A Requested transfer of rights approved
B21A Patent or certificate of addition expired [chapter 21.1 patent gazette]

Free format text: PATENTE EXTINTA EM 19.10.2020