BR9900856A - Antibioticos macrolideos de 3,6-cetal e enol-éter - Google Patents
Antibioticos macrolideos de 3,6-cetal e enol-éterInfo
- Publication number
- BR9900856A BR9900856A BR9900856-4A BR9900856A BR9900856A BR 9900856 A BR9900856 A BR 9900856A BR 9900856 A BR9900856 A BR 9900856A BR 9900856 A BR9900856 A BR 9900856A
- Authority
- BR
- Brazil
- Prior art keywords
- formulas
- compounds
- enol
- ether
- parasitic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Communicable Diseases (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Patente de Invenção: <B>"ANTIBIóTICOS MACROLìDEOS DE 3,6-CETAL E ENOL-éTER"<D>. Esta invenção refere-se a compostos de fórmulas <MU>1<MV> e <MU>2<MV> e aos seus sais e solvatos farmaceuticamente aceitáveis, em que X, X^ 1^, R^ 1^, R^ 2^, R^ 7^, R^ 17^ e R^ 19^ são conforme acima definidos. Os compostos de fórmulas <MU>1<MV> e <MU>2<MV> podem ser úteis no tratamento de infecções bacterianas, parasíticas e protozoárias, bem como em distúrbios relacionados com infecções bacterianas, parasíticas e protozoárias, em mamíferos, peixes e aves. A invenção também diz respeito a composições farmacêuticas que contêm os compostos de fórmulas <MU>1<MV> e <MU>2<MV> e a métodos de tratamento de infecções bacterianas, parasíticas e protozoárias pela administração dos compostos de fórmulas <MU>1<MV> e <MU>2<MV>.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7663098P | 1998-03-03 | 1998-03-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9900856A true BR9900856A (pt) | 2000-04-25 |
Family
ID=22133253
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9900856-4A BR9900856A (pt) | 1998-03-03 | 1999-03-03 | Antibioticos macrolideos de 3,6-cetal e enol-éter |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US6043226A (pt) |
| EP (1) | EP0941998B1 (pt) |
| JP (1) | JP3666788B2 (pt) |
| CN (1) | CN1244532A (pt) |
| AR (1) | AR016715A1 (pt) |
| AT (1) | ATE275151T1 (pt) |
| AU (1) | AU741435B2 (pt) |
| BR (1) | BR9900856A (pt) |
| CA (1) | CA2263203C (pt) |
| DE (1) | DE69919769T2 (pt) |
| DK (1) | DK0941998T3 (pt) |
| ES (1) | ES2226282T3 (pt) |
| HU (1) | HUP9900492A3 (pt) |
| NO (1) | NO312366B1 (pt) |
| NZ (1) | NZ334442A (pt) |
| PT (1) | PT941998E (pt) |
| ZA (1) | ZA991664B (pt) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AP1060A (en) * | 1998-01-02 | 2002-04-23 | Pfizer Prod Inc | Novel erythromycin derivatives. |
| AP9801420A0 (en) * | 1998-01-02 | 1998-12-31 | Pfizer Prod Inc | Novel macrolides. |
| BR9914998A (pt) | 1998-11-03 | 2001-07-10 | Pfizer Prod Inc | Antibióticos macrólidos |
| US6590083B1 (en) * | 1999-04-16 | 2003-07-08 | Ortho-Mcneil Pharmaceutical, Inc. | Ketolide antibacterials |
| US6514944B2 (en) * | 1999-04-16 | 2003-02-04 | Kosan Biosciences, Inc. | Macrolide antiinfective agents |
| US6939861B2 (en) | 1999-04-16 | 2005-09-06 | Kosan Biosciences, Inc. | Amido macrolides |
| WO2000063224A2 (en) | 1999-04-16 | 2000-10-26 | Kosan Biosciences, Inc. | Macrolide antiinfective agents |
| US6451768B1 (en) | 1999-04-16 | 2002-09-17 | Kosan Biosciences, Inc. | Macrolide antiinfective agents |
| CA2373117C (en) * | 1999-05-24 | 2006-02-28 | Pfizer Products Inc. | 13-methyl-erythromycin derivatives |
| EP1146051A3 (en) * | 2000-04-10 | 2001-10-31 | Pfizer Products Inc. | Erythromycin A derivatives |
| EP1343879B1 (en) * | 2000-11-07 | 2014-01-08 | Morphotek, Inc. | Methods for isolating novel antimicrobial agents from hypermutable mammalian cells |
| US8063021B2 (en) * | 2002-01-17 | 2011-11-22 | Kosan Biosciences Incorporated | Ketolide anti-infective compounds |
| ITMI20021726A1 (it) | 2002-08-01 | 2004-02-02 | Zambon Spa | Macrolidi ad attivita' antiinfiammatoria. |
| ITMI20022292A1 (it) * | 2002-10-29 | 2004-04-30 | Zambon Spa | 9a-azalidi ad attivita' antiinfiammatoria. |
| WO2004073492A2 (en) * | 2003-02-14 | 2004-09-02 | Massachusetts Eye And Ear Infirmary | Chlamydia pneumoniae associated chronic intraocular disorders and treatment thereof |
| WO2006067589A1 (en) | 2004-12-21 | 2006-06-29 | Pfizer Products Inc. | Macrolides |
| US7517859B2 (en) * | 2005-05-04 | 2009-04-14 | Enanta Pharmaceuticals, Inc. | Spirocyclic bicyclolides |
| MX2010002932A (es) * | 2007-09-17 | 2010-05-27 | Enanta Pharm Inc | Macrolidos de biarilo con puente en 6, 11. |
| WO2018193111A1 (en) * | 2017-04-20 | 2018-10-25 | Novintum Biotechnology Gmbh | Azithromycin derivatives containing a phosphonium ion as anticancer agents |
| CN111148750A (zh) * | 2017-04-20 | 2020-05-12 | 来兴泰德基金会 | 作为抗癌剂的包含鏻离子的阿奇霉素衍生物 |
| GB201706299D0 (en) * | 2017-04-20 | 2017-06-07 | Novintum Biotechnology Gmbh | Compounds |
| WO2018193126A1 (en) * | 2017-04-20 | 2018-10-25 | Novintum Biotechnology Gmbh | Azithromycin derivatives containing a phosphonium ion as antibacterial agents |
| JP2020517748A (ja) * | 2017-04-20 | 2020-06-18 | ライジング タイド ファウンデーション | 抗がん剤としてホスホニウムイオンを含むアジスロマイシン誘導体 |
| WO2018193116A1 (en) * | 2017-04-20 | 2018-10-25 | Novintum Biotechnology Gmbh | Azithromycin derivatives containing a phosphonium ion as anticancer agents |
| WO2018195434A1 (en) | 2017-04-21 | 2018-10-25 | Lisanti Michael P | Vitamin c and doxycycline: a synthetic lethal combination therapy for eradicating cancer stem cells (cscs) |
| EP3612177A4 (en) | 2017-04-21 | 2021-01-13 | Lunella Biotech, Inc. | TARGETING HYPOXIC CARCINOUS STEM CELLS (SCC) USING DOXYCYCLINE: IMPLICATIONS FOR IMPROVING ANTI-ANGIOGENIC THERAPY |
| JP6938682B2 (ja) | 2017-05-19 | 2021-09-22 | ルネラ・バイオテック・インコーポレーテッド | アンチミトシン：癌幹細胞を根絶するためのミトコンドリア生合成の標的阻害薬 |
| US12006553B2 (en) | 2017-05-19 | 2024-06-11 | Lunella Biotech, Inc. | Companion diagnostics for mitochondrial inhibitors |
| IL292109B2 (en) | 2017-06-26 | 2024-02-01 | Lunella Biotech Inc | MITOKETOSCINS: Mitochondrial-Based Therapies Targeting Reduction Metabolism in Cancer Cells |
| GB201817083D0 (en) * | 2018-10-19 | 2018-12-05 | Novintum Biotechnology Gmbh | Compounds |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8721165D0 (en) * | 1987-09-09 | 1987-10-14 | Beecham Group Plc | Chemical compounds |
| EP0344106A3 (de) * | 1988-05-24 | 1990-01-31 | Ciba-Geigy Ag | Blaue Dispersionsfarbstoffe und Mischungen blauer Dispersionsfarbstoffe |
| US5302705A (en) * | 1989-10-07 | 1994-04-12 | Taisho Pharmaceutical Co., Ltd. | 6-O-methylerythromycin a oxime derivatives |
| EP0682038A4 (en) * | 1993-01-26 | 1996-12-27 | Taisho Pharmaceutical Co Ltd | 5-0-DESOSAMINYLERYTHRONOLIDE DERIVATIVE. |
| CA2253338C (en) * | 1996-05-07 | 2007-05-08 | Abbott Laboratories | 6-o-substituted erythromycins and method for making them |
-
1999
- 1999-02-23 ES ES99301325T patent/ES2226282T3/es not_active Expired - Lifetime
- 1999-02-23 PT PT99301325T patent/PT941998E/pt unknown
- 1999-02-23 DE DE69919769T patent/DE69919769T2/de not_active Expired - Fee Related
- 1999-02-23 AT AT99301325T patent/ATE275151T1/de not_active IP Right Cessation
- 1999-02-23 EP EP99301325A patent/EP0941998B1/en not_active Expired - Lifetime
- 1999-02-23 DK DK99301325T patent/DK0941998T3/da active
- 1999-02-25 US US09/257,709 patent/US6043226A/en not_active Expired - Fee Related
- 1999-03-01 CA CA002263203A patent/CA2263203C/en not_active Expired - Fee Related
- 1999-03-01 AR ARP990100858A patent/AR016715A1/es unknown
- 1999-03-02 JP JP05371599A patent/JP3666788B2/ja not_active Expired - Fee Related
- 1999-03-02 NZ NZ334442A patent/NZ334442A/xx unknown
- 1999-03-02 ZA ZA9901664A patent/ZA991664B/xx unknown
- 1999-03-02 HU HU9900492A patent/HUP9900492A3/hu unknown
- 1999-03-02 NO NO19991012A patent/NO312366B1/no not_active IP Right Cessation
- 1999-03-03 AU AU18562/99A patent/AU741435B2/en not_active Ceased
- 1999-03-03 CN CN99105681A patent/CN1244532A/zh active Pending
- 1999-03-03 BR BR9900856-4A patent/BR9900856A/pt not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| HU9900492D0 (en) | 1999-04-28 |
| HUP9900492A2 (hu) | 1999-09-28 |
| HUP9900492A3 (en) | 2001-08-28 |
| ATE275151T1 (de) | 2004-09-15 |
| AU741435B2 (en) | 2001-11-29 |
| ES2226282T3 (es) | 2005-03-16 |
| ZA991664B (en) | 2000-10-12 |
| US6043226A (en) | 2000-03-28 |
| CA2263203A1 (en) | 1999-09-03 |
| EP0941998A3 (en) | 1999-10-06 |
| NZ334442A (en) | 2000-03-27 |
| DE69919769T2 (de) | 2005-01-27 |
| NO991012D0 (no) | 1999-03-02 |
| NO312366B1 (no) | 2002-04-29 |
| CA2263203C (en) | 2002-09-03 |
| EP0941998B1 (en) | 2004-09-01 |
| NO991012L (no) | 1999-09-06 |
| AR016715A1 (es) | 2001-07-25 |
| JPH11315093A (ja) | 1999-11-16 |
| DK0941998T3 (da) | 2004-09-20 |
| EP0941998A2 (en) | 1999-09-15 |
| DE69919769D1 (de) | 2004-10-07 |
| CN1244532A (zh) | 2000-02-16 |
| PT941998E (pt) | 2004-12-31 |
| AU1856299A (en) | 1999-09-16 |
| JP3666788B2 (ja) | 2005-06-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 8A E 9A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO PUBLICADO1976 DE 18/11/2008. |