BR9900523A - Pharmaceutical composition of spiny proteins and their use - Google Patents
Pharmaceutical composition of spiny proteins and their useInfo
- Publication number
- BR9900523A BR9900523A BR9900523-9A BR9900523A BR9900523A BR 9900523 A BR9900523 A BR 9900523A BR 9900523 A BR9900523 A BR 9900523A BR 9900523 A BR9900523 A BR 9900523A
- Authority
- BR
- Brazil
- Prior art keywords
- spiny
- vehicle
- protein
- proteins
- pharmaceutical composition
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title abstract 7
- 108090000623 proteins and genes Proteins 0.000 title abstract 7
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- 229920000936 Agarose Polymers 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 230000003111 delayed effect Effects 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 239000000178 monomer Substances 0.000 abstract 1
- 230000007935 neutral effect Effects 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Biological Depolymerization Polymers (AREA)
- Medicines Containing Plant Substances (AREA)
- Steroid Compounds (AREA)
Abstract
Patente de Invenção: <B>"COMPOSIçãO FARMACêUTICA DE PROTEìNAS ESPINHOSAS E USO DAS MESMAS"<D>. Composição farmacêutica de uma proteína espinhosa, que é caracterizada pelo fato de a proteína espinhosa estar ligada a um veículo hidrofílico que é biocompatível e biodegradável, em que o veículo é um polímero que - se liga à proteína espinhosa como um veículo negativamente carregado, como resultado de interações iónicas, - não desnatura a proteína espinhosa quando ela se liga ao veículo, - contém pelo menos de 0,1 a 2 resíduos negativamente carregados por monómero sob condições neutras, - contém a carga na forma de grupos ácidos, - tem um peso molecular médio de pelo menos 50.000 Da, - e não contém agarose, que libera de maneira reversível e ativa proteínas espinhosas 'in vivo' de um veículo, de maneira retardada.Invention Patent: <B> "PHARMACEUTICAL COMPOSITION OF SPINY PROTEINS AND USE OF THE SAME" <D>. Pharmaceutical composition of a spiny protein, which is characterized by the fact that the spiny protein is linked to a hydrophilic vehicle that is biocompatible and biodegradable, in which the vehicle is a polymer that - binds to the spiny protein as a negatively charged vehicle, as a result of ionic interactions, - does not denature the spiny protein when it binds to the vehicle, - contains at least 0.1 to 2 negatively charged residues per monomer under neutral conditions, - contains the charge in the form of acidic groups, - has a weight average molecular weight of at least 50,000 Da, - and does not contain agarose, which reversibly releases and activates thorny proteins 'in vivo' from a vehicle, in a delayed manner.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98101893 | 1998-02-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9900523A true BR9900523A (en) | 2000-05-02 |
Family
ID=8231349
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9900523-9A BR9900523A (en) | 1998-02-04 | 1999-02-03 | Pharmaceutical composition of spiny proteins and their use |
Country Status (8)
| Country | Link |
|---|---|
| AR (1) | AR014530A1 (en) |
| BR (1) | BR9900523A (en) |
| HR (1) | HRP990036A2 (en) |
| ID (1) | ID22356A (en) |
| PE (1) | PE20000241A1 (en) |
| PL (1) | PL331201A1 (en) |
| TR (1) | TR199900197A2 (en) |
| ZA (1) | ZA99887B (en) |
-
1999
- 1999-02-01 PE PE1999000072A patent/PE20000241A1/en not_active Application Discontinuation
- 1999-02-02 TR TR1999/00197A patent/TR199900197A2/en unknown
- 1999-02-02 ID IDP990071D patent/ID22356A/en unknown
- 1999-02-02 AR ARP990100423 patent/AR014530A1/en unknown
- 1999-02-03 PL PL33120199A patent/PL331201A1/en unknown
- 1999-02-03 HR HRP990036 patent/HRP990036A2/en not_active Application Discontinuation
- 1999-02-03 BR BR9900523-9A patent/BR9900523A/en not_active IP Right Cessation
- 1999-02-04 ZA ZA9900887A patent/ZA99887B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL331201A1 (en) | 1999-08-16 |
| ZA99887B (en) | 1999-08-04 |
| HRP990036A2 (en) | 1999-08-31 |
| AR014530A1 (en) | 2001-02-28 |
| TR199900197A2 (en) | 1999-08-23 |
| PE20000241A1 (en) | 2000-04-08 |
| ID22356A (en) | 1999-10-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| TC | Change of proprietor's name | ||
| B08F | Application fees: dismissal - article 86 of industrial property law |
Free format text: REFERENTE A 3A, 4A, 5A, 6A, 7A E 8A ANUDIDADES |
|
| B08K | Lapse as no evidence of payment of the annual fee has been furnished to inpi (acc. art. 87) |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1909 DE 07/08/2007. |
|
| B15K | Others concerning applications: alteration of classification |
Ipc: A61K 9/22 (2006.01), A61K 31/728 (2006.0 |