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BR9815580A - Vaccine composition, processes to generate an anti-idiotype response in a subject, to treat or prevent cancer, to treat or prevent an infectious disease, to prepare a first immunoglobulin molecule, and, first immunoglobulin molecule - Google Patents

Vaccine composition, processes to generate an anti-idiotype response in a subject, to treat or prevent cancer, to treat or prevent an infectious disease, to prepare a first immunoglobulin molecule, and, first immunoglobulin molecule

Info

Publication number
BR9815580A
BR9815580A BR9815580-6A BR9815580A BR9815580A BR 9815580 A BR9815580 A BR 9815580A BR 9815580 A BR9815580 A BR 9815580A BR 9815580 A BR9815580 A BR 9815580A
Authority
BR
Brazil
Prior art keywords
treat
prevent
immunoglobulin molecule
processes
generate
Prior art date
Application number
BR9815580-6A
Other languages
Portuguese (pt)
Inventor
Ronald M Burch
Original Assignee
Euro Celtique Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Euro Celtique Sa filed Critical Euro Celtique Sa
Publication of BR9815580A publication Critical patent/BR9815580A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4208—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
    • C07K16/4241—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig
    • C07K16/4258—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig against anti-receptor Ig
    • C07K16/4266—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig against anti-receptor Ig against anti-tumor receptor Ig
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3046—Stomach, Intestines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/18—Kallidins; Bradykinins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2318/00—Antibody mimetics or scaffolds
    • C07K2318/10—Immunoglobulin or domain(s) thereof as scaffolds for inserted non-Ig peptide sequences, e.g. for vaccination purposes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • AIDS & HIV (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

"COMPOSIçãO DE VACINA, PROCESSOS PARA GERAR UMA RESPOSTA DE ANTI-IDIóTIPO EM UM SUJEITO, PARA TRATAR OU PREVENIR CâNCER, PARA TRATAR OU PREVENIR UMA DOENçA INFECCIOSA, PARA PREPARAR UMA PRIMEIRA MOLéCULA DE IMUNOGLOBULINA, E, PRIMEIRA MOLéCULA DE IMUNOGLOBULINA". A invenção refere-se às moléculas de imunoglobulina modificada nas quais um ou mais resíduos de região variável que formam pontes de dissulfeto de intracadeias são substituídos por resíduos de aminoácido que não contêm grupos sulfidrila, de tal modo que não possa ser formada a ponte de dissulfeto de intracadeia. Tais moléculas de imunoglobulina apresentam uma capacidade aumentada de gerar uma resposta de anti-idiótipo. A invenção proporciona adicionalmente os processos para prevenção e tratamento de câncer e/ou de doenças infecciosas usando as imunoglobulinas modificadas da invenção."VACCINE COMPOSITION, PROCESSES TO GENERATE AN ANTI-IDIOTYPE RESPONSE IN A SUBJECT, TO TREAT OR PREVENT CANCER, TO TREAT OR PREVENT AN INFECTIOUS DISEASE, TO PREPARE A FIRST IMMUNOGLOBULINE MOLECULE, AND, IMMOLCULINE, AND IMMOLCULINE. The invention relates to modified immunoglobulin molecules in which one or more residues of variable region that form intrachain disulfide bridges are replaced by amino acid residues that do not contain sulfhydryl groups, so that the disulfide bridge cannot be formed of intrachain. Such immunoglobulin molecules have an increased ability to generate an anti-idiotype response. The invention further provides the processes for preventing and treating cancer and / or infectious diseases using the modified immunoglobulins of the invention.

BR9815580-6A 1997-11-14 1998-11-13 Vaccine composition, processes to generate an anti-idiotype response in a subject, to treat or prevent cancer, to treat or prevent an infectious disease, to prepare a first immunoglobulin molecule, and, first immunoglobulin molecule BR9815580A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6571697P 1997-11-14 1997-11-14
US8140398P 1998-04-10 1998-04-10
PCT/US1998/024303 WO1999025379A1 (en) 1997-11-14 1998-11-13 Modified antibodies with enhanced ability to elicit an anti-idiotype response

Publications (1)

Publication Number Publication Date
BR9815580A true BR9815580A (en) 2002-01-29

Family

ID=26745908

Family Applications (2)

Application Number Title Priority Date Filing Date
BR9815289-0A BR9815289A (en) 1997-11-14 1998-11-13 Modified immunoglobulin, molecule, isolated nucleic acid, cell containing the same, recombinant non-human animal, pharmaceutical composition, vaccine composition, processes for identifying or measuring or detecting a cancer antigen, an antigen from an infectious disease agent, a ligand, and a receptor in a sample. to be tested, kits for detecting a cancer antigen, an infectious disease agent antigen, a cell receptor for an infectious disease agent, a ligand, and a cancer antigen, diagnostic processes or testing for the presence of or a predisposition for the development of a cancer by the increased presence of a cancer antigen, and for the presence of an infectious disease, treatment or prevention of a cancer by the presence of a cancer antigen, of an infectious disease typified by the presence of an antigen infectious disease agent, and a disease caused by an infectious disease agent that binds to a cell receptor, processes for modulating activity of a first member of a binding pair, process for producing a modified immunoglobulin, process for producing a modified immunoglobulin nucleic acid, and, isolated nucleic acid
BR9815580-6A BR9815580A (en) 1997-11-14 1998-11-13 Vaccine composition, processes to generate an anti-idiotype response in a subject, to treat or prevent cancer, to treat or prevent an infectious disease, to prepare a first immunoglobulin molecule, and, first immunoglobulin molecule

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BR9815289-0A BR9815289A (en) 1997-11-14 1998-11-13 Modified immunoglobulin, molecule, isolated nucleic acid, cell containing the same, recombinant non-human animal, pharmaceutical composition, vaccine composition, processes for identifying or measuring or detecting a cancer antigen, an antigen from an infectious disease agent, a ligand, and a receptor in a sample. to be tested, kits for detecting a cancer antigen, an infectious disease agent antigen, a cell receptor for an infectious disease agent, a ligand, and a cancer antigen, diagnostic processes or testing for the presence of or a predisposition for the development of a cancer by the increased presence of a cancer antigen, and for the presence of an infectious disease, treatment or prevention of a cancer by the presence of a cancer antigen, of an infectious disease typified by the presence of an antigen infectious disease agent, and a disease caused by an infectious disease agent that binds to a cell receptor, processes for modulating activity of a first member of a binding pair, process for producing a modified immunoglobulin, process for producing a modified immunoglobulin nucleic acid, and, isolated nucleic acid

Country Status (9)

Country Link
EP (2) EP1030684A4 (en)
JP (2) JP2002507544A (en)
KR (2) KR20010015817A (en)
CN (2) CN1294517A (en)
AU (2) AU763029B2 (en)
BR (2) BR9815289A (en)
CA (2) CA2309990A1 (en)
IL (2) IL136114A0 (en)
WO (2) WO1999025378A1 (en)

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AU2001261628A1 (en) * 2000-05-16 2001-11-26 Euroceltique S.A. Cd28 synthebody for the modulation of immune responses
US7396917B2 (en) 2000-12-05 2008-07-08 Alexion Pharmaceuticals, Inc. Rationally designed antibodies
ES2316919T3 (en) 2000-12-05 2009-04-16 Alexion Pharmaceuticals, Inc. RATIONALALLY DESIGNED ANTIBODIES.
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AU2002307064A1 (en) * 2001-04-02 2002-10-15 Purdue Pharma L.P. Immunoglobulin construct containing anti-mucin variable domain sequences for eliciting an anti-idiotype anti-tumor response
AU2002365926A1 (en) * 2001-10-25 2003-09-02 Euro-Celtique S.A. Compositions and methods directed to anthrax toxin
EP1938834B1 (en) * 2002-04-09 2012-04-25 The Curators Of The University Of Missouri Treatment of type 1 diabetes before and after expression of predisposition markers
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US20090208486A1 (en) * 2004-03-09 2009-08-20 Makoto Taketo Pharmaceutical composition comprising cxcr3 inhibitor
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EA019517B1 (en) * 2008-03-12 2014-04-30 Имклоун Элэлси Anti-tyrp1 antibodies and use thereof
ES2495367T3 (en) * 2009-04-29 2014-09-17 The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. ERG monoclonal antibodies
CN102816240B (en) * 2011-03-08 2014-02-12 中国人民解放军第三军医大学第二附属医院 A fusion protein and its fusion protein expression vector
CA2837472A1 (en) * 2011-05-27 2012-12-06 Fox Chase Cancer Center Rationally-designed anti-mullerian inhibiting substance type ii receptor antibodies
CN108864261A (en) * 2011-11-23 2018-11-23 拜奥文斯瑞有限公司 Recombinant proteins and their therapeutic uses
JP5437525B1 (en) 2012-12-28 2014-03-12 株式会社ナード研究所 Tyrosine derivative and method for producing tyrosine derivative
US20160206732A1 (en) * 2013-05-14 2016-07-21 Shanghai Hycharm Inc. Epitope vaccine for low immunogenic protein and preparing method and usage thereof
CN103275914B (en) * 2013-06-03 2015-04-01 中国人民解放军军事医学科学院微生物流行病研究所 Bacterial ghost presenting protective antigens and application thereof
CN105263953B (en) * 2014-01-15 2020-01-07 勃林格殷格翰动物保健美国有限公司 Porcine parvovirus 5A, method of use and vaccine
CN107073089A (en) * 2014-05-19 2017-08-18 瓦洛治疗公司 coated oncolytic adenovirus for cancer vaccine
CN105693859B (en) * 2016-03-22 2019-06-21 苏州莱泰生物科技有限公司 Anti-human G2A monoclonal antibody and the kit for detecting human macrophage G2A expression quantity
CN111978382B (en) * 2020-09-03 2022-03-04 吉林大学第一医院 Preparation method and application of recombinant protein of Sporothrix globosum Gp70
CN112646029B (en) * 2020-12-30 2022-07-29 深圳清华大学研究院 Antibody of mature brain-derived neurotrophic factor, application thereof and diagnostic kit
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Also Published As

Publication number Publication date
AU1459799A (en) 1999-06-07
JP2002507544A (en) 2002-03-12
WO1999025378A1 (en) 1999-05-27
EP1030684A4 (en) 2004-09-15
EP1032420A1 (en) 2000-09-06
KR20010015817A (en) 2001-02-26
KR20010015818A (en) 2001-02-26
AU1459899A (en) 1999-06-07
JP2001526021A (en) 2001-12-18
AU763029B2 (en) 2003-07-10
EP1032420A4 (en) 2004-09-15
WO1999025378A9 (en) 1999-08-12
IL136114A0 (en) 2001-05-20
CA2309990A1 (en) 1999-05-27
WO1999025379A1 (en) 1999-05-27
AU2003252902A1 (en) 2003-11-06
CN1327388A (en) 2001-12-19
AU737457B2 (en) 2001-08-23
CN1294517A (en) 2001-05-09
BR9815289A (en) 2001-12-26
IL136113A0 (en) 2001-05-20
CA2310269A1 (en) 1999-05-27
EP1030684A1 (en) 2000-08-30

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

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B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1890 DE 27/03/2007.