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BR9813808A - Processo para produção de comprimidos para dispersão na mordida - Google Patents

Processo para produção de comprimidos para dispersão na mordida

Info

Publication number
BR9813808A
BR9813808A BR9813808-1A BR9813808A BR9813808A BR 9813808 A BR9813808 A BR 9813808A BR 9813808 A BR9813808 A BR 9813808A BR 9813808 A BR9813808 A BR 9813808A
Authority
BR
Brazil
Prior art keywords
bite
tablets
dispersion
producing tablets
producing
Prior art date
Application number
BR9813808-1A
Other languages
English (en)
Inventor
Gopadi M Venkatesh
Nageswara R Palepu
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of BR9813808A publication Critical patent/BR9813808A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

"PROCESSO PARA PRODUçãO DE COMPRIMIDOS PARA DISPERSãO NA MORDIDA". A invenção refere-se a um método para produção de comprimidos que se desintegram com uma mordida e que se dispersam fácil e rapidamente na cavidade bucal, após uma leve mordida, sem auxílio de água e, caso necessário, incluem a dissimulação do sabor amargo dos medicamentos. O processo compreende preparar uma granulação seca de um ou mais dos medicamentos misturados com excipientes adequados, aromatizantes e uma combinação de um material ceroso e fosfolipídeo ( BMI-60 ) ou um adoçante intenso derivado de flavonóides de fruta ( Neohesperidina ) para dissimulação do sabor e compressão em comprimidos, que podem ser embalados em frascos ou empolas usando equipamento convencional.
BR9813808-1A 1997-12-19 1998-12-17 Processo para produção de comprimidos para dispersão na mordida BR9813808A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6825897P 1997-12-19 1997-12-19
PCT/US1998/027061 WO1999032092A1 (en) 1997-12-19 1998-12-17 Process for manufacturing bite-dispersion tablets

Publications (1)

Publication Number Publication Date
BR9813808A true BR9813808A (pt) 2002-05-28

Family

ID=22081416

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9813808-1A BR9813808A (pt) 1997-12-19 1998-12-17 Processo para produção de comprimidos para dispersão na mordida

Country Status (20)

Country Link
US (1) US6475510B1 (pt)
EP (1) EP1047407A4 (pt)
JP (1) JP2001526212A (pt)
KR (1) KR100775154B1 (pt)
CN (1) CN100379407C (pt)
AR (1) AR014133A1 (pt)
AU (2) AU1931999A (pt)
BR (1) BR9813808A (pt)
CA (1) CA2315088A1 (pt)
CO (1) CO4990940A1 (pt)
HU (1) HUP0100469A2 (pt)
IL (2) IL136831A0 (pt)
NO (1) NO20003150L (pt)
NZ (1) NZ505123A (pt)
PL (1) PL197989B1 (pt)
SA (1) SA99191111B1 (pt)
TR (1) TR200001856T2 (pt)
TW (1) TW586943B (pt)
WO (1) WO1999032092A1 (pt)
ZA (1) ZA9811630B (pt)

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Also Published As

Publication number Publication date
AU2002300238C1 (en) 2004-03-04
PL341353A1 (en) 2001-04-09
ZA9811630B (en) 1999-06-21
TR200001856T2 (tr) 2000-11-21
CO4990940A1 (es) 2000-12-26
NO20003150L (no) 2000-08-11
SA99191111B1 (ar) 2006-10-11
HUP0100469A2 (hu) 2001-08-28
SA99191111A (ar) 2005-12-03
AR014133A1 (es) 2001-02-07
CN1284867A (zh) 2001-02-21
PL197989B1 (pl) 2008-05-30
TW586943B (en) 2004-05-11
NO20003150D0 (no) 2000-06-16
NZ505123A (en) 2003-07-25
CA2315088A1 (en) 1999-07-01
EP1047407A1 (en) 2000-11-02
US6475510B1 (en) 2002-11-05
EP1047407A4 (en) 2007-05-02
AU1931999A (en) 1999-07-12
AU2002300238B2 (en) 2003-01-02
KR20010033328A (ko) 2001-04-25
JP2001526212A (ja) 2001-12-18
IL136831A0 (en) 2001-06-14
KR100775154B1 (ko) 2007-11-12
IL136831A (en) 2006-12-10
CN100379407C (zh) 2008-04-09
WO1999032092A1 (en) 1999-07-01

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