[go: up one dir, main page]

BR9812928A - Novos derivados de 3-oxo-(2h) -1,2,4-triazina, processo de preparação de compostos quìmicos, e, composição farmacêutica - Google Patents

Novos derivados de 3-oxo-(2h) -1,2,4-triazina, processo de preparação de compostos quìmicos, e, composição farmacêutica

Info

Publication number
BR9812928A
BR9812928A BR9812928-7A BR9812928A BR9812928A BR 9812928 A BR9812928 A BR 9812928A BR 9812928 A BR9812928 A BR 9812928A BR 9812928 A BR9812928 A BR 9812928A
Authority
BR
Brazil
Prior art keywords
alkyl
optionally substituted
group
oxo
hydrogen
Prior art date
Application number
BR9812928-7A
Other languages
English (en)
Other versions
BR9812928B1 (pt
Inventor
Jean-Francois Patoisseau
Elisabeth Dupont-Passelaigue
Wouter Koek
Original Assignee
Pf Medicament
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pf Medicament filed Critical Pf Medicament
Publication of BR9812928A publication Critical patent/BR9812928A/pt
Publication of BR9812928B1 publication Critical patent/BR9812928B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D253/075—Two hetero atoms, in positions 3 and 5
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

"DERIVADOS DE 3-OXO-(2H)-1,2,4-TRIAZINA, PROCESSO DE PREPARAçãO DE COMPOSTOS QUìMICOS, E, COMPOSIçãO FARMACêUTICA". A invenção refere-se a novos derivados de 3-oxo-(2H)-1,2,4-triazina de fórmula geral I em que - R ~ 1~ representa <sym> hidrogênio, quando A é um átomo de nitrogênio eventualmente substituído. <sym> um grupo alquila C~ 1~C~ 4~ linear ou ramificado; <sym> um grupo fenilalquila C~ 1~-C~ 4~, o núcleo fenila sendo eventualmente substituído por um ou vários grupamentos como alquila C~ 1~-C~ 4~, alcoxi C~ 1~-C~ 3~, halogênio, trilfuorometila, - R~ 2~ representa <sym> hidrogênio, <sym> um radical alquila C~ 1~-C~ 4~, linear ou ramificado; <sym> um grupamento fenila ou fenil alquila C~ 1~-C~ 4~, o núcleo fenila sendo eventualmente substituído por um ou vários grupamentos como alquila C~ 1~-C~ 4~, alcoxi C~ 1~-C~ 3~, halogênio, trilfuorometila, - A representa um átomo de oxigênio ou um átomo de nitrogênio eventualmente substituído NR~ 3~, - R~ 3~ representa hidrogênio ou um grupo metila, - B representa um grupamento de tipo (IIa)
BRPI9812928-7A 1997-10-16 1998-10-14 derivados de 3-oxo-(2h)-1,2,4-triazina, compostos, processo de preparaÇço de compostos quÍmicos, e, composiÇço farmacÊutica. BR9812928B1 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9712955A FR2769912B1 (fr) 1997-10-16 1997-10-16 Nouveaux derives de la 3-oxo- (2h)-1,2,4 triazine leur preparation et leur application en therapeutique humaine
PCT/FR1998/002205 WO1999020622A1 (fr) 1997-10-16 1998-10-14 Derives de la 3-oxo-2(h)-1,2,4-triazine en tant que ligands des recepteurs 5ht1a

Publications (2)

Publication Number Publication Date
BR9812928A true BR9812928A (pt) 2000-08-08
BR9812928B1 BR9812928B1 (pt) 2013-03-19

Family

ID=9512298

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI9812928-7A BR9812928B1 (pt) 1997-10-16 1998-10-14 derivados de 3-oxo-(2h)-1,2,4-triazina, compostos, processo de preparaÇço de compostos quÍmicos, e, composiÇço farmacÊutica.

Country Status (14)

Country Link
US (1) US6303603B1 (pt)
EP (1) EP1023287B1 (pt)
JP (1) JP4413424B2 (pt)
CN (1) CN1128147C (pt)
AT (1) ATE219076T1 (pt)
AU (1) AU761653B2 (pt)
BR (1) BR9812928B1 (pt)
CA (1) CA2306428C (pt)
DE (1) DE69806036T2 (pt)
DK (1) DK1023287T3 (pt)
ES (1) ES2177063T3 (pt)
FR (1) FR2769912B1 (pt)
PT (1) PT1023287E (pt)
WO (1) WO1999020622A1 (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001085168A1 (en) * 2000-05-12 2001-11-15 Solvay Pharmaceuticals B.V. Use of compounds having combined dopamine d2, 5-ht1a and alpha adrenoreceptor agonistic action for treating cns disorders
EP1558589A4 (en) * 2002-10-11 2008-01-09 Cytokinetics Inc COMPOUNDS, COMPOSITIONS AND METHODS
US7160888B2 (en) 2003-08-22 2007-01-09 Warner Lambert Company Llc [1,8]naphthyridin-2-ones and related compounds for the treatment of schizophrenia
EP1856126A2 (en) * 2005-02-17 2007-11-21 Wyeth a Corporation of the State of Delaware Cycloalkylfused indole, benzothiophene, benzofuran and indene derivatives

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2707294B1 (fr) * 1993-07-06 1995-09-29 Pf Medicament Nouveaux dérivés de la 3,5-dioxo-(2H,4H)-1,2,4-triazine, leur préparation et leur application en thérapeutique humaine.
DE4442229A1 (de) * 1994-11-28 1996-05-30 Hoechst Schering Agrevo Gmbh Alkylidenhydrazinophenylsulfonylharnstoffe, Verfahren zu ihrer Herstellung und ihre Verwendung als Herbizide und Pflanzenwachstumsregulatoren
FR2727682A1 (fr) * 1994-12-02 1996-06-07 Pf Medicament Nouveaux derives de 3,5-dioxo-(2h,4h)-1,2,4-triazines, leur preparation et leur application a titre de medicament

Also Published As

Publication number Publication date
CA2306428A1 (fr) 1999-04-29
EP1023287B1 (fr) 2002-06-12
PT1023287E (pt) 2002-11-29
AU9545798A (en) 1999-05-10
DK1023287T3 (da) 2002-10-14
BR9812928B1 (pt) 2013-03-19
DE69806036T2 (de) 2003-01-30
EP1023287A1 (fr) 2000-08-02
DE69806036D1 (de) 2002-07-18
CA2306428C (fr) 2010-01-12
WO1999020622A1 (fr) 1999-04-29
ATE219076T1 (de) 2002-06-15
ES2177063T3 (es) 2002-12-01
US6303603B1 (en) 2001-10-16
JP4413424B2 (ja) 2010-02-10
JP2001520226A (ja) 2001-10-30
CN1278815A (zh) 2001-01-03
FR2769912A1 (fr) 1999-04-23
AU761653B2 (en) 2003-06-05
CN1128147C (zh) 2003-11-19
FR2769912B1 (fr) 2000-03-10

Similar Documents

Publication Publication Date Title
ATE169008T1 (de) 3,5-dioxo-(2h,4h)-1,2,4-triazinderivate ihre herstellung und verwendung als medikament
CO4970780A1 (es) Nuevos compuestos heterociclicos de piridazina
DE69332792D1 (de) 4,1-Benzoxazepinderivate als Squalen-Synthetase Inhibitoren und ihre Verwendung zur Behandlung von Hypercholesterämie und als Fungizide
PH12015501098A1 (en) Antituberculous composition comprising oxazole compounds
ES2176311T3 (es) Nuevos derivados imidazol y procedimiento para su preparacion.
BG104287A (en) Halogensubstituted tetracyclic derivatives of tetrahydrofuran
PL327466A1 (en) Novel derivatives of barbituric acid, method of obtaining them and pharmaceutic agents containing such compounds
EP1184373A4 (en) TRICYCLIC CONNECTIONS
HUP0001165A2 (hu) NK1 és NK2 antagonista hatású acil-amino-alkil-amid-származékok, a vegyületeket tartalmazó gyógyszerkészítmények, eljárás előállításukra
DK0947504T3 (da) 16-en-vitamin D-derivater
NO955328L (no) Pyridazinon-derivater
YU43902A (sh) Novi razgranati supstituisani amino derivati od 3-amino-1- -fenil-1h(1,2,4) triazola, postupak za njihovo dobijanje i farmaceutski preparati koji ih sadrže
BR9812928A (pt) Novos derivados de 3-oxo-(2h) -1,2,4-triazina, processo de preparação de compostos quìmicos, e, composição farmacêutica
MY109714A (en) Process for preparing 8-chloroquinolone derivatives
MXPA04000371A (es) 6- (2-tolil) - triazolopirimidinas substituidas.
DE69915471D1 (de) Analoga von distamycin-zimtsäurederivaten, verfahren zu ihrer herstellung und ihre verwendung als antitumormittel
TW350843B (en) 2-(4-pyrazolyloxy-pyrimidin-5-yl) acetic acid derivatives
DE69626624D1 (de) Medikamente gegen trhombocytopenie
EP1340753A4 (en) CARBAMATE DERIVATIVES, AND METHOD FOR THE PRODUCTION AND USE THEREOF
DE69217148D1 (de) Isoxazole derivate als lichtschutzmittel
DE60239324D1 (de) Phenyl- und pyridyl-piperidine mit tnf-wirkung
YU28701A (sh) N-(2-(heteroaril)etil)-3-fenilpiperidini, n-(2-(heteroaril) etil)-4-fenilpiperidin i srodna jedinjenja sa supstituentom u položaju 4 piperidinskog prstena

Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: ALTERADA DA INT. CL 6: A61K 31/35; C07D 403/12; C07D 253/06; C07D 405/12; C07D 471/04; A61P 25/00

Ipc: A61K 31/53 (2007.10), C07D 403/12 (2007.10), C07D

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRIDO O PRESENTE PEDIDO, UMA QUE NAO ATENDE AOS ARTS. 24 E 25 DA LPI.

B12B Appeal against refusal [chapter 12.2 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 19/03/2013, OBSERVADAS AS CONDICOES LEGAIS. DESCONSIDERAR A PALAVRA "NOVOS" NO INICIO DO TITULO DO RESUMO.

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 18A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2385 DE 20-09-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.