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BR9812649A - Compounds containing six-membered rings, process for their preparation, and their use as medicines - Google Patents

Compounds containing six-membered rings, process for their preparation, and their use as medicines

Info

Publication number
BR9812649A
BR9812649A BR9812649-0A BR9812649A BR9812649A BR 9812649 A BR9812649 A BR 9812649A BR 9812649 A BR9812649 A BR 9812649A BR 9812649 A BR9812649 A BR 9812649A
Authority
BR
Brazil
Prior art keywords
compounds
medicines
preparation
neuraminidase
compounds containing
Prior art date
Application number
BR9812649-0A
Other languages
Portuguese (pt)
Inventor
Norbert W Bischofberger
Terrence C Dahl
Michael J M Hitchcock
Choung U Kim
Willard Lew
Hongtao Liu
Roger G Mills
Matthew A Williams
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of BR9812649A publication Critical patent/BR9812649A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C233/62—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/52—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C233/63—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/16—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Patente de Invenção: <B>"COMPOSTOS CONTENDO ANéIS DE SEIS MEMBROS, PROCESSO PARA SUA PREPARAçãO, E SEU USO COMO MEDICAMENTOS"<D> São descritos compostos novos. Os compostos geralmente compreendem um grupo ácido, um grupo básico, um amino ou N-acila substituídos e um grupo tendo uma porção alcano opcionalmente hidroxilada. Composições farmacêuticas compreendendo os inibidores da invenção também estão descritas. Métodos para inibir neuraminidase em amostras suspeitas de conter neuraminidase também estão descritos. Materiais antigênicos, polímeros, anticorpos, conjugados dos compostos da invenção com rótulos, e métodos de ensaio para detectar atividade de neuraminidase também estão descritos.Invention Patent: <B> "COMPOUNDS CONTAINING SIX-MEMBER RINGS, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS MEDICINES" <D> New compounds are described. The compounds generally comprise an acid group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane moiety. Pharmaceutical compositions comprising the inhibitors of the invention are also described. Methods for inhibiting neuraminidase in samples suspected of containing neuraminidase are also described. Antigenic materials, polymers, antibodies, conjugates of the compounds of the invention with labels, and assay methods for detecting neuraminidase activity are also described.

BR9812649-0A 1997-09-17 1998-09-15 Compounds containing six-membered rings, process for their preparation, and their use as medicines BR9812649A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US5930897P 1997-09-17 1997-09-17
US93864497A 1997-09-26 1997-09-26
US6019597P 1997-09-26 1997-09-26
PCT/US1998/019355 WO1999014185A1 (en) 1997-09-17 1998-09-15 Compounds containing six-membered rings, processes for their preparation, and their use as medicaments

Publications (1)

Publication Number Publication Date
BR9812649A true BR9812649A (en) 2000-08-22

Family

ID=27369627

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9812649-0A BR9812649A (en) 1997-09-17 1998-09-15 Compounds containing six-membered rings, process for their preparation, and their use as medicines

Country Status (15)

Country Link
EP (1) EP1015417A1 (en)
JP (1) JP2001516739A (en)
KR (1) KR20010024123A (en)
CN (1) CN1272105A (en)
AR (1) AR013960A1 (en)
AU (1) AU747702B2 (en)
BR (1) BR9812649A (en)
CA (1) CA2303323A1 (en)
EA (1) EA003989B1 (en)
ID (1) ID25516A (en)
IL (1) IL134691A0 (en)
IN (1) IN190983B (en)
NZ (1) NZ502988A (en)
TR (1) TR200000723T2 (en)
WO (1) WO1999014185A1 (en)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA9811595B (en) * 1997-12-17 2000-06-19 Biocryst Pharm Inc Substituted cyclopentane and cyclopentene compounds useful as neuraminidase inhibitors.
US6455571B1 (en) 1998-04-23 2002-09-24 Abbott Laboratories Inhibitors of neuraminidases
US6518305B1 (en) 1998-04-23 2003-02-11 Abbott Laboratories Five-membered carbocyclic and heterocyclic inhibitors of neuraminidases
ES2198244T3 (en) * 1999-06-11 2004-02-01 F. Hoffmann-La Roche Ag PROCEDURE FOR PREPARATION OF RO-64-0796 INHIBITOR OF NEURAMINIDASA.
BR0010525A (en) * 1999-10-19 2002-11-26 Abbott Lab  1-cyclohexene-1-carboxylic acid and 1-cyclohexene-1carboxylates as neuraminidase inhibitors
US6593314B1 (en) 1999-10-19 2003-07-15 Abbott Laboratories Neuraminidase inhibitors
JP2001131144A (en) * 1999-11-02 2001-05-15 Sagami Chem Res Center Method for producing 7-azabicyclo [4.1.0] hept-3-en-3-carboxylic acid esters
US6403824B2 (en) * 2000-02-22 2002-06-11 Hoffmann-La Roche Inc. Process for the preparation for 4,5-diamino shikimic acid derivatives
WO2001080892A1 (en) * 2000-04-25 2001-11-01 Sankyo Company, Limited Preventives for influenza
WO2002092555A1 (en) * 2001-05-11 2002-11-21 Sankyo Company, Limited Sialic acid derivatives
US7122684B2 (en) 2003-03-13 2006-10-17 Roche Colorado Corporation Process for preparing 1,2-diamino compounds
CN101351438A (en) 2005-12-28 2009-01-21 弗·哈夫曼-拉罗切有限公司 Epoxide intermediate in the synthesis of Tamiflu
US8334319B2 (en) * 2008-01-04 2012-12-18 Roche Palo Alto Llc Polymorphic forms of oseltamivir phosphate
US8703877B2 (en) * 2009-11-11 2014-04-22 3M Innovative Properties Company Polymeric compositions and method of making and articles thereof
DE102011117128A1 (en) 2011-10-28 2013-05-02 Christian-Albrechts-Universität Zu Kiel Compounds for the treatment of influenza
RU2469020C1 (en) * 2011-11-08 2012-12-10 Александр Васильевич Иващенко (3r,4r,5s)-4-acylamino-5-amino-3-(1-ethyl-propoxy)-cyclohex-1-ene-carboxylic acids, their esters and method for using
CN102659615B (en) * 2012-05-09 2014-05-07 中国药科大学 Derivatives of oseltamivir, and preparation method and medical application thereof
RU2520836C1 (en) * 2013-02-27 2014-06-27 Александр Васильевич Иващенко (3r,4r,5s)-4-amino-5-(2,2-difluoroacetylamino)-3-(1-ethylpropoxy)-cyclohex-1-enecarboxylic acid and its ethers, method of obtaining and applying thereof
RU2633085C2 (en) * 2014-05-20 2017-10-11 Российская Федерация, от имени которой выступает Федеральное государственное казенное учреждение "Войсковая часть 68240" Antiviral drug as capsules and method for its preparation
CN105439884A (en) * 2015-10-27 2016-03-30 沈阳药科大学 Oseltamivir preparation method
CN108047076B (en) * 2017-12-26 2020-05-08 杭州新博思生物医药有限公司 Preparation method of oseltamivir enantiomer
CN110194728B (en) * 2019-06-19 2021-04-30 湖南华腾制药有限公司 Continuous synthesis method of oseltamivir phosphate intermediate
CN114057599A (en) * 2020-07-29 2022-02-18 广州市恒诺康医药科技有限公司 Neuraminidase inhibitor compound, pharmaceutical composition and application thereof
CN116375595A (en) * 2023-03-31 2023-07-04 重庆医药高等专科学校 A kind of preparation method and refining method of oseltamivir phosphate
CN117105801A (en) * 2023-07-24 2023-11-24 四川青木制药有限公司 A kind of preparation method and intermediate of oseltamivir and its phosphate
CN116666669B (en) * 2023-07-25 2023-10-03 四川大学 VN-supported Ir clusters, their preparation methods and their use in catalysts

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK282950B6 (en) * 1990-04-24 2003-01-09 Biota Scientific Management Pty Ltd Alpha-D-neuraminic acid derivatives, processes for their preparation, their use, and pharmaceutical compositions based thereon
WO1992006691A1 (en) * 1990-10-19 1992-04-30 Biota Scientific Management Pty. Ltd. Anti-viral compounds that bind the active site of influenza neuramidase and display in vivo activity against orthomyxovirus and paramyxovirus
RU2181357C2 (en) * 1995-02-27 2002-04-20 Джилид Сайэнс, Инк. Composition of selective inhibitors of viral or bacterial neuraminidases (variants), compound and method of treatment or prophylaxis of influenza disease
US5763483A (en) * 1995-12-29 1998-06-09 Gilead Sciences, Inc. Carbocyclic compounds
PT920410E (en) * 1996-08-23 2002-07-31 Gilead Sciences Inc PREPARATION OF CYCLOHEXENE CARBOXYLATE DERIVATIVES

Also Published As

Publication number Publication date
TR200000723T2 (en) 2001-06-21
EP1015417A1 (en) 2000-07-05
KR20010024123A (en) 2001-03-26
CN1272105A (en) 2000-11-01
IN190983B (en) 2003-09-06
EA003989B1 (en) 2003-12-25
IL134691A0 (en) 2001-04-30
JP2001516739A (en) 2001-10-02
EA200000332A1 (en) 2000-10-30
AR013960A1 (en) 2001-01-31
AU747702B2 (en) 2002-05-16
ID25516A (en) 2000-10-05
CA2303323A1 (en) 1999-03-25
AU9569498A (en) 1999-04-05
NZ502988A (en) 2002-08-28
WO1999014185A1 (en) 1999-03-25

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PRESENTE PEDIDO DE ACORDO COM OS ARTIGOS 8O, 10 (INCISO VIII), 24 E 25 DA LPI.

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.