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BR9810465A - Inibidores da farnesiltransferase de proteìnas - Google Patents

Inibidores da farnesiltransferase de proteìnas

Info

Publication number
BR9810465A
BR9810465A BR9810465-9A BR9810465A BR9810465A BR 9810465 A BR9810465 A BR 9810465A BR 9810465 A BR9810465 A BR 9810465A BR 9810465 A BR9810465 A BR 9810465A
Authority
BR
Brazil
Prior art keywords
protein
farnesyltransferase inhibitors
protein farnesyltransferase
compounds
useful
Prior art date
Application number
BR9810465-9A
Other languages
English (en)
Inventor
Rajeev S Bhide
Charles Z Ding
John T Hunt
Soong-Hoon Kim
Katerina Leftheris
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of BR9810465A publication Critical patent/BR9810465A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

"INIBIDORES DA FARNESILTRANSFERASE DE PROTEìNAS" Descreve-se derivados de quinolina e benzazepina que inibem a farnesiltransferase de proteínas (FTase) e a farnesilação da proteína oncogênica Ras. Assim sendo, os compostos são úteis como agentes anticâncer. Os compostos são úteis também no tratamento de doenças que não o câncer.
BR9810465-9A 1997-07-02 1998-06-16 Inibidores da farnesiltransferase de proteìnas BR9810465A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5159497P 1997-07-02 1997-07-02
PCT/US1998/012549 WO1999001434A1 (en) 1997-07-02 1998-06-16 Inhibitors of farnesyl protein transferase

Publications (1)

Publication Number Publication Date
BR9810465A true BR9810465A (pt) 2002-04-16

Family

ID=21972255

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9810465-9A BR9810465A (pt) 1997-07-02 1998-06-16 Inibidores da farnesiltransferase de proteìnas

Country Status (24)

Country Link
US (2) US6387926B1 (pt)
EP (1) EP0994856A4 (pt)
JP (1) JP2002507989A (pt)
KR (1) KR100385941B1 (pt)
CN (1) CN1261880A (pt)
AR (1) AR016304A1 (pt)
AU (1) AU734721B2 (pt)
BR (1) BR9810465A (pt)
CA (1) CA2294530A1 (pt)
CO (1) CO4950556A1 (pt)
HU (1) HUP0004148A3 (pt)
ID (1) ID24076A (pt)
IL (1) IL133470A0 (pt)
MY (1) MY117961A (pt)
NO (1) NO316117B1 (pt)
NZ (1) NZ501293A (pt)
PE (1) PE86599A1 (pt)
PL (1) PL337697A1 (pt)
RU (1) RU2211838C2 (pt)
TR (1) TR199903331T2 (pt)
TW (1) TW527355B (pt)
UY (1) UY25074A1 (pt)
WO (1) WO1999001434A1 (pt)
ZA (1) ZA985778B (pt)

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US8003624B2 (en) * 2005-08-25 2011-08-23 Schering Corporation Functionally selective ALPHA2C adrenoreceptor agonists
EP2545919A1 (en) * 2005-12-23 2013-01-16 Link Medicine Corporation Treatment of synucleinopathies
JP4669040B2 (ja) * 2006-03-06 2011-04-13 日本たばこ産業株式会社 ４−オキソキノリン化合物の製造方法
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Also Published As

Publication number Publication date
CO4950556A1 (es) 2000-09-01
NO316117B1 (no) 2003-12-15
PL337697A1 (en) 2000-08-28
HUP0004148A3 (en) 2002-09-30
KR100385941B1 (ko) 2003-06-09
HUP0004148A2 (hu) 2001-10-28
US6602883B1 (en) 2003-08-05
MY117961A (en) 2004-08-30
AR016304A1 (es) 2001-07-04
AU734721B2 (en) 2001-06-21
NO996571L (no) 2000-02-23
NZ501293A (en) 2001-10-26
RU2211838C2 (ru) 2003-09-10
AU7971998A (en) 1999-01-25
JP2002507989A (ja) 2002-03-12
UY25074A1 (es) 2000-12-29
CA2294530A1 (en) 1999-01-14
CN1261880A (zh) 2000-08-02
ID24076A (id) 2000-07-06
IL133470A0 (en) 2001-04-30
ZA985778B (en) 2000-01-20
KR20010014258A (ko) 2001-02-26
WO1999001434A1 (en) 1999-01-14
EP0994856A4 (en) 2000-12-06
EP0994856A1 (en) 2000-04-26
PE86599A1 (es) 1999-11-28
TR199903331T2 (xx) 2000-06-21
NO996571D0 (no) 1999-12-30
TW527355B (en) 2003-04-11
US6387926B1 (en) 2002-05-14

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