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BR9809809A - Processo para a preparação de um composto, e, proxetina - Google Patents

Processo para a preparação de um composto, e, proxetina

Info

Publication number
BR9809809A
BR9809809A BR9809809-8A BR9809809A BR9809809A BR 9809809 A BR9809809 A BR 9809809A BR 9809809 A BR9809809 A BR 9809809A BR 9809809 A BR9809809 A BR 9809809A
Authority
BR
Brazil
Prior art keywords
compound
preparation
proxetina
formula
proxetine
Prior art date
Application number
BR9809809-8A
Other languages
English (en)
Other versions
BR9809809B1 (pt
Inventor
James Patrick Brennan
Original Assignee
Knoll Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Knoll Ag filed Critical Knoll Ag
Publication of BR9809809A publication Critical patent/BR9809809A/pt
Publication of BR9809809B1 publication Critical patent/BR9809809B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

"PROCESSO PARA A PREPARAçãO DE UM COMPOSTO, E, PROXETINA" Processo para a preparação de um composto de fórmula (I), em que R~ 1~ representa um grupo amino protetor, em que um composto de fórmula (II), em que R~ 1~ é como definido acima, é reduzido por um hidreto de metal na presença de um sal inorgânico na presença de um diluente.
BRPI9809809-8A 1997-05-17 1998-05-13 processo para a preparação de um composto (-)-trans-1-benzil-3-hidroximetil-4-(4-fluorofenil) piperidina, e, processo para a preparação de paroxetina. BR9809809B1 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9710004.4A GB9710004D0 (en) 1997-05-17 1997-05-17 Chemical process
PCT/EP1998/002826 WO1998052920A1 (en) 1997-05-17 1998-05-13 Chemical process for the reduction of 1-substituted -3-hydroxymethyl-4- (4-fluorophenyl)tetrahydropyridines

Publications (2)

Publication Number Publication Date
BR9809809A true BR9809809A (pt) 2000-06-27
BR9809809B1 BR9809809B1 (pt) 2009-05-05

Family

ID=10812456

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI9809809-8A BR9809809B1 (pt) 1997-05-17 1998-05-13 processo para a preparação de um composto (-)-trans-1-benzil-3-hidroximetil-4-(4-fluorofenil) piperidina, e, processo para a preparação de paroxetina.

Country Status (28)

Country Link
US (1) US6326496B1 (pt)
EP (1) EP0983237B1 (pt)
JP (1) JP4463883B2 (pt)
KR (1) KR100515852B1 (pt)
CN (1) CN1121386C (pt)
AR (1) AR012688A1 (pt)
AT (1) ATE212013T1 (pt)
AU (1) AU748902B2 (pt)
BG (1) BG63847B1 (pt)
BR (1) BR9809809B1 (pt)
CA (1) CA2289013C (pt)
CZ (1) CZ292282B6 (pt)
DE (1) DE69803178T2 (pt)
DK (1) DK0983237T3 (pt)
ES (1) ES2171299T3 (pt)
GB (1) GB9710004D0 (pt)
HU (1) HUP0002709A3 (pt)
ID (1) ID24181A (pt)
IL (1) IL132360A (pt)
NO (1) NO313326B1 (pt)
NZ (1) NZ501692A (pt)
PL (1) PL189464B1 (pt)
PT (1) PT983237E (pt)
RU (1) RU2205178C2 (pt)
SK (1) SK149599A3 (pt)
TR (1) TR199902823T2 (pt)
UA (1) UA61952C2 (pt)
WO (1) WO1998052920A1 (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ20023694A3 (cs) * 2000-05-12 2003-05-14 Synthon B. V. Tosylátové soli 4-(p-fluorfenyl)-piperidin-3-methanolů
GB0021147D0 (en) 2000-08-30 2000-10-11 Knoll Ag Chemical process
US6777554B2 (en) 2001-02-05 2004-08-17 Teva Pharmaceutical Industries Ltd. Preparation of N-methylparoxetine and related intermediate compounds
JP2006512278A (ja) * 2001-06-13 2006-04-13 テバ ファーマシューティカル インダストリーズ リミティド アルコキシ不純物を実質的に含有しないパロキセチンの製造方法
US20050266082A1 (en) * 2004-05-26 2005-12-01 Patel Satishkumar A Preparation of stable paroxetine HC1 ER tablets using a melt granulation process
US20070112031A1 (en) * 2005-11-14 2007-05-17 Gant Thomas G Substituted phenylpiperidines with serotoninergic activity and enhanced therapeutic properties
US20080033050A1 (en) * 2006-08-04 2008-02-07 Richards Patricia Allison Tewe Method of treating thermoregulatory disfunction with paroxetine
US9138430B2 (en) * 2007-12-27 2015-09-22 Mylan Specialty L.P. Formulation and method for the release of paroxetine in the large intestine

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3849542A (en) 1966-05-09 1974-11-19 Dow Chemical Co Lithium magnesium aluminum hydride
GB1422263A (en) * 1973-01-30 1976-01-21 Ferrosan As 4-phenyl-piperidine compounds
EP0223334B1 (en) * 1985-08-10 1991-07-10 Beecham Group Plc Process for the preparation of aryl-piperidine carbinols
EP0299549A3 (en) * 1987-07-09 1989-02-08 Duphar International Research B.V Tertiary 2,5-dialkyl-3-phenyl-piperidine derivatives having opiate-antagonistic activity
GB9100505D0 (en) * 1991-01-10 1991-02-20 Shell Int Research Piperidine derivatives
US5258517A (en) * 1992-08-06 1993-11-02 Sepracor, Inc. Method of preparing optically pure precursors of paroxetine
GB9305175D0 (en) * 1993-03-13 1993-04-28 Smithkline Beecham Plc Novel process
BR9608471A (pt) 1995-05-17 1998-12-29 Novo Nordisk As Processo para a preparação de um composto
EP1384711A1 (en) * 1996-06-13 2004-01-28 SUMIKA FINE CHEMICALS Co., Ltd. Optical resolution of a piperidine derivative
HU221921B1 (hu) 1996-07-08 2003-02-28 Richter Gedeon Vegyészeti Gyár Rt. N-benzil-piperidin- és tetrahidropiridinszármazékok és eljárás azok előállítására
GB9623359D0 (en) * 1996-11-09 1997-01-08 Smithkline Beecham Plc Novel process

Also Published As

Publication number Publication date
KR100515852B1 (ko) 2005-09-21
RU2205178C2 (ru) 2003-05-27
NO313326B1 (no) 2002-09-16
EP0983237A1 (en) 2000-03-08
BG103834A (en) 2000-07-31
DE69803178T2 (de) 2002-10-31
IL132360A0 (en) 2001-03-19
US6326496B1 (en) 2001-12-04
BR9809809B1 (pt) 2009-05-05
PL336796A1 (en) 2000-07-17
PL189464B1 (pl) 2005-08-31
NZ501692A (en) 2001-05-25
PT983237E (pt) 2002-05-31
HUP0002709A3 (en) 2002-01-28
ATE212013T1 (de) 2002-02-15
AU748902B2 (en) 2002-06-13
SK149599A3 (en) 2000-05-16
BG63847B1 (bg) 2003-03-31
NO995619D0 (no) 1999-11-16
KR20010012620A (ko) 2001-02-26
GB9710004D0 (en) 1997-07-09
CZ408199A3 (cs) 2000-04-12
ID24181A (id) 2000-07-13
CZ292282B6 (cs) 2003-08-13
AU7912198A (en) 1998-12-11
NO995619L (no) 1999-11-16
HUP0002709A1 (hu) 2001-01-29
TR199902823T2 (xx) 2000-05-22
IL132360A (en) 2003-02-12
DE69803178D1 (de) 2002-02-21
ES2171299T3 (es) 2002-09-01
CA2289013C (en) 2007-11-13
UA61952C2 (en) 2003-12-15
WO1998052920A1 (en) 1998-11-26
EP0983237B1 (en) 2002-01-16
CN1255916A (zh) 2000-06-07
DK0983237T3 (da) 2002-03-25
JP4463883B2 (ja) 2010-05-19
AR012688A1 (es) 2000-11-08
CN1121386C (zh) 2003-09-17
JP2001525838A (ja) 2001-12-11
CA2289013A1 (en) 1998-11-26

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Legal Events

Date Code Title Description
B25D Requested change of name of applicant approved

Owner name: KNOLL GMBH (DE)

Free format text: ALTERADO DE: KNOLL AKTIENGESELLSCHAFT

B25A Requested transfer of rights approved

Owner name: ABBOTT GMBH (DE)

Free format text: TRANSFERIDO POR FUSAO DE: KNOLL GMBH

B25D Requested change of name of applicant approved

Owner name: ABBOTT GMBH AND CO. KG (DE)

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B25A Requested transfer of rights approved

Owner name: AESICA PHARMACEUTICALS LTD. (GB)

Free format text: TRANSFERIDO DE: ABBOTT GMBH AND CO. KG

B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 30/06/2009, OBSERVADAS AS CONDICOES LEGAIS.

B24H Lapse because of non-payment of annual fees (definitively: art 78 iv lpi)
B24F Patent annual fee: publication cancelled

Free format text: ANULADA A PUBLICACAO CODIGO 24.8 NA RPI NO 2259 DE 22/04/2014 POR TER SIDO INDEVIDA.

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE AS 12A, 13A, 14A, 15A, 16A, 17A, 18A, 19A, 20A, 21A E 22A ANUIDADES.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2607 DE 22-12-2020 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.