BR9809762A - Composição farmacêutica promotora de osteoblastos compreendendo um composto de carnitina e dhea ou dhea-s - Google Patents
Composição farmacêutica promotora de osteoblastos compreendendo um composto de carnitina e dhea ou dhea-sInfo
- Publication number
- BR9809762A BR9809762A BR9809762-8A BR9809762A BR9809762A BR 9809762 A BR9809762 A BR 9809762A BR 9809762 A BR9809762 A BR 9809762A BR 9809762 A BR9809762 A BR 9809762A
- Authority
- BR
- Brazil
- Prior art keywords
- dhea
- pharmaceutical composition
- osteoblast
- carnitine
- compound
- Prior art date
Links
- FMGSKLZLMKYGDP-USOAJAOKSA-N dehydroepiandrosterone Chemical compound C1[C@@H](O)CC[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CC=C21 FMGSKLZLMKYGDP-USOAJAOKSA-N 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- PHIQHXFUZVPYII-ZCFIWIBFSA-O (R)-carnitinium Chemical compound C[N+](C)(C)C[C@H](O)CC(O)=O PHIQHXFUZVPYII-ZCFIWIBFSA-O 0.000 title 1
- 229960004203 carnitine Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- FMGSKLZLMKYGDP-UHFFFAOYSA-N Dehydroepiandrosterone Natural products C1C(O)CCC2(C)C3CCC(C)(C(CC4)=O)C4C3CC=C21 FMGSKLZLMKYGDP-UHFFFAOYSA-N 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- CZWCKYRVOZZJNM-USOAJAOKSA-N dehydroepiandrosterone sulfate Chemical compound C1[C@@H](OS(O)(=O)=O)CC[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CC=C21 CZWCKYRVOZZJNM-USOAJAOKSA-N 0.000 abstract 1
- 229960002847 prasterone Drugs 0.000 abstract 1
- 229950009829 prasterone sulfate Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Patente de Invenção: <B>"COMPOSIçãO FARMACêUTICA PROMOTORA DE OSTEOBLASTOS COMPREENDENDO UM COMPOSTO DE CARNITINA E DHEA OU DHEA-S"<D>. Apresenta-se o uso de algumas alcanoil L-carnitinas inferior ou seus sais farmacologicamente aceitáveis em combinação com desidroepiandrosterona ou sulfato de desidroepiandrosterona para promover a formação de calo ósseo e para a cicatrização de fraturas.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT97RM000217A IT1291141B1 (it) | 1997-04-16 | 1997-04-16 | Composizione farmaceutica comprendente una alcanoil l-carnitina, atta a stimolare la moltiplicazione e la crescita degli osteoblasti |
| PCT/IT1998/000076 WO1998046233A1 (en) | 1997-04-16 | 1998-04-03 | Osteoblast-promoting pharmaceutical composition comprising a carnitine compound and dhea or dhea-s |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9809762A true BR9809762A (pt) | 2000-06-20 |
Family
ID=11404977
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9809762-8A BR9809762A (pt) | 1997-04-16 | 1998-04-03 | Composição farmacêutica promotora de osteoblastos compreendendo um composto de carnitina e dhea ou dhea-s |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US6329358B1 (pt) |
| EP (1) | EP0977576B1 (pt) |
| JP (1) | JP2001520644A (pt) |
| KR (1) | KR20010006465A (pt) |
| AT (1) | ATE269707T1 (pt) |
| AU (1) | AU730710B2 (pt) |
| BR (1) | BR9809762A (pt) |
| CA (1) | CA2286719C (pt) |
| DE (1) | DE69824718T2 (pt) |
| DK (1) | DK0977576T3 (pt) |
| ES (1) | ES2224380T3 (pt) |
| IT (1) | IT1291141B1 (pt) |
| NZ (1) | NZ500533A (pt) |
| PT (1) | PT977576E (pt) |
| SI (1) | SI0977576T1 (pt) |
| WO (1) | WO1998046233A1 (pt) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1317079B1 (it) | 2000-12-21 | 2003-05-26 | Sigma Tau Ind Farmaceuti | Uso della isovaleril l-carnitina per la preparazione di un medicamentoper la prevenzione e cura dell'osteoporosi. |
| US6911438B2 (en) * | 2001-09-12 | 2005-06-28 | Jonathan V. Wright | Hormone replacement formulation |
| US20080069814A1 (en) * | 2005-01-05 | 2008-03-20 | Novacea, Inc. | Prevention of Thrombotic Disorders with Active Vitamin D Compounds or Mimics Thereof |
| KR20080028860A (ko) * | 2005-04-22 | 2008-04-02 | 노바세아, 인크. | 활성 비타민 d 화합물 또는 그의 유사체에 의한 화학 요법또는 방사선 치료와 관련된 폐 장애의 치료, 예방 및 개선 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1245869B (it) * | 1991-06-05 | 1994-10-25 | Sigma Tau Ind Farmaceuti | Impiego di propionil l-carnitina per il recupero del tono muscolare in soggetti immobilizzati |
| US5240961A (en) * | 1992-07-02 | 1993-08-31 | Shug Austin L | Method of treating reduced insulin-like growth factor and bone loss associated with aging |
| US5326569A (en) * | 1992-12-23 | 1994-07-05 | Abbott Laboratories | Medical foods for the nutritional support of child/adult metabolic diseases |
| WO1994016709A2 (en) * | 1993-01-19 | 1994-08-04 | Endorecherche Inc. | Therapeutic uses and delivery systems of dehydroepiandrosterone |
| WO1995005168A1 (en) * | 1993-08-19 | 1995-02-23 | Shug Austin L | Delayed release carnitine |
| US5569457A (en) * | 1994-11-18 | 1996-10-29 | Shug; Austin L. | Method of stimulating antibody formation |
| US5945412A (en) * | 1996-12-09 | 1999-08-31 | Merck & Co., Inc. | Methods and compositions for preventing and treating bone loss |
-
1997
- 1997-04-16 IT IT97RM000217A patent/IT1291141B1/it active IP Right Grant
-
1998
- 1998-04-03 NZ NZ500533A patent/NZ500533A/xx not_active IP Right Cessation
- 1998-04-03 CA CA002286719A patent/CA2286719C/en not_active Expired - Fee Related
- 1998-04-03 BR BR9809762-8A patent/BR9809762A/pt not_active IP Right Cessation
- 1998-04-03 AT AT98917594T patent/ATE269707T1/de active
- 1998-04-03 US US09/402,653 patent/US6329358B1/en not_active Expired - Fee Related
- 1998-04-03 DK DK98917594T patent/DK0977576T3/da active
- 1998-04-03 KR KR1019997009555A patent/KR20010006465A/ko not_active Ceased
- 1998-04-03 SI SI9830678T patent/SI0977576T1/xx unknown
- 1998-04-03 WO PCT/IT1998/000076 patent/WO1998046233A1/en not_active Ceased
- 1998-04-03 PT PT98917594T patent/PT977576E/pt unknown
- 1998-04-03 EP EP98917594A patent/EP0977576B1/en not_active Expired - Lifetime
- 1998-04-03 AU AU70774/98A patent/AU730710B2/en not_active Ceased
- 1998-04-03 DE DE69824718T patent/DE69824718T2/de not_active Expired - Lifetime
- 1998-04-03 JP JP54369198A patent/JP2001520644A/ja active Pending
- 1998-04-03 ES ES98917594T patent/ES2224380T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0977576A1 (en) | 2000-02-09 |
| IT1291141B1 (it) | 1998-12-29 |
| CA2286719A1 (en) | 1998-10-22 |
| WO1998046233A1 (en) | 1998-10-22 |
| US6329358B1 (en) | 2001-12-11 |
| DE69824718D1 (de) | 2004-07-29 |
| HK1025243A1 (en) | 2000-11-10 |
| KR20010006465A (ko) | 2001-01-26 |
| AU730710B2 (en) | 2001-03-15 |
| CA2286719C (en) | 2008-06-10 |
| ATE269707T1 (de) | 2004-07-15 |
| DK0977576T3 (da) | 2004-11-01 |
| EP0977576B1 (en) | 2004-06-23 |
| NZ500533A (en) | 2001-03-30 |
| ES2224380T3 (es) | 2005-03-01 |
| PT977576E (pt) | 2004-11-30 |
| DE69824718T2 (de) | 2005-06-30 |
| AU7077498A (en) | 1998-11-11 |
| JP2001520644A (ja) | 2001-10-30 |
| SI0977576T1 (en) | 2004-10-31 |
| ITRM970217A1 (it) | 1998-10-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B15K | Others concerning applications: alteration of classification |
Free format text: ALTERADA DE INT.CL.8: A61K 31/225, A61K 31/565, A61P 19/08 Ipc: A61K 31/225 (2007.10), A61K 31/565 (2007.10), A61P |
|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 13A ANUIDADE(S). |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2125 DE 27/09/2011. |