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BR9809115A - Methods to treat inflammation and inflammatory diseases using padprt inhibitors - Google Patents

Methods to treat inflammation and inflammatory diseases using padprt inhibitors

Info

Publication number
BR9809115A
BR9809115A BR9809115-8A BR9809115A BR9809115A BR 9809115 A BR9809115 A BR 9809115A BR 9809115 A BR9809115 A BR 9809115A BR 9809115 A BR9809115 A BR 9809115A
Authority
BR
Brazil
Prior art keywords
methods
inflammatory diseases
padprt
treat inflammation
inhibitors
Prior art date
Application number
BR9809115-8A
Other languages
Portuguese (pt)
Inventor
Ernest Kun
Original Assignee
Octamer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/855,616 external-priority patent/US5908861A/en
Application filed by Octamer Inc filed Critical Octamer Inc
Publication of BR9809115A publication Critical patent/BR9809115A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A61K31/37—Coumarins, e.g. psoralen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

"MéTODOS PARA TRATAR INFLAMAçãO E DOENçAS INFLAMATóRIAS USANDO INIBIDORES DE pADPRT". A presente invenção e direcionada a um processo para tratamento de inflamação ou doença inflamatória em um animal ou mamífero, que compreende as etapas de administração de uma quantidade eficaz de um composto inibidor de pADPRT para o dito animal ou mamífero."METHODS FOR TREATING INFLAMMATION AND INFLAMMATORY DISEASES USING pADPRT INHIBITORS". The present invention is directed to a process for treating inflammation or inflammatory disease in an animal or mammal, which comprises the steps of administering an effective amount of a pADPRT inhibiting compound to said animal or mammal.

BR9809115-8A 1997-05-13 1998-05-13 Methods to treat inflammation and inflammatory diseases using padprt inhibitors BR9809115A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/855,616 US5908861A (en) 1997-05-13 1997-05-13 Methods for treating inflammation and inflammatory disease using pADPRT inhibitors
US09/056,396 US6303629B1 (en) 1997-05-13 1998-04-06 Methods for treating inflammation, inflammatory diseases, arthritis and stroke using pADPRT inhibitors
PCT/US1998/010033 WO1998051308A1 (en) 1997-05-13 1998-05-13 METHODS FOR TREATING INFLAMMATION AND INFLAMMATORY DISEASES USING pADPRT INHIBITORS

Publications (1)

Publication Number Publication Date
BR9809115A true BR9809115A (en) 2002-01-02

Family

ID=26735288

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9809115-8A BR9809115A (en) 1997-05-13 1998-05-13 Methods to treat inflammation and inflammatory diseases using padprt inhibitors

Country Status (9)

Country Link
EP (1) EP1009404A4 (en)
JP (1) JP4362638B2 (en)
CN (1) CN1198614C (en)
AU (2) AU745790B2 (en)
BR (1) BR9809115A (en)
CA (1) CA2289119C (en)
IL (1) IL132758A0 (en)
NZ (1) NZ501650A (en)
WO (2) WO1998051308A1 (en)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK287338B6 (en) 1999-01-11 2010-07-07 Agouron Pharmaceuticals, Inc. Tricyclic compound, its thereof and pharmaceutical composition containing thereof
ECSP003637A (en) 1999-08-31 2002-03-25 Agouron Pharma TRICYCLE POLY INHIBITORS (ADP-RIBOSA) POLYMERASES
DE60218458T2 (en) 2001-05-08 2007-11-15 Kudos Pharmaceuticals Ltd. ISOCHINOLINONE DERIVATIVES AS PARP INHIBITORS
EP1501822B1 (en) 2002-04-30 2010-12-15 Kudos Pharmaceuticals Limited Phthalazinone derivatives
GB0305681D0 (en) 2003-03-12 2003-04-16 Kudos Pharm Ltd Phthalazinone derivatives
US7449464B2 (en) 2003-03-12 2008-11-11 Kudos Pharmaceuticals Limited Phthalazinone derivatives
TW200536830A (en) 2004-02-06 2005-11-16 Chugai Pharmaceutical Co Ltd 1-(2H)-isoquinolone derivative
GB0419072D0 (en) 2004-08-26 2004-09-29 Kudos Pharm Ltd Phthalazinone derivatives
TWI389897B (en) 2005-02-22 2013-03-21 Chugai Pharmaceutical Co Ltd 1- (2H) -isoquinolinone derivatives
BRPI0611814A2 (en) * 2005-06-10 2008-12-09 Bipar Sciences Inc parp modulators and cancer treatment
GB0521373D0 (en) 2005-10-20 2005-11-30 Kudos Pharm Ltd Pthalazinone derivatives
US20080076778A1 (en) * 2006-09-05 2008-03-27 Bipar Sciences, Inc. Methods for designing parp inhibitors and uses thereof
EP2061479A4 (en) * 2006-09-05 2010-08-04 Bipar Sciences Inc Inhibition of fatty acid synthesis by parp inhibitors and methods of treatment thereof
US9623021B2 (en) 2007-01-22 2017-04-18 Gtx, Inc. Nuclear receptor binding agents
KR101763674B1 (en) 2007-01-22 2017-08-01 지티엑스, 인코포레이티드 Nuclear receptor binding agents
US9604931B2 (en) 2007-01-22 2017-03-28 Gtx, Inc. Nuclear receptor binding agents
CN101641339B (en) 2007-02-01 2013-07-17 雷斯韦洛吉克斯公司 Compounds for the prevention and treatment of cardiovascular diseases
RU2010108008A (en) 2007-09-14 2011-10-20 Астразенека Аб (Se) Phthalazinone derivatives
UY31603A1 (en) 2008-01-23 2009-08-31 DERIVATIVES OF FTALAZINONA
KR101629356B1 (en) 2008-06-26 2016-06-13 리스버로직스 코퍼레이션 Methods of preparing quinazolinone derivatives
RS55157B2 (en) 2008-10-07 2023-10-31 Kudos Pharm Ltd Pharmaceutical formulation 514
EP2377871A4 (en) 2008-11-28 2012-07-25 Chugai Pharmaceutical Co Ltd 1- (2H) -ISOQUINOLONE DERIVATIVE
US8952021B2 (en) 2009-01-08 2015-02-10 Resverlogix Corp. Compounds for the prevention and treatment of cardiovascular disease
AU2010224523B2 (en) 2009-03-18 2014-05-08 Resverlogix Corp. Novel anti-inflammatory agents
MX374414B (en) 2009-04-22 2025-03-06 Resverlogix Corp NEW ANTI-INFLAMMATORY AGENTS.
SI2773354T1 (en) 2011-11-01 2019-08-30 Resverlogix Corp. Oral immediate release formulations for substituted quinazolinones
US9073878B2 (en) 2012-11-21 2015-07-07 Zenith Epigenetics Corp. Cyclic amines as bromodomain inhibitors
US9765039B2 (en) 2012-11-21 2017-09-19 Zenith Epigenetics Ltd. Biaryl derivatives as bromodomain inhibitors
CN105073744B (en) 2012-12-21 2019-11-08 齐尼思表观遗传学有限公司 Novel heterocyclic compounds as bromodomain inhibitors
CN107530356A (en) 2015-03-13 2018-01-02 雷斯韦洛吉克斯公司 Compositions and methods of treatment for treating complement-associated diseases
US11433074B2 (en) 2017-06-22 2022-09-06 Triact Therapeutics, Inc. Methods of treating glioblastoma
WO2019067991A1 (en) 2017-09-29 2019-04-04 Triact Therapeutics, Inc. Iniparib formulations and uses thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05503073A (en) 1989-09-26 1993-05-27 オクタマー，インコーポレイテッド 6-Amino-1,2-benzopyrone useful in the treatment of viral diseases
US5484951A (en) * 1990-10-19 1996-01-16 Octamer, Incorporated 5-iodo-6-amino-6-nitroso-1,2-benzopyrones useful as cytostatic and antiviral agents
US5516941A (en) 1991-10-22 1996-05-14 Octamer, Inc. Specific inactivators of "retroviral" (asymmetric) zinc fingers
US5473074A (en) 1991-10-22 1995-12-05 Octamer, Incorporated Adenosine diphosphoribose polymerase binding nitroso aromatic compounds useful as retroviral inactivating agents, anti-retroviral agents and anti-tumor agents-54
US5482975A (en) 1991-10-22 1996-01-09 Octamer, Inc. Adenosine diphosphoribose polymerase binding nitroso aromatic compounds useful as retroviral inactivating agents, anti-retroviral agents and anti-tumor agents
US5464871A (en) 1993-05-12 1995-11-07 Octamer, Inc. Aromatic nitro and nitroso compounds and their metabolites useful as anti-viral and anti-tumor agents
DE4436127A1 (en) 1994-09-27 1996-03-28 Deutsches Rheumaforschungszent Use of benzoic or pyridine:carboxylic acid or amide cpds.
AU5259296A (en) * 1995-04-07 1996-10-23 Warner-Lambert Company Flavones and coumarins as agents for the treatment of athero sclerosis
US10766598B2 (en) 2017-06-14 2020-09-08 The Boeing Company Wing-to-fuselage joints and aircraft including the same

Also Published As

Publication number Publication date
EP1009404A4 (en) 2009-07-01
WO1998051307A1 (en) 1998-11-19
JP2002502367A (en) 2002-01-22
WO1998051308A1 (en) 1998-11-19
CN1198614C (en) 2005-04-27
IL132758A0 (en) 2001-03-19
CA2289119A1 (en) 1998-11-19
CN1261278A (en) 2000-07-26
AU7492698A (en) 1998-12-08
AU7484798A (en) 1998-12-08
AU745790B2 (en) 2002-03-28
NZ501650A (en) 2001-11-30
JP4362638B2 (en) 2009-11-11
EP1009404A1 (en) 2000-06-21
CA2289119C (en) 2011-03-15

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PRESENTE PEDIDO, UMA VEZ QUE O MESMO NAO SE CONSIDERA UM INVENCAO, CONFORME DISPISTO NOARTIGO 10 ( VIII ) DA LPI