BR9808150A - Aromatic sulfonyl alpha hydroxy hydroxamic acid compounds - Google Patents
Aromatic sulfonyl alpha hydroxy hydroxamic acid compoundsInfo
- Publication number
- BR9808150A BR9808150A BR9808150-0A BR9808150A BR9808150A BR 9808150 A BR9808150 A BR 9808150A BR 9808150 A BR9808150 A BR 9808150A BR 9808150 A BR9808150 A BR 9808150A
- Authority
- BR
- Brazil
- Prior art keywords
- hydroxamic
- acid compounds
- hydroxamic acid
- alpha hydroxy
- alpha
- Prior art date
Links
- 239000002253 acid Substances 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title abstract 2
- -1 hydroxy hydroxamic Chemical compound 0.000 title 1
- NEAQRZUHTPSBBM-UHFFFAOYSA-N 2-hydroxy-3,3-dimethyl-7-nitro-4h-isoquinolin-1-one Chemical compound C1=C([N+]([O-])=O)C=C2C(=O)N(O)C(C)(C)CC2=C1 NEAQRZUHTPSBBM-UHFFFAOYSA-N 0.000 abstract 2
- 102000005741 Metalloproteases Human genes 0.000 abstract 2
- 108010006035 Metalloproteases Proteins 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 239000011159 matrix material Substances 0.000 abstract 2
- 102000002274 Matrix Metalloproteinases Human genes 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 230000001575 pathological effect Effects 0.000 abstract 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 abstract 1
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Patente de Invenção: <B>"COMPOSTOS DE áCIDO SULFONIL ALFA-HIDRóXI HIDROXâMICO AROMáTICOS'<D>. é descrito um composto de ácido sulfonil alfa-hidróxi hidroxâmico aromático que inter alia inibe a atividade de metaloprotease de matriz, como é um processo de tratamento que compreende administrar um composto de ácido sulfonil alfa-hidróxi hidroxâmico aromático, contemplado, em uma quantidade efetiva de inibição da enzima MMP, a um hospedeiro tendo uma condição associada com a atividade de metaloprotease de matriz patológica.Invention Patent: <B> "ALPHA-HYDROXAMIC HYDROXAMIC AROMATIC ACID COMPOUNDS" <D>. A sulfonyl alpha-hydroxamic aromatic acid compound is described which inter alia inhibits matrix metalloprotease activity, as is a process of treatment comprising administering a compound of aromatic hydroxamic hydroxamic alpha-hydroxy sulfonyl acid, contemplated, in an effective amount of inhibition of the MMP enzyme, to a host having a condition associated with the pathological matrix metalloprotease activity.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BR9808150-0A BR9808150A (en) | 1998-03-04 | 1998-03-04 | Aromatic sulfonyl alpha hydroxy hydroxamic acid compounds |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BR9808150-0A BR9808150A (en) | 1998-03-04 | 1998-03-04 | Aromatic sulfonyl alpha hydroxy hydroxamic acid compounds |
| PCT/US1998/004277 WO1998039326A1 (en) | 1997-03-04 | 1998-03-04 | Aromatic sulfonyl alpha-hydroxy hydroxamic acid compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9808150A true BR9808150A (en) | 2000-03-28 |
Family
ID=25665107
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9808150-0A BR9808150A (en) | 1998-03-04 | 1998-03-04 | Aromatic sulfonyl alpha hydroxy hydroxamic acid compounds |
Country Status (1)
| Country | Link |
|---|---|
| BR (1) | BR9808150A (en) |
-
1998
- 1998-03-04 BR BR9808150-0A patent/BR9808150A/en not_active Application Discontinuation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements |