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BR9807824A - Derivatives of n-hydroxy-beta-sulfonyl-propionamide and its use as matrix metalloproteinase inhibitors - Google Patents

Derivatives of n-hydroxy-beta-sulfonyl-propionamide and its use as matrix metalloproteinase inhibitors

Info

Publication number
BR9807824A
BR9807824A BR9807824-0A BR9807824A BR9807824A BR 9807824 A BR9807824 A BR 9807824A BR 9807824 A BR9807824 A BR 9807824A BR 9807824 A BR9807824 A BR 9807824A
Authority
BR
Brazil
Prior art keywords
sulfonyl
beta
hydroxy
derivatives
propionamide
Prior art date
Application number
BR9807824-0A
Other languages
Portuguese (pt)
Inventor
Ralf Pelton Robinson
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of BR9807824A publication Critical patent/BR9807824A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C07C317/46—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Patente de Invenção:<B>"DERIVADOS DE N-HIDRóXI-BETA-SULFONIL-PRO-PIONAMIDA E SEU USO COMO INIBIDORES DE MATALOPROTEINASES DE MATRIZ"<D>. Um composto da fórmula (I) em que R^ 1^, R^ 2^, R^ 3^ , R^ 4^ e Q são conforme definidos no relatório descritivo, para composições farmacêuticas que os contêm e ao seu uso medicinal como inibidores de metaloproteinases de matriz e para produção de fator de necrose de tumor.Invention Patent: <B> "N-HYDROXY-BETA-SULFONYL-PRO-PIONAMIDE DERIVATIVES AND THEIR USE AS MATRIX MATALOPROTEINASE INHIBITORS" <D>. A compound of the formula (I) in which R ^ 1 ^, R ^ 2 ^, R ^ 3 ^, R ^ 4 ^ and Q are as defined in the specification, for pharmaceutical compositions containing them and for their medicinal use as inhibitors of matrix metalloproteinases and for the production of tumor necrosis factor.

BR9807824-0A 1997-02-07 1998-01-27 Derivatives of n-hydroxy-beta-sulfonyl-propionamide and its use as matrix metalloproteinase inhibitors BR9807824A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3740297P 1997-02-07 1997-02-07
PCT/IB1998/000101 WO1998034915A1 (en) 1997-02-07 1998-01-27 N-hydroxy-beta-sulfonyl-propionamide derivatives and their use as inhibitors of matrix metalloproteinases

Publications (1)

Publication Number Publication Date
BR9807824A true BR9807824A (en) 2000-03-08

Family

ID=21894150

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9807824-0A BR9807824A (en) 1997-02-07 1998-01-27 Derivatives of n-hydroxy-beta-sulfonyl-propionamide and its use as matrix metalloproteinase inhibitors

Country Status (13)

Country Link
EP (1) EP0966438A1 (en)
JP (1) JP2000507975A (en)
AP (1) AP9801169A0 (en)
AR (1) AR011116A1 (en)
AU (1) AU5493598A (en)
BR (1) BR9807824A (en)
CA (1) CA2279863A1 (en)
HR (1) HRP980062A2 (en)
MA (1) MA26472A1 (en)
PA (1) PA8446001A1 (en)
TN (1) TNSN98022A1 (en)
WO (1) WO1998034915A1 (en)
ZA (1) ZA98970B (en)

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