BR9802894A - Benzoxazindione derivative, application of a benzoxazindione derivative and medication. - Google Patents
Benzoxazindione derivative, application of a benzoxazindione derivative and medication.Info
- Publication number
- BR9802894A BR9802894A BR9802894A BR9802894A BR9802894A BR 9802894 A BR9802894 A BR 9802894A BR 9802894 A BR9802894 A BR 9802894A BR 9802894 A BR9802894 A BR 9802894A BR 9802894 A BR9802894 A BR 9802894A
- Authority
- BR
- Brazil
- Prior art keywords
- derivative
- antibiotics
- benzoxazindione
- benzoxazindiona
- conjugates
- Prior art date
Links
- 239000003814 drug Substances 0.000 title abstract 2
- 229940079593 drug Drugs 0.000 title abstract 2
- UXTZUUVTGMDXNG-UHFFFAOYSA-N 1,2-benzoxazine-3,4-dione Chemical class C1=CC=C2C(=O)C(=O)NOC2=C1 UXTZUUVTGMDXNG-UHFFFAOYSA-N 0.000 title 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 abstract 4
- 239000003242 anti bacterial agent Substances 0.000 abstract 3
- 229940088710 antibiotic agent Drugs 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 2
- 230000001580 bacterial effect Effects 0.000 abstract 2
- 229910052742 iron Inorganic materials 0.000 abstract 2
- 150000005206 1,2-dihydroxybenzenes Chemical class 0.000 abstract 1
- 241000894006 Bacteria Species 0.000 abstract 1
- 206010027940 Mood altered Diseases 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 239000002738 chelating agent Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 238000002483 medication Methods 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
- C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D265/24—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in positions 2 and 4
- C07D265/26—Two oxygen atoms, e.g. isatoic anhydride
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Abstract
"DERIVADO DE BENZOXAZINDIONA, APLICAçãO DE UM DERIVADO DE BENZOXAZINDIONA E MEDICAMENTO". A invençãoa fórmula geral I e seus conjugados com elementos ativos, por exemplo, antibióticos. As combinações de acordo com a presente invenção apresentam derivados catecol heterocíclicos e protegidos e são ativos principalmente em bactérias gram-negativas, paemplo, antibióticos (como conjugados "siderofor - antibióticos") as quais encapsulam as células bactte também frente a outros gêneros de bacteérias resistentes a <225>-lactamas. Além disso as combinações mencionadas são úteis potencialmente como pro-medicamentos para queladores de ferro para utilização em doenças que resdem na alteração da troca de ferro. A utilização da invençõa pode ser na pesquisa farmacêutica, indústria e agro-pecuária. Fórmu ou fenil e R3 = diferentes grupos ácidos derivadoemplo antibióticos. As combinações mencionadas podem se apresentar como ácidos livres na forma de seus sais ou ésteres facilmente dissociáveis."BENZOXAZINDIONA DERIVATIVE, APPLICATION OF A BENZOXAZINDIONA DERIVATIVE AND MEDICINE". The invention is general formula I and its conjugates with active elements, for example, antibiotics. The combinations according to the present invention have heterocyclic and protected catechol derivatives and are active mainly in gram-negative bacteria, for example, antibiotics (such as "siderophor - antibiotic" conjugates) which encapsulate bacterial cells also against other resistant bacterial genera. <225> -lactams. In addition, the aforementioned combinations are potentially useful as pro-medications for iron chelators for use in diseases that affect altered iron exchange. The use of the invention can be in pharmaceutical research, industry and agribusiness. Form or phenyl and R3 = different acid groups derived from antibiotics. The aforementioned combinations can be presented as free acids in the form of their easily dissociable salts or esters.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19708846A DE19708846A1 (en) | 1997-03-05 | 1997-03-05 | New benzoxazinedione derivatives, process for their preparation and their use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9802894A true BR9802894A (en) | 2000-03-21 |
Family
ID=7822233
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9802894A BR9802894A (en) | 1997-03-05 | 1998-03-05 | Benzoxazindione derivative, application of a benzoxazindione derivative and medication. |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US6013647A (en) |
| EP (1) | EP0863139B1 (en) |
| JP (1) | JPH10316666A (en) |
| KR (1) | KR19980079905A (en) |
| CN (1) | CN1075064C (en) |
| AR (1) | AR010125A1 (en) |
| AT (1) | ATE200080T1 (en) |
| AU (1) | AU737760B2 (en) |
| BR (1) | BR9802894A (en) |
| CA (1) | CA2230965A1 (en) |
| CO (1) | CO4950613A1 (en) |
| CZ (1) | CZ65098A3 (en) |
| DE (2) | DE19708846A1 (en) |
| DK (1) | DK0863139T3 (en) |
| ES (1) | ES2157617T3 (en) |
| GR (1) | GR3035834T3 (en) |
| HU (1) | HUP9800472A3 (en) |
| IL (1) | IL123535A (en) |
| NO (1) | NO310657B1 (en) |
| NZ (1) | NZ329883A (en) |
| PE (1) | PE71799A1 (en) |
| PL (1) | PL325142A1 (en) |
| PT (1) | PT863139E (en) |
| RU (1) | RU2184114C2 (en) |
| SI (1) | SI0863139T1 (en) |
| SK (1) | SK28898A3 (en) |
| UA (1) | UA45414C2 (en) |
| UY (1) | UY24915A1 (en) |
| ZA (1) | ZA981847B (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6115157A (en) * | 1997-12-24 | 2000-09-05 | Nortel Networks Corporation | Methods for equalizing WDM systems |
| US6509334B1 (en) * | 1999-05-04 | 2003-01-21 | American Home Products Corporation | Cyclocarbamate derivatives as progesterone receptor modulators |
| DE10111164A1 (en) * | 2001-03-01 | 2002-09-05 | Gruenenthal Gmbh | New catechol derivatives derived from amino acids have siderophore activity and are useful as growth factors in bacterial cultures and as prodrugs for iron chelators |
| US7595073B2 (en) * | 2003-02-28 | 2009-09-29 | Kraft Foods Global Brands Llc | Use of siderophores and organic acids to retard lipid oxidation |
| US20040186087A1 (en) * | 2003-03-20 | 2004-09-23 | Ceramoptec Industries, Inc. | Siderophore conjugates of photoactive dyes for photodynamic therapy |
| CA2608687A1 (en) * | 2005-05-25 | 2006-11-30 | Actelion Pharmaceuticals Ltd. | New antibiotic derivatives |
| TWI603962B (en) * | 2016-09-10 | 2017-11-01 | 國立清華大學 | Thioxo-containiing oxazine compound and the synthesis method thereof |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3047573A (en) * | 1962-07-31 | N-alkylamido substituted | ||
| FR831710A (en) * | 1937-02-02 | 1938-09-13 | Manufacturing process of zippers, from non-metallic material | |
| GB878603A (en) * | 1959-07-01 | 1961-10-04 | Nippon Shinyaku Co Ltd | Salicyclic acid derivatives |
| DE1147583B (en) * | 1959-07-01 | 1963-04-25 | Nippon Shinyaku Co Ltd | Process for the preparation of 2, 4-dioxo-dihydro-1, 3-benzoxazinyl- (3) -acetic acid dialkylamides |
| US4319028A (en) * | 1976-08-26 | 1982-03-09 | Eli Lilly And Company | 7-(2-(Substituted benzoyl)amino)acetamido)cephalosporins |
| US4338436A (en) * | 1976-08-26 | 1982-07-06 | Eli Lilly And Company | 7-[2-[(Substituted benzoyl)amino]acetamido]cephalosporins |
| US4338439A (en) * | 1976-08-26 | 1982-07-06 | Eli Lilly And Company | 7-[2-[(Substituted benzoyl]amino]acetamido]cephalosporins |
| US4665070A (en) * | 1985-06-25 | 1987-05-12 | Syntex (U.S.A.) Inc. | 2-oxy-4H-3,1-benzoxazin-4-ones and pharmaceutical use |
| GB8811055D0 (en) * | 1988-05-10 | 1988-06-15 | Ici Plc | Antibiotic compounds |
| JP2807577B2 (en) * | 1990-06-15 | 1998-10-08 | エーザイ株式会社 | Cyclic amide derivative |
| AU644008B2 (en) * | 1990-08-10 | 1993-12-02 | Sumitomo Pharmaceuticals Company, Limited | Beta-lactam compounds, and their production and use |
| DE4102234A1 (en) * | 1991-01-23 | 1992-07-30 | Dresden Arzneimittel | NEW (ALPHA) -AMINOCHINOLINOYL- (3) -PENICILLINES, METHOD FOR THE PRODUCTION THEREOF AND ANTIBACTERIAL AGENTS CONTAINING THEM |
| IT1256023B (en) * | 1992-06-10 | 1995-11-20 | Italfarmaco Spa | BENZOSSAZINONIC AND BENZOTHIAZINONIC DERIVATIVES WITH CARDIOVASCULAR ACTIVITY |
| DE19654920A1 (en) * | 1996-06-26 | 1998-01-08 | Gruenenthal Gmbh | New synthetic catechol derivatives, process for their preparation and their use |
-
1997
- 1997-03-05 DE DE19708846A patent/DE19708846A1/en not_active Withdrawn
-
1998
- 1998-02-11 ES ES98102312T patent/ES2157617T3/en not_active Expired - Lifetime
- 1998-02-11 SI SI9830019T patent/SI0863139T1/en unknown
- 1998-02-11 DE DE59800568T patent/DE59800568D1/en not_active Expired - Fee Related
- 1998-02-11 EP EP98102312A patent/EP0863139B1/en not_active Expired - Lifetime
- 1998-02-11 AT AT98102312T patent/ATE200080T1/en not_active IP Right Cessation
- 1998-02-11 DK DK98102312T patent/DK0863139T3/en active
- 1998-02-11 PT PT98102312T patent/PT863139E/en unknown
- 1998-03-02 CN CN98107749A patent/CN1075064C/en not_active Expired - Fee Related
- 1998-03-03 NZ NZ329883A patent/NZ329883A/en unknown
- 1998-03-03 CA CA002230965A patent/CA2230965A1/en not_active Abandoned
- 1998-03-03 UY UY24915A patent/UY24915A1/en unknown
- 1998-03-03 UA UA98031095A patent/UA45414C2/en unknown
- 1998-03-04 CZ CZ98650A patent/CZ65098A3/en unknown
- 1998-03-04 SK SK288-98A patent/SK28898A3/en unknown
- 1998-03-04 PL PL98325142A patent/PL325142A1/en unknown
- 1998-03-04 AU AU56455/98A patent/AU737760B2/en not_active Ceased
- 1998-03-04 ZA ZA981847A patent/ZA981847B/en unknown
- 1998-03-04 CO CO98011756A patent/CO4950613A1/en unknown
- 1998-03-04 JP JP10052425A patent/JPH10316666A/en not_active Withdrawn
- 1998-03-04 PE PE1998000152A patent/PE71799A1/en not_active Application Discontinuation
- 1998-03-04 IL IL12353598A patent/IL123535A/en active IP Right Grant
- 1998-03-04 RU RU98104414/04A patent/RU2184114C2/en not_active IP Right Cessation
- 1998-03-04 AR ARP980100970A patent/AR010125A1/en not_active Application Discontinuation
- 1998-03-04 HU HU9800472A patent/HUP9800472A3/en unknown
- 1998-03-04 NO NO19980929A patent/NO310657B1/en not_active IP Right Cessation
- 1998-03-05 US US09/035,344 patent/US6013647A/en not_active Expired - Fee Related
- 1998-03-05 KR KR1019980007193A patent/KR19980079905A/en not_active Ceased
- 1998-03-05 BR BR9802894A patent/BR9802894A/en not_active IP Right Cessation
-
2001
- 2001-05-07 GR GR20010400682T patent/GR3035834T3/en not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A,8A E 9A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1908 DE 31/07/2007. |