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BR9714269A - Composto, composição farmacêutica, e, processos para controlar uma infecção bacteriana em um mamìfero e para a preparação de compostos macrólidos tricìclicos - Google Patents

Composto, composição farmacêutica, e, processos para controlar uma infecção bacteriana em um mamìfero e para a preparação de compostos macrólidos tricìclicos

Info

Publication number
BR9714269A
BR9714269A BR9714269-7A BR9714269A BR9714269A BR 9714269 A BR9714269 A BR 9714269A BR 9714269 A BR9714269 A BR 9714269A BR 9714269 A BR9714269 A BR 9714269A
Authority
BR
Brazil
Prior art keywords
processes
compound
preparation
pharmaceutical composition
bacterial infection
Prior art date
Application number
BR9714269-7A
Other languages
English (en)
Inventor
Yat Sun Or
Ly Tam Phan
Daniel T Chu
Kenneth P Spina
Robert Hallas
Richard L Elliot
Michael Tufano
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of BR9714269A publication Critical patent/BR9714269A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"COMPOSTO, COMPOSIçãO FARMACêUTICA, E, PROCESSO PARA CONTROLAR UMA INFECçãO BACTERIANA EM UM MAMìFERO E PARA A PREPARAçãO DE COMPOSTOS MACRóLIDOS TRICìCLICOS". Compostos ou seus sais ou ésteres farmaceuticamente aceitáveis, das fórmulas (I) ou (IV) em que A,B,D eE, R^ 1^, R^ 2^ e Z especificamente definidos, tendo atividade antibacteriana, composições farmacêuticas contendo os ditos compostos, tratamento de infecções bacterianas com tais composições e processos para preparação dos compostos.
BR9714269-7A 1997-01-07 1997-04-07 Composto, composição farmacêutica, e, processos para controlar uma infecção bacteriana em um mamìfero e para a preparação de compostos macrólidos tricìclicos BR9714269A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/779,786 US6274715B1 (en) 1995-11-08 1997-01-07 Tricyclic erythromycin derivatives
PCT/US1997/005871 WO1998030574A1 (en) 1997-01-07 1997-04-07 Tricyclic erythromycin derivatives

Publications (1)

Publication Number Publication Date
BR9714269A true BR9714269A (pt) 2000-04-18

Family

ID=25117567

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9714269-7A BR9714269A (pt) 1997-01-07 1997-04-07 Composto, composição farmacêutica, e, processos para controlar uma infecção bacteriana em um mamìfero e para a preparação de compostos macrólidos tricìclicos

Country Status (15)

Country Link
US (1) US6274715B1 (pt)
EP (1) EP0961776A1 (pt)
JP (1) JP2001507714A (pt)
KR (1) KR20000069935A (pt)
CN (1) CN1244202A (pt)
AR (1) AR006678A1 (pt)
AU (1) AU2449597A (pt)
BR (1) BR9714269A (pt)
CA (1) CA2277116A1 (pt)
CZ (1) CZ231599A3 (pt)
HU (1) HUP0001518A3 (pt)
IL (1) IL130328A0 (pt)
NZ (1) NZ336174A (pt)
TW (1) TW442490B (pt)
WO (1) WO1998030574A1 (pt)

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KR100576988B1 (ko) 1996-09-04 2006-05-10 아보트 러보러터리즈 항균 활성을 지닌 6-ｏ-치환된 케톨라이드
FR2781484B1 (fr) * 1998-07-21 2001-08-10 Hoechst Marion Roussel Inc Nouveaux derives de la 6-deoxy erythromycine, leur procede de preparation et leur application comme medicaments
FR2784682B1 (fr) * 1998-10-15 2002-12-06 Hoechst Marion Roussel Inc Nouveaux derives 2-halogene de 5-0-desosaminylerythronolide a, leur procede de preparation et leur application comme medicaments
NZ515027A (en) 1999-04-16 2004-01-30 Kosan Biosciences Inc Erythromycin derivatives as antibiotics
US6514944B2 (en) 1999-04-16 2003-02-04 Kosan Biosciences, Inc. Macrolide antiinfective agents
US6939861B2 (en) 1999-04-16 2005-09-06 Kosan Biosciences, Inc. Amido macrolides
US6451768B1 (en) 1999-04-16 2002-09-17 Kosan Biosciences, Inc. Macrolide antiinfective agents
CN1351608A (zh) * 1999-05-24 2002-05-29 辉瑞产品公司 13－甲基红霉素衍生物
US6569836B2 (en) 1999-12-02 2003-05-27 Abbott Laboratories 6-O-alkyl-2-nor-2-substituted ketolide derivatives
TWI290136B (en) 2000-04-05 2007-11-21 Daiichi Seiyaku Co Ethylenediamine derivatives
EP1146051A3 (en) * 2000-04-10 2001-10-31 Pfizer Products Inc. Erythromycin A derivatives
WO2003000657A1 (en) 2001-06-20 2003-01-03 Daiichi Pharmaceutical Co., Ltd. Diamine derivatives
CN1826333B (zh) 2001-06-20 2012-12-26 第一三共株式会社 二胺衍生物
AU2002328596B2 (en) 2001-08-09 2007-09-20 Daiichi Pharmaceutical Co., Ltd. Diamine derivatives
US20040014690A1 (en) * 2002-02-13 2004-01-22 Zhenkun Ma Macrolides with activity against methicillin-resistant staphylococcus aureus
US7273853B2 (en) * 2002-05-13 2007-09-25 Enanta Pharmaceuticals, Inc. 6-11 bicyclic ketolide derivatives
US6841664B2 (en) * 2002-07-25 2005-01-11 Enanra Pharmaceuticals, Inc. 6,11-4-carbon bridged ketolides
US7910558B2 (en) * 2002-05-13 2011-03-22 Enanta Pharmaceuticals, Inc. Bridged macrocyclic compounds and processes for the preparation thereof
CA2487918A1 (en) * 2002-05-31 2003-12-11 Janssen Pharmaceutica N.V. 3-descladinosyl-6-o-carbamoyl and 6-o-carbonoyl macrolide antibacterial agents
US6750204B2 (en) 2002-06-25 2004-06-15 Enanta Pharmaceuticals, Inc. 11-C-substituted ketolides
US6812216B2 (en) 2002-06-25 2004-11-02 Enanta Pharmaceuticals, Inc. 11-C-substituted derivatives of clarithromycin
US7091196B2 (en) * 2002-09-26 2006-08-15 Rib-X Pharmaceuticals, Inc. Bifunctional heterocyclic compounds and methods of making and using same
WO2004078770A1 (en) * 2003-03-05 2004-09-16 Rib-X Pharmaceuticals, Inc. Bifunctional heterocyclic compounds and methods of making and using the same
EP3738591A3 (en) 2003-03-10 2021-03-24 Merck Sharp & Dohme Corp. Novel antibacterial agents
US20070149463A1 (en) * 2003-10-30 2007-06-28 Oyelere Adegboyega K Bifunctional macrolide heterocyclic compounds and methods of making and using the same
US20070270357A1 (en) * 2003-11-18 2007-11-22 Farmer Jay J Bifunctional Macrolide Heterocyclic Compounds and Methods of Making and Using the Same
AU2003304705A1 (en) 2003-12-24 2005-08-03 Enanta Pharmaceuticals, Inc. 11-csubsituted erythromycin derivatives
US7414030B2 (en) * 2004-01-07 2008-08-19 Enanta Pharmaceuticals, Inc. 6-11 Bicyclic erythromycin derivatives
WO2005070113A2 (en) * 2004-01-09 2005-08-04 Enanta Pharmaceuticals, Inc. 9n-substituted 6-11 bicyclic erythromycin derivatives
US7384921B2 (en) * 2004-02-20 2008-06-10 Enanta Pharmaceuticals, Inc. Polymorphic forms of 6-11 bicyclic ketolide derivatives
US8202843B2 (en) 2004-02-27 2012-06-19 Rib-X Pharmaceuticals, Inc. Macrocyclic compounds and methods of making and using the same
WO2006065743A2 (en) * 2004-12-13 2006-06-22 Enanta Pharmaceuticals, Inc. Tetracylic bicyclolides
US20060252710A1 (en) * 2005-05-04 2006-11-09 Guoqiang Wang 6-11 Bridged oxime erythromycin derivatives
US7384922B2 (en) * 2005-05-04 2008-06-10 Enanta Pharmaceuticals, Inc. 6-11 bridged oxime erythromycin derivatives
US8273720B2 (en) * 2007-09-17 2012-09-25 Enanta Pharmaceuticals, Inc. 6,11-bicyclolides: bridged biaryl macrolide derivatives
US20090118506A1 (en) * 2007-09-17 2009-05-07 In Jong Kim 6,11-bridged biaryl macrolides
US8354383B2 (en) * 2007-09-17 2013-01-15 Enanta Pharmaceuticals, Inc. 6,11-bridged biaryl macrolides
WO2009055557A1 (en) * 2007-10-25 2009-04-30 Cempra Pharmaceuticals, Inc. Process for the preparation of macrolide antibacterial agents
US8208698B2 (en) * 2007-12-14 2012-06-26 Mela Sciences, Inc. Characterizing a texture of an image
TW200946109A (en) * 2008-05-09 2009-11-16 Enanta Pharm Inc Anti-bacterial activity of 9-hydroxy derivatives 6, 11-bicyclolides
DK2358379T3 (en) 2008-10-24 2016-03-07 Cempra Pharmaceuticals Inc BIOFORSVAR USING TRIAZOLHOLDIGE macrolides
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
EP2475253B1 (en) 2009-09-10 2016-10-26 Cempra Pharmaceuticals, Inc. Methods for treating malaria, tuberculosis and mac diseases
US20110064287A1 (en) * 2009-09-14 2011-03-17 Alexandru Bogdan Characterizing a texture of an image
CN104698749B (zh) * 2010-01-25 2019-11-19 罗门哈斯电子材料有限公司 包含含氮化合物的光致抗蚀剂
JP5711352B2 (ja) 2010-03-22 2015-04-30 センプラ ファーマシューティカルズ，インコーポレイテッド マクロライドの結晶形、およびその使用
WO2011146829A1 (en) 2010-05-20 2011-11-24 Cempra Pharmaceuticals, Inc. Processes for preparing macrolides and ketolides and intermediates therefor
US9815863B2 (en) 2010-09-10 2017-11-14 Cempra Pharmaceuticals, Inc. Hydrogen bond forming fluoro ketolides for treating diseases
US10188674B2 (en) 2012-03-27 2019-01-29 Cempra Pharmaceuticals, Inc. Parenteral formulations for administering macrolide antibiotics
EP2968801B1 (en) 2013-03-14 2018-09-26 Cempra Pharmaceuticals, Inc. Methods for treating respiratory diseases and formulations therefor
CN105188712A (zh) 2013-03-15 2015-12-23 森普拉制药公司 用于制备大环内酯抗菌剂的收敛方法
CN104650166B (zh) * 2014-11-17 2017-12-05 广东东阳光药业有限公司 一种大环内酯的制备方法

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CA2096969C (en) 1990-11-28 2000-11-21 Masato Kashimura 6-0-methylerythromycin a derivatives
US5523399A (en) 1991-12-27 1996-06-04 Taisho Pharmaceutical Co., Ltd. 5-O-desosaminylerythronolide derivatives
AU662420B2 (en) 1992-04-22 1995-08-31 Taisho Pharmaceutical Co., Ltd. 5-O-desosaminylerythronolide A derivative
JP3227871B2 (ja) * 1993-02-25 2001-11-12 大正製薬株式会社 ６−ｏ−メチルエリスロマイシンａ誘導体
DE69631609T2 (de) 1995-11-08 2005-01-05 Abbott Laboratories, Abbott Park Tricyclische erythromycinderivate

Also Published As

Publication number Publication date
HUP0001518A2 (hu) 2000-09-28
NZ336174A (en) 2001-02-23
HUP0001518A3 (en) 2001-11-28
CN1244202A (zh) 2000-02-09
US6274715B1 (en) 2001-08-14
EP0961776A1 (en) 1999-12-08
CZ231599A3 (cs) 1999-12-15
KR20000069935A (ko) 2000-11-25
CA2277116A1 (en) 1998-07-16
JP2001507714A (ja) 2001-06-12
IL130328A0 (en) 2000-06-01
AU2449597A (en) 1998-08-03
AR006678A1 (es) 1999-09-08
WO1998030574A1 (en) 1998-07-16
TW442490B (en) 2001-06-23

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A,8A E 9A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1833 DE 21/02/2006.

B15K Others concerning applications: alteration of classification

Free format text: PROCEDIMENTO AUTOMATICO DE RECLASSIFICACAO. AS CLASSIFICACOES IPC ANTERIORES ERAM: C07H 17/00; C07H 17/08; A61K 31/71.

Ipc: C07H 17/08 (2006.01), C07H 17/00 (2006.01)

Ipc: C07H 17/08 (2006.01), C07H 17/00 (2006.01)