BR9713400A - Processos e compostos para inibir liberação de peptìdeo beta-amilóide e/ou sua sìntese. - Google Patents

Processos e compostos para inibir liberação de peptìdeo beta-amilóide e/ou sua sìntese.

Info

Publication number: BR9713400A
Authority: BR; Brazil
Prior art keywords: synthesis; amyloid peptide; compounds; processes; release
Prior art date: 1996-11-22

Application number

BR9713400-7A

Other languages

English (en)

Portuguese (pt)

Inventor

James E Audia

Thomas C Britton

James J Droste

Beverly K Folmer

George W Huffman

Varghese John

Lee H Latimer

Thomas E Mabry

Jeffrey S Nissen

Warren J Porter

Jon K Reel

Eugene D Thorsett

Jay S Tung

Jing Wu

Clark Norman Eid

William Leonard Scott

Original Assignee

Elan Pharm Inc

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-11-22

Filing date

1997-11-21

Publication date

2000-01-25

1997-11-21 Application filed by Elan Pharm Inc, Lilly Co Eli filed Critical Elan Pharm Inc

2000-01-25 Publication of BR9713400A publication Critical patent/BR9713400A/pt

Links

230000015572 biosynthetic process Effects 0.000 title abstract 4
150000001875 compounds Chemical class 0.000 title abstract 4
238000003786 synthesis reaction Methods 0.000 title abstract 4
238000000034 method Methods 0.000 title abstract 3
DZHSAHHDTRWUTF-SIQRNXPUSA-N amyloid-beta polypeptide 42 Chemical compound C([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O)[C@@H](C)CC)C(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(C)C)C1=CC=CC=C1 DZHSAHHDTRWUTF-SIQRNXPUSA-N 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 abstract 2
108090000765 processed proteins & peptides Proteins 0.000 abstract 2
208000024827 Alzheimer disease Diseases 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C07K5/06043—Leu-amino acid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurosurgery (AREA)
Engineering & Computer Science (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Psychiatry (AREA)
Pharmacology & Pharmacy (AREA)
Hospice & Palliative Care (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Hydrogenated Pyridines (AREA)

BR9713400-7A 1996-11-22 1997-11-21 Processos e compostos para inibir liberação de peptìdeo beta-amilóide e/ou sua sìntese. BR9713400A (pt)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US75544296A	1996-11-22	1996-11-22
US80852897A	1997-02-28	1997-02-28
US80752897A	1997-02-28	1997-02-28
US80742797A	1997-02-28	1997-02-28
PCT/US1997/020804 WO1998022494A2 (en)	1996-11-22	1997-11-21	METHODS AND COMPOUNDS FOR INHIBITING β-AMYLOID PEPTIDE RELEASE AND/OR SYNTHESIS

Publications (1)

Publication Number	Publication Date
BR9713400A true BR9713400A (pt)	2000-01-25

Family

ID=27505670

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BR9713400-7A BR9713400A (pt)	1996-11-22	1997-11-21	Processos e compostos para inibir liberação de peptìdeo beta-amilóide e/ou sua sìntese.

Country Status (21)

Country	Link
EP (1)	EP0942924A2 (es)
JP (1)	JP2001503782A (es)
KR (1)	KR20000069064A (es)
CN (1)	CN1238779A (es)
AR (1)	AR016751A1 (es)
AU (1)	AU5356198A (es)
BR (1)	BR9713400A (es)
CA (1)	CA2267634A1 (es)
CO (1)	CO4910156A1 (es)
CZ (1)	CZ122899A3 (es)
EA (1)	EA199900490A1 (es)
HR (1)	HRP970627A2 (es)
HU (1)	HUP0100270A3 (es)
ID (1)	ID22044A (es)
IL (1)	IL129083A0 (es)
NO (1)	NO992368L (es)
NZ (1)	NZ334690A (es)
PE (1)	PE16999A1 (es)
TR (3)	TR199901133T2 (es)
WO (1)	WO1998022494A2 (es)
YU (1)	YU46097A (es)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE122010000020I1 (de)	1996-04-25	2010-07-08	Prosidion Ltd	Verfahren zur Senkung des Blutglukosespiegels in Säugern
US6191166B1 (en) *	1997-11-21	2001-02-20	Elan Pharmaceuticals, Inc.	Methods and compounds for inhibiting β-amyloid peptide release and/or its synthesis
US6635632B1 (en)	1996-12-23	2003-10-21	Athena Neurosciences, Inc.	Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
DE19823831A1 (de)	1998-05-28	1999-12-02	Probiodrug Ges Fuer Arzneim	Neue pharmazeutische Verwendung von Isoleucyl Thiazolidid und seinen Salzen
US6552013B1 (en)	1998-06-22	2003-04-22	Elan Pharmaceuticals, Inc.	Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
EP1089980A1 (en) *	1998-06-22	2001-04-11	Elan Pharmaceuticals, Inc.	Compounds for inhibiting beta-amyloid peptide release and/or its synthesis
EP1093372A4 (en) *	1998-06-22	2004-09-29	Elan Pharm Inc	CYCLIC AMINO ACID COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND METHODS OF INHIBITING PEPTIDE RELEASE $ g (b) -AMYLOID AND / OR ITS SYNTHESIS USING THE SAME
US6958330B1 (en)	1998-06-22	2005-10-25	Elan Pharmaceuticals, Inc.	Polycyclic α-amino-ε-caprolactams and related compounds
AU4707999A (en) *	1998-06-22	2000-01-10	Elan Pharmaceuticals, Inc.	Compounds for inhibiting beta-amyloid peptide release and/or its synthesis
DE19828114A1 (de)	1998-06-24	2000-01-27	Probiodrug Ges Fuer Arzneim	Produgs instabiler Inhibitoren der Dipeptidyl Peptidase IV
DE19828113A1 (de)	1998-06-24	2000-01-05	Probiodrug Ges Fuer Arzneim	Prodrugs von Inhibitoren der Dipeptidyl Peptidase IV
DE19834591A1 (de)	1998-07-31	2000-02-03	Probiodrug Ges Fuer Arzneim	Verfahren zur Steigerung des Blutglukosespiegels in Säugern
EP1131634A2 (en)	1998-09-30	2001-09-12	Elan Pharmaceuticals, Inc.	Determining the mechanism of beta-amyloid peptide generation
US6737038B1 (en)	1998-11-12	2004-05-18	Bristol-Myers Squibb Company	Use of small molecule radioligands to discover inhibitors of amyloid-beta peptide production and for diagnostic imaging
CA2352740A1 (en)	1998-12-10	2000-06-15	F. Hoffmann-La Roche Ag	Procollagen c-proteinase inhibitors
US6972296B2 (en)	1999-05-07	2005-12-06	Encysive Pharmaceuticals Inc.	Carboxylic acid derivatives that inhibit the binding of integrins to their receptors
MXPA01011341A (es) *	1999-05-07	2002-06-21	Texas Biotechnology Corp	Derivados de acido propanoico que inhiben la union de las integrinas a sus receptores.
US6723711B2 (en)	1999-05-07	2004-04-20	Texas Biotechnology Corporation	Propanoic acid derivatives that inhibit the binding of integrins to their receptors
DE19926233C1 (de)	1999-06-10	2000-10-19	Probiodrug Ges Fuer Arzneim	Verfahren zur Herstellung von Thiazolidin
DE19940130A1 (de)	1999-08-24	2001-03-01	Probiodrug Ges Fuer Arzneim	Neue Effektoren der Dipeptidyl Peptidase IV zur topischen Anwendung
CA2388750A1 (en) *	1999-11-09	2001-05-17	James Edmund Audia	.beta.-aminoacid compounds useful for inhibiting .beta.-amyloid peptide release and/or its synthesis
CA2400226C (en)	2000-03-31	2007-01-02	Probiodrug Ag	Method for the improvement of islet signaling in diabetes mellitus and for its prevention
AU2001261728A1 (en)	2000-05-17	2001-11-26	Bristol-Myers Squibb Pharma Company	Use of small molecule radioligands for diagnostic imaging
HK1049333A1 (zh)	2000-06-01	2003-05-09	Bristol-Myers Squibb Pharma Company	以环状琥珀酸酯代替内酰胺，作为制造Aβ蛋白质的抑制剂
FR2832152A1 (fr) *	2001-11-09	2003-05-16	Aventis Pharma Sa	Utilisation de derives de 2-amino-thiazoline comme inhibiteurs de no-synthase inductible
US6432944B1 (en)	2000-07-06	2002-08-13	Bristol-Myers Squibb Company	Benzodiazepinone β-amyloid inhibitors: arylacetamidoalanyl derivatives
GB0016681D0 (en)	2000-07-06	2000-08-23	Merck Sharp & Dohme	Therapeutic compounds
US7132104B1 (en)	2000-10-27	2006-11-07	Probiodrug Ag	Modulation of central nervous system (CNS) dipeptidyl peptidase IV (DPIV) -like activity for the treatment of neurological and neuropsychological disorders
US6890905B2 (en)	2001-04-02	2005-05-10	Prosidion Limited	Methods for improving islet signaling in diabetes mellitus and for its prevention
US20030130199A1 (en)	2001-06-27	2003-07-10	Von Hoersten Stephan	Dipeptidyl peptidase IV inhibitors and their uses as anti-cancer agents
US7368421B2 (en)	2001-06-27	2008-05-06	Probiodrug Ag	Use of dipeptidyl peptidase IV inhibitors in the treatment of multiple sclerosis
DE10150203A1 (de)	2001-10-12	2003-04-17	Probiodrug Ag	Peptidylketone als Inhibitoren der DPIV
AR039059A1 (es)	2001-08-06	2005-02-09	Sanofi Aventis	Compuesto derivado de acilaminotiazol, su utilizacion, procedimientos para prepararlo, composicion farmaceutica que lo comprende, y compuestos intermediarios
FR2840899B1 (fr) *	2002-06-12	2005-02-25	Sanofi Synthelabo	Derives d'acylaminothiazole, leur preparation et leur utilisation en therapeutique
DE10143840A1 (de) *	2001-09-06	2003-03-27	Probiodrug Ag	Neue Inhibitoren der Dipeptidylpeptidase I
US6844316B2 (en)	2001-09-06	2005-01-18	Probiodrug Ag	Inhibitors of dipeptidyl peptidase I
PL370324A1 (en)	2001-11-09	2005-05-16	Aventis Pharma S.A.	2-amino-thiazoline derivatives and their use as inhibitors of inducible no-synthase
EA007434B1 (ru)	2002-02-28	2006-10-27	Прозидион Лимитед	Ингибиторы dpiv на основе глутаминила
ES2387803T3 (es) *	2003-01-08	2012-10-02	Novartis Vaccines And Diagnostics, Inc.	Agentes antibacterianos
KR20110059664A (ko)	2003-05-05	2011-06-02	프로비오드룩 아게	글루타미닐 및 글루타메이트 사이클라제의 이펙터의 용도
WO2004098591A2 (en)	2003-05-05	2004-11-18	Probiodrug Ag	Inhibitors of glutaminyl cyclase and their use in the treatment of neurological diseases
WO2005027969A1 (ja) *	2003-09-24	2005-03-31	Santen Pharmaceutical Co., Ltd.	視神経障害を伴う眼疾患の治療剤
EP2289498A1 (en)	2003-10-15	2011-03-02	Probiodrug AG	Use of inhibitors of glutaminyl clyclase
CA2691987C (en)	2007-06-12	2016-08-16	Achaogen, Inc.	Antibacterial agents
EP2062909A1 (en) *	2007-11-21	2009-05-27	SOLVAY (Société Anonyme)	Peptide production and purification process
BG110141A (en)	2008-05-23	2009-12-31	"Софарма" Ад	GALANTAMINE DERIVATIVES, METHODS FOR THEIR PREPARATION AND USE
EP2847168A1 (en)	2012-05-10	2015-03-18	Achaogen, Inc.	Antibacterial agents
WO2017004560A1 (en) *	2015-07-02	2017-01-05	The Regents Of The University Of California	Methods and compositions for amyloid aggregates
EP4274559A4 (en) *	2021-01-05	2024-12-11	Southern Research Institute	PROGRAMMED DEATH-LIGAND-1 MODULATORS
WO2024076635A2 (en) *	2022-10-05	2024-04-11	Buck Institute For Research On Aging	Suppressors of site iq electron leak and uses thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IE910713A1 (en) *	1990-03-05	1991-09-11	Cephalon Inc	Chymotrypsin-like proteases
WO1995013084A1 (en) *	1992-05-11	1995-05-18	Miles Inc.	Cathepsin d is an amyloidogenic protease in alzheimer's disease
ZA945719B (en) *	1993-08-09	1996-02-01	Lilly Co Eli	Identification and use of protease inhibitors
PT721449E (pt) *	1993-10-01	2002-06-28	Merrell Pharma Inc	Inibidores da producao da proteina beta-amiloide
US5863902A (en) *	1995-01-06	1999-01-26	Sibia Neurosciences, Inc.	Methods of treating neurodegenerative disorders using protease inhibitors
US5804560A (en) *	1995-01-06	1998-09-08	Sibia Neurosciences, Inc.	Peptide and peptide analog protease inhibitors
WO1996039194A1 (en) *	1995-06-06	1996-12-12	Athena Neurosciences, Inc.	Novel cathepsin and methods and compositions for inhibition thereof

1997
- 1997-11-18 AR ARP970105393A patent/AR016751A1/es not_active Application Discontinuation
- 1997-11-19 HR HR08/808,528A patent/HRP970627A2/hr not_active Application Discontinuation
- 1997-11-20 PE PE1997001056A patent/PE16999A1/es not_active Application Discontinuation
- 1997-11-21 CO CO97068215A patent/CO4910156A1/es unknown
- 1997-11-21 TR TR1999/01133T patent/TR199901133T2/xx unknown
- 1997-11-21 JP JP52375698A patent/JP2001503782A/ja active Pending
- 1997-11-21 KR KR1019997004486A patent/KR20000069064A/ko not_active Withdrawn
- 1997-11-21 TR TR1999/02938T patent/TR199902938T2/xx unknown
- 1997-11-21 CA CA002267634A patent/CA2267634A1/en not_active Abandoned
- 1997-11-21 CN CN97199803A patent/CN1238779A/zh active Pending
- 1997-11-21 TR TR1999/02937T patent/TR199902937T2/xx unknown
- 1997-11-21 EP EP97950601A patent/EP0942924A2/en not_active Withdrawn
- 1997-11-21 AU AU53561/98A patent/AU5356198A/en not_active Abandoned
- 1997-11-21 HU HU0100270A patent/HUP0100270A3/hu unknown
- 1997-11-21 CZ CZ991228A patent/CZ122899A3/cs unknown
- 1997-11-21 WO PCT/US1997/020804 patent/WO1998022494A2/en not_active Ceased
- 1997-11-21 IL IL12908397A patent/IL129083A0/xx unknown
- 1997-11-21 BR BR9713400-7A patent/BR9713400A/pt not_active IP Right Cessation
- 1997-11-21 YU YU46097A patent/YU46097A/sh unknown
- 1997-11-21 EA EA199900490A patent/EA199900490A1/ru unknown
- 1997-11-21 NZ NZ334690A patent/NZ334690A/en unknown
- 1997-11-21 ID IDW990394A patent/ID22044A/id unknown
1999
- 1999-05-14 NO NO992368A patent/NO992368L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
EA199900490A1 (ru)	2000-02-28
YU46097A (sh)	2000-10-30
KR20000069064A (ko)	2000-11-25
EP0942924A2 (en)	1999-09-22
HUP0100270A2 (hu)	2001-08-28
AR016751A1 (es)	2001-08-01
NO992368L (no)	1999-06-21
HRP970627A2 (en)	1998-08-31
TR199901133T2 (xx)	1999-07-21
NO992368D0 (no)	1999-05-14
WO1998022494A2 (en)	1998-05-28
HUP0100270A3 (en)	2001-09-28
AU5356198A (en)	1998-06-10
PE16999A1 (es)	1999-02-19
CO4910156A1 (es)	2000-04-24
IL129083A0 (en)	2000-02-17
CZ122899A3 (cs)	1999-10-13
ID22044A (id)	1999-08-26
CN1238779A (zh)	1999-12-15
NZ334690A (en)	2001-09-28
WO1998022494A3 (en)	1998-11-26
TR199902937T2 (xx)	2001-01-22
CA2267634A1 (en)	1998-05-28
TR199902938T2 (xx)	2002-06-21
JP2001503782A (ja)	2001-03-21

Publication	Publication Date	Title
BR9713400A (pt)	2000-01-25	Processos e compostos para inibir liberação de peptìdeo beta-amilóide e/ou sua sìntese.
BR9714517A (pt)	2000-07-04	Cicloalquila, lactama, lactona e compostos correlatos, composições farmacêuticas compreendendo os mesmos e processos para inibir liberação de peptìdeo beta-amilóide e/ou sua sìntese por uso de tais compostos
BR9713404A (pt)	2000-01-25	ésteres de n-(aril/heteroarilacetil) aminoácidos, composições farmacêuticas compreendendo os mesmos, e métodos para a inibição da liberação de peptìdeo beta-amilóide e/ou de sua sìntese por uso de tais compostos.
BR9807876A (pt)	2000-02-29	Compostos heterocìclicos e seu uso para inibição de peptìdeo beta-amilóide
BR9714358A (pt)	2000-03-21	Derivados de n- (arila/heteroarila) amino ácido,composições farmacêuticas compreendendo os mesmos, e métodos para a inibição de liberação de peptìdeo beta-amilóide e/ou sua sìntese por uso de tais compostos
BG101118A (en)	1998-04-30	Therapeutical compounds
BR0008922A (pt)	2002-01-15	Compostos úteis como agentes antiinflamatórios
GB0129260D0 (en)	2002-01-23	Pharmaceutical compositions and their uses
NO961326L (no)	1996-04-01	Inhibitorer av -amyloidproteinproduksjon
DE69738581D1 (de)	2008-04-30	Menschliche dnase i hyperaktive varianten
BR0115427A (pt)	2003-10-07	Composto, composição farmacêutica, métodos para inibir a liberação de peptìdeo beta-amilóide e/ou sua sìntese, para tratar a doença de alzheimer, e para prevenir a doença e o progresso da doença de alzheimer, e, uso de um composto
BG104599A (en)	2001-03-30	Inhibition of raf kinase using symmetrical and unsymmetrical substituted diphenyl ureas
BR9913072A (pt)	2001-05-15	Sistemas de anel azacìclico, composição farmacêutica, e, processo para induzir a analgesia
EA199700032A1 (ru)	1997-12-30	Дезинфицирующий состав "велтолен"
BR9712141A (pt)	1999-08-31	Aplicação de 1-hifróxi-2-piridonas para tratamento de infecções cutâneas.
BG104179A (en)	2000-10-31	Phanquinon administration for the treatment of the alzheimer's disease
IL113940A (en)	1999-12-31	Synthetic peptides which are elastase inhibitors and pharmaceutical compositions for the treatment of neutrophil associated inflammatory disease containing said inhibitors
AU4568400A (en)	2000-12-18	Sphingomyelinase inhibitor
DE69420574D1 (de)	1999-10-14	Derivate von therapeutisch in der blutgerinnungskaskade wirksamen peptiden, verfahren zur herstellung und sie enthaltende pharmazeutische zubereitungen
ECSP972320A (es)	1999-05-17	METODOS Y COMPOSICIONES PARA INHIBIR LA LIBERACION DE PEPTIDO ß- AMILOIDE Y/O SU SINTESIS
UA31266A (uk)	2000-12-15	Лікувальний засіб "дінальгін"

Legal Events

Date	Code	Title	Description
2007-04-27	B08F	Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]	Free format text: REFERENTE A 6A, 7A, 8A E 9A ANUIDADES.
2011-11-29	B08K	Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]	Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1894 DE 24/04/2007.