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BR9713339A - Process for preparing salts and esters of clavulanic acid. - Google Patents

Process for preparing salts and esters of clavulanic acid.

Info

Publication number
BR9713339A
BR9713339A BR9713339-6A BR9713339A BR9713339A BR 9713339 A BR9713339 A BR 9713339A BR 9713339 A BR9713339 A BR 9713339A BR 9713339 A BR9713339 A BR 9713339A
Authority
BR
Brazil
Prior art keywords
esters
clavulanic acid
preparing salts
preparation
salts
Prior art date
Application number
BR9713339-6A
Other languages
Portuguese (pt)
Inventor
Johannes Booij
Antonius Van Den Heuvel
Original Assignee
Gist Brocades Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gist Brocades Bv filed Critical Gist Brocades Bv
Publication of BR9713339A publication Critical patent/BR9713339A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

''PROCESSO PARA PREPARACãO DE SAIS E éSTERES DO áCIDO CLAVULâNICO'' Fornece-se um processo aprimorado para a preparação de sais ou ésteres de metais alcalinos do ácido clavulânico, de uso farmacêutico. Além disso, fornece-se clavulanato de potássio com um teor de amina extremamente baixo e composições farmacêuticas que compreendem o mesmo.'' PROCESS FOR THE PREPARATION OF CLAVULANIC ACID SALTS AND ESTERS '' An improved process is provided for the preparation of alkaline metal salts or esters of clavulanic acid, for pharmaceutical use. In addition, potassium clavulanate with an extremely low amine content and pharmaceutical compositions comprising the same are provided.

BR9713339-6A 1996-11-11 1997-11-10 Process for preparing salts and esters of clavulanic acid. BR9713339A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP96203117 1996-11-11
PCT/EP1997/006263 WO1998021212A1 (en) 1996-11-11 1997-11-10 Process for the preparation of salts and esters of clavulanic acid

Publications (1)

Publication Number Publication Date
BR9713339A true BR9713339A (en) 2000-05-09

Family

ID=8224563

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9713339-6A BR9713339A (en) 1996-11-11 1997-11-10 Process for preparing salts and esters of clavulanic acid.

Country Status (11)

Country Link
EP (1) EP0937084A1 (en)
JP (1) JP2001503763A (en)
CN (1) CN1238776A (en)
AU (1) AU5551698A (en)
BR (1) BR9713339A (en)
CA (1) CA2271847A1 (en)
NO (1) NO992225D0 (en)
PL (1) PL333247A1 (en)
TR (1) TR199901631T2 (en)
WO (1) WO1998021212A1 (en)
ZA (1) ZA9710141B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT400033B (en) 1992-03-10 1995-09-25 Biochemie Gmbh NEW METHOD FOR ISOLATING AND PURIFYING CLAVULANIC ACID AND FOR PRODUCING PHARMACOLOGICALLY COMPATIBLE SALTS THEREOF
SI9500134B (en) * 1995-04-20 2004-04-30 Lek, Preparation procedure of pure alkali salts of clavulanic acid
AT403375B (en) * 1995-11-15 1998-01-26 Biochemie Gmbh METHOD FOR FILLING ALKALINE SALTS OF CLAVULANIC ACID
CA2337072A1 (en) * 1998-07-16 2000-01-27 Dsm N.V. Improved process for the preparation of salts and esters of clavulanic acid
CA2364342C (en) * 1999-04-01 2011-02-01 Dsm N.V. Agglomerates by crystallisation
US7767823B2 (en) * 2000-05-13 2010-08-03 Smithkline Beecham Limited Process for the purification of a salt of clavulanic acid
KR20090094261A (en) * 2006-12-01 2009-09-04 디에스엠 아이피 어셋츠 비.브이. Process for the production of clavulanic acid

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI9300296B (en) * 1992-06-11 1998-06-30 Smithkline Beecham P.L.C. The process and intermediates for the preparation of clavulanic acid
KR100200239B1 (en) * 1992-10-21 1999-06-15 김충환 Process for preparing salts of clavulanic acid
GB9305565D0 (en) * 1993-03-18 1993-05-05 Smithkline Beecham Plc Novel compounds and processes
SI9400107A (en) * 1994-03-02 1995-10-31 Lek Tovarna Farmacevtskih New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804.
GB9426261D0 (en) * 1994-12-24 1995-02-22 Spurcourt Ltd Clavulanic acid salts
SI9500074A (en) * 1995-03-10 1996-10-31 Lek Tovarna Farmacevtskih Process for preparation of alkani salts of clavulanic acid.
SI9500134B (en) * 1995-04-20 2004-04-30 Lek, Preparation procedure of pure alkali salts of clavulanic acid
KR100200242B1 (en) * 1995-05-16 1999-06-15 김충환 Process for preparing clavulanic acid salt

Also Published As

Publication number Publication date
CN1238776A (en) 1999-12-15
PL333247A1 (en) 1999-11-22
AU5551698A (en) 1998-06-03
EP0937084A1 (en) 1999-08-25
NO992225L (en) 1999-05-07
CA2271847A1 (en) 1998-05-22
TR199901631T2 (en) 1999-09-21
JP2001503763A (en) 2001-03-21
ZA9710141B (en) 1998-06-25
NO992225D0 (en) 1999-05-07
WO1998021212A1 (en) 1998-05-22

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Legal Events

Date Code Title Description
FA10 Dismissal: dismissal - article 33 of industrial property law
B11Y Definitive dismissal acc. article 33 of ipl - extension of time limit for request of examination expired