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BR9712715A - Isoquinolonas - Google Patents

Isoquinolonas

Info

Publication number
BR9712715A
BR9712715A BR9712715-9A BR9712715A BR9712715A BR 9712715 A BR9712715 A BR 9712715A BR 9712715 A BR9712715 A BR 9712715A BR 9712715 A BR9712715 A BR 9712715A
Authority
BR
Brazil
Prior art keywords
isoquinolones
preparation
useful
diones
isoquinoline
Prior art date
Application number
BR9712715-9A
Other languages
English (en)
Inventor
Albert Kudzoi Amegadzie
Maureen Elizabeth Carey
John Michael Domagala
Liren Huang
Ronald George Micetich
Rajeshwar Singh
Michael Andrew Stier
Arkadii Vaisburg
Joseph Peter Sanchez
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of BR9712715A publication Critical patent/BR9712715A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/14—Aza-phenalenes, e.g. 1,8-naphthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/06—Peri-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

Patente de Invenção: <B>"ISOQUINOLONAS"<D>. Esta invenção refere-se a benzo[de]isoquinolino-1,3-dionas que são inibidores seletivos de DNA girase e DNA topoisomerase bacterianas úteis em agentes antibacterianos, bem como se refere a métodos para sua preparação e formulação. Novos intermediários úteis na preparação dos produtos finais são também descritos.
BR9712715-9A 1996-11-01 1997-10-31 Isoquinolonas BR9712715A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2990996P 1996-11-01 1996-11-01
PCT/US1997/019872 WO1998019648A2 (en) 1996-11-01 1997-10-31 N-oxy-naphthalimides as antibacterial agents

Publications (1)

Publication Number Publication Date
BR9712715A true BR9712715A (pt) 2000-05-16

Family

ID=21851529

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9712715-9A BR9712715A (pt) 1996-11-01 1997-10-31 Isoquinolonas

Country Status (12)

Country Link
US (2) US6177423B1 (pt)
EP (1) EP0939754A2 (pt)
JP (1) JP2001505554A (pt)
KR (1) KR20000052949A (pt)
AU (1) AU748749B2 (pt)
BR (1) BR9712715A (pt)
CA (1) CA2263301A1 (pt)
IL (1) IL128516A0 (pt)
NO (1) NO314304B1 (pt)
NZ (1) NZ334896A (pt)
PL (1) PL333238A1 (pt)
WO (1) WO1998019648A2 (pt)

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US7410746B2 (en) * 2002-03-29 2008-08-12 Dai Nippon Printing Co., Ltd. Photoradical polymerization initiator, radical generator, photosensitive compound and photosensitive resin composition containing these materials and product or its accessory portions using the composition
CA2491673A1 (en) * 2002-07-08 2004-01-15 Chemgenex Pharmaceuticals, Inc. Naphthalimide synthesis including amonafide synthesis and pharmaceutical preparations thereof
US7346199B2 (en) * 2002-11-30 2008-03-18 Intuitive Software, Inc. Anatomic triangulation
EP1711634A4 (en) * 2004-01-30 2008-04-02 Chemgenex Pharmaceuticals Inc NAPHTHALIMIDE ASSAY BY GENOTYPING N-ACETYL TRANSFERASE
WO2005117893A2 (en) * 2004-06-04 2005-12-15 Chemgenex Pharmaceuticals, Inc. Methods of treating cellular proliferative disease using naphthalimide and parp-1 inhibitors
US20070213354A1 (en) * 2006-03-08 2007-09-13 Amplimed Corporation Compositions and Methods for the Treatment of Multiple Sclerosis
AR061185A1 (es) * 2006-05-26 2008-08-13 Chugai Pharmaceutical Co Ltd Compuestos heterociclicos como inhibidores de hsp90. composiciones farmaceuticas.
TW200904435A (en) 2007-03-01 2009-02-01 Chugai Pharmaceutical Co Ltd Macrocyclic compounds
JP5781947B2 (ja) * 2010-01-13 2015-09-24 株式会社Adeka 新規スルホン酸誘導体化合物及び新規ナフタル酸誘導体化合物
CN103012185A (zh) * 2012-12-24 2013-04-03 辽宁本源制药有限公司 一种治疗抑郁症的药物阿戈美拉汀的制备方法
CN107417616A (zh) 2013-05-01 2017-12-01 中央研究院 治疗β‑地中海贫血和镰状细胞病的方法和组合物
CN106083850B (zh) * 2016-07-13 2018-01-02 河南大学 一类嘧啶并萘酰亚胺衍生物及其制备方法和应用
CN109384720B (zh) * 2018-11-01 2022-06-28 上海博栋化学科技有限公司 合成6-(2-甲氧基乙氧基)-n-羟基萘酰亚胺三氟甲磺酸的方法
CN109932349B (zh) * 2019-04-04 2021-04-20 济南大学 一种检测次氯酸的有机硅小分子荧光探针
CN110078666B (zh) * 2019-06-15 2023-01-24 山东省医学科学院药物研究所(山东省抗衰老研究中心山东省新技术制药研究所) 一种基于萘酰亚胺的镍离子荧光探针、制备方法及其应用
CN110194740B (zh) * 2019-07-08 2022-06-17 桂林医学院 4-叔丁氧羰基哌嗪-1,8-萘酰亚胺衍生物及其合成方法和应用
CN110272388B (zh) * 2019-07-08 2022-06-17 桂林医学院 4-二硫代甲酸哌嗪-3-硝基-1,8-萘酰亚胺衍生物及其合成方法和应用
CN110317171B (zh) * 2019-07-08 2022-06-17 桂林医学院 4-二硫代甲酸哌嗪-1,8-萘酰亚胺衍生物及其制备方法和应用
CN110283163B (zh) * 2019-07-08 2023-03-14 桂林医学院 4-叔丁氧羰基哌嗪-3-硝基-1,8-萘酰亚胺衍生物及其合成方法和应用
CN110194741B (zh) * 2019-07-08 2022-09-09 桂林医学院 4-苯甲酰哌嗪-3-硝基-1,8-萘酰亚胺衍生物及其制备方法和应用
CN110283123B (zh) * 2019-07-08 2022-06-17 桂林医学院 4-对甲苯磺酰基哌嗪-3-硝基-1,8-萘酰亚胺衍生物及其合成方法和应用

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5115057B1 (pt) * 1970-05-27 1976-05-14
JPS4914326B1 (pt) * 1970-07-31 1974-04-06
DE2114634A1 (de) 1971-03-26 1972-10-05 Badische Anilin- & Soda-Fabrik Ag, 6700 Ludwigshafen Dispersionsfarbstoffe der Thioxanthenreihe
FR2140087B1 (pt) 1971-06-03 1978-03-17 Basf Ag
DE2147706A1 (de) * 1971-09-24 1973-03-29 Basf Ag Verbindungen der naphthalimidreihe
BE788719A (fr) 1971-09-13 1973-01-02 Cabot Corp Alliage a base de nickel resistant a l'oxydation aux temperatures elevees et thermiquement stables
US3941791A (en) 1972-06-28 1976-03-02 Basf Aktiengesellschaft Compounds of the naphthalimide series
DE2231609C3 (de) * 1972-06-28 1980-09-04 Basf Ag, 6700 Ludwigshafen Verbindungen der Naphthalimidreihe
US4007192A (en) 1972-09-20 1977-02-08 Hoechst Aktiengesellschaft Naphthalimide-4,5-dicarboxylic acids
DE2246111C3 (de) * 1972-09-20 1980-07-31 Hoechst Ag, 6000 Frankfurt Verfahren zur Herstellung von Naphthalimid-43-dicarbonsäuren
JPS5122935B2 (pt) * 1973-07-30 1976-07-13
DE2415027A1 (de) * 1974-03-28 1975-10-16 Basf Ag Farbstoffe der naphthalimidreihe
DE2417789A1 (de) * 1974-04-11 1975-10-30 Basf Ag Naphtholactamderivate
JPS5116673A (en) * 1974-07-30 1976-02-10 Mitsubishi Chem Ind Nitorochikan 4*55 jikuroronafutarusanimidono seizohoho
JPS51109020A (en) * 1975-03-22 1976-09-27 Nippon Kayaku Kk 1*88 nafutaarusanimidojudotaino shinkinaseiho
JPS5917111B2 (ja) * 1976-01-28 1984-04-19 三菱化学株式会社 ニトロ置換４，５−ジクロロナフタル酸イミド類
JPS6012352B2 (ja) * 1976-02-19 1985-04-01 日本化薬株式会社 染料中間体の製造法
JPS609503B2 (ja) * 1976-04-27 1985-03-11 日本化薬株式会社 テトラクロルナフタル酸イミド誘導体とその製造方法
JP2572458B2 (ja) * 1989-10-20 1997-01-16 富士写真フイルム株式会社 電子写真感光体
CA2030129A1 (en) 1989-11-29 1991-05-30 Thomas Saupe 1,8-napthalenedicarboximides as antidotes
JPH053671A (ja) * 1991-01-24 1993-01-08 Tdk Corp Ｄｃ−ｄｃコンバータ
JPH05774A (ja) * 1991-04-23 1993-01-08 Nisca Corp 原稿給送装置
AUPM910994A0 (en) * 1994-10-28 1994-11-24 Commonwealth Scientific And Industrial Research Organisation Bisallyloxyimides
DE19612193A1 (de) * 1996-03-27 1997-10-02 Consortium Elektrochem Ind Mehrkomponentensystem zum Verändern, Abbau oder Bleichen von Lignin, ligninhaltigen Materialien oder ähnlichen Stoffen sowie Verfahren zu seiner Anwendung

Also Published As

Publication number Publication date
NO992104D0 (no) 1999-04-30
US6362181B1 (en) 2002-03-26
KR20000052949A (ko) 2000-08-25
PL333238A1 (en) 1999-11-22
NO992104L (no) 1999-04-30
WO1998019648A3 (en) 1999-03-04
CA2263301A1 (en) 1998-05-14
JP2001505554A (ja) 2001-04-24
US6177423B1 (en) 2001-01-23
IL128516A0 (en) 2000-01-31
WO1998019648A2 (en) 1998-05-14
NZ334896A (en) 2001-01-26
NO314304B1 (no) 2003-03-03
AU748749B2 (en) 2002-06-13
AU5160498A (en) 1998-05-29
EP0939754A2 (en) 1999-09-08

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Legal Events

Date Code Title Description
B09B Patent application refused [chapter 9.2 patent gazette]