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BR9712073A - Processo para produção de compostos de ecteinascidina - Google Patents

Processo para produção de compostos de ecteinascidina

Info

Publication number
BR9712073A
BR9712073A BR9712073-1A BR9712073A BR9712073A BR 9712073 A BR9712073 A BR 9712073A BR 9712073 A BR9712073 A BR 9712073A BR 9712073 A BR9712073 A BR 9712073A
Authority
BR
Brazil
Prior art keywords
ecteinascidin
compounds
formation
present
producing
Prior art date
Application number
BR9712073-1A
Other languages
English (en)
Other versions
BR9712073B1 (pt
Inventor
Elias J Corey
David Gin
Original Assignee
Harvard College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard College filed Critical Harvard College
Publication of BR9712073A publication Critical patent/BR9712073A/pt
Publication of BR9712073B1 publication Critical patent/BR9712073B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/64—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Patente de Invenção: "PROCESSO PARA PRODUZIR COMPOSTOS DE ECTEINASCIDINA". A presente invenção refere-se a um processo sintético para a formação de compostos de ecteinascidina e estruturas relacionadas, tais como as saframicinas. Em uma modalidade particularmente preferida, a presente invenção fornece um caminho de síntese para a formação de ecteinascidina 743 (1) um agente antitumoral derivado de animal marinho raro e extraordinariamente potente que é indicado para experiências clínicas. O processo desta invenção é enantio e estereocontrolado, convergente e rápido. Também são apresentados novos intermediários processuais, úteis não apenas na síntese total da ecteinascidina 743, mas também outros compostos conhecidos do tipo ecteinascidina, incluindo derivados e análogos dos mesmos.
BRPI9712073-1B1A 1996-09-18 1997-09-17 mÉtodo para a produÇço de ecteinascidina 743 e intermediÁrios. BR9712073B1 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/715,541 US5721362A (en) 1996-09-18 1996-09-18 Process for producing ecteinascidin compounds
PCT/US1997/016470 WO1998012198A1 (en) 1996-09-18 1997-09-17 Process for producing ecteinascidin compounds

Publications (2)

Publication Number Publication Date
BR9712073A true BR9712073A (pt) 2002-01-15
BR9712073B1 BR9712073B1 (pt) 2013-06-18

Family

ID=24874473

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI9712073-1B1A BR9712073B1 (pt) 1996-09-18 1997-09-17 mÉtodo para a produÇço de ecteinascidina 743 e intermediÁrios.

Country Status (21)

Country Link
US (1) US5721362A (pt)
EP (1) EP0931083B1 (pt)
JP (1) JP4425995B2 (pt)
KR (1) KR100358832B1 (pt)
CN (1) CN1096463C (pt)
AT (1) ATE232868T1 (pt)
AU (1) AU738282B2 (pt)
BR (1) BR9712073B1 (pt)
CA (1) CA2266081C (pt)
CZ (1) CZ299596B6 (pt)
DE (1) DE69719201T2 (pt)
DK (1) DK0931083T3 (pt)
ES (1) ES2192273T3 (pt)
HU (1) HU229407B1 (pt)
IL (2) IL128993A0 (pt)
NO (1) NO325345B1 (pt)
NZ (1) NZ334704A (pt)
PL (1) PL188572B1 (pt)
PT (1) PT931083E (pt)
RU (1) RU2194709C2 (pt)
WO (1) WO1998012198A1 (pt)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL138856A0 (en) * 1998-04-06 2001-10-31 Univ Illinois Semi-synthetic ecteinascidins
CA2331593C (en) * 1998-05-11 2008-08-05 Pharma Mar, S.A. Metabolites of ecteinascidin 743
US6124292A (en) 1998-09-30 2000-09-26 President And Fellows Of Harvard College Synthetic analogs of ecteinascidin-743
MY164077A (en) * 1999-05-13 2017-11-30 Pharma Mar Sa Compositions and uses of et743 for treating cancer
BG65893B1 (bg) * 1999-05-14 2010-04-30 Pharma Mar S.A. Полусинтетичен метод и нови съединения
GB9918178D0 (en) * 2000-05-15 1999-10-06 Pharma Mar Sa Synthetic methods
MY130271A (en) * 1999-05-14 2007-06-29 Pharma Mar Sa Hemisynthetic method and new compounds
JP2003520801A (ja) * 2000-01-19 2003-07-08 ザ・トラスティーズ・オブ・コランビア・ユニバーシティー・イン・ザ・シティー・オブ・ニューヨーク サフラマイシン−エクテイナシジン系列の化合物、それらの使用及び合成
US6815544B2 (en) 2000-02-11 2004-11-09 President And Fellows Of Harvard College Synthetic process for an intermediate for ecteinascidin and phthalascidin compounds
HU229511B1 (en) * 2000-02-11 2014-01-28 Harvard College Synthetic process for an intermediate for ecteinascidin and phthalascidin compounds
US6569859B1 (en) 2000-02-22 2003-05-27 President And Fellows Of Harvard College Synthetic analogs of ecteinascidin-743
US7919493B2 (en) * 2000-04-12 2011-04-05 Pharma Mar, S.A. Anititumoral ecteinascidin derivatives
CA2406080C (en) * 2000-04-12 2011-11-29 Pharma Mar, S.A. Antitumoral ecteinascidin derivatives
IL152125A (en) * 2000-05-15 2008-04-13 Pharma Mar Sa Process for the manufacture of ecteinascidin derivatives
MXPA02011319A (es) * 2000-05-15 2003-06-06 Pharma Mar Sa Analogos antitumorales de ecteinascidina 743.
US7420051B2 (en) * 2000-05-15 2008-09-02 Pharma Mar, S.A. Synthetic process for the manufacture of an ecteinaschidin compound
AU2002239565B2 (en) * 2000-11-03 2007-11-15 President And Fellows Of Harvard College Saframycins, analogues and uses thereof
JP4391083B2 (ja) * 2000-11-06 2009-12-24 ファルマ・マール・ソシエダード・アノニマ 効果的な抗腫瘍治療
GB0117402D0 (en) * 2001-07-17 2001-09-05 Pharma Mar Sa New antitumoral derivatives of et-743
GB0119243D0 (en) 2001-08-07 2001-10-03 Pharma Mar Sa Antitumoral analogs of ET-743
JP4208469B2 (ja) * 2002-01-29 2009-01-14 独立行政法人科学技術振興機構 エクテナサイジン類の全合成方法、エクテナサイジン類に類縁構造を持つ前記全合成用中間体化合物類、及び該中間体化合物類の合成方法
GB0202544D0 (en) * 2002-02-04 2002-03-20 Pharma Mar Sa The synthesis of naturally occuring ecteinascidins and related compounds
GB0312407D0 (en) * 2003-05-29 2003-07-02 Pharma Mar Sau Treatment
US7183054B2 (en) 2003-06-03 2007-02-27 President And Fellows Of Harvard College Assay for identifying biological targets of polynucleotide-binding compounds
GB0324201D0 (en) * 2003-10-15 2003-11-19 Pharma Mar Sau Improved antitumoral combinations
DK1689404T3 (da) * 2003-11-13 2009-01-26 Pharma Mar Sau Kombination af et-743 med 5-fluoracil-prodrugs til behandling af cancer
GB0326486D0 (en) * 2003-11-14 2003-12-17 Pharma Mar Sau Combination treatment
WO2005049030A1 (en) * 2003-11-14 2005-06-02 Pharma Mar, S.A. Combination therapy comprising the use of et-743 and paclitaxel for treating cancer
CA2573072A1 (en) * 2004-07-09 2006-01-19 Rafael Rosell Costa Use of ecteinascidin in the treatment of cancer in patients with low level of brca1
CN100396178C (zh) * 2004-08-06 2008-06-25 中国科学院海洋研究所 一种玻璃海鞘的全人工养殖方法及简易型连续投饵装置
WO2006035244A2 (en) * 2004-09-29 2006-04-06 Pharma Mar S.A., Sociedad Unipersonal Ecteinascidin compounds as anti -inflammatory agents
WO2006046080A2 (en) * 2004-10-26 2006-05-04 Pharma Mar S.A., Sociedad Unipersonal Pegylated liposomal doxorubicin in combination with ecteinescidin 743
SI1658848T1 (sl) 2004-10-29 2007-12-31 Pharma Mar Sa Formulacije vsebujoäśe ekteinascidin in disaharid
GB0522082D0 (en) * 2005-10-31 2005-12-07 Pharma Mar Sa Formulations
CN101157929B (zh) * 2007-02-02 2012-05-23 中国科学院上海有机化学研究所 番红霉素的生物合成基因簇
EP2201141A1 (en) * 2007-10-19 2010-06-30 Pharma Mar S.A. Prognostic molecular markers for et-743 treatment
JP6037337B2 (ja) * 2010-05-25 2016-12-07 ファルマ、マール、ソシエダード、アノニマＰｈａｒｍａ Ｍｒｓ，Ｓ．Ａ． エクチナサイジン化合物の製造のための合成方法
JP6382516B2 (ja) 2010-11-12 2018-08-29 ファルマ・マール・ソシエダード・アノニマ 抗腫瘍アルカロイドを用いる、組み合わせの治療法
CN103304478B (zh) * 2013-06-28 2016-04-20 四川大学 一类合成renieramycins型生物碱的中间体及其制备方法
CN108084146B (zh) * 2013-10-29 2020-07-28 江苏盛迪医药有限公司 一种海鞘碱-743中间体的制备方法
CN103709101B (zh) * 2013-12-19 2016-06-29 四川大学 一类renieramycin G的合成中间体及其制备方法
JOP20190254A1 (ar) 2017-04-27 2019-10-27 Pharma Mar Sa مركبات مضادة للأورام
CN111518110B (zh) 2019-02-01 2023-11-03 博瑞生物医药（苏州）股份有限公司 一种海鞘素化合物及其中间体的制备方法
CN110092802B (zh) * 2019-06-21 2022-01-07 爱斯特（成都）生物制药股份有限公司 一种制备曲贝替定中间体的方法
WO2020261301A1 (en) * 2019-06-27 2020-12-30 Msn Laboratories Private Limited, R&D Center IMPROVED PROCESS FOR THE PREPARATON OF PURE (1'R,6R,6aR,7R,13S,14S,16R)-5-(ACETYLOXY)-3',4',6,6a,7,13,14,16-OCTAHYDRO-6',8,14-TRIHYDROXY-7',9-DIMETHOXY-4,10,23-TRIMETHYLSPIRO[6,16-(EPITHIOPROPANOXYMETH ANO)-7,13-IMINO-12H-1,3-DIOXOLO[7,8]ISOQUINO[3,2-b][3]BENZAZOCINE-20,1'(2'H)-ISOQUINOLIN]-19-ONE POLYMORPH THERE OF
CR20220289A (es) 2019-11-21 2022-10-27 Pharma Mar Sa Métodos de tratamiento del cáncer de pulmón de células pequeñas con formulaciones de lurbinectedina
CN114621245A (zh) * 2020-12-11 2022-06-14 江苏恒瑞医药股份有限公司 一种曲贝替定中间体的晶型及其制备方法
US12303506B2 (en) 2022-01-20 2025-05-20 Extrovis Ag Trabectedin composition

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5089273A (en) * 1986-06-09 1992-02-18 Board Of Trustees Of The University Of Illinois Ecteinascidins 729, 743, 745, 759A, 759B and 770
US5256663A (en) * 1986-06-09 1993-10-26 The Board Of Trustees Of The University Of Illinois Compositions comprising ecteinascidins and a method of treating herpes simplex virus infections therewith
US5149804A (en) * 1990-11-30 1992-09-22 The Board Of Trustees Of The University Of Illinois Ecteinascidins 736 and 722
DE3923985C1 (pt) * 1989-07-20 1990-06-28 Daimler-Benz Aktiengesellschaft, 7000 Stuttgart, De
GB2252781B (en) * 1991-02-14 1994-08-17 Sanwa Shutter Corp Architectural shutter curtain device
US5478932A (en) * 1993-12-02 1995-12-26 The Board Of Trustees Of The University Of Illinois Ecteinascidins

Also Published As

Publication number Publication date
AU738282B2 (en) 2001-09-13
HUP0000068A3 (en) 2001-12-28
AU4420597A (en) 1998-04-14
DE69719201T2 (de) 2003-12-11
PL188572B1 (pl) 2005-02-28
KR20000036242A (ko) 2000-06-26
HU229407B1 (en) 2013-12-30
ES2192273T3 (es) 2003-10-01
CZ299596B6 (cs) 2008-09-17
EP0931083A1 (en) 1999-07-28
CA2266081C (en) 2006-12-12
KR100358832B1 (ko) 2002-11-21
JP4425995B2 (ja) 2010-03-03
CN1096463C (zh) 2002-12-18
IL128993A0 (en) 2000-02-17
CN1237974A (zh) 1999-12-08
CA2266081A1 (en) 1998-03-26
EP0931083A4 (en) 2000-05-24
DE69719201D1 (de) 2003-03-27
ATE232868T1 (de) 2003-03-15
NO991301L (no) 1999-05-14
NO991301D0 (no) 1999-03-17
JP2001501196A (ja) 2001-01-30
NO325345B1 (no) 2008-04-07
PL332206A1 (en) 1999-08-30
DK0931083T3 (da) 2003-05-26
RU2194709C2 (ru) 2002-12-20
IL128993A (en) 2006-06-11
PT931083E (pt) 2003-07-31
US5721362A (en) 1998-02-24
CZ91499A3 (cs) 1999-08-11
WO1998012198A1 (en) 1998-03-26
NZ334704A (en) 2000-09-29
HUP0000068A2 (hu) 2000-06-28
BR9712073B1 (pt) 2013-06-18
EP0931083B1 (en) 2003-02-19

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B06A Patent application procedure suspended [chapter 6.1 patent gazette]
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B12B Appeal against refusal [chapter 12.2 patent gazette]
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B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

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