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BR9711661A - Composto composi-Æo farmac-utica e processos para controlar uma infec-Æo bacteriana em um mam¡fero e para preparar um composto - Google Patents

Composto composi-Æo farmac-utica e processos para controlar uma infec-Æo bacteriana em um mam¡fero e para preparar um composto

Info

Publication number
BR9711661A
BR9711661A BR9711661A BR9711661A BR9711661A BR 9711661 A BR9711661 A BR 9711661A BR 9711661 A BR9711661 A BR 9711661A BR 9711661 A BR9711661 A BR 9711661A BR 9711661 A BR9711661 A BR 9711661A
Authority
BR
Brazil
Prior art keywords
alkyl
substituted
heteroaryl
aryl
optionally substituted
Prior art date
Application number
BR9711661A
Other languages
English (en)
Inventor
Yat Sun Or
Zhenkun Ma
Richard F Clark
Daniel T Chu
Jacob J Plattner
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27107953&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR9711661(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US08/888,350 external-priority patent/US5866549A/en
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of BR9711661A publication Critical patent/BR9711661A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Cephalosporin Compounds (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
BR9711661A 1996-09-04 1997-09-02 Composto composi-Æo farmac-utica e processos para controlar uma infec-Æo bacteriana em um mam¡fero e para preparar um composto BR9711661A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US70777696A 1996-09-04 1996-09-04
US08/888,350 US5866549A (en) 1996-09-04 1997-07-03 6-O-substituted ketolides having antibacterial activity
PCT/US1997/015506 WO1998009978A1 (en) 1996-09-04 1997-09-02 6-o-substituted ketolides having antibacterial activity

Publications (1)

Publication Number Publication Date
BR9711661A true BR9711661A (pt) 1999-08-24

Family

ID=27107953

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9711661A BR9711661A (pt) 1996-09-04 1997-09-02 Composto composi-Æo farmac-utica e processos para controlar uma infec-Æo bacteriana em um mam¡fero e para preparar um composto

Country Status (27)

Country Link
US (4) US6147197A (pt)
EP (5) EP1291351B1 (pt)
JP (1) JP4597274B2 (pt)
KR (5) KR100576988B1 (pt)
CN (4) CN100441591C (pt)
AT (5) ATE296307T1 (pt)
BG (1) BG63547B1 (pt)
BR (1) BR9711661A (pt)
CA (1) CA2263972C (pt)
CZ (1) CZ300106B6 (pt)
DE (5) DE69733723T2 (pt)
DK (5) DK1291352T3 (pt)
ES (5) ES2242813T3 (pt)
HR (5) HRP970473B1 (pt)
HU (1) HU230166B1 (pt)
ID (1) ID19406A (pt)
IL (1) IL128681A0 (pt)
NO (1) NO314230B1 (pt)
NZ (1) NZ334274A (pt)
PL (1) PL188173B1 (pt)
PT (5) PT929563E (pt)
RO (1) RO121473B1 (pt)
RU (1) RU2192427C2 (pt)
SI (1) SI20023B (pt)
SK (5) SK286181B6 (pt)
TR (1) TR199901127T2 (pt)
WO (1) WO1998009978A1 (pt)

Families Citing this family (86)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6495348B1 (en) 1993-10-07 2002-12-17 Regents Of The University Of Minnesota Mitomycin biosynthetic gene cluster
UA51730C2 (uk) * 1996-09-04 2002-12-16 Ебботт Лабораторіз 6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців
AP1060A (en) * 1998-01-02 2002-04-23 Pfizer Prod Inc Novel erythromycin derivatives.
ATE243219T1 (de) 1998-04-24 2003-07-15 Pfizer Prod Inc 9a, 11b-dehydro derivative von 9-oxime-3-keto-6-0-methylerythromycin
US6265202B1 (en) 1998-06-26 2001-07-24 Regents Of The University Of Minnesota DNA encoding methymycin and pikromycin
JP4573925B2 (ja) 1998-07-09 2010-11-04 アベンティス・ファーマ・ソシエテ・アノニム 新規のエリスロマイシン誘導体、その製造方法及びその薬剤としての使用
FR2792637B1 (fr) * 1999-04-26 2001-06-01 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2780977B1 (fr) * 1998-07-09 2000-09-01 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2785612A1 (fr) * 1998-11-10 2000-05-12 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
AU5995299A (en) 1998-11-03 2000-05-22 Pfizer Products Inc. Novel macrolide antibiotics
NZ513206A (en) * 1999-03-15 2004-02-27 Abbott Lab 6-O-substituted macrolides having antibacterial activity
US6451768B1 (en) 1999-04-16 2002-09-17 Kosan Biosciences, Inc. Macrolide antiinfective agents
US6514944B2 (en) 1999-04-16 2003-02-04 Kosan Biosciences, Inc. Macrolide antiinfective agents
US6939861B2 (en) 1999-04-16 2005-09-06 Kosan Biosciences, Inc. Amido macrolides
NZ515027A (en) 1999-04-16 2004-01-30 Kosan Biosciences Inc Erythromycin derivatives as antibiotics
EP1181300B1 (en) * 1999-06-07 2003-09-17 Abbott Laboratories 6-o-carbamate ketolide derivatives
US6420535B1 (en) * 1999-06-07 2002-07-16 Abbott Laboratories 6-O-carbamate ketolide derivatives
US6437106B1 (en) 1999-06-24 2002-08-20 Abbott Laboratories Process for preparing 6-o-substituted erythromycin derivatives
US6417366B2 (en) * 1999-06-24 2002-07-09 Abbott Laboratories Preparation of quinoline-substituted carbonate and carbamate derivatives
EP1101769A3 (en) 1999-11-18 2001-10-24 Pfizer Products Inc. Nitrogen containing erythromycin derivatives
US6472372B1 (en) 2000-12-06 2002-10-29 Ortho-Mcneil Pharmaceuticals, Inc. 6-O-Carbamoyl ketolide antibacterials
AU2002316550A1 (en) * 2001-07-03 2003-01-21 Chiron Corporation C12 modified erythromycin macrolides and ketolides having antibacterial activity
EP1430068A1 (en) 2001-09-17 2004-06-23 Ortho-Mcneil Pharmaceutical, Inc. 6-o-carbamate-11,12-lacto-ketolide antimicrobials
US6673774B2 (en) * 2001-12-03 2004-01-06 Enanta Pharmaceuticals, Inc. 11-O-substituted macrolides and their descladinose derivatives
IL162292A0 (en) 2001-12-05 2005-11-20 Ortho Mcneil Pharm Inc 6-O-acyl ketolide derivatives of erythromycine useful as antibacterials
US6831068B2 (en) * 2002-02-13 2004-12-14 Abbott Laboratories Macrolide antibacterial compounds
US20030162729A1 (en) * 2002-02-13 2003-08-28 Zhenkun Ma Macrolides with activity against methicillin-resistant staphylococcus aureus
EP1474431A2 (en) * 2002-02-13 2004-11-10 Abbott Laboratories Macrolide antibacterial compounds
AU2003217676B2 (en) 2002-02-22 2009-06-11 Takeda Pharmaceutical Company Limited Active agent delivery systems and methods for protecting and administering active agents
US6995143B2 (en) 2002-02-28 2006-02-07 Basilea Pharmaceutica Ag Macrolides with antibacterial activity
US6841664B2 (en) * 2002-07-25 2005-01-11 Enanra Pharmaceuticals, Inc. 6,11-4-carbon bridged ketolides
US7273853B2 (en) * 2002-05-13 2007-09-25 Enanta Pharmaceuticals, Inc. 6-11 bicyclic ketolide derivatives
US7910558B2 (en) * 2002-05-13 2011-03-22 Enanta Pharmaceuticals, Inc. Bridged macrocyclic compounds and processes for the preparation thereof
CA2487918A1 (en) * 2002-05-31 2003-12-11 Janssen Pharmaceutica N.V. 3-descladinosyl-6-o-carbamoyl and 6-o-carbonoyl macrolide antibacterial agents
JPWO2004078771A1 (ja) * 2003-03-07 2006-06-08 大正製薬株式会社 ２−フルオロ−６−ｏ−置換ケトライド誘導体
EP3738591A3 (en) 2003-03-10 2021-03-24 Merck Sharp & Dohme Corp. Novel antibacterial agents
WO2004096823A2 (en) * 2003-04-25 2004-11-11 Chiron Corporation Novel ketolide derivatives
US6790835B1 (en) * 2003-06-05 2004-09-14 Enanta Pharmaceuticals, Inc. Bicyclic macrolide derivatives
US20040254126A1 (en) * 2003-06-05 2004-12-16 Yao-Ling Qiu 11-12 Bicyclic erythromycin derivatives
WO2005028493A1 (en) * 2003-09-12 2005-03-31 Chiron Corporation Antimicrobial derivatives
GB0327720D0 (en) 2003-11-28 2003-12-31 Biotica Tech Ltd Erythromycins and process for their preparation
US7414030B2 (en) * 2004-01-07 2008-08-19 Enanta Pharmaceuticals, Inc. 6-11 Bicyclic erythromycin derivatives
WO2005070113A2 (en) * 2004-01-09 2005-08-04 Enanta Pharmaceuticals, Inc. 9n-substituted 6-11 bicyclic erythromycin derivatives
US7384921B2 (en) * 2004-02-20 2008-06-10 Enanta Pharmaceuticals, Inc. Polymorphic forms of 6-11 bicyclic ketolide derivatives
WO2006080954A1 (en) * 2004-07-28 2006-08-03 Ranbaxy Laboratories Limited Ketolide derivatives as antibacterial agents
FR2874922A1 (fr) * 2004-07-30 2006-03-10 Palumed Sa Molecules hybrides qa ou q est une aminoquinoleine et a est un residu antibiotique, leur synthese et leurs utilisations en tant qu'agent antibacterien
JP2008508243A (ja) * 2004-07-30 2008-03-21 パルメド・ソシエテ・アノニム アミノキノリンをｑとし、抗生物質残基をａとする混成分子ｑａ、その合成及び抗菌剤としての使用
WO2006065743A2 (en) * 2004-12-13 2006-06-22 Enanta Pharmaceuticals, Inc. Tetracylic bicyclolides
EP2233493A1 (en) * 2004-12-21 2010-09-29 Pfizer Products Inc. Macrolides
US20060252710A1 (en) * 2005-05-04 2006-11-09 Guoqiang Wang 6-11 Bridged oxime erythromycin derivatives
US7384922B2 (en) * 2005-05-04 2008-06-10 Enanta Pharmaceuticals, Inc. 6-11 bridged oxime erythromycin derivatives
US7517859B2 (en) * 2005-05-04 2009-04-14 Enanta Pharmaceuticals, Inc. Spirocyclic bicyclolides
EP1985620A4 (en) 2006-02-07 2012-08-15 Taisho Pharmaceutical Co Ltd COMPOUND 10a-AZALIDE
WO2008023248A2 (en) 2006-08-24 2008-02-28 Wockhardt Research Centre Novel macrolides and ketolides having antimicrobial activity
WO2009019868A1 (ja) 2007-08-06 2009-02-12 Taisho Pharmaceutical Co., Ltd. １０ａ、１２位架橋型１０ａ－アザライド化合物
US8273720B2 (en) * 2007-09-17 2012-09-25 Enanta Pharmaceuticals, Inc. 6,11-bicyclolides: bridged biaryl macrolide derivatives
US20090118506A1 (en) * 2007-09-17 2009-05-07 In Jong Kim 6,11-bridged biaryl macrolides
US8354383B2 (en) * 2007-09-17 2013-01-15 Enanta Pharmaceuticals, Inc. 6,11-bridged biaryl macrolides
WO2009055557A1 (en) * 2007-10-25 2009-04-30 Cempra Pharmaceuticals, Inc. Process for the preparation of macrolide antibacterial agents
TW200946109A (en) * 2008-05-09 2009-11-16 Enanta Pharm Inc Anti-bacterial activity of 9-hydroxy derivatives 6, 11-bicyclolides
JPWO2009139181A1 (ja) 2008-05-15 2011-09-15 大正製薬株式会社 ４員環構造を有する１０ａ−アザライド化合物
DK2358379T3 (en) 2008-10-24 2016-03-07 Cempra Pharmaceuticals Inc BIOFORSVAR USING TRIAZOLHOLDIGE macrolides
BRPI1011959A2 (pt) 2009-05-27 2016-04-26 Wockhardt Research Center compostos de cetolídeo tendo atividade antimicrobiana.
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
EP2475253B1 (en) 2009-09-10 2016-10-26 Cempra Pharmaceuticals, Inc. Methods for treating malaria, tuberculosis and mac diseases
JP5711352B2 (ja) 2010-03-22 2015-04-30 センプラ ファーマシューティカルズ，インコーポレイテッド マクロライドの結晶形、およびその使用
WO2011146829A1 (en) 2010-05-20 2011-11-24 Cempra Pharmaceuticals, Inc. Processes for preparing macrolides and ketolides and intermediates therefor
US8796474B1 (en) 2010-08-23 2014-08-05 Rutgers, The State University Of New Jersey Macrolide compounds and methods and intermediates useful for their preparation
US9815863B2 (en) 2010-09-10 2017-11-14 Cempra Pharmaceuticals, Inc. Hydrogen bond forming fluoro ketolides for treating diseases
PT2673285T (pt) 2010-12-09 2017-10-19 Wockhardt Ltd Resumo
AR085286A1 (es) * 2011-02-21 2013-09-18 Taisho Pharmaceutical Co Ltd Derivado de macrolido sustituido en la posicion c-4
US9206214B2 (en) 2011-03-01 2015-12-08 Wockhardt Ltd. Process for preparation of ketolide intermediates
EP2688900B1 (en) 2011-03-22 2016-09-28 Wockhardt Limited Process for preparation of ketolide compounds
CN102766089A (zh) * 2011-05-06 2012-11-07 上海医药工业研究院 3-(3-喹啉基)-2-丙烯-1-卤代物及其制备方法
CN102766181A (zh) * 2011-05-06 2012-11-07 上海医药工业研究院 6-o-取代的红霉素衍生物的制备方法
US10188674B2 (en) 2012-03-27 2019-01-29 Cempra Pharmaceuticals, Inc. Parenteral formulations for administering macrolide antibiotics
JP5857008B2 (ja) * 2012-08-20 2016-02-10 大正製薬株式会社 Ｃ−４”位置換マクロライド誘導体を含有する医薬
GB201217310D0 (en) 2012-09-27 2012-11-14 C10 Pharma As Compounds
EP2968801B1 (en) 2013-03-14 2018-09-26 Cempra Pharmaceuticals, Inc. Methods for treating respiratory diseases and formulations therefor
CN105188712A (zh) 2013-03-15 2015-12-23 森普拉制药公司 用于制备大环内酯抗菌剂的收敛方法
AR102810A1 (es) 2014-08-18 2017-03-29 Taisho Pharmaceutical Co Ltd Derivado de macrólido sustituido en la posición c-4
JP2019533669A (ja) * 2016-10-04 2019-11-21 バイオファーマティ ソシエテ アノニム 抗菌活性を有するケトライド
EP3589327A4 (en) * 2017-03-03 2022-04-06 Synovo GmbH NOVEL ANTI-INFECTION AND ANTI-INFLAMMATORY COMPOUNDS
CN109942653B (zh) * 2019-02-27 2021-06-25 北京理工大学 一种红霉素衍生物及其制备方法
CA3163337A1 (en) 2019-12-02 2021-06-10 AliquantumRx, Inc. Salts and polymorphs of cethromycin for the treatment of disease salts and polymorphs of cethromycin
CN113817008B (zh) * 2021-07-15 2023-05-23 湖州师范学院 新型琥珀酰基十六元大环内酯的制备方法及用途

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4670549A (en) * 1985-03-18 1987-06-02 Taisho Pharmaceutical Co., Ltd. Method for selective methylation of erythromycin a derivatives
KR960000434B1 (ko) * 1986-12-17 1996-01-06 다이쇼 세이야꾸 가부시끼가이샤 에리스로마이신 a유도체 및 그의 제조 방법
US5350839A (en) * 1990-10-15 1994-09-27 Taisho Pharmaceutical Co., Ltd. 2'-position modified compound of erythromycin or its derivative
IL114589A (en) * 1990-11-21 1999-12-22 Roussel Uclaf Intermediates for the preparation of erythromycin derivatives
CA2096969C (en) * 1990-11-28 2000-11-21 Masato Kashimura 6-0-methylerythromycin a derivatives
WO1993013663A1 (en) * 1992-01-17 1993-07-22 Abbott Laboratories Method of directing biosynthesis of specific polyketides
US5523399A (en) * 1991-12-27 1996-06-04 Taisho Pharmaceutical Co., Ltd. 5-O-desosaminylerythronolide derivatives
CA2093303C (en) * 1992-04-09 1998-11-24 Abraham Araya Aluminosilicates
JP3259429B2 (ja) * 1992-04-22 2002-02-25 大正製薬株式会社 ５−ｏ−デソサミニルエリスロノライドａ誘導体
AU662420B2 (en) * 1992-04-22 1995-08-31 Taisho Pharmaceutical Co., Ltd. 5-O-desosaminylerythronolide A derivative
FR2697524B1 (fr) * 1992-11-05 1994-12-23 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
US5527780A (en) * 1992-11-05 1996-06-18 Roussel Uclaf Erythromycin derivatives
FR2702480B1 (fr) * 1993-03-09 1995-04-28 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
FR2713226B1 (fr) * 1993-12-03 1996-01-05 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
FR2718450B1 (fr) * 1994-04-08 1997-01-10 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
FR2719587B1 (fr) * 1994-05-03 1996-07-12 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
FR2732023B1 (fr) * 1995-03-22 1997-04-30 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2732684B1 (fr) * 1995-04-06 1997-04-30 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2738571B1 (fr) * 1995-09-11 1997-10-17 Roussel Uclaf Nouveaux derives de la 5-0-desosaminyl 6-0-methyl- erythronolide a, leur procede de preparation et leur application a la preparation de produits biologiquement actifs
US6274715B1 (en) * 1995-11-08 2001-08-14 Abbott Laboratories Tricyclic erythromycin derivatives
DE69631609T2 (de) * 1995-11-08 2005-01-05 Abbott Laboratories, Abbott Park Tricyclische erythromycinderivate
UA51730C2 (uk) * 1996-09-04 2002-12-16 Ебботт Лабораторіз 6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців
AU4472797A (en) * 1996-10-31 1998-05-22 Taisho Pharmaceutical Co., Ltd. Erythromycin a derivatives
US6171807B1 (en) * 1996-11-13 2001-01-09 Associates Of Cape Cod, Inc. Detection and quantitation of endotoxin by fluorescence polarization

Also Published As

Publication number Publication date
CN100460415C (zh) 2009-02-11
ES2242813T3 (es) 2005-11-16
ATE299508T1 (de) 2005-07-15
DE69733422T2 (de) 2006-05-04
HRP20060276A2 (en) 2007-10-31
RU2192427C2 (ru) 2002-11-10
DE69733370T2 (de) 2006-02-02
ES2242812T3 (es) 2005-11-16
AU4178097A (en) 1998-03-26
DE69733439D1 (de) 2005-07-07
HRP20060275B1 (hr) 2014-04-11
PL332009A1 (en) 1999-08-16
ES2242983T3 (es) 2005-11-16
NZ334274A (en) 2001-02-23
HRP970473B1 (en) 2007-02-28
JP4597274B2 (ja) 2010-12-15
HUP9902869A3 (en) 2001-04-28
AU729348B2 (en) 2001-02-01
HRP20060275A2 (en) 2007-10-31
HU230166B1 (hu) 2015-09-28
CN1680419A (zh) 2005-10-12
KR20050044816A (ko) 2005-05-12
NO314230B1 (no) 2003-02-17
US6147197A (en) 2000-11-14
KR20050043994A (ko) 2005-05-11
EP1291350B1 (en) 2005-05-25
KR100576988B1 (ko) 2006-05-10
EP0929563A1 (en) 1999-07-21
CZ300106B6 (cs) 2009-02-11
DK1291352T3 (da) 2005-09-19
PL188173B1 (pl) 2004-12-31
HK1021537A1 (en) 2000-06-16
ATE296307T1 (de) 2005-06-15
WO1998009978A1 (en) 1998-03-12
BG63547B1 (bg) 2002-04-30
CN1680418A (zh) 2005-10-12
ATE296831T1 (de) 2005-06-15
KR20050043993A (ko) 2005-05-11
CN1273475C (zh) 2006-09-06
CA2263972C (en) 2008-01-29
EP1291350A1 (en) 2003-03-12
DK1291351T3 (da) 2005-10-24
HRP20060277A2 (en) 2007-10-31
EP1291351A1 (en) 2003-03-12
EP1291353A1 (en) 2003-03-12
HUP9902869A2 (hu) 2000-02-28
HRP20060278B1 (hr) 2014-04-11
HRP20060276B1 (hr) 2014-04-25
TR199901127T2 (xx) 1999-07-21
JP2001500855A (ja) 2001-01-23
ATE296308T1 (de) 2005-06-15
PT1291353E (pt) 2005-10-31
SK286181B6 (sk) 2008-04-07
USRE39591E1 (en) 2007-04-24
SK285535B6 (sk) 2007-03-01
HRP20060277B1 (hr) 2014-04-11
ATE296832T1 (de) 2005-06-15
DE69733369D1 (de) 2005-06-30
EP1291351B1 (en) 2005-07-13
DK0929563T3 (da) 2005-10-03
RO121473B1 (ro) 2007-06-29
CN100441591C (zh) 2008-12-10
PT929563E (pt) 2005-10-31
DE69733439T2 (de) 2006-05-04
KR100610043B1 (ko) 2006-08-08
ID19406A (id) 1998-07-09
HRP970473A2 (en) 1998-08-31
SK28699A3 (en) 2000-03-13
PT1291351E (pt) 2005-11-30
HRP20060278A2 (en) 2007-10-31
SK285536B6 (sk) 2007-03-01
KR20050044815A (ko) 2005-05-12
CN1680420A (zh) 2005-10-12
NO991022D0 (no) 1999-03-02
SI20023B (en) 2001-02-28
EP1291352A1 (en) 2003-03-12
DE69733422D1 (de) 2005-07-07
CN1237183A (zh) 1999-12-01
SI20023A (sl) 2000-02-29
DE69733723D1 (de) 2005-08-18
EP1291352B1 (en) 2005-05-25
SK285534B6 (sk) 2007-03-01
BG103292A (en) 1999-12-30
ES2242811T3 (es) 2005-11-16
DK1291350T3 (da) 2005-09-26
US6028181A (en) 2000-02-22
DE69733370D1 (de) 2005-06-30
EP0929563B1 (en) 2005-06-01
SK285533B6 (sk) 2007-03-01
US6075133A (en) 2000-06-13
DE69733723T2 (de) 2006-04-20
KR100568455B1 (ko) 2006-04-07
DK1291353T3 (da) 2005-10-03
DE69733369T2 (de) 2006-01-26
ES2244716T3 (es) 2005-12-16
CZ68599A3 (cs) 1999-08-11
KR100523679B1 (ko) 2005-10-26
CA2263972A1 (en) 1998-03-12
KR20000068435A (ko) 2000-11-25
EP1291353B1 (en) 2005-06-01
NO991022L (no) 1999-05-03
PT1291352E (pt) 2005-09-30
IL128681A0 (en) 2000-01-31
PT1291350E (pt) 2005-09-30

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