[go: up one dir, main page]

BR9711194A - Uso de agente quelante clioquinol para a fabricação de uma composição farmacêutica para o tratamento de doença de alzheimer. - Google Patents

Uso de agente quelante clioquinol para a fabricação de uma composição farmacêutica para o tratamento de doença de alzheimer.

Info

Publication number
BR9711194A
BR9711194A BR9711194-5A BR9711194A BR9711194A BR 9711194 A BR9711194 A BR 9711194A BR 9711194 A BR9711194 A BR 9711194A BR 9711194 A BR9711194 A BR 9711194A
Authority
BR
Brazil
Prior art keywords
alzheimer
disease
manufacture
treatment
pharmaceutical composition
Prior art date
Application number
BR9711194-5A
Other languages
English (en)
Inventor
Panayotis Nikolas Gerolymatos
Original Assignee
Gerolymatos P N Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gerolymatos P N Sa filed Critical Gerolymatos P N Sa
Publication of BR9711194A publication Critical patent/BR9711194A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Quinoline Compounds (AREA)

Abstract

Patente de Invenção:<B>"USO DE AGENTE QUELANTE CLIOQUINOL PARA A FABRICAçãO DE UMA COMPOSIçãO FARMACêUTICA PARA O TRATAMENTO DE DOENçA DE ALZHEIMER"<D>. é descrito o uso de agente quelante clioquinol para a fabricação de uma composição farmacêutica para o tratamento de doença de Alzheimer.
BR9711194-5A 1996-08-13 1997-08-08 Uso de agente quelante clioquinol para a fabricação de uma composição farmacêutica para o tratamento de doença de alzheimer. BR9711194A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GR96100286 1996-08-13
PCT/IB1997/000983 WO1998006403A1 (en) 1996-08-13 1997-08-08 Use of the chelating agent clioquinol for the manufacture of a pharmaceutical composition for the treatment of alzheimer's disease

Publications (1)

Publication Number Publication Date
BR9711194A true BR9711194A (pt) 2000-01-11

Family

ID=10942479

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9711194-5A BR9711194A (pt) 1996-08-13 1997-08-08 Uso de agente quelante clioquinol para a fabricação de uma composição farmacêutica para o tratamento de doença de alzheimer.

Country Status (25)

Country Link
US (1) US6001852A (pt)
EP (1) EP0959888B1 (pt)
JP (1) JP2000516606A (pt)
KR (1) KR100489969B1 (pt)
CN (1) CN1114407C (pt)
AT (1) ATE205086T1 (pt)
AU (1) AU720643B2 (pt)
BR (1) BR9711194A (pt)
CA (1) CA2264097C (pt)
CZ (2) CZ292411B6 (pt)
DE (1) DE69706566T2 (pt)
DK (1) DK0959888T3 (pt)
ES (1) ES2162319T3 (pt)
HU (1) HUP9903906A3 (pt)
IL (1) IL128416A (pt)
IS (1) IS1907B (pt)
NO (1) NO316768B1 (pt)
NZ (1) NZ334124A (pt)
PL (1) PL188838B1 (pt)
PT (1) PT959888E (pt)
RU (1) RU2193406C2 (pt)
SI (1) SI0959888T1 (pt)
SK (1) SK283117B6 (pt)
TR (1) TR199900293T2 (pt)
WO (1) WO1998006403A1 (pt)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7045531B1 (en) 1997-03-11 2006-05-16 The General Hospital Corporation Composition comprising a metal chelator and a method of treating amyloidosis by administering the metal chelator
CZ299739B6 (cs) 1997-08-21 2008-11-05 P. N. Gerolymatos S. A. Farmaceutický prostredek
WO1999021565A1 (en) * 1997-10-24 1999-05-06 Cornell Research Foundation, Inc. Nutritional supplement for cerebral metabolic insufficiencies
US5994323A (en) * 1997-12-31 1999-11-30 P.N. Gerolymatos S.A. Pharmaceutical compositions comprising clioquinol in combination with vitamin B12 and therapeutic and prophylactic uses thereof
US20020025944A1 (en) * 2000-04-28 2002-02-28 Bush Ashley I. Use of clioquinol for the therapy of Alzheimer's disease
US6323218B1 (en) * 1998-03-11 2001-11-27 The General Hospital Corporation Agents for use in the treatment of Alzheimer's disease
US6638711B1 (en) 1999-04-29 2003-10-28 The General Hospital Corporation Methods for identifying an agent that inhibits oxygen-dependent hydrogen peroxide formation activity but does not inhibit superoxide-dependent hydrogen peroxide formation
US20050112543A1 (en) * 1998-03-11 2005-05-26 The General Hospital Corporation Method of screening for drugs useful in treating Alzheimer's disease
JP2002534386A (ja) * 1999-01-07 2002-10-15 パイ・ニュー・ゲロリュマトス・ソシエテ・アノニム 記憶欠陥の治療又は予防にファンキノンを使用する方法
US6692234B2 (en) 1999-03-22 2004-02-17 Water Management Systems Pump system with vacuum source
US20040054182A1 (en) * 2000-02-09 2004-03-18 Hideo Kato 1h-imidazopyridine derivatives
FR2818551B1 (fr) * 2000-12-22 2007-06-01 Claude Marc Pierre Hannoun Utilisation de chelateurs pour le traitement des maladies a prions
US6803379B2 (en) * 2002-06-04 2004-10-12 Jose A. Fernandez-Pol Pharmacological agents and methods of treatment that inactivate pathogenic prokaryotic and eukaryotic cells and viruses by attacking highly conserved domains in structural metalloprotein and metalloenzyme targets
AU2002950217A0 (en) 2002-07-16 2002-09-12 Prana Biotechnology Limited 8- Hydroxy Quinoline Derivatives
CA2500952C (en) 2002-10-04 2011-04-26 Prana Biotechnology Limited Neurologically-active compounds
US20080063599A1 (en) * 2002-11-18 2008-03-13 Jorge Setoain Quinquer Compounds Which Can Be Used To Diagnose And Monitor Diseases Associated With The Formation Of Amyloid Protein Fibrils
AU2004226876A1 (en) * 2003-04-03 2004-10-14 Prana Biotechnology Ltd Treatment of neurological conditions
MXPA06005743A (es) * 2003-11-19 2007-04-17 Acrux Dds Pty Ltd Metodo y composicion para el tratamiento o profilaxis de trastornos de amiloidosis.
US20060194723A1 (en) * 2005-02-28 2006-08-31 Rabinoff Michael D Novel medication treatment and delivery strategies for Alzheimer's Disease, other disorders with memory impairment, and possible treatment strategies for memory improvement
CN101073584B (zh) * 2005-10-14 2012-10-10 全面技术公司 改变细胞功能的方法和组合物
US8871715B2 (en) 2005-10-14 2014-10-28 Alltech, Inc. Use of selenium compounds, especially selenium yeasts for altering cognitive function
US8865763B2 (en) 2005-10-14 2014-10-21 Alltech, Inc. Methods and compositions for altering cell function
EP1976877B2 (en) * 2005-11-30 2016-10-05 AbbVie Inc. Monoclonal antibodies against amyloid beta protein and uses thereof
CA2628703C (en) * 2005-11-30 2019-10-29 Abbott Laboratories Anti-a.beta. globulomer antibodies, antigen-binding moieties thereof, corresponding hybridomas, nucleic acids, vectors, host cells, methods of producing said antibodies, compositions comprising said antibodies, uses of said antibodies and methods of using said antibodies
WO2007118276A1 (en) 2006-04-14 2007-10-25 Prana Biotechnology Ltd Method of treatment of age-related macular degeneration(amd)
TWI551607B (zh) * 2006-07-14 2016-10-01 Ａｃ免疫公司 人類化抗體
MY165105A (en) * 2006-07-14 2018-02-28 Ac Immune Sa Humanized antibody against amyloid beta
RU2338542C1 (ru) * 2007-03-20 2008-11-20 Игорь Анатольевич Помыткин Применение воды с пониженным содержанием дейтерия для приготовления средств лечения нейродегенеративных заболеваний и улучшения когнитивной функции
US8048420B2 (en) 2007-06-12 2011-11-01 Ac Immune S.A. Monoclonal antibody
US8613923B2 (en) 2007-06-12 2013-12-24 Ac Immune S.A. Monoclonal antibody
SG10201505369QA (en) 2007-10-05 2015-08-28 Genentech Inc Use of anti-amyloid beta antibody in ocular diseases
ES2332687B1 (es) * 2008-03-13 2011-01-10 Proyecto De Biomedicina Cima, S.L. Nuevos usos de 4pba y sus sales farmaceuticamente aceptables.
KR101713365B1 (ko) 2010-07-30 2017-03-08 에이씨 이뮨 에스.에이. 안전하고 기능적인 인간화 항 베타-아밀로이드 항체
FR2966827B1 (fr) 2010-10-27 2014-08-22 Kimonella Ventures Ltd Compose peptidique utile pour l'inhibition de la formation de plaques amyloides
KR101802048B1 (ko) * 2013-04-02 2017-12-28 안지 파마슈티컬 코퍼레이션 리미티드 항신경퇴행성제로서의 다작용성 퀴놀린 유도체
WO2015162870A1 (ja) 2014-04-24 2015-10-29 想い出創造株式会社 アミロイド線維形成の抑制又は阻害剤
KR20160057500A (ko) * 2014-11-05 2016-05-24 아카데미아 시니카 클리오퀴놀을 포함하는 자폐증 스펙트럼 장애의 치료용 약학적 조성물

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE393238C (de) * 1923-05-12 1924-03-31 Maschb Akt Ges H Flottmann & C Bohrhammer
US3174899A (en) * 1960-12-30 1965-03-23 Ciba Geigy Corp Composition for the management of post antibiotic enteritis
US3178343A (en) * 1962-11-27 1965-04-13 Ciba Geigy Corp Pharmaceutical compositions and method of using same
DE1617417A1 (de) * 1966-12-08 1971-03-25 Ciba Geigy Pharmazeutisches Praeparat
RU2057531C1 (ru) * 1986-07-01 1996-04-10 Всероссийский научный центр по безопасности биологически активных веществ Средство для стимуляции обучения и памяти
DE3932338A1 (de) * 1989-09-28 1991-04-11 Nmi Naturwissenschaftl U Mediz Verfahren zur praeventiven therapie von morbus alzheimer
GB9010039D0 (en) * 1990-05-03 1990-06-27 Reckitt & Colmann Prod Ltd Medicament preparation
GB9108080D0 (en) * 1991-04-15 1991-06-05 Smithkline Beecham Plc Pharmaceutical composition
US5206264A (en) * 1991-11-04 1993-04-27 Cypros Pharmaceutical Corporation Use of disulfiram to prevent cardiovascular damage
CA2123211C (en) * 1991-11-12 2008-09-16 Colin L. Masters A method for assaying and treating alzheimer's disease
US5607691A (en) * 1992-06-12 1997-03-04 Affymax Technologies N.V. Compositions and methods for enhanced drug delivery
WO1995019178A1 (en) * 1994-01-13 1995-07-20 Research Foundation For Mental Hygiene, Inc. Methods and compositions for treatment and diagnosis of alzheimer disease and other disorders
WO1995031199A1 (en) * 1994-05-11 1995-11-23 P.N. Gerolymatos S.A. Use of clioquinol for treating helicobacter, including h. pylori, infections and related diseases
US5505958A (en) * 1994-10-31 1996-04-09 Algos Pharmaceutical Corporation Transdermal drug delivery device and method for its manufacture

Also Published As

Publication number Publication date
AU3632497A (en) 1998-03-06
PL331822A1 (en) 1999-08-02
DK0959888T3 (da) 2001-11-05
KR20000029958A (ko) 2000-05-25
WO1998006403A1 (en) 1998-02-19
SI0959888T1 (en) 2002-10-31
CZ48499A3 (cs) 1999-07-14
CZ295118B6 (cs) 2005-05-18
JP2000516606A (ja) 2000-12-12
PL188838B1 (pl) 2005-04-29
CN1114407C (zh) 2003-07-16
CA2264097C (en) 2007-11-27
HUP9903906A2 (hu) 2000-04-28
PT959888E (pt) 2002-02-28
ES2162319T3 (es) 2001-12-16
ATE205086T1 (de) 2001-09-15
IS4972A (is) 1999-02-10
EP0959888B1 (en) 2001-09-05
CA2264097A1 (en) 1998-02-19
HUP9903906A3 (en) 2001-01-29
IS1907B (is) 2003-12-16
SK283117B6 (sk) 2003-02-04
US6001852A (en) 1999-12-14
CZ292411B6 (cs) 2003-09-17
AU720643B2 (en) 2000-06-08
RU2193406C2 (ru) 2002-11-27
HK1022437A1 (en) 2000-08-11
SK17999A3 (en) 1999-09-10
NO990595D0 (no) 1999-02-09
NO990595L (no) 1999-04-12
KR100489969B1 (ko) 2005-05-17
IL128416A0 (en) 2000-01-31
IL128416A (en) 2004-06-01
EP0959888A1 (en) 1999-12-01
DE69706566D1 (de) 2001-10-11
NO316768B1 (no) 1999-04-12
NZ334124A (en) 2000-10-27
DE69706566T2 (de) 2002-07-11
TR199900293T2 (xx) 1999-06-21
CN1230115A (zh) 1999-09-29

Similar Documents

Publication Publication Date Title
BR9711194A (pt) Uso de agente quelante clioquinol para a fabricação de uma composição farmacêutica para o tratamento de doença de alzheimer.
BR9406979A (pt) Composto,composicão farmaceutica para tratar uma doenca inflamatória suscetivel de tratamento com um agente anti- inflamatório nao esteroidal processos para tratar uma doenca inflamatória e para preparar um composto sal famacéuticamente aceitável uso de um composto composicão farmaceutica anti-inflamatória nao esteroidal
GB0108592D0 (en) Therapeutic agents
HUP9801240A2 (en) Oral compositions
BR0213358A (pt) Uso de flibanserina
BR9106864A (pt) Composicoes de liberacao prolongada para o tratamento de doencas periodontais
BR9611015A (pt) Composto, composição farmacêutica e processo para o tratamento de uma doença inflamatória suscetìvel ao tratamento com um agente não-tóxico anti-inflamatório não-esteróide, sal farmaceuticamente aceitável, utilização de um composto
MY127980A (en) A pyrrolidineacetamide derivative alone or in combination for treatment of cns disorders
IL127714A0 (en) Use of topiramate or derivatives thereof for the manufacture of a medicament for the treatment of manic depressive bipolar disorders
PT956858E (pt) Composicoes farmaceuticas contendo lactobacilos para o tratamento de infeccoes vaginais
ES2193337T3 (es) Utilizacion de sales de estroncio para el tratamiento de la artrosis.
SE9603669D0 (sv) New combination
BR9803756A (pt) Polimento da unha antipsoriático.
FI972308A0 (fi) 2-substituoituja 1,2,5-tiadiatsolidin-3-oni-1,1-dioksideja ja niitä sisältäviä koostumuksia ja menetelmiä niiden käyttämiseksi
RU95106680A (ru) Бициклические ароматические соединения и содержащие их фармацевтические и косметические композиции
ES2177024T3 (es) Empleo de la fanquinoma para el tratamiento de la enfermedaad de alzheimer.
AU4179399A (en) Use of nmda antagonists and/or sodium channel antagonists for the treatment of inflammatory disorders
AU623805B2 (en) New use of anti-progestomimetic compounds
BR9911005A (pt) Uso de ozÈnio para a preparação de medicamentos para o tratamento de cáries dentárias
HUP9902135A2 (hu) (+)-alfa-(2,3-Dimetoxi-fenil)-1-[2-(4-fluor-fenil)-etil]-4-piperidin-metanol alkalmazása depresszív és bipoláris rendellenességek kezelésére alkalmas gyógyszerkészítmény előállítására
BR9814199A (pt) Utilização dos quetólidos para prevenir as complicações trombóticas arteriais ligadas à aterosclerose
GR1002576B (el) Φαρμακευτικες συνθεσεις και μια μεθοδος παρασκευης τους.
BR9507732A (pt) Composição farmacêutica para o tratamento de glaucoma
BR0104005A (pt) Composição farmacêutica para a prevenção ou para o tratamento de uma doença associada com um excesso de produção de il-2
FR2759587B1 (fr) Composition pharmaceutique pour l&#39;administration buccale de thiocolchicoside

Legal Events

Date Code Title Description
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFERIMENTO DO PRESENTE PEDIDO, POIS NAO ATENDE AOS ARTIGOS 8 E 13 DA LPI, LEI DE NUMERO 9.279 DE 14 DE MAIO DE 1996.

B12B Appeal against refusal [chapter 12.2 patent gazette]