BR9709791A - Intermediários para a síntese de oligonucleotíedeos - Google Patents

Intermediários para a síntese de oligonucleotíedeos

Info

Publication number: BR9709791A
Authority: BR; Brazil
Prior art keywords: group; hydrogen; formula; nucleoside; nuc
Prior art date: 1996-06-13

Application number

BR9709791A

Other languages

English (en)

Inventor

Stephen Paul Collingwood

Heinz Ernst Moser

Karl-Heinz Altmann

Mark Edward Douglas

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-06-13

Filing date

1997-06-03

Publication date

1999-08-10

1997-06-03 Application filed by Novartis Ag filed Critical Novartis Ag

1999-08-10 Publication of BR9709791A publication Critical patent/BR9709791A/pt

Links

108091034117 Oligonucleotide Proteins 0.000 title abstract 2
JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 title 1
230000015572 biosynthetic process Effects 0.000 title 1
239000000543 intermediate Substances 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1
239000001257 hydrogen Substances 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 3
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 2
125000003342 alkenyl group Chemical group 0.000 abstract 2
125000003710 aryl alkyl group Chemical group 0.000 abstract 2
125000003118 aryl group Chemical group 0.000 abstract 2
125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 2
239000002777 nucleoside Substances 0.000 abstract 2
150000003833 nucleoside derivatives Chemical class 0.000 abstract 2
125000004429 atom Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
125000004430 oxygen atom Chemical group O* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Health & Medical Sciences (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Life Sciences & Earth Sciences (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

BR9709791A 1996-06-13 1997-06-03 Intermediários para a síntese de oligonucleotíedeos BR9709791A (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9612600.8A GB9612600D0 (en)	1996-06-13	1996-06-13	Chemical compounds
PCT/GB1997/001490 WO1997047636A2 (en)	1996-06-13	1997-06-03	Intermediates for oligonucleotide synthesis

Publications (1)

Publication Number	Publication Date
BR9709791A true BR9709791A (pt)	1999-08-10

Family

ID=10795396

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BR9709791A BR9709791A (pt)	1996-06-13	1997-06-03	Intermediários para a síntese de oligonucleotíedeos

Country Status (12)

Country	Link
US (1)	US6329519B1 (pt)
EP (1)	EP0906327B1 (pt)
JP (1)	JP2000512288A (pt)
CN (1)	CN1221423A (pt)
AT (1)	ATE210675T1 (pt)
AU (1)	AU2971997A (pt)
BR (1)	BR9709791A (pt)
CA (1)	CA2257453A1 (pt)
DE (1)	DE69709098T2 (pt)
GB (1)	GB9612600D0 (pt)
WO (1)	WO1997047636A2 (pt)
ZA (1)	ZA975197B (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
USRE44779E1 (en)	1997-03-07	2014-02-25	Santaris Pharma A/S	Bicyclonucleoside and oligonucleotide analogues
JP3756313B2 (ja) *	1997-03-07	2006-03-15	武今西	新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体
US6770748B2 (en)	1997-03-07	2004-08-03	Takeshi Imanishi	Bicyclonucleoside and oligonucleotide analogue
US7030230B2 (en)	2002-10-25	2006-04-18	Isis Pharmaceuticals, Inc.	Process of purifying phosphoramidites
EP1692139B1 (en)	2003-11-13	2013-02-13	Isis Pharmaceuticals, Inc.	5,6 -dihydroxy-isoindole derivatives as linkers for oligomer solid phase synthesis
US7427675B2 (en)	2004-08-23	2008-09-23	Isis Pharmaceuticals, Inc.	Compounds and methods for the characterization of oligonucleotides

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3307744A1 (de)	1983-03-04	1984-09-06	Gesellschaft für Biotechnologische Forschung mbH (GBF), 3300 Braunschweig	2'-desoxy-3'-phosphonylmethyl-nucleoside
JPH03503894A (ja) *	1988-03-25	1991-08-29	ユニバーシィティ　オブ　バージニア　アランミ　パテンツ　ファウンデイション	オリゴヌクレオチド　ｎ‐アルキルホスホラミデート
DE4037363A1 (de)	1990-04-09	1991-10-10	Europ Lab Molekularbiolog	2-0-alkylnukleotide sowie polymere, die solche nukleotide enthalten
US5658731A (en) *	1990-04-09	1997-08-19	Europaisches Laboratorium Fur Molekularbiologie	2'-O-alkylnucleotides as well as polymers which contain such nucleotides
US5378825A (en)	1990-07-27	1995-01-03	Isis Pharmaceuticals, Inc.	Backbone modified oligonucleotide analogs
US5386023A (en) *	1990-07-27	1995-01-31	Isis Pharmaceuticals	Backbone modified oligonucleotide analogs and preparation thereof through reductive coupling
GB9304618D0 (en)	1993-03-06	1993-04-21	Ciba Geigy Ag	Chemical compounds
GB9311682D0 (en)	1993-06-05	1993-07-21	Ciba Geigy Ag	Chemical compounds
GB9417746D0 (en)	1994-09-03	1994-10-19	Ciba Geigy Ag	Chemical compounds

1996
- 1996-06-13 GB GBGB9612600.8A patent/GB9612600D0/en active Pending
1997
- 1997-06-03 US US09/202,294 patent/US6329519B1/en not_active Expired - Lifetime
- 1997-06-03 AT AT97924155T patent/ATE210675T1/de active
- 1997-06-03 JP JP10501337A patent/JP2000512288A/ja active Pending
- 1997-06-03 EP EP97924155A patent/EP0906327B1/en not_active Expired - Lifetime
- 1997-06-03 BR BR9709791A patent/BR9709791A/pt not_active Application Discontinuation
- 1997-06-03 WO PCT/GB1997/001490 patent/WO1997047636A2/en not_active Ceased
- 1997-06-03 CN CN97195452A patent/CN1221423A/zh active Pending
- 1997-06-03 AU AU29719/97A patent/AU2971997A/en not_active Abandoned
- 1997-06-03 DE DE69709098T patent/DE69709098T2/de not_active Expired - Lifetime
- 1997-06-03 CA CA002257453A patent/CA2257453A1/en not_active Abandoned
- 1997-06-12 ZA ZA9705197A patent/ZA975197B/xx unknown

Also Published As

Publication number	Publication date
DE69709098D1 (de)	2002-01-24
ZA975197B (en)	1997-12-15
GB9612600D0 (en)	1996-08-21
ATE210675T1 (de)	2001-12-15
JP2000512288A (ja)	2000-09-19
CA2257453A1 (en)	1997-12-18
AU2971997A (en)	1998-01-07
WO1997047636A2 (en)	1997-12-18
EP0906327B1 (en)	2001-12-12
US6329519B1 (en)	2001-12-11
WO1997047636A3 (en)	1998-02-12
CN1221423A (zh)	1999-06-30
EP0906327A2 (en)	1999-04-07
DE69709098T2 (de)	2002-09-05

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PT915866E (pt)	2002-07-31	Processo aperfeicoado para a sintese de esteres protegidos do acido (s)-3,4-di-hidroxibutirico
ATE188216T1 (de)	2000-01-15	Therapeutische mittel für die parkinsonsche krankheit
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ATE303063T1 (de)	2005-09-15	Synthetische analoge des ecteinascidin-743
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ATE238294T1 (de)	2003-05-15	Zwischenprodukte und verfahren zu ihrer herstellung
HUP0003484A2 (hu)	2002-01-28	Pirrolidin-3-karbonsav-származékok és alkalmazásuk endotelin antagonistaként
FR2636625B1 (fr)	1990-11-09	Benzylamines disubstituees, leur procede de preparation, leur utilisation comme medicament et leurs intermediaires de synthese
TR199801039T2 (xx)	1998-08-21	Yeni fenilamidin t�revlerinin elde edilmesine y�nelik usul.
MY138051A (en)	2009-04-30	Compounds and processes
NZ228065A (en)	1990-09-26	1,2,4-triazinediones and parasiticidal compositions; processes for preparation
EP0714900A3 (de)	1996-07-31	Alkylhydrogenchlorsilane, Verfahren zu deren Herstellung und deren Verwendung
PT1022276E (pt)	2003-10-31	Derivados de epoxissuccinamida
BR9709791A (pt)	1999-08-10	Intermediários para a síntese de oligonucleotíedeos
DE69028610D1 (de)	1996-10-24	Chirale 1,5-diiodo-2-methoxy oder benzyloxy Zwischenprodukte
TR200001239T2 (tr)	2001-07-23	Tiyazolidinediyon türevlerini hazırlama prosesi.
MY101618A (en)	1991-12-17	Intermediates for the production of epipodophyloxin and related compounds and processes for the preparation and use thereof
TR200100286T2 (tr)	2001-07-23	(1H)-Benzo[C]kuinolizin-3-on türevlerinin sentezi için proses.
SE8501988L (sv)	1985-10-26	Iminotiazolidinderivat
DE69709252D1 (de)	2002-01-31	Coumarin-Derivate, Verfahren zu deren Herstellung und deren Verwendung
PT1250335E (pt)	2005-11-30	Processo e intermediarios para a preparacao de imidazopiridinas
ATE258187T1 (de)	2004-02-15	Herstellung von 2'-substitutierter rns
FR2633622B1 (fr)	1991-05-17	Derives de sulfonyl indolizine, leur procede de preparation et leur utilisation comme intermediaires de synthese
ID19038A (id)	1998-06-04	Turunan feniletanolaminotetralinkarboksamida

Legal Events

Date	Code	Title	Description
2003-10-21	FA10	Dismissal: dismissal - article 33 of industrial property law
2004-06-08	B11Y	Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]