BR9709630A - Antagonistas de receptor de dopamina D4 de benzoxazinona - Google Patents
Antagonistas de receptor de dopamina D4 de benzoxazinonaInfo
- Publication number
- BR9709630A BR9709630A BR9709630A BR9709630A BR9709630A BR 9709630 A BR9709630 A BR 9709630A BR 9709630 A BR9709630 A BR 9709630A BR 9709630 A BR9709630 A BR 9709630A BR 9709630 A BR9709630 A BR 9709630A
- Authority
- BR
- Brazil
- Prior art keywords
- benzoxazinone
- dopamine
- receptor antagonists
- antagonists
- receptor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
- C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1838396P | 1996-05-29 | 1996-05-29 | |
| US4020897P | 1997-03-06 | 1997-03-06 | |
| PCT/US1997/008524 WO1997045419A1 (en) | 1996-05-29 | 1997-05-20 | Benzoxazinone dopamine d4 receptor antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9709630A true BR9709630A (pt) | 1999-08-10 |
Family
ID=26691052
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9709630A BR9709630A (pt) | 1996-05-29 | 1997-05-20 | Antagonistas de receptor de dopamina D4 de benzoxazinona |
Country Status (36)
| Country | Link |
|---|---|
| EP (1) | EP0906294B1 (pt) |
| JP (1) | JP2000511534A (pt) |
| KR (1) | KR20000016151A (pt) |
| CN (1) | CN1074764C (pt) |
| AR (1) | AR008372A1 (pt) |
| AT (1) | ATE231846T1 (pt) |
| AU (1) | AU731104B2 (pt) |
| BG (1) | BG64049B1 (pt) |
| BR (1) | BR9709630A (pt) |
| CA (1) | CA2253406A1 (pt) |
| CO (1) | CO4940505A1 (pt) |
| CZ (1) | CZ384698A3 (pt) |
| DE (1) | DE69718786T2 (pt) |
| DK (1) | DK0906294T3 (pt) |
| EA (1) | EA001486B1 (pt) |
| EE (1) | EE03686B1 (pt) |
| ES (1) | ES2191180T3 (pt) |
| GE (1) | GEP20012389B (pt) |
| HN (1) | HN1997000075A (pt) |
| HR (1) | HRP970301B1 (pt) |
| HU (1) | HUP9903758A3 (pt) |
| ID (1) | ID17266A (pt) |
| IL (1) | IL126895A (pt) |
| NO (1) | NO312296B1 (pt) |
| NZ (1) | NZ332737A (pt) |
| PA (1) | PA8431101A1 (pt) |
| PE (1) | PE69398A1 (pt) |
| PL (1) | PL330195A1 (pt) |
| PT (1) | PT906294E (pt) |
| RO (1) | RO120845B1 (pt) |
| SI (1) | SI0906294T1 (pt) |
| SK (1) | SK282703B6 (pt) |
| SV (1) | SV1997000047A (pt) |
| TW (1) | TW542833B (pt) |
| UY (1) | UY24569A1 (pt) |
| WO (1) | WO1997045419A1 (pt) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6177422B1 (en) | 1996-05-29 | 2001-01-23 | Warner-Lambert Company | Benzoxazinone dopamine D4 receptor antagonists |
| GB9801392D0 (en) * | 1998-01-22 | 1998-03-18 | Smithkline Beecham Plc | Novel compounds |
| US6291463B1 (en) | 1998-06-30 | 2001-09-18 | Neurogen Corporation | 1-(Benzothiazol-2-yl)-4-(1-phenylmethyl) piperazines: dopamine receptor subtype specific ligands |
| EP1091949A2 (en) * | 1998-06-30 | 2001-04-18 | Neurogen Corporation | 6-(4-arylalkylpiperazin-1-yl)benzodioxane and 6-(4-arylalkylpiperazin-1-yl)chromane derivatives: dopamine receptor subtype specific ligands |
| CA2336150A1 (en) * | 1998-06-30 | 2000-01-06 | Neurogen Corporation | 1-(benzothiazol-2-yl)-4-(1-phenylmethyl)piperazines: dopamine receptor subtype specific ligands |
| US6177566B1 (en) | 1998-06-30 | 2001-01-23 | Neurogen Corporation | 6-(4-arylalkylpiperazin-1-yl) benzodioxane and 6-(4-arylalkylpiperazin-1-yl) chromane derivatives: dopamine receptor subtype specific ligands |
| DE19844291A1 (de) * | 1998-09-18 | 2000-03-23 | Schering Ag | Benzoxazin- und Benzothiazin-Derivate und deren Verwendung in Arzneimitteln |
| GB9912411D0 (en) * | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
| JP4242643B2 (ja) | 2000-10-26 | 2009-03-25 | スミスクライン ビーチャム ピー エル シー | ベンズオキサジノン誘導体、その製造および使用 |
| GB0203804D0 (en) | 2002-02-18 | 2002-04-03 | Glaxo Group Ltd | Compounds |
| GB0209244D0 (en) * | 2002-04-23 | 2002-06-05 | Glaxo Group Ltd | Compounds |
| GB0227240D0 (en) * | 2002-11-21 | 2002-12-31 | Glaxo Group Ltd | Compounds |
| ES2232292B1 (es) * | 2003-07-30 | 2006-11-01 | Laboratorios Del Dr. Esteve, S.A. | Compuestos sulfonamidicos derivados de benzoxazinona, su preparacion y uso como medicamentos. |
| CN100455573C (zh) * | 2005-11-11 | 2009-01-28 | 华东理工大学 | 一种制备1,4-苯并噁唑嗪-3-酮化合物的微波合成方法 |
| KR200482995Y1 (ko) | 2015-08-19 | 2017-03-23 | 이현진 | 물 공급부를 구비하는 얼음 트레이 |
| CA3215823A1 (en) * | 2021-04-23 | 2022-10-27 | Peng Gao | Heterocyclic derivative inhibitor and preparation method therefor and application thereof |
| EP4493551A1 (en) | 2022-03-14 | 2025-01-22 | Slap Pharmaceuticals LLC | Multicyclic compounds |
| JP2025517106A (ja) * | 2022-04-28 | 2025-06-03 | ニンボー・ニューベイ・テクノロジー・ディベロップメント・カンパニー・リミテッド | Parp1阻害剤としての化合物 |
| CN117903159A (zh) * | 2022-12-30 | 2024-04-19 | 成都硕德药业有限公司 | 一种内酰胺类衍生物、其制备方法及用途 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4613598A (en) * | 1984-03-13 | 1986-09-23 | Mitsubishi Chemical Industries Limited | Piperazine derivatives and their acid addition salts |
| EP0233728A1 (en) * | 1986-02-11 | 1987-08-26 | Takeda Chemical Industries, Ltd. | 1,4-Benzoxazine derivatives their production and use |
| JPH07509705A (ja) * | 1992-08-06 | 1995-10-26 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | ドーパミンd3レセプター拮抗薬用5−(2−オキシフェニル)−ピロール誘導体 |
-
1997
- 1997-05-20 IL IL12689597A patent/IL126895A/en not_active IP Right Cessation
- 1997-05-20 JP JP09542647A patent/JP2000511534A/ja not_active Ceased
- 1997-05-20 DK DK97925651T patent/DK0906294T3/da active
- 1997-05-20 PL PL97330195A patent/PL330195A1/xx unknown
- 1997-05-20 HU HU9903758A patent/HUP9903758A3/hu unknown
- 1997-05-20 BR BR9709630A patent/BR9709630A/pt not_active Application Discontinuation
- 1997-05-20 AT AT97925651T patent/ATE231846T1/de not_active IP Right Cessation
- 1997-05-20 PT PT97925651T patent/PT906294E/pt unknown
- 1997-05-20 EA EA199800987A patent/EA001486B1/ru not_active IP Right Cessation
- 1997-05-20 ES ES97925651T patent/ES2191180T3/es not_active Expired - Lifetime
- 1997-05-20 EE EE9800417A patent/EE03686B1/xx not_active IP Right Cessation
- 1997-05-20 RO RO98-01622A patent/RO120845B1/ro unknown
- 1997-05-20 SI SI9730482T patent/SI0906294T1/xx unknown
- 1997-05-20 CA CA002253406A patent/CA2253406A1/en not_active Abandoned
- 1997-05-20 NZ NZ332737A patent/NZ332737A/en unknown
- 1997-05-20 EP EP97925651A patent/EP0906294B1/en not_active Expired - Lifetime
- 1997-05-20 GE GEAP19974623A patent/GEP20012389B/en unknown
- 1997-05-20 AU AU30727/97A patent/AU731104B2/en not_active Ceased
- 1997-05-20 DE DE69718786T patent/DE69718786T2/de not_active Expired - Fee Related
- 1997-05-20 SK SK1627-98A patent/SK282703B6/sk unknown
- 1997-05-20 KR KR1019980709719A patent/KR20000016151A/ko not_active Ceased
- 1997-05-20 CZ CZ983846A patent/CZ384698A3/cs unknown
- 1997-05-20 CN CN97195015A patent/CN1074764C/zh not_active Expired - Fee Related
- 1997-05-20 WO PCT/US1997/008524 patent/WO1997045419A1/en not_active Ceased
- 1997-05-22 HN HN1997000075A patent/HN1997000075A/es unknown
- 1997-05-27 AR ARP970102249A patent/AR008372A1/es unknown
- 1997-05-28 CO CO97029474A patent/CO4940505A1/es unknown
- 1997-05-28 PE PE1997000432A patent/PE69398A1/es not_active Application Discontinuation
- 1997-05-28 PA PA19978431101A patent/PA8431101A1/es unknown
- 1997-05-28 SV SV1997000047A patent/SV1997000047A/es not_active Application Discontinuation
- 1997-05-28 ID IDP971778A patent/ID17266A/id unknown
- 1997-05-28 TW TW086107221A patent/TW542833B/zh active
- 1997-05-28 UY UY24569A patent/UY24569A1/es not_active Application Discontinuation
- 1997-05-29 HR HR970301A patent/HRP970301B1/xx not_active IP Right Cessation
-
1998
- 1998-11-26 BG BG102959A patent/BG64049B1/bg unknown
- 1998-11-27 NO NO19985531A patent/NO312296B1/no not_active IP Right Cessation
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: INDEFERIMENTO DO PRESENTE PEDIDO, UMA VEZ QUE O MESMO NAO ATENDE AO DISPOSTO NOS ARTIGOS 8O, 10, 13, 24 E 25 DA LPI NO 9.279/96 |
|
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL. |