BR9709196A - Azetidinone derivatives for the treatment of atherosclerosis - Google Patents

Azetidinone derivatives for the treatment of atherosclerosis

Info

Publication number: BR9709196A
Authority: BR; Brazil
Prior art keywords: atherosclerosis; treatment; azetidinone derivatives; azetidinone; derivatives
Prior art date: 1996-04-26

Application number

BR9709196A

Other languages

Portuguese (pt)

Inventor

Colin Andrew Leach

Deirdre Mary Bernadette Hickey

Robert John Ife

Dashyant Dhanak

Colin Theobald

Original Assignee

Smithkline Beecham Plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-04-26

Filing date

1997-04-15

Publication date

1999-05-25

1996-04-26 Priority claimed from GBGB9608646.7A external-priority patent/GB9608646D0/en

1996-11-15 Priority claimed from GBGB9623756.5A external-priority patent/GB9623756D0/en

1996-12-03 Priority claimed from GBGB9625121.0A external-priority patent/GB9625121D0/en

1997-04-15 Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc

1999-05-25 Publication of BR9709196A publication Critical patent/BR9709196A/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
- C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Toxicology (AREA)
Physical Education & Sports Medicine (AREA)
Dermatology (AREA)
Rheumatology (AREA)
Hematology (AREA)
Obesity (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Cardiology (AREA)
Biochemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

BR9709196A 1996-04-26 1997-04-15 Azetidinone derivatives for the treatment of atherosclerosis BR9709196A (en)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GBGB9608646.7A GB9608646D0 (en)	1996-04-26	1996-04-26	Novel compounds
GBGB9623756.5A GB9623756D0 (en)	1996-11-15	1996-11-15	Novel compounds
GBGB9625121.0A GB9625121D0 (en)	1996-12-03	1996-12-03	Novel compounds
PCT/EP1997/001898 WO1997041098A1 (en)	1996-04-26	1997-04-15	Azetidinone derivatives for the treatment of atherosclerosis

Publications (1)

Publication Number	Publication Date
BR9709196A true BR9709196A (en)	1999-05-25

Family

ID=27268259

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BR9709196A BR9709196A (en)	1996-04-26	1997-04-15	Azetidinone derivatives for the treatment of atherosclerosis

Country Status (17)

Country	Link
EP (1)	EP0915843A1 (en)
JP (1)	JP2000509049A (en)
AR (1)	AR006833A1 (en)
AU (1)	AU2698697A (en)
BR (1)	BR9709196A (en)
CA (1)	CA2252696A1 (en)
CZ (1)	CZ341098A3 (en)
HU (1)	HUP9901359A3 (en)
ID (1)	ID16660A (en)
IL (1)	IL126696A0 (en)
MA (1)	MA26426A1 (en)
NO (1)	NO984939L (en)
NZ (1)	NZ332476A (en)
PE (1)	PE64398A1 (en)
PL (1)	PL329530A1 (en)
TR (1)	TR199802160T2 (en)
WO (1)	WO1997041098A1 (en)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE437862T1 (en)	2000-02-16	2009-08-15	Smithkline Beecham Plc	PYRIMIDINE-5-ONE DERIVATIVES AS LDL-PLA2 INHIBITORS
US6982251B2 (en)	2000-12-20	2006-01-03	Schering Corporation	Substituted 2-azetidinones useful as hypocholesterolemic agents
US7071181B2 (en)	2001-01-26	2006-07-04	Schering Corporation	Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors
MEP27808A (en)	2001-01-26	2010-10-10	Schering Corp	Combinations of peroxisome proliferator-activated receptor (ppar) activator(s) and sterol absorption inhibitor(s) and treatments for vascular indications
ATE331512T1 (en)	2001-01-26	2006-07-15	Schering Corp	USE OF AZETIDINONE SUBSTITUTED COMPOUNDS FOR THE TREATMENT OF SITOSTEROLHEMIA
CN1275949C (en)	2001-03-28	2006-09-20	先灵公司	Enantioselective Synthesis of 2-Azetidinone Intermediates
AR038956A1 (en) *	2001-05-25	2005-02-02	Schering Corp	USE OF A COMPOUND REGULATING THE PRODUCTION OR LEVELS OF BETA AMILOID PEPTIDES FOR THE MANUFACTURE OF A MEDICINAL PRODUCT TO TREAT ALZHEIMER'S DISEASE AND / OR TO REGULATE SUCH LEVELS OF BETA AMILOID PEPTIDES IN A SUBJECT
US7053080B2 (en)	2001-09-21	2006-05-30	Schering Corporation	Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors
JP2005504091A (en)	2001-09-21	2005-02-10	シェーリング　コーポレイション	Treatment of xanthomas with azetidinone as a sterol absorption inhibitor
US7056906B2 (en)	2001-09-21	2006-06-06	Schering Corporation	Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women
WO2004043457A1 (en)	2002-11-06	2004-05-27	Schering Corporation	Cholesterol absorptions inhibitors for the treatment of autoimmune disorders
US7459442B2 (en)	2003-03-07	2008-12-02	Schering Corporation	Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
MXPA05009501A (en)	2003-03-07	2005-10-18	Schering Corp	Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholeterolemia.
CA2517571C (en)	2003-03-07	2011-07-05	Schering Corporation	Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
EP1606287B1 (en)	2003-03-07	2013-10-02	Merck Sharp & Dohme Corp.	Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholesterolemia
US8962633B2 (en)	2007-05-11	2015-02-24	Thomas Jefferson University	Methods of treatment and prevention of metabolic bone diseases and disorders
WO2008140449A1 (en)	2007-05-11	2008-11-20	Thomas Jefferson University	Methods of treatment and prevention of neurodegenerative diseases and disorders
EP2155225B1 (en)	2007-05-11	2015-07-08	The Trustees of the University of Pennsylvania	Methods of treatment of skin ulcers
UY33766A (en)	2010-12-06	2012-06-29	Glaxo Group Ltd	COMPOUNDS WITH PYRIMIDINONE STRUCTURE FOR USE IN THE TREATMENT OF DISEASES MEDIATED BY Lp-PLA2
WO2012080497A2 (en)	2010-12-17	2012-06-21	Glaxo Group Limited	Methods of treatment and prevention of eye diseases
US20140171431A1 (en)	2011-06-27	2014-06-19	Jianhua Shen	Azole heterocyclic compound, preparation method, pharmaceutical composition and use
TW201321382A (en)	2011-07-27	2013-06-01	Glaxo Group Ltd	Compounds
WO2013013503A1 (en)	2011-07-27	2013-01-31	Glaxo Group Limited	2,3-dihydroimidazo[1,2-c] pyrimidin-5(1h)-one compounds use as lp-pla2 inhibitors
PE20151251A1 (en)	2013-01-25	2015-09-10	Glaxosmithkline Ip Dev Ltd	DERIVATIVES [5,6] IMIDAZO PYRIMIDONE BICYCLIC WITH ACTIVITY ON LP-PLA2 ENZYMES
AU2014210259B2 (en)	2013-01-25	2016-11-03	Glaxosmithkline Intellectual Property Development Limited	Compounds
WO2014114249A1 (en)	2013-01-25	2014-07-31	Glaxosmithkline Intellectual Property Development Limited	Bicyclic pyrimidone compounds as inhibitors of lp-pla2
WO2016012917A1 (en)	2014-07-22	2016-01-28	Glaxosmithkline Intellectual Property Development Limited	1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidine derivatives useful in the treatment of diseases and disorders mediated by lp-pla2
WO2016012916A1 (en)	2014-07-22	2016-01-28	Glaxosmithkline Intellectual Property Development Limited	1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidine derivatives useful in the treatment of diseases and disorders mediated by lp-pla2
EP4056571A4 (en)	2019-11-09	2024-01-24	Shanghai Simr Biotechnology Co., Ltd.	Tricyclic dihydroimidazopyrimidone derivative, preparation method therefor, pharmaceutical composition and use thereof
CN115304620A (en)	2021-05-07	2022-11-08	上海赛默罗生物科技有限公司	Pyrimidone derivatives, preparation method, pharmaceutical composition and application thereof

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4680391A (en) *	1983-12-01	1987-07-14	Merck & Co., Inc.	Substituted azetidinones as anti-inflammatory and antidegenerative agents
IL89835A0 (en) *	1988-04-11	1989-12-15	Merck & Co Inc	Substituted azetidinones,their preparation and pharmaceutical compositions containing them
IL99658A0 (en) *	1990-10-15	1992-08-18	Merck & Co Inc	Substituted azetidinones and pharmaceutical compositions containing them
WO1993000332A1 (en) *	1991-06-25	1993-01-07	Merck & Co., Inc.	Substituted azetidinones as anti-inflammatory and antidegenerative agents
IL102582A0 (en) *	1991-07-23	1993-01-14	Schering Corp	Substituted beta-lactam compounds useful as hypocholesterolemic agents and processes for the preparation thereof
CA2108584C (en) *	1992-10-27	1998-11-24	James B. Doherty	Substituted azetidinones as anti-inflammatory and antidegenerative agents
WO1994013636A1 (en) *	1992-12-17	1994-06-23	Merck & Co., Inc.	New substituted azetidinones as anti-inflammatory and antidegenerative agents
EP0658205B1 (en) *	1993-06-25	2000-03-15	Smithkline Beecham Plc	Lipoprotein associated phospholipase a2, inhibitors thereof and use of the same in diagnosis and therapy
DE69434609T2 (en) *	1993-10-06	2006-09-21	Icos Corp., Bothell	Acethylhydrolase of the platelet activating factor
GB9421816D0 (en) *	1994-10-29	1994-12-14	Smithkline Beecham Plc	Novel compounds
MA23834A1 (en) *	1994-12-22	1996-10-01	Smithkline Beecham Plc	PROCESS FOR THE PREPARATION OF INHIBITOR COMPOUNDS OF THE LP-PLA2 ENZYME AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
WO1996029307A1 (en) *	1995-03-23	1996-09-26	Japan Tobacco Inc.	Diphenylmethyl-azetidinone compounds and elastase inhibitor
TR199701762T1 (en) *	1995-07-01	1998-05-21	Smithkline Beecham P.L.C.	Azetidinone derivatives for the treatment of atherosclerosis.
WO1997021676A1 (en) *	1995-12-08	1997-06-19	Smithkline Beecham Plc	Azetidinone compounds for the treatment of atherosclerosis

1997
- 1997-04-15 IL IL12669697A patent/IL126696A0/en unknown
- 1997-04-15 CA CA002252696A patent/CA2252696A1/en not_active Abandoned
- 1997-04-15 HU HU9901359A patent/HUP9901359A3/en unknown
- 1997-04-15 CZ CZ983410A patent/CZ341098A3/en unknown
- 1997-04-15 WO PCT/EP1997/001898 patent/WO1997041098A1/en not_active Ceased
- 1997-04-15 JP JP9538507A patent/JP2000509049A/en active Pending
- 1997-04-15 TR TR1998/02160T patent/TR199802160T2/en unknown
- 1997-04-15 AU AU26986/97A patent/AU2698697A/en not_active Abandoned
- 1997-04-15 PL PL97329530A patent/PL329530A1/en unknown
- 1997-04-15 BR BR9709196A patent/BR9709196A/en not_active Application Discontinuation
- 1997-04-15 EP EP97920699A patent/EP0915843A1/en not_active Withdrawn
- 1997-04-15 NZ NZ332476A patent/NZ332476A/en unknown
- 1997-04-24 PE PE1997000311A patent/PE64398A1/en not_active Application Discontinuation
- 1997-04-24 AR ARP970101682A patent/AR006833A1/en unknown
- 1997-04-24 MA MA24565A patent/MA26426A1/en unknown
- 1997-04-25 ID IDP971394A patent/ID16660A/en unknown
1998
- 1998-10-23 NO NO984939A patent/NO984939L/en not_active Application Discontinuation

Also Published As

Publication number	Publication date
NO984939L (en)	1998-12-23
HUP9901359A2 (en)	1999-08-30
MA26426A1 (en)	2004-12-20
HUP9901359A3 (en)	2000-03-28
PE64398A1 (en)	1999-01-06
NZ332476A (en)	2000-06-23
CZ341098A3 (en)	1999-03-17
JP2000509049A (en)	2000-07-18
NO984939D0 (en)	1998-10-23
CA2252696A1 (en)	1997-11-06
AR006833A1 (en)	1999-09-29
WO1997041098A1 (en)	1997-11-06
EP0915843A1 (en)	1999-05-19
IL126696A0 (en)	1999-08-17
PL329530A1 (en)	1999-03-29
TR199802160T2 (en)	1999-04-21
ID16660A (en)	1997-10-30
AU2698697A (en)	1997-11-19

Publication	Publication Date	Title
BR9709196A (en)	1999-05-25	Azetidinone derivatives for the treatment of atherosclerosis
FI972584A0 (en)	1997-06-17	Substituted azetidin-2-ones for the treatment of atherosclerosis
ZA959100B (en)	1996-06-20	Azetidinone derivatives for the treatment of atherosclerosis
PT977748E (en)	2003-07-31	SUBSTITUTED BENZOPIRAN DERIVATIVES FOR THE TREATMENT OF INFLAMMATION
BR9711530A (en)	1999-08-24	Combination of therapy for the treatment of psychoses
FI954880L (en)	1996-04-15	Treated inorganic solids
PT946542E (en)	2003-02-28	DERIVATIVES FROM INDANO OR DIHYDROINDOL
NO983266D0 (en)	1998-07-15	Distributed Treatment
BR9505688A (en)	1997-11-11	Rotation atomizer
PT934320E (en)	2003-07-31	NAFTIRIDINE DERIVATIVES
PT891332E (en)	2004-07-30	6-PHENYLPYRIDYL-2-AMINE DERIVATIVES
ID20531A (en)	1999-01-07	TREATMENT TOOL
DE69733470D1 (en)	2005-07-14	LASER TREATMENT
NO976158D0 (en)	1997-12-30	Azetidinone derivatives for the treatment of atherosclerosis
BR9709065A (en)	1999-08-03	Alkylaminobenzothiazole derivatives e-benzoxazole
ID17723A (en)	1998-01-22	COMPOUND FOR TREATMENT
IS4789A (en)	1998-06-30	treatment Compounds
NO983263L (en)	1998-07-15	Distributed treatment
PT906279E (en)	2003-02-28	PIRROL DERIVATIVES
PT931087E (en)	2002-09-30	NEW PYRANOSID DERIVATIVES
PT1051172E (en)	2005-03-31	METHOD FOR TREATMENT OF THE DPCO
PT970080E (en)	2003-07-31	IMINO-AZA-ANTHRACYCLINONE DERIVATIVES FOR THE AMYLOIDS TREATMENT
PT822287E (en)	2004-05-31	FIBER TREATMENT PRODUCT
BR9706980A (en)	1999-04-06	Isooxacefem derivatives
BR9708310A (en)	1999-08-03	2-Thioxotetrahydropyrimidin-4-one derivatives

Legal Events

Date	Code	Title	Description
2003-10-21	FA10	Dismissal: dismissal - article 33 of industrial property law
2004-06-08	B11Y	Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]