BR9708963A - Process for the preparation of ivermectin - Google Patents
Process for the preparation of ivermectinInfo
- Publication number
- BR9708963A BR9708963A BR9708963-0A BR9708963A BR9708963A BR 9708963 A BR9708963 A BR 9708963A BR 9708963 A BR9708963 A BR 9708963A BR 9708963 A BR9708963 A BR 9708963A
- Authority
- BR
- Brazil
- Prior art keywords
- preparation
- ivermectin
- invermectin
- avermectin
- quantitative
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- AZSNMRSAGSSBNP-UHFFFAOYSA-N 22,23-dihydroavermectin B1a Natural products C1CC(C)C(C(C)CC)OC21OC(CC=C(C)C(OC1OC(C)C(OC3OC(C)C(O)C(OC)C3)C(OC)C1)C(C)C=CC=C1C3(C(C(=O)O4)C=C(C)C(O)C3OC1)O)CC4C2 AZSNMRSAGSSBNP-UHFFFAOYSA-N 0.000 title abstract 2
- 229960002418 ivermectin Drugs 0.000 title abstract 2
- SPBDXSGPUHCETR-JFUDTMANSA-N 8883yp2r6d Chemical compound O1[C@@H](C)[C@H](O)[C@@H](OC)C[C@@H]1O[C@@H]1[C@@H](OC)C[C@H](O[C@@H]2C(=C/C[C@@H]3C[C@@H](C[C@@]4(O[C@@H]([C@@H](C)CC4)C(C)C)O3)OC(=O)[C@@H]3C=C(C)[C@@H](O)[C@H]4OC\C([C@@]34O)=C/C=C/[C@@H]2C)/C)O[C@H]1C.C1C[C@H](C)[C@@H]([C@@H](C)CC)O[C@@]21O[C@H](C\C=C(C)\[C@@H](O[C@@H]1O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C1)[C@@H](C)\C=C\C=C/1[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\1)O)C[C@H]4C2 SPBDXSGPUHCETR-JFUDTMANSA-N 0.000 title 1
- AZSNMRSAGSSBNP-XPNPUAGNSA-N 22,23-dihydroavermectin B1a Chemical compound C1C[C@H](C)[C@@H]([C@@H](C)CC)O[C@@]21O[C@H](C\C=C(C)\[C@@H](O[C@@H]1O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C1)[C@@H](C)\C=C\C=C/1[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\1)O)C[C@H]4C2 AZSNMRSAGSSBNP-XPNPUAGNSA-N 0.000 abstract 1
- 239000005660 Abamectin Substances 0.000 abstract 1
- RRZXIRBKKLTSOM-XPNPUAGNSA-N avermectin B1a Chemical compound C1=C[C@H](C)[C@@H]([C@@H](C)CC)O[C@]11O[C@H](C\C=C(C)\[C@@H](O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C2)[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 RRZXIRBKKLTSOM-XPNPUAGNSA-N 0.000 abstract 1
- 239000012467 final product Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Patente de Invenção: <B>''PROCESSO PARA A PREPARAçãO DE IVERMECTINA''<D>. A presente invenção descreve um processo para preparação de invermectina pela redução de avermectina que permite obter um produto final apresentando uma alta pureza e rendimento quese quantitativos.Invention Patent: <B> '' PROCESS FOR THE PREPARATION OF IVERMECTIN '' <D>. The present invention describes a process for the preparation of invermectin by reducing avermectin that allows to obtain a final product showing a high purity and yield which is quantitative.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT97MI000439A IT1289993B1 (en) | 1997-02-27 | 1997-02-27 | IVERMECTIN PREPARATION PROCESS |
| PCT/EP1997/004227 WO1998038201A1 (en) | 1997-02-27 | 1997-08-04 | Process for the preparation of ivermectin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9708963A true BR9708963A (en) | 2000-05-09 |
Family
ID=11376223
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9708963-0A BR9708963A (en) | 1997-02-27 | 1997-08-04 | Process for the preparation of ivermectin |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP0915900A1 (en) |
| JP (1) | JP2000509729A (en) |
| KR (1) | KR20000065035A (en) |
| AU (1) | AU8842798A (en) |
| BR (1) | BR9708963A (en) |
| IT (1) | IT1289993B1 (en) |
| WO (1) | WO1998038201A1 (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19644050A1 (en) * | 1996-10-31 | 1998-05-07 | Bayer Ag | Process for the preparation of ivermectin |
| US6265571B1 (en) | 1999-07-12 | 2001-07-24 | Magellan Laboratories, Inc. | Purification process for anti-parasitic fermentation product |
| CN100396691C (en) * | 2004-12-06 | 2008-06-25 | 四川大学 | A kind of preparation method of ivermectin |
| CN100486986C (en) * | 2007-01-29 | 2009-05-13 | 四川大学 | A kind of preparation method of ivermectin |
| EP2341528A1 (en) | 2010-01-05 | 2011-07-06 | ABB Technology AG | Power Semiconductor Device and its manufacturing method |
| CN114195840B (en) * | 2021-12-20 | 2024-02-27 | 台州科技职业学院 | Method for identifying structure of macrolide compound |
| CN117430650B (en) * | 2023-09-18 | 2025-10-28 | 华北制药集团爱诺有限公司 | A method for purifying low-content ivermectin recovery powder |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4413118A (en) * | 1981-03-02 | 1983-11-01 | Merck & Co., Inc. | Process for removal of homogeneous catalyst group VIII metals from process streams |
| DE19507018A1 (en) * | 1995-03-01 | 1996-09-05 | Bayer Ag | Process for the preparation of ivermectin |
-
1997
- 1997-02-27 IT IT97MI000439A patent/IT1289993B1/en active IP Right Grant
- 1997-08-04 KR KR1019980708579A patent/KR20000065035A/en not_active Withdrawn
- 1997-08-04 AU AU88427/98A patent/AU8842798A/en not_active Abandoned
- 1997-08-04 WO PCT/EP1997/004227 patent/WO1998038201A1/en not_active Ceased
- 1997-08-04 BR BR9708963-0A patent/BR9708963A/en unknown
- 1997-08-04 EP EP97941910A patent/EP0915900A1/en not_active Withdrawn
- 1997-08-04 JP JP10537199A patent/JP2000509729A/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO1998038201A1 (en) | 1998-09-03 |
| IT1289993B1 (en) | 1998-10-19 |
| KR20000065035A (en) | 2000-11-06 |
| EP0915900A1 (en) | 1999-05-19 |
| JP2000509729A (en) | 2000-08-02 |
| AU8842798A (en) | 1998-09-18 |
| ITMI970439A1 (en) | 1998-08-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application fees: application dismissed [chapter 8.6 patent gazette] |