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BR9708261A - Composto antagonista de crf, composiçãofarmacêutica, método de tratamento dedistúrbios, processo para a produção depirimidina, pirimidona, método para a produção deum composto e composto - Google Patents

Composto antagonista de crf, composiçãofarmacêutica, método de tratamento dedistúrbios, processo para a produção depirimidina, pirimidona, método para a produção deum composto e composto

Info

Publication number
BR9708261A
BR9708261A BR9708261-9A BR9708261A BR9708261A BR 9708261 A BR9708261 A BR 9708261A BR 9708261 A BR9708261 A BR 9708261A BR 9708261 A BR9708261 A BR 9708261A
Authority
BR
Brazil
Prior art keywords
compound
production
pyrimidone
pyrimidine
pharmaceutical composition
Prior art date
Application number
BR9708261-9A
Other languages
English (en)
Inventor
Rajagopal Bakthavatchalam
Argyrios Georgios Arvanitis
Jamespeter Beck
Gary Avonn Cain
Robert John Chorvat
Paul Josephgilligan
Richard Eric Olson
Original Assignee
Du Pont Pharm Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont Pharm Co filed Critical Du Pont Pharm Co
Publication of BR9708261A publication Critical patent/BR9708261A/pt

Links

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Reproductive Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Luminescent Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

"COMPOSTO ANTAGONISTA DE CRF, COMPOSIçãOFARMACêUTICA, MéTODO DE TRATAMENTO DEDISTúRBIOS, PROCESSO PARA A PRODUçãO DEPIRIMIDINA, PIRIMIDONA, MéTODO PARA A PRODUçãO DEUM COMPOSTO E COMPOSTO". A presente invenção se refere aantagonistas (CRF) de fator de liberação de coticotropina defórmula (I) ou fórmula (II) e ao seu uso no tratamento da ansiedade,depressão, e outros distúrbios psiáquitricos e neurológicos.
BR9708261-9A 1996-03-27 1997-03-25 Composto antagonista de crf, composiçãofarmacêutica, método de tratamento dedistúrbios, processo para a produção depirimidina, pirimidona, método para a produção deum composto e composto BR9708261A (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US1415796P 1996-03-27 1996-03-27
US64661296A 1996-05-08 1996-05-08
US3053696P 1996-10-31 1996-10-31
US3912497P 1997-02-25 1997-02-25
PCT/US1997/004852 WO1997035539A2 (en) 1996-03-27 1997-03-25 Arylamino fused pyridines and pyrimidines

Publications (1)

Publication Number Publication Date
BR9708261A true BR9708261A (pt) 2001-12-04

Family

ID=27486365

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9708261-9A BR9708261A (pt) 1996-03-27 1997-03-25 Composto antagonista de crf, composiçãofarmacêutica, método de tratamento dedistúrbios, processo para a produção depirimidina, pirimidona, método para a produção deum composto e composto

Country Status (21)

Country Link
US (2) US6107300A (pt)
EP (1) EP0935601A4 (pt)
JP (1) JP2002515032A (pt)
KR (1) KR20000005037A (pt)
CN (1) CN1230184A (pt)
AU (1) AU2545897A (pt)
BR (1) BR9708261A (pt)
CA (1) CA2250241A1 (pt)
CZ (1) CZ304098A3 (pt)
EA (1) EA199800868A1 (pt)
EE (1) EE9800329A (pt)
HR (1) HRP970173A2 (pt)
HU (1) HUP9902340A3 (pt)
IL (1) IL126316A0 (pt)
LV (1) LV12262B (pt)
NO (1) NO984418L (pt)
NZ (1) NZ331874A (pt)
PL (1) PL335258A1 (pt)
SI (1) SI9720026A (pt)
SK (1) SK131798A3 (pt)
WO (1) WO1997035539A2 (pt)

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Also Published As

Publication number Publication date
NZ331874A (en) 2000-03-27
IL126316A0 (en) 1999-05-09
CZ304098A3 (cs) 1999-02-17
EE9800329A (et) 1999-06-15
EP0935601A4 (en) 2002-08-07
PL335258A1 (en) 2000-04-10
NO984418L (no) 1998-11-03
HUP9902340A2 (hu) 1999-11-29
SK131798A3 (en) 2000-05-16
CN1230184A (zh) 1999-09-29
WO1997035539A3 (en) 1999-05-14
US6107300A (en) 2000-08-22
JP2002515032A (ja) 2002-05-21
HUP9902340A3 (en) 2001-02-28
AU2545897A (en) 1997-10-17
EP0935601A2 (en) 1999-08-18
CA2250241A1 (en) 1997-10-02
HRP970173A2 (en) 1999-08-31
SI9720026A (sl) 1999-04-30
NO984418D0 (no) 1998-09-22
EA199800868A1 (ru) 1999-04-29
LV12262A (lv) 1999-04-20
US6448261B1 (en) 2002-09-10
LV12262B (en) 1999-10-20
WO1997035539A2 (en) 1997-10-02
KR20000005037A (ko) 2000-01-25

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