BR9708194A - Composição para a entrega e a produção in vivo de uma combinação de enzimas vetor composição para a produção in vivo de um análogo de nucleosidio trifosfato método para a destruição de células proliferativas processo de trifosforilação de uma análogo de nucleosidio utilização da nucleosidio difosfato quinase ácido nucléico e proteina codificada - Google Patents
Composição para a entrega e a produção in vivo de uma combinação de enzimas vetor composição para a produção in vivo de um análogo de nucleosidio trifosfato método para a destruição de células proliferativas processo de trifosforilação de uma análogo de nucleosidio utilização da nucleosidio difosfato quinase ácido nucléico e proteina codificadaInfo
- Publication number
- BR9708194A BR9708194A BR9708194A BR9708194A BR9708194A BR 9708194 A BR9708194 A BR 9708194A BR 9708194 A BR9708194 A BR 9708194A BR 9708194 A BR9708194 A BR 9708194A BR 9708194 A BR9708194 A BR 9708194A
- Authority
- BR
- Brazil
- Prior art keywords
- composition
- vivo production
- nucleoside analog
- nucleoside
- triphosphorylation
- Prior art date
Links
- 238000001727 in vivo Methods 0.000 title 2
- 238000000034 method Methods 0.000 title 2
- 239000002777 nucleoside Substances 0.000 title 2
- 150000003833 nucleoside derivatives Chemical class 0.000 title 2
- 102000004190 Enzymes Human genes 0.000 title 1
- 108090000790 Enzymes Proteins 0.000 title 1
- 102000013901 Nucleoside diphosphate kinase Human genes 0.000 title 1
- 101710100179 UMP-CMP kinase Proteins 0.000 title 1
- 101710119674 UMP-CMP kinase 2, mitochondrial Proteins 0.000 title 1
- 230000006378 damage Effects 0.000 title 1
- 102000039446 nucleic acids Human genes 0.000 title 1
- 108020004707 nucleic acids Proteins 0.000 title 1
- 150000007523 nucleic acids Chemical class 0.000 title 1
- 230000002062 proliferating effect Effects 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 239000001226 triphosphate Substances 0.000 title 1
- 235000011178 triphosphate Nutrition 0.000 title 1
- UNXRWKVEANCORM-UHFFFAOYSA-N triphosphoric acid Chemical compound OP(O)(=O)OP(O)(=O)OP(O)(O)=O UNXRWKVEANCORM-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/45—Transferases (2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
- C12N9/1211—Thymidine kinase (2.7.1.21)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biotechnology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9603267A FR2746016B1 (fr) | 1996-03-15 | 1996-03-15 | Combinaisons d'enzymes pour la destruction de cellules proliferatives |
| PCT/FR1997/000436 WO1997035024A1 (fr) | 1996-03-15 | 1997-03-12 | Combinaisons d'enzymes pour la destruction des cellules proliferatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9708194A true BR9708194A (pt) | 1999-07-27 |
Family
ID=9490214
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9708194A BR9708194A (pt) | 1996-03-15 | 1997-03-12 | Composição para a entrega e a produção in vivo de uma combinação de enzimas vetor composição para a produção in vivo de um análogo de nucleosidio trifosfato método para a destruição de células proliferativas processo de trifosforilação de uma análogo de nucleosidio utilização da nucleosidio difosfato quinase ácido nucléico e proteina codificada |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US6518062B1 (pt) |
| EP (1) | EP0910654A1 (pt) |
| JP (1) | JP2000507814A (pt) |
| KR (1) | KR20000064581A (pt) |
| AU (1) | AU732432B2 (pt) |
| BR (1) | BR9708194A (pt) |
| CA (1) | CA2248629A1 (pt) |
| CZ (1) | CZ291398A3 (pt) |
| FR (1) | FR2746016B1 (pt) |
| HU (1) | HUP9902320A3 (pt) |
| IL (1) | IL126154A0 (pt) |
| NO (1) | NO984132D0 (pt) |
| SK (1) | SK124598A3 (pt) |
| WO (1) | WO1997035024A1 (pt) |
| ZA (1) | ZA972247B (pt) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2386629A1 (en) | 1997-10-14 | 2011-11-16 | Darwin Molecular Corporation | Thymidine kinase mutants and fusion proteins having thymidine kinase and guanylate kinase activities |
| EP1914304A1 (en) * | 1998-10-14 | 2008-04-23 | Darwin Molecular Corporation | Thymidine kinase mutants and fusion proteins having thymidine kinase and guanylate kinase activities |
| GB9924981D0 (en) * | 1999-10-21 | 1999-12-22 | Univ Manchester | Gene therapy |
| CA2342040C (en) * | 2000-09-21 | 2012-07-10 | Kyowa Hakko Kogyo Co., Ltd. | Anaerobic bacterium as a drug for cancer gene therapy |
| WO2002056022A2 (en) * | 2000-11-27 | 2002-07-18 | Minerva Biotechnologies Corp | Diagnostics, drug screening and treatment for cancer |
| EP1786474B1 (en) * | 2004-08-12 | 2011-06-01 | Cedars-Sinai Medical Center | Combined gene therapy for the treatment of macroscopic gliomas |
| WO2008095027A2 (en) * | 2007-01-30 | 2008-08-07 | Cedars-Sinai Medical Center | Adenoviral vector comprising herpes simplex virus type 1 thymidine kinase and a transgene for increasing the expression of the transgene |
| AU2016219350A1 (en) | 2015-02-10 | 2017-08-24 | Minerva Biotechnologies Corporation | Humanized anti-MUC1* antibodies |
| US10399291B2 (en) | 2015-04-24 | 2019-09-03 | Phi Biomed Co., Ltd. | Smart contact lenses and smart glasses |
| KR102303140B1 (ko) | 2018-05-30 | 2021-09-16 | 이화여자대학교 산학협력단 | 신규 바이페닐 유도체 화합물 및 이의 용도 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE72122T1 (de) * | 1987-04-24 | 1992-02-15 | Wellcome Found | Antivirale mischungen. |
| CN1151186A (zh) * | 1994-05-02 | 1997-06-04 | 华盛顿大学 | 胸苷激酶突变体 |
| FR2723962B1 (fr) * | 1994-08-25 | 1996-10-31 | Univ Paris Curie | Hsv1-tk modifiee fonctionnelle |
| US5856153A (en) | 1994-11-17 | 1999-01-05 | Cayla | Suicide genes and new associations of pyrimidine nucleobase and nucleoside analogs with new suicide genes for gene therapy of acquired diseases |
-
1996
- 1996-03-15 FR FR9603267A patent/FR2746016B1/fr not_active Expired - Fee Related
-
1997
- 1997-03-12 CZ CZ982913A patent/CZ291398A3/cs unknown
- 1997-03-12 BR BR9708194A patent/BR9708194A/pt not_active IP Right Cessation
- 1997-03-12 HU HU9902320A patent/HUP9902320A3/hu unknown
- 1997-03-12 SK SK1245-98A patent/SK124598A3/sk unknown
- 1997-03-12 KR KR1019980707184A patent/KR20000064581A/ko not_active Ceased
- 1997-03-12 EP EP97914376A patent/EP0910654A1/fr not_active Withdrawn
- 1997-03-12 IL IL12615497A patent/IL126154A0/xx unknown
- 1997-03-12 CA CA002248629A patent/CA2248629A1/fr not_active Abandoned
- 1997-03-12 WO PCT/FR1997/000436 patent/WO1997035024A1/fr not_active Ceased
- 1997-03-12 JP JP9533187A patent/JP2000507814A/ja not_active Ceased
- 1997-03-12 US US09/125,576 patent/US6518062B1/en not_active Expired - Fee Related
- 1997-03-12 AU AU21642/97A patent/AU732432B2/en not_active Ceased
- 1997-03-14 ZA ZA9702247A patent/ZA972247B/xx unknown
-
1998
- 1998-09-08 NO NO984132A patent/NO984132D0/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| US6518062B1 (en) | 2003-02-11 |
| FR2746016A1 (fr) | 1997-09-19 |
| AU2164297A (en) | 1997-10-10 |
| IL126154A0 (en) | 1999-05-09 |
| AU732432B2 (en) | 2001-04-26 |
| NO984132L (no) | 1998-09-08 |
| CZ291398A3 (cs) | 1998-12-16 |
| WO1997035024A1 (fr) | 1997-09-25 |
| FR2746016B1 (fr) | 1998-04-17 |
| ZA972247B (en) | 1997-09-17 |
| KR20000064581A (ko) | 2000-11-06 |
| JP2000507814A (ja) | 2000-06-27 |
| HUP9902320A3 (en) | 2001-05-28 |
| CA2248629A1 (fr) | 1997-09-25 |
| NO984132D0 (no) | 1998-09-08 |
| SK124598A3 (en) | 1999-03-12 |
| HUP9902320A2 (hu) | 1999-10-28 |
| EP0910654A1 (fr) | 1999-04-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 9A E 10A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1882 DE 30/01/2007. |