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BR9708099A - Formulações de propofol em microgotìculas. - Google Patents

Formulações de propofol em microgotìculas.

Info

Publication number
BR9708099A
BR9708099A BR9708099-3A BR9708099A BR9708099A BR 9708099 A BR9708099 A BR 9708099A BR 9708099 A BR9708099 A BR 9708099A BR 9708099 A BR9708099 A BR 9708099A
Authority
BR
Brazil
Prior art keywords
formulations
propofol
microgroots
fat
free
Prior art date
Application number
BR9708099-3A
Other languages
English (en)
Other versions
BR9708099B8 (pt
BR9708099B1 (pt
Inventor
Dunchan H Haynes
Original Assignee
Res Triangle Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24469788&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR9708099(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Res Triangle Pharm Ltd filed Critical Res Triangle Pharm Ltd
Publication of BR9708099A publication Critical patent/BR9708099A/pt
Publication of BR9708099B1 publication Critical patent/BR9708099B1/pt
Publication of BR9708099B8 publication Critical patent/BR9708099B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Anesthesiology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Motorcycle And Bicycle Frame (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Fats And Perfumes (AREA)

Abstract

Patente de Invenção: <B>"FORMULAçõES DE PROPOFOL EM MICROGOTìCULAS"<D>. Formulações de microgotículas de propofol revestidas com fosfolipídio isentas de gorduras e triglicerídios proporcionam sedação crónica durante períodos prolongados de tempo sem sobrecarga de gordura. Sendo isenta de nutrientes que favorecem desenvolvimento bacteriano, essas formulações em microgotículas são bacteriostáticas e bactericidas (por exemplo, auto-esterilizantes) e, assim, possuem vida útil prolongada.
BRPI9708099-3B8A 1996-03-19 1997-03-17 Microgotícula de propofol e composição farmacêutica compreendendo a referida microgotícula. BR9708099B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US616511 1996-03-19
US08/616,511 US5637625A (en) 1996-03-19 1996-03-19 Propofol microdroplet formulations
PCT/US1997/004168 WO1997034588A1 (en) 1996-03-19 1997-03-17 Propofol microdroplet formulations

Publications (3)

Publication Number Publication Date
BR9708099A true BR9708099A (pt) 2000-01-04
BR9708099B1 BR9708099B1 (pt) 2010-02-23
BR9708099B8 BR9708099B8 (pt) 2014-04-29

Family

ID=24469788

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI9708099-3B8A BR9708099B8 (pt) 1996-03-19 1997-03-17 Microgotícula de propofol e composição farmacêutica compreendendo a referida microgotícula.

Country Status (19)

Country Link
US (1) US5637625A (pt)
EP (1) EP0796616B1 (pt)
JP (1) JP2000507244A (pt)
KR (1) KR100484516B1 (pt)
CN (1) CN1124845C (pt)
AT (1) ATE182074T1 (pt)
AU (1) AU719756B2 (pt)
BR (1) BR9708099B8 (pt)
CA (1) CA2249375C (pt)
DE (1) DE69700317T2 (pt)
DK (1) DK0796616T3 (pt)
ES (1) ES2135969T3 (pt)
FI (1) FI982009L (pt)
GR (1) GR3031414T3 (pt)
HU (1) HU225046B1 (pt)
NO (1) NO324498B1 (pt)
NZ (1) NZ331669A (pt)
RU (1) RU2186564C2 (pt)
WO (1) WO1997034588A1 (pt)

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CH692322A5 (it) * 1997-05-26 2002-05-15 Westy Ag Formulazione iniettabile limpida di Propofol.
US6638621B2 (en) * 2000-08-16 2003-10-28 Lyotropic Therapeutics, Inc. Coated particles, methods of making and using
WO1999039696A1 (en) * 1998-02-10 1999-08-12 Sicor Inc. Propofol composition containing sulfite
CN1289091C (zh) * 1998-02-11 2006-12-13 Rtp药品公司 治疗炎症的药物组合物和相关用途
US6979456B1 (en) 1998-04-01 2005-12-27 Jagotec Ag Anticancer compositions
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WO1999061001A1 (en) 1998-05-29 1999-12-02 Rtp Pharma Inc. Thermoprotected microparticle compositions and process for terminal steam sterilization thereof
US6204257B1 (en) 1998-08-07 2001-03-20 Universtiy Of Kansas Water soluble prodrugs of hindered alcohols
CA2338703C (en) 1998-08-19 2009-03-24 Rtp Pharma Inc. Injectable aqueous dispersions of propofol
US6150423A (en) 1998-10-15 2000-11-21 Phoenix Scientific, Inc. Propofol-based anesthetic and method of making same
US6140374A (en) * 1998-10-23 2000-10-31 Abbott Laboratories Propofol composition
SK288117B6 (sk) 1998-11-20 2013-09-03 Skyepharma Canada Inc. Rapidly dispersing solid dry therapeutic dosage form
DE69922252T2 (de) * 1999-01-28 2005-12-01 Patel, Dinesh Shantilal Parenterale lösungen enthaltend propofol (2,6-diisopropylphenol) und 2.5-di-0-methyl-1.4;3.6-dianhydro-d-glucitol als lösungsmittel
US6177477B1 (en) * 1999-03-24 2001-01-23 American Home Products Corporation Propofol formulation containing TRIS
US6100302A (en) * 1999-04-05 2000-08-08 Baxter International Inc. Propofol formulation with enhanced microbial characteristics
GB2350297A (en) * 1999-05-27 2000-11-29 Abbott Lab Injectable halogenated anesthetic formulation in emulsion form
JP2003509453A (ja) * 1999-09-21 2003-03-11 アールティーピー・ファーマ・インコーポレーテッド 生物学的に活性な物質の、表面改質された粒状組成物
US6071933A (en) * 1999-12-03 2000-06-06 Diversified Medical Innovations, Inc. Homogeneous remifentanil-propofol blend for patient controlled anesthesia and process for its use
GB2359747B (en) 2000-02-29 2002-04-24 Maelor Pharmaceuticals Ltd Anaesthetic formulations
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WO2001097779A2 (en) 2000-06-16 2001-12-27 Rtp Pharma Inc. Improved injectable dispersions of propofol
US6623765B1 (en) 2000-08-01 2003-09-23 University Of Florida, Research Foundation, Incorporated Microemulsion and micelle systems for solubilizing drugs
EP1313451B1 (en) 2000-08-31 2009-03-11 Jagotec AG Milled particles
US8586094B2 (en) 2000-09-20 2013-11-19 Jagotec Ag Coated tablets
ATE522211T1 (de) * 2000-09-20 2011-09-15 Jagotec Ag Stabilisierte fibrat-mikropartikel
ES2284646T3 (es) * 2001-02-22 2007-11-16 Jagotec Ag Combinaciones de estatina-fibrato con efectos secundarios en ayunas-alimentado reducidos.
CA2451432A1 (en) 2001-06-23 2003-01-03 Lyotropic Therapeutics, Inc. Particles with improved solubilization capacity
US20030054042A1 (en) * 2001-09-14 2003-03-20 Elaine Liversidge Stabilization of chemical compounds using nanoparticulate formulations
WO2003026632A2 (en) 2001-09-26 2003-04-03 Theravance, Inc. Substituted phenol compounds useful for anesthesia and sedation
BR0212833A (pt) * 2001-09-26 2004-10-13 Baxter Int Preparação de nanopartìculas de tamanho submìcron através de dispersão e de remoção de solvente ou de fase lìquida
US7112340B2 (en) * 2001-10-19 2006-09-26 Baxter International Inc. Compositions of and method for preparing stable particles in a frozen aqueous matrix
US20050042280A1 (en) * 2001-12-28 2005-02-24 Rogers Tracey L. Aqueous based pharmaceutical formulations of water-soluble prodrugs of propofol
US20080220075A1 (en) * 2002-03-20 2008-09-11 Elan Pharma International Ltd. Nanoparticulate compositions of angiogenesis inhibitors
DE60309300T3 (de) * 2002-03-20 2011-02-24 Elan Pharma International Ltd. Nanopartikelzusammensetzungen von angiogeneseinhibitoren
IL164217A0 (en) * 2002-04-08 2005-12-18 Guilford Pharm Inc Pharmaceutical compositions containing water-soluble propofol and methods of administering same
HRP20050182A2 (en) * 2002-07-29 2006-11-30 Transform Pharmaceuticals Aqueous 2,6-diisopropylphenol pharmaceutical compositions
US7550155B2 (en) * 2002-07-29 2009-06-23 Transform Pharmaceuticals Inc. Aqueous pharmaceutical compositions of 2,6-diisopropylphenol (propofol) and their uses
US20040220283A1 (en) * 2002-07-29 2004-11-04 Transform Pharmaceuticals, Inc. Aqueous 2,6-diisopropylphenol pharmaceutical compositions
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US7182948B2 (en) * 2003-08-04 2007-02-27 Ko Manufacturing, Inc. Topical veterinary compositions and methods for the treatment and prevention of infection
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ES2784794T3 (es) * 2005-08-31 2020-10-01 Abraxis Bioscience Llc Composiciones que comprenden agentes farmacéuticos poco solubles en agua y agentes antimicrobianos
US8034765B2 (en) * 2005-08-31 2011-10-11 Abraxis Bioscience, Llc Compositions and methods for preparation of poorly water soluble drugs with increased stability
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US8426467B2 (en) 2007-05-22 2013-04-23 Baxter International Inc. Colored esmolol concentrate
US8722736B2 (en) * 2007-05-22 2014-05-13 Baxter International Inc. Multi-dose concentrate esmolol with benzyl alcohol
RU2535001C1 (ru) * 2013-07-11 2014-12-10 Общество с ограниченной ответственностью "ВИК-здоровье животных" Микроколлоидный раствор пропофола для анестезии
WO2016196648A1 (en) * 2015-06-01 2016-12-08 Autotelic Llc Phospholipid-coated therapeutic agent nanoparticles and related methods
US20160346221A1 (en) 2015-06-01 2016-12-01 Autotelic Llc Phospholipid-coated therapeutic agent nanoparticles and related methods
WO2017218630A2 (en) * 2016-06-15 2017-12-21 Autotelic Llc Phospholipid-coated therapeutic agent nanoparticles and related methods
KR20220118399A (ko) * 2019-12-20 2022-08-25 프레제니우스 카비 오스트리아 게엠베하 수중유 에멀젼의 제조 방법
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Also Published As

Publication number Publication date
US5637625A (en) 1997-06-10
AU719756B2 (en) 2000-05-18
NZ331669A (en) 2000-01-28
EP0796616A1 (en) 1997-09-24
CN1218398A (zh) 1999-06-02
RU2186564C2 (ru) 2002-08-10
NO984370L (no) 1998-09-18
FI982009A7 (fi) 1998-09-17
HUP9902553A3 (en) 2001-04-28
BR9708099B8 (pt) 2014-04-29
DK0796616T3 (da) 1999-11-29
CA2249375C (en) 2002-06-18
ATE182074T1 (de) 1999-07-15
DE69700317T2 (de) 1999-12-02
AU2329297A (en) 1997-10-10
ES2135969T3 (es) 1999-11-01
HUP9902553A2 (hu) 2000-10-28
NO984370D0 (no) 1998-09-18
CN1124845C (zh) 2003-10-22
EP0796616B1 (en) 1999-07-14
FI982009A0 (fi) 1998-09-17
NO324498B1 (no) 2007-10-29
BR9708099B1 (pt) 2010-02-23
CA2249375A1 (en) 1997-09-25
HU225046B1 (hu) 2006-05-29
DE69700317D1 (de) 1999-08-19
GR3031414T3 (en) 2000-01-31
KR20000064762A (ko) 2000-11-06
JP2000507244A (ja) 2000-06-13
WO1997034588A1 (en) 1997-09-25
FI982009L (fi) 1998-09-17
KR100484516B1 (ko) 2005-09-02

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: ALTERADA DE INT.CL: A61K 9/107, A61K 31/05, A61P 23/00

Ipc: A61K 31/05 (2008.04), A61K 9/107 (2008.04)

B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 23/02/2010, OBSERVADAS AS CONDICOES LEGAIS.

B22O Other matters related to patents and certificates of addition of invention: legal action concerning patent

Free format text: INPI-52400.061597/2013 ORIGEM: JUIZO DA 013A VARA FEDERAL DO RIO DE JANEIRO PROCESSO NO 0132275-84.2013.4.02.5101 ACAO DE NULIDADE DAS PATENTES SUBMETIDAS AO MAILBOX (ART. 229, PARAGRAFO UNICO DA LPI); ALTERNATIVAMENTE, A DECRETACAO DA NULIDADE PARCIAL PARA CORRECAO DO PRAZO DE VIGENCIA; SUBSIDIARIAMENTE, CASO SE ENTENDA NAO SER O CASO DE NULIDADE, A CORRECAO DO ATO ADMINISTRATIVO PARA ADEQUACAO DA VIGENCIA DAS PATENTES. AUTOR: INSTITUTO NACIONAL DA PROPRIEDADE INDUSTRIAL - INPI REU: RAQUALIA PHARMA INC., RESEARCH TRIANGLE PHAMACEUTICALS LTD., SHIONOGI AND CO., LTD. E SIEMSENS HEALTHCARE DIAGNOSTICS PRODUCTS GMBH

B19A Notification of judicial decision: notification of judicial decision

Free format text: INPI-52400.061597/2013 SECAO JUDICIARIA DO RIO DE JANEIRO-13A VARA FEDERAL DO RIO DE JANEIRO PROCESSO NO0132275-84.2013.4.02.5101 AUTOR: INPI-INSTITUTO NACIONAL DE PROPRIEDADE INDUSTRIAL REU(S): RAQUALIA PHARMA INC.,RESEARCH TRIANGLE PHARMACEUTICALS LTD.,SHIONOGIAND CO.,LTD.E SIEMSENS HEALTHCARE DIAGNOSTICS PRODUCTS GMBH DECISAO: HOMOLOGO OS ACORDOS FIRMADOS, JULGANDO EXTINTO O PROCESSO COM RESOLUCAO DE MERITO, FORTE NO ART.269,III DO CODIGO DE PROCESSO CIVIL

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: CONFORME DETERMINACAO DO MM. JUIZ DA 13A VARA FEDERAL DO RIO DE JANEIRO, O PRAZO DE VIGENCIA DA PATENTE CONCEDIDA EM 23/02/2010 ATRAVES DA RPI 2042, E RETIFICADO PARA 17/03/2017.