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BR9706471A - Derivados de propiofenona e processo para preparação dos mesmos - Google Patents

Derivados de propiofenona e processo para preparação dos mesmos

Info

Publication number
BR9706471A
BR9706471A BR9706471A BR9706471A BR9706471A BR 9706471 A BR9706471 A BR 9706471A BR 9706471 A BR9706471 A BR 9706471A BR 9706471 A BR9706471 A BR 9706471A BR 9706471 A BR9706471 A BR 9706471A
Authority
BR
Brazil
Prior art keywords
preparing
propiophenone derivatives
propiophenone
derivatives
Prior art date
Application number
BR9706471A
Other languages
English (en)
Other versions
BR9706471B1 (pt
Inventor
Kenji Tsujihara
Kunio Saito
Mitsuya Hongu
Mamoru Matsumoto
Akira Oku
Original Assignee
Tanabe Seiyaku Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co filed Critical Tanabe Seiyaku Co
Publication of BR9706471A publication Critical patent/BR9706471A/pt
Publication of BR9706471B1 publication Critical patent/BR9706471B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
BRPI9706471-8A 1996-12-26 1997-12-26 derivados de propiofenona, processo para prepração dos mesmos, composição farmacêutica compreendendo os mesmos, bem com seu uso. BR9706471B1 (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP34740696 1996-12-26

Publications (2)

Publication Number Publication Date
BR9706471A true BR9706471A (pt) 1999-05-18
BR9706471B1 BR9706471B1 (pt) 2012-09-04

Family

ID=18390010

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI9706471-8A BR9706471B1 (pt) 1996-12-26 1997-12-26 derivados de propiofenona, processo para prepração dos mesmos, composição farmacêutica compreendendo os mesmos, bem com seu uso.

Country Status (22)

Country Link
US (1) US6048842A (pt)
EP (1) EP0850948B1 (pt)
KR (1) KR100407029B1 (pt)
CN (1) CN1094942C (pt)
AR (1) AR010385A1 (pt)
AT (1) ATE216704T1 (pt)
AU (1) AU719726B2 (pt)
BG (1) BG63546B1 (pt)
BR (1) BR9706471B1 (pt)
CA (1) CA2225439C (pt)
DE (1) DE69712172T2 (pt)
DK (1) DK0850948T3 (pt)
ES (1) ES2176600T3 (pt)
HU (1) HU228514B1 (pt)
ID (1) ID19290A (pt)
IL (1) IL122666A (pt)
MY (1) MY119350A (pt)
NO (1) NO311804B1 (pt)
PT (1) PT850948E (pt)
RU (1) RU2156247C2 (pt)
TW (1) TW406086B (pt)
ZA (1) ZA9711560B (pt)

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US6683056B2 (en) 2000-03-30 2004-01-27 Bristol-Myers Squibb Company O-aryl glucoside SGLT2 inhibitors and method
US6555519B2 (en) 2000-03-30 2003-04-29 Bristol-Myers Squibb Company O-glucosylated benzamide SGLT2 inhibitors and method
WO2002036602A1 (en) 2000-11-02 2002-05-10 Ajinomoto Co., Inc. Novel pyrazole derivatives and diabetes remedies containing the same
US6936590B2 (en) 2001-03-13 2005-08-30 Bristol Myers Squibb Company C-aryl glucoside SGLT2 inhibitors and method
US20030045553A1 (en) * 2001-04-04 2003-03-06 Bussolari Jacqueline C. Combination therapy comprising glucose reabsorption inhibitors and PPAR modulators
EP1392326B1 (en) * 2001-04-04 2009-09-09 Ortho-McNeil-Janssen Pharmaceuticals, Inc. Combination therapy comprising glucose reabsorption inhibitors and retinoid-x receptor modulators
US7956041B2 (en) 2002-04-26 2011-06-07 Ajinomoto Co., Inc. Prophylactic and therapeutic agent of diabetes mellitus
JP4424203B2 (ja) * 2002-04-26 2010-03-03 味の素株式会社 糖尿病予防・治療剤
WO2004014931A1 (ja) * 2002-08-09 2004-02-19 Taisho Pharmaceutical Co., Ltd. アリール５−チオ−β−Ｄ−グルコピラノシド誘導体及びそれを含有する糖尿病治療薬
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US8785403B2 (en) 2003-08-01 2014-07-22 Mitsubishi Tanabe Pharma Corporation Glucopyranoside compound
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EA010655B1 (ru) * 2003-08-01 2008-10-30 Янссен Фармацевтика Н.В. Замещенные индазол-о-глюкозиды
CN103214471B (zh) * 2003-08-01 2018-02-06 田边三菱制药株式会社 具有钠依赖型葡萄糖转运体抑制活性的化合物的制备方法
EP1679966A4 (en) * 2003-08-01 2009-05-27 Janssen Pharmaceutica Nv SUBSTITUTED BENZIMIDAZOLE, BENZOTRIAZOL AND BENZIMIDAZOLON-O-GLUCOSIDES
WO2005012318A2 (en) * 2003-08-01 2005-02-10 Janssen Pharmaceutica Nv Substituted fused heterocyclic c-glycosides
FR2862303B1 (fr) * 2003-11-17 2006-01-06 Agronomique Inst Nat Rech Preparations colorantes hydrosolubles jaunes derivees des dihydrochalcones, leur procede des preparation, et leurs utilisations
DE102004028241B4 (de) * 2004-06-11 2007-09-13 Sanofi-Aventis Deutschland Gmbh Neue Fluorglykosidderivate von Pyrazolen, diese Verbindungen enthaltende Arzneimittel und Herstellung dieser Arzneimittel
TW200606129A (en) * 2004-07-26 2006-02-16 Chugai Pharmaceutical Co Ltd Novel cyclohexane derivative, its prodrug, its salt and diabetic therapeutic agent containing the same
TW200637869A (en) * 2005-01-28 2006-11-01 Chugai Pharmaceutical Co Ltd The spiroketal derivatives and the use as therapeutical agent for diabetes of the same
RU2437876C2 (ru) 2006-05-19 2011-12-27 Тайсо Фармасьютикал Ко., Лтд. Соединение с-фенилглицитола для лечения диабета
DE102006028862A1 (de) 2006-06-23 2007-12-27 Merck Patent Gmbh 3-Amino-imidazo[1,2-a]pyridinderivate
JP5152519B2 (ja) 2006-06-29 2013-02-27 大正製薬株式会社 Ｃ−フェニル１−チオグルシト−ル化合物
US7993687B2 (en) * 2006-07-12 2011-08-09 Julianne Marie Kawa Compositions and methods for management of diabetes
UY30730A1 (es) * 2006-12-04 2008-07-03 Mitsubishi Tanabe Pharma Corp Forma cristalina del hemihidrato de 1-(b (beta)-d-glucopiranosil) -4-metil-3-[5-(4-fluorofenil) -2-tienilmetil]benceno
CN101611023A (zh) 2006-12-14 2009-12-23 大正制药株式会社 1－苯基1－硫代－d－山梨醇衍生物
DE102007008420A1 (de) 2007-02-21 2008-08-28 Merck Patent Gmbh Benzimidazolderivate
SI2200606T1 (sl) * 2007-09-10 2017-12-29 Janssen Pharmaceutica N.V. Postopek za pripravo spojin, uporabnih kot inhibitorjev SGLT
DE102007048716A1 (de) 2007-10-11 2009-04-23 Merck Patent Gmbh Imidazo[1,2-a]pyrimidinderivate
CL2008003653A1 (es) 2008-01-17 2010-03-05 Mitsubishi Tanabe Pharma Corp Uso de un inhibidor de sglt derivado de glucopiranosilo y un inhibidor de dppiv seleccionado para tratar la diabetes; y composicion farmaceutica.
DE102008017590A1 (de) 2008-04-07 2009-10-08 Merck Patent Gmbh Glucopyranosidderivate
BRPI0913129A2 (pt) 2008-05-22 2016-01-05 Bristol Myers Squibb Co método para tratamento de hiperuricemia empregando um inibidor de sglt2 e composição contendo o mesmo
AU2009286380B2 (en) 2008-08-28 2011-09-15 Pfizer Inc. Dioxa-bicyclo[3.2.1.]octane-2,3,4-triol derivatives
US9056850B2 (en) * 2008-10-17 2015-06-16 Janssen Pharmaceutica N.V. Process for the preparation of compounds useful as inhibitors of SGLT
US20110009347A1 (en) 2009-07-08 2011-01-13 Yin Liang Combination therapy for the treatment of diabetes
ES2416459T3 (es) 2009-07-10 2013-08-01 Janssen Pharmaceutica, N.V. Procedimiento de cristalización para 1-( -D-glucopiranosil)-4-metil-3-[5-(4-fluorofenil)-2-tienilmetil]benceno
EP2298782A1 (en) * 2009-08-26 2011-03-23 Sanofi-Aventis Method for producing pyrazole glycoside derivatives
ME02634B (me) * 2009-10-14 2017-06-20 Janssen Pharmaceutica Nv Proces za pripremu jedinjenja koja su korisna kao inhibitori sglt2
JP5696156B2 (ja) 2009-11-02 2015-04-08 ファイザー・インク ジオキサ−ビシクロ［３．２．１］オクタン−２，３，４−トリオール誘導体
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
ES2596291T3 (es) 2010-05-11 2017-01-05 Janssen Pharmaceutica, N.V. Formulaciones farmacéuticas que comprenden derivados de 1-(beta-d-glucopiranosil)-2-tienilmetilbenceno como inhibidores de sglt
KR101913587B1 (ko) 2011-04-13 2018-10-31 얀센 파마슈티카 엔.브이. Sglt2의 억제제로서 유용한 화합물의 제조 방법
TWI542596B (zh) 2011-05-09 2016-07-21 健生藥品公司 （２ｓ,３ｒ,４ｒ,５ｓ,６ｒ）－２－（３－（（５－（４－氟苯基）噻吩－２－基）甲基）－４－甲基苯基）－６－（羥甲基）四氫－２ｈ－哌喃－３,４,５－三醇之ｌ－脯胺酸及檸檬酸共晶體
EP2774619B1 (de) 2013-03-04 2016-05-18 BioActive Food GmbH Zusammensetzung zur Behandlung von hyperglykämischen Erkrankungen
US20160033480A1 (en) * 2013-12-16 2016-02-04 Amy Huimeei Lo Immunovir and Components, Immunovir A, B, C, D Utility and Useful Processes
EP2944311A1 (de) 2014-05-16 2015-11-18 BioActive Food GmbH Kombination von biologisch aktiven Substanzen zur Behandlung von hyperglykämischen Erkrankungen
CN104478956A (zh) * 2015-01-14 2015-04-01 佛山市赛维斯医药科技有限公司 苯基双o-葡萄糖苷衍生物、其制备方法和用途
CN104497069A (zh) * 2015-01-15 2015-04-08 佛山市赛维斯医药科技有限公司 一类胺基苯基s-葡萄糖苷衍生物、其制备方法和用途
CN104478961A (zh) * 2015-01-15 2015-04-01 佛山市赛维斯医药科技有限公司 含丙烯腈和胺基苯o-葡萄糖苷结构衍生物、其制备方法和用途
CN104497071A (zh) * 2015-01-15 2015-04-08 佛山市赛维斯医药科技有限公司 一种含丙烯腈基和腈基苯o-葡萄糖苷结构化合物及用途
CN104497068A (zh) * 2015-01-15 2015-04-08 佛山市赛维斯医药科技有限公司 一种含三氟甲氧基苯s-葡萄糖苷结构的化合物及其用途
US20170071970A1 (en) 2015-09-15 2017-03-16 Janssen Pharmaceutica Nv Co-therapy comprising canagliflozin and phentermine for the treatment of obesity and obesity related disorders
CN107827753A (zh) * 2017-11-14 2018-03-23 湖北工业大学 一种对甲基二乙酰氧基碘苯的制备方法
US11826376B2 (en) 2018-07-19 2023-11-28 Astrazeneca Ab Methods of treating heart failure with preserved ejection fraction employing dapagliflozin and compositions comprising the same
LT4188389T (lt) 2020-07-27 2025-11-10 Dapagliflozinas, skirtas panaudoti taikant lėtinės inkstų ligos gydymo būdą
US12409186B2 (en) 2020-07-27 2025-09-09 Astrazeneca Ab Methods of treating chronic kidney disease with dapagliflozin
AU2022251165A1 (en) 2021-04-01 2023-11-09 Astrazeneca Uk Limited Systems and methods for managing prediabetes with a gliflozin sodium-glucose cotransport 2 inhibitor pharmaceutical composition
US20250108065A1 (en) 2022-01-26 2025-04-03 Astrazeneca Ab Methods of treating prediabetes or reducing the risk of developing type 2 diabetes with dapagliflozin
WO2025125513A1 (en) 2023-12-15 2025-06-19 AstraZeneca Ireland Limited Sglt2 inhibitors and baxdrostat for treating chronic kidney disease and hypertension

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Also Published As

Publication number Publication date
IL122666A0 (en) 1998-08-16
CA2225439C (en) 2005-06-07
EP0850948A1 (en) 1998-07-01
HU228514B1 (hu) 2013-03-28
AU4841697A (en) 1998-07-02
DE69712172T2 (de) 2002-10-31
BG102148A (en) 1998-09-30
EP0850948B1 (en) 2002-04-24
BG63546B1 (bg) 2002-04-30
ATE216704T1 (de) 2002-05-15
HU9702534D0 (en) 1998-03-02
CA2225439A1 (en) 1998-06-26
TW406086B (en) 2000-09-21
NO976072D0 (no) 1997-12-23
DE69712172D1 (de) 2002-05-29
NO976072L (no) 1998-06-29
KR100407029B1 (ko) 2004-03-30
RU2156247C2 (ru) 2000-09-20
MY119350A (en) 2005-05-31
HUP9702534A2 (hu) 1998-07-28
HUP9702534A3 (en) 1999-01-28
ZA9711560B (en) 1998-06-24
HK1014960A1 (en) 1999-10-08
DK0850948T3 (da) 2002-07-29
ID19290A (id) 1998-07-02
NO311804B1 (no) 2002-01-28
AU719726B2 (en) 2000-05-18
AR010385A1 (es) 2000-06-07
IL122666A (en) 2000-06-01
BR9706471B1 (pt) 2012-09-04
CN1190097A (zh) 1998-08-12
KR19980064710A (ko) 1998-10-07
US6048842A (en) 2000-04-11
CN1094942C (zh) 2002-11-27
PT850948E (pt) 2002-08-30
ES2176600T3 (es) 2002-12-01

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B25D Requested change of name of applicant approved

Owner name: MITSUBISHI TANABE PHARMA CORPORATION (JP)

Free format text: ALTERADO DE: TANABE SEIYAKU CO., LTD.

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 04/09/2012, OBSERVADAS AS CONDICOES LEGAIS.

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 19A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)