BR9703500A - Compostos de xantia tendo cadeias laterais de alquinol terminalmente aminadas - Google Patents

Compostos de xantia tendo cadeias laterais de alquinol terminalmente aminadas

Info

Publication number: BR9703500A
Authority: BR; Brazil
Prior art keywords: xanthia; terminated; compounds; side chains; alkynol
Prior art date: 1996-06-07

Application number

BR9703500A

Other languages

English (en)

Other versions

BR9703500B1 (pt

Inventor

Uwe Heinelt

Karl Rudolph

Ulrich Gebert

John J Grome

Elisabeth Defossa

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-06-07

Filing date

1997-06-09

Publication date

1998-10-06

1996-06-07 Priority claimed from DE19622734A external-priority patent/DE19622734A1/de

1996-09-11 Priority claimed from DE1996136882 external-priority patent/DE19636882A1/de

1997-06-09 Application filed by Hoechst Ag filed Critical Hoechst Ag

1998-10-06 Publication of BR9703500A publication Critical patent/BR9703500A/pt

2010-05-18 Publication of BR9703500B1 publication Critical patent/BR9703500B1/pt

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Epidemiology (AREA)
Urology & Nephrology (AREA)
Hospice & Palliative Care (AREA)
Vascular Medicine (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

BRPI9703500-9A 1996-06-07 1997-06-09 compostos de xantina tendo cadeias laterais de alquinol terminalmente aminadas, processo para sua preparação, produto farmacêutico compreendendo os mesmos e seu uso. BR9703500B1 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19622734A DE19622734A1 (de)	1996-06-07	1996-06-07	Xanthinverbindungen mit terminal aminierten Alkinol-Seitenketten
DE1996136882 DE19636882A1 (de)	1996-09-11	1996-09-11	Xanthinverbindungen mit terminal aminierten Alkinol-Seitenketten

Publications (2)

Publication Number	Publication Date
BR9703500A true BR9703500A (pt)	1998-10-06
BR9703500B1 BR9703500B1 (pt)	2010-05-18

Family

ID=26026371

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI9703500-9A BR9703500B1 (pt)	1996-06-07	1997-06-09	compostos de xantina tendo cadeias laterais de alquinol terminalmente aminadas, processo para sua preparação, produto farmacêutico compreendendo os mesmos e seu uso.

Country Status (26)

Country	Link
US (1)	US5965555A (pt)
EP (1)	EP0811623B1 (pt)
JP (1)	JP4263778B2 (pt)
KR (1)	KR100531964B1 (pt)
CN (1)	CN1064361C (pt)
AR (1)	AR013821A1 (pt)
AT (1)	ATE200288T1 (pt)
AU (1)	AU712717B2 (pt)
BR (1)	BR9703500B1 (pt)
CA (1)	CA2207258C (pt)
CZ (1)	CZ292509B6 (pt)
DE (1)	DE59703271D1 (pt)
DK (1)	DK0811623T3 (pt)
ES (1)	ES2155640T3 (pt)
GR (1)	GR3035711T3 (pt)
HU (1)	HU224702B1 (pt)
ID (1)	ID17468A (pt)
IL (1)	IL120998A (pt)
MX (1)	MX9704201A (pt)
MY (1)	MY117764A (pt)
NO (1)	NO307787B1 (pt)
NZ (1)	NZ328018A (pt)
PL (1)	PL186238B1 (pt)
PT (1)	PT811623E (pt)
RU (1)	RU2204561C2 (pt)
TW (1)	TW384289B (pt)

Families Citing this family (32)

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GB2284708A (en) *	1993-12-07	1995-06-14	At & T Corp	Method for passivation of multi-quantum well infrared photodetectors (QWIPS) to reduce dark current and to improve dark current uniformity
EE05735B1 (et) *	2001-02-24	2015-01-15	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Ksantiini derivaadid, nende valmistamine ja kasutamine ravimina
AU2002322562A1 (en) *	2001-07-19	2003-03-03	Medical College Of Georgia Research Institute	Novel analogs of choline for neuroprotection and cognitive enhancement in neurodegenerative disorders
KR101150449B1 (ko) *	2002-08-21	2012-06-01	베링거 잉겔하임 파르마 게엠베하 운트 코 카게	8-［3-아미노-피페리딘-1-일］-크산틴, 이의 제조방법 및 이를 포함하는 약제학적 조성물
US7407955B2 (en)	2002-08-21	2008-08-05	Boehringer Ingelheim Pharma Gmbh & Co., Kg	8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
US7501426B2 (en)	2004-02-18	2009-03-10	Boehringer Ingelheim International Gmbh	8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions
DE102004054054A1 (de)	2004-11-05	2006-05-11	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine
DE102005035891A1 (de)	2005-07-30	2007-02-08	Boehringer Ingelheim Pharma Gmbh & Co. Kg	8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel
MX2008014024A (es)	2006-05-04	2008-11-14	Boehringer Ingelheim Int	Formas poliformas.
PE20080251A1 (es) *	2006-05-04	2008-04-25	Boehringer Ingelheim Int	Usos de inhibidores de dpp iv
EP1852108A1 (en)	2006-05-04	2007-11-07	Boehringer Ingelheim Pharma GmbH & Co.KG	DPP IV inhibitor formulations
EP3542801A1 (en) *	2007-08-17	2019-09-25	Boehringer Ingelheim International GmbH	Purin derivatives for use in the treatment of fap-related diseases
PE20091730A1 (es) *	2008-04-03	2009-12-10	Boehringer Ingelheim Int	Formulaciones que comprenden un inhibidor de dpp4
PE20100156A1 (es) *	2008-06-03	2010-02-23	Boehringer Ingelheim Int	Tratamiento de nafld
KR20200118243A (ko)	2008-08-06	2020-10-14	베링거 인겔하임 인터내셔날 게엠베하	메트포르민 요법이 부적합한 환자에서의 당뇨병 치료
UY32030A (es)	2008-08-06	2010-03-26	Boehringer Ingelheim Int	"tratamiento para diabetes en pacientes inapropiados para terapia con metformina"
KR101657960B1 (ko) *	2008-08-15	2016-09-20	베링거 인겔하임 인터내셔날 게엠베하	Ｆａｂ-관련 질환의 치료에 사용하기 위한 푸린 유도체
JP2012502081A (ja)	2008-09-10	2012-01-26	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	糖尿病及び関連症状の治療のための組み合わせ治療
US20200155558A1 (en)	2018-11-20	2020-05-21	Boehringer Ingelheim International Gmbh	Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug
CN102256976A (zh)	2008-12-23	2011-11-23	贝林格尔.英格海姆国际有限公司	有机化合物的盐形式
TW201036975A (en)	2009-01-07	2010-10-16	Boehringer Ingelheim Int	Treatment for diabetes in patients with inadequate glycemic control despite metformin therapy
CN107115530A (zh)	2009-11-27	2017-09-01	勃林格殷格翰国际有限公司	基因型糖尿病患者利用dpp‑iv抑制剂例如利拉利汀的治疗
CA2797310C (en)	2010-05-05	2020-03-31	Boehringer Ingelheim International Gmbh	Glp-1 receptor agonist and dpp-4 inhibitor combination therapy
EP3124041A1 (en)	2010-06-24	2017-02-01	Boehringer Ingelheim International GmbH	Diabetes therapy
AR083878A1 (es)	2010-11-15	2013-03-27	Boehringer Ingelheim Int	Terapia antidiabetica vasoprotectora y cardioprotectora, linagliptina, metodo de tratamiento
HUE061596T2 (hu)	2011-07-15	2023-07-28	Boehringer Ingelheim Int	Szubsztituált dimer kinazolin származék, annak elõállítása és alkalmazása az I. és II. típusú cukorbetegség kezelésére szolgáló gyógyszerkészítményekben
US9555001B2 (en)	2012-03-07	2017-01-31	Boehringer Ingelheim International Gmbh	Pharmaceutical composition and uses thereof
EP3685839A1 (en)	2012-05-14	2020-07-29	Boehringer Ingelheim International GmbH	Linagliptin for use in the treatment of albuminuria and kidney related diseases
EP4151218A1 (en)	2012-05-14	2023-03-22	Boehringer Ingelheim International GmbH	Linagliptin, a xanthine derivative as dpp-4 inhibitor, for use in the treatment of sirs and/or sepsis
WO2013174767A1 (en)	2012-05-24	2013-11-28	Boehringer Ingelheim International Gmbh	A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference
WO2015128453A1 (en)	2014-02-28	2015-09-03	Boehringer Ingelheim International Gmbh	Medical use of a dpp-4 inhibitor
US10155000B2 (en)	2016-06-10	2018-12-18	Boehringer Ingelheim International Gmbh	Medical use of pharmaceutical combination or composition

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US4007197A (en) *	1975-06-10	1977-02-08	The Dow Chemical Company	Process for preparing phosphorothioates and phenylphosphonothioates
DE3525801A1 (de) *	1985-07-19	1987-01-22	Hoechst Ag	Tertiaere hydroxyalkylxanthine, verfahren zu ihrer herstellung, die sie enthaltenden arzneimittel und ihre verwendung
ES2058061T3 (es) *	1985-10-25	1994-11-01	Beecham Group Plc	Derivado de piperidina, su preparacion y su uso como medicamento.
GB8621870D0 (en) *	1986-09-11	1986-10-15	Beecham Group Plc	Active compounds
GB8826595D0 (en) *	1988-11-14	1988-12-21	Beecham Wuelfing Gmbh & Co Kg	Active compounds
US5473070A (en) *	1992-11-16	1995-12-05	Cell Therapeutics, Inc.	Substituted long chain alcohol xanthine compounds
IT1274241B (it) *	1993-12-03	1997-07-15	Smithkline Beecham Farma	Complessi agente terapeutico/matrice polimerica dotati di migliorate caratteristiche di sapore e composizioni farmaceutiche che li contengono
RU2075572C1 (ru) *	1994-11-22	1997-03-20	Алексей Егорович Пережилов	Способ формирования изоляционной завесы вокруг горных выработок

1997
- 1997-05-30 US US08/866,347 patent/US5965555A/en not_active Expired - Lifetime
- 1997-06-03 AT AT97108871T patent/ATE200288T1/de active
- 1997-06-03 DK DK97108871T patent/DK0811623T3/da active
- 1997-06-03 DE DE59703271T patent/DE59703271D1/de not_active Expired - Lifetime
- 1997-06-03 EP EP97108871A patent/EP0811623B1/de not_active Expired - Lifetime
- 1997-06-03 ES ES97108871T patent/ES2155640T3/es not_active Expired - Lifetime
- 1997-06-03 PT PT97108871T patent/PT811623E/pt unknown
- 1997-06-04 CN CN97112930A patent/CN1064361C/zh not_active Expired - Fee Related
- 1997-06-05 AU AU24699/97A patent/AU712717B2/en not_active Ceased
- 1997-06-05 NZ NZ328018A patent/NZ328018A/en not_active IP Right Cessation
- 1997-06-05 AR ARP970102447A patent/AR013821A1/es active IP Right Grant
- 1997-06-05 CZ CZ19971742A patent/CZ292509B6/cs not_active IP Right Cessation
- 1997-06-05 ID IDP971927A patent/ID17468A/id unknown
- 1997-06-05 IL IL12099897A patent/IL120998A/xx not_active IP Right Cessation
- 1997-06-06 JP JP16346697A patent/JP4263778B2/ja not_active Expired - Fee Related
- 1997-06-06 MY MYPI97002536A patent/MY117764A/en unknown
- 1997-06-06 RU RU97109533/04A patent/RU2204561C2/ru not_active IP Right Cessation
- 1997-06-06 MX MX9704201A patent/MX9704201A/es not_active IP Right Cessation
- 1997-06-06 NO NO972581A patent/NO307787B1/no not_active IP Right Cessation
- 1997-06-06 PL PL97320414A patent/PL186238B1/pl not_active IP Right Cessation
- 1997-06-06 HU HU9701018A patent/HU224702B1/hu not_active IP Right Cessation
- 1997-06-06 CA CA002207258A patent/CA2207258C/en not_active Expired - Fee Related
- 1997-06-07 KR KR1019970023483A patent/KR100531964B1/ko not_active Expired - Fee Related
- 1997-06-09 BR BRPI9703500-9A patent/BR9703500B1/pt not_active IP Right Cessation
- 1997-06-24 TW TW086108159A patent/TW384289B/zh active
2001
- 2001-04-06 GR GR20010400561T patent/GR3035711T3/el unknown

Also Published As

Publication number	Publication date
CN1169994A (zh)	1998-01-14
NO972581L (no)	1997-12-08
JPH1059968A (ja)	1998-03-03
US5965555A (en)	1999-10-12
HU9701018D0 (en)	1997-07-28
GR3035711T3 (en)	2001-07-31
HUP9701018A2 (hu)	1998-12-28
ID17468A (id)	1998-01-08
EP0811623B1 (de)	2001-04-04
BR9703500B1 (pt)	2010-05-18
CZ292509B6 (cs)	2003-10-15
AR013821A1 (es)	2001-01-31
MY117764A (en)	2004-08-30
ES2155640T3 (es)	2001-05-16
CN1064361C (zh)	2001-04-11
IL120998A (en)	2000-07-16
MX9704201A (es)	1998-04-30
TW384289B (en)	2000-03-11
PL320414A1 (en)	1997-12-08
CA2207258A1 (en)	1997-12-07
HUP9701018A3 (en)	2000-01-28
AU2469997A (en)	1997-12-11
EP0811623A1 (de)	1997-12-10
NO307787B1 (no)	2000-05-29
KR19980024046A (ko)	1998-07-06
AU712717B2 (en)	1999-11-11
ATE200288T1 (de)	2001-04-15
RU2204561C2 (ru)	2003-05-20
CA2207258C (en)	2006-08-08
HU224702B1 (en)	2006-01-30
PL186238B1 (pl)	2003-12-31
JP4263778B2 (ja)	2009-05-13
CZ174297A3 (en)	1997-12-17
DE59703271D1 (de)	2001-05-10
PT811623E (pt)	2001-09-28
NZ328018A (en)	1998-09-24
NO972581D0 (no)	1997-06-06
KR100531964B1 (ko)	2006-03-17
IL120998A0 (en)	1997-11-20
DK0811623T3 (da)	2001-07-23

Publication	Publication Date	Title
BR9703500A (pt)	1998-10-06	Compostos de xantia tendo cadeias laterais de alquinol terminalmente aminadas
PT836119E (pt)	2004-03-31	Composicao de resiste amplificado quimicamente
TR199700163A3 (tr)	1997-09-21	Reolojisi tadil edilmis polimerler.
DE69727511D1 (de)	2004-03-11	Druckmaschine
DE69724843D1 (de)	2003-10-16	Verbrennungsvorrichtung
BR9701960A (pt)	1998-09-15	Séries localizadas de múltiplos valores
DE59709565D1 (de)	2003-04-24	Pressenpartie
NO990497D0 (no)	1999-02-03	Modifiserte oligosakkarider
DE69704068D1 (de)	2001-03-22	Führungskette
DE59709953D1 (de)	2003-06-05	Photoadressierbare Seitengruppenpolymere
DE69712574D1 (de)	2002-06-20	Verbrennungsvorrichtung
DE69729492T2 (de)	2004-10-07	Verbrennungsvorrichtung
DE59707554D1 (de)	2002-07-25	Pressenpartie
BR9711604A (pt)	1999-08-24	Incinerador
FI972250A7 (fi)	1997-12-04	Jatkuvatoiminen puristin
PT811522E (pt)	2004-02-27	Cadeia de traccao multicorrentes
DE69627332D1 (de)	2003-05-15	Verbesserte phenolische vorvernetzungshemmende mittel
FI972249A7 (fi)	1997-12-04	Jatkuvatoiminen puristin
FR2719791B1 (fr)	1996-10-25	Déconsigneur de déchets.
DE69720746D1 (de)	2003-05-15	Verbrennungsanlage
KR960016763U (ko)	1996-06-17	자동차용 체인
ES1035518Y (es)	1997-11-16	Contenedor de basura.
KR970049150U (ko)	1997-08-12	음식쓰레기 탈취장치
KR960017034U (ko)	1996-06-17	차량용 휴지통
KR970006455U (ko)	1997-02-21	소각기

Legal Events

Date	Code	Title	Description
2002-06-04	FB34	Technical and formal requirements: requirement - article 34 of industrial property law
2006-06-20	B06A	Patent application procedure suspended [chapter 6.1 patent gazette]
2009-07-14	B09A	Decision: intention to grant [chapter 9.1 patent gazette]
2010-05-18	B16A	Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]	Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 18/05/2010, OBSERVADAS AS CONDICOES LEGAIS.
2014-04-22	B24H	Lapse because of non-payment of annual fees (definitively: art 78 iv lpi)
2020-12-08	B24F	Patent annual fee: publication cancelled	Free format text: ANULADA A PUBLICACAO CODIGO 24.8 NA RPI NO 2259 DE 22/04/2014 POR TER SIDO INDEVIDA.
2020-12-22	B21F	Lapse acc. art. 78, item iv - on non-payment of the annual fees in time	Free format text: REFERENTE AS 16A, 17A, 18A, 19A, 20A, 21A, 22A E 23A ANUIDADES.
2021-04-13	B24J	Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)	Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2607 DE 22-12-2020 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.