BR9612800A - Pharmaceutical dosage form for colonic distribution. - Google Patents
Pharmaceutical dosage form for colonic distribution.Info
- Publication number
- BR9612800A BR9612800A BR9612800-3A BR9612800A BR9612800A BR 9612800 A BR9612800 A BR 9612800A BR 9612800 A BR9612800 A BR 9612800A BR 9612800 A BR9612800 A BR 9612800A
- Authority
- BR
- Brazil
- Prior art keywords
- dosage form
- colon
- coating material
- polymeric coating
- distribution
- Prior art date
Links
Landscapes
- Medicinal Preparation (AREA)
Abstract
Patente de Invenção:<B>"FORMA DE DOSAGEM FARMACêUTICA PARA DISTRIBUIçãO COLÈNICA"<D>. A presente invenção se refere a uma composição farmacêutica em uma forma de dosagem em nidade para administração peroral em um ser humano ou animal inferior, tendo um trato gastroinstetinal compreendendo um intestino delgado e um cólon com um lúmen tendo uma entrada ao cólon a partir do intestino delgado, compreendendo: a. uma quantidade segura e efetiva de um agente terapêutico incorporado ou revestido sobre a superfície de uma forma de dosagem selecionada do grupo consistindo de um substrato esférico, um substrato elíptico, uma cápsula rígida, ou um tablete comprimido, com um diâmetro máximo de cerca de 3mm a cerca de 10 mm; e b. um material de revestimento polimérico entérico; em que a forma de dosagem possui uma superfície lisa isenta de bordas ou curvas cortantes; o substrato elíptico e a cápsula rígida possuem uma proporção dos diâmetros longo para curto de não mais do que cerca de 1,5; o agente terapêutico é liberado em um ponto próximo à entrada ou dentro do cólon; o material de revestimento polimérico entérico começa a se dissolver em um meio aquoso em um pH entre cerca de 5 a cerca de 6,3; e o material de revestimento polimérico entérico possui uma espessura de revestimento de pelo menos cerca de 250<109>m.Invention Patent: <B> "PHARMACEUTICAL DOSAGE FORM FOR COLOGNICAL DISTRIBUTION" <D>. The present invention relates to a pharmaceutical composition in a standard dosage form for peroral administration in a human or lower animal, having a gastroinstetinal tract comprising a small intestine and a colon with a lumen having an entry to the colon from the intestine. slender, comprising: a. a safe and effective amount of a therapeutic agent incorporated or coated on the surface of a dosage form selected from the group consisting of a spherical substrate, an elliptical substrate, a rigid capsule, or a compressed tablet, with a maximum diameter of about 3mm at about 10 mm; and b. an enteric polymeric coating material; wherein the dosage form has a smooth surface free of sharp edges or curves; the elliptical substrate and the rigid capsule have a ratio of long to short diameters of no more than about 1.5; the therapeutic agent is released at a point near the entrance or inside the colon; the enteric polymeric coating material begins to dissolve in an aqueous medium at a pH between about 5 to about 6.3; and the enteric polymeric coating material has a coating thickness of at least about 250 µm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BR9612800-3A BR9612800A (en) | 1996-11-15 | 1996-11-15 | Pharmaceutical dosage form for colonic distribution. |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US1996/018257 WO1998022095A1 (en) | 1996-11-15 | 1996-11-15 | Pharmaceutical dosage form for colonic delivery |
| BR9612800-3A BR9612800A (en) | 1996-11-15 | 1996-11-15 | Pharmaceutical dosage form for colonic distribution. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9612800A true BR9612800A (en) | 2000-03-28 |
Family
ID=25664823
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9612800-3A BR9612800A (en) | 1996-11-15 | 1996-11-15 | Pharmaceutical dosage form for colonic distribution. |
Country Status (1)
| Country | Link |
|---|---|
| BR (1) | BR9612800A (en) |
-
1996
- 1996-11-15 BR BR9612800-3A patent/BR9612800A/en not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B25A | Requested transfer of rights approved |
Free format text: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) |
|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A,8, 9A E 10A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1860 DE 29/08/2006. |