[go: up one dir, main page]

BR9610241A - Processos para análise de imagem de diagnóstico utilizando bioconjgados de complexos de metal de ligandos macrocíclicos contendo nitrogênio - Google Patents

Processos para análise de imagem de diagnóstico utilizando bioconjgados de complexos de metal de ligandos macrocíclicos contendo nitrogênio

Info

Publication number
BR9610241A
BR9610241A BR9610241A BR9610241A BR9610241A BR 9610241 A BR9610241 A BR 9610241A BR 9610241 A BR9610241 A BR 9610241A BR 9610241 A BR9610241 A BR 9610241A BR 9610241 A BR9610241 A BR 9610241A
Authority
BR
Brazil
Prior art keywords
bioconjugates
processes
image analysis
metal complexes
containing nitrogen
Prior art date
Application number
BR9610241A
Other languages
English (en)
Inventor
William L Neumann
Dennis P Riley
Randy H Weiss
Susan L Henke
Patrick J Lennon
Karl W Aston
Original Assignee
Monsanto Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Monsanto Co filed Critical Monsanto Co
Publication of BR9610241A publication Critical patent/BR9610241A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
BR9610241A 1995-08-17 1996-08-16 Processos para análise de imagem de diagnóstico utilizando bioconjgados de complexos de metal de ligandos macrocíclicos contendo nitrogênio BR9610241A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US239495P 1995-08-17 1995-08-17
PCT/US1996/013044 WO1997006830A1 (en) 1995-08-17 1996-08-16 Methods of diagnostic image analysis using bioconjugates of metal complexes of nitrogen-containing macrocyclic ligands

Publications (1)

Publication Number Publication Date
BR9610241A true BR9610241A (pt) 1999-06-29

Family

ID=21700561

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9610241A BR9610241A (pt) 1995-08-17 1996-08-16 Processos para análise de imagem de diagnóstico utilizando bioconjgados de complexos de metal de ligandos macrocíclicos contendo nitrogênio

Country Status (8)

Country Link
US (3) US20040057904A1 (pt)
EP (1) EP0846003A1 (pt)
JP (1) JPH11511168A (pt)
AU (1) AU6896796A (pt)
BR (1) BR9610241A (pt)
CA (1) CA2229781A1 (pt)
NO (1) NO980647L (pt)
WO (1) WO1997006830A1 (pt)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6127356A (en) 1993-10-15 2000-10-03 Duke University Oxidant scavengers
BR9610241A (pt) * 1995-08-17 1999-06-29 Monsanto Co Processos para análise de imagem de diagnóstico utilizando bioconjgados de complexos de metal de ligandos macrocíclicos contendo nitrogênio
EP1045851B1 (en) 1997-11-03 2003-04-23 Duke University Substituted porphyrins
EP1616869B1 (en) 1999-01-25 2012-04-04 National Jewish Health Substituted porphyrins and their therapeutic use
JP2003500174A (ja) 1999-05-27 2003-01-07 フアルマシア・コーポレーシヨン スーパーオキシド・ジスムターゼ模倣体で修飾された生体材料
US20040137638A1 (en) * 2002-03-04 2004-07-15 Slomczynska Urszula J. Chromatography of metal complexes
EP2312309B1 (en) * 2001-03-02 2017-11-01 Galera Labs, LLC Enzyme mimetic metal complexes
WO2002098431A1 (en) 2001-06-01 2002-12-12 National Jewish Medical And Research Center Oxidant scavengers for treatment of diabetes or use in transplantation or induction of immune tolerance
WO2003103680A1 (en) 2002-06-07 2003-12-18 Duke University Substituted porphyrins
ES2725023T3 (es) 2006-10-12 2019-09-18 Galera Labs Llc Métodos para el tratamiento de la mucositis oral
ES2600469T3 (es) 2008-05-23 2017-02-09 National Jewish Health Un compuesto para su uso en el tratamiento de lesiones asociadas con la exposición al gas fosgeno o al gas de cloro
US20110105417A1 (en) * 2008-06-26 2011-05-05 The Curators Of The University Of Missouri Drug Conjugates
AU2012316397B2 (en) 2011-09-26 2016-07-21 Galera Labs, Llc Methods for treatment of diseases
WO2017027728A1 (en) 2015-08-11 2017-02-16 Galera Labs, Llc Pentaaza macrocyclic ring complexes possessing oral bioavailability
EA201892510A3 (ru) 2016-05-03 2019-09-30 ГАЛЕРА ЛЭБЗ, ЭлЭлСи Комбинированная терапия для лечения рака
WO2018045348A2 (en) 2016-09-01 2018-03-08 Galera Labs, Llc Combination cancer therapy with pentaaza macrocyclic ring complex and ascorbate compound
IL269915B (en) 2017-04-13 2022-09-01 Galera Labs Llc Cancer immunotherapy combined with a macrocyclic ring pentase complex

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4001212A (en) * 1973-10-03 1977-01-04 E. I. Du Pont De Nemours And Company Macrocyclic polyamines
US3930867A (en) * 1974-01-07 1976-01-06 E. I. Du Pont De Nemours And Company Macrocyclic polyamines as sensitizers for silver halide emulsions
NO149961C (no) 1981-06-01 1984-07-25 Borregaard Ind Fremgangsmaate for fremstilling av n-(2-hydroksyetyl)-derivater av makrocykliske polyaminer, inneholdende flere nitrogenatomer i 1,4-forhold i ringen
US4647447A (en) * 1981-07-24 1987-03-03 Schering Aktiengesellschaft Diagnostic media
US4749560A (en) * 1984-08-13 1988-06-07 Research Corporation Metal organo phosphorous compounds for NMR analysis
US5316757A (en) 1984-10-18 1994-05-31 Board Of Regents, The University Of Texas System Synthesis of polyazamacrocycles with more than one type of side-chain chelating groups
JPS61226751A (ja) * 1985-03-30 1986-10-08 Konishiroku Photo Ind Co Ltd ハロゲン化銀写真感光材料用処理液及びその処理方法
US4880832A (en) 1987-03-06 1989-11-14 Sumitomo Pharmaceuticals Company, Ltd. Liposoluble platinum (II) complex and preparation thereof
FR2614020B1 (fr) 1987-04-14 1989-07-28 Guerbet Sa Nouveaux ligands cycliques azotes, complexes metalliques formes par ces ligands, compositions de diagnostic contenant ces complexes et procede de preparation des ligands.
US4994560A (en) 1987-06-24 1991-02-19 The Dow Chemical Company Functionalized polyamine chelants and radioactive rhodium complexes thereof for conjugation to antibodies
US4952289A (en) * 1988-05-09 1990-08-28 Aquanautics Corporation Macrocyclic amine complexes for ligand extraction and generation
CA1340527C (en) 1988-05-31 1999-05-04 Lidia Vallarino Macrocyclic complexes of yttrium, the lanthanides and the actinides having peripheral coupling functionalities
US5096724A (en) * 1988-06-03 1992-03-17 Aquanautics Corporation Methods, compositions, and systems for ligand extraction
WO1990007261A2 (en) 1988-12-22 1990-07-12 The Dow Chemical Company Process for preparing mono-n-alkylated polyazamacrocycles
US5252720A (en) 1989-03-06 1993-10-12 Board Of Regents, The University Of Texas System Metal complexes of water soluble texaphyrins
FR2644785B1 (fr) 1989-03-24 1991-07-05 Guerbet Sa Nouveaux ligands macrocycliques azotes, procede de preparation, complexes metalliques formes par ces ligands et composition de diagnostic les contenant
US5914095A (en) 1989-04-07 1999-06-22 Salutar, Inc. Polychelants containg amide bonds
EP0511275A1 (en) * 1990-01-19 1992-11-04 Nycomed Imaging As Chelating compounds
GB9001245D0 (en) 1990-01-19 1990-03-21 Salutar Inc Compounds
GB9008724D0 (en) 1990-04-18 1990-06-13 Celltech Ltd Chemical compounds
US5162109A (en) * 1990-09-13 1992-11-10 Mallinckrodt Medical, Inc. Magnetic resonance imaging agents
GB9024208D0 (en) 1990-11-07 1990-12-19 Salutar Inc Compounds
AU660033B2 (en) 1991-05-23 1995-06-08 Imarx Pharmaceutical Corp. Liposoluble compounds for magnetic resonance imaging
CA2072934C (en) * 1991-07-19 2007-08-28 Karl William Aston Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide
EP0524161A1 (en) * 1991-07-19 1993-01-20 Monsanto Company Manganese complexes of nitrogen containing macrocyclic ligands effective as catalysts for dismutating superoxide
US5248498A (en) * 1991-08-19 1993-09-28 Mallinckrodt Medical, Inc. Fullerene compositions for magnetic resonance spectroscopy and imaging
FR2680787B1 (fr) 1991-08-30 1994-11-04 Cis Bio Int Complexes macrocycliques de terres rares et leur utilisation pour reduire les interferences dans un dosage par fluorescence.
EP0588229A3 (en) 1992-09-12 1994-06-15 Hoechst Ag Macrocyclic chelating agents for the preparation of technetium or rhenium complexes
US6204259B1 (en) * 1993-01-14 2001-03-20 Monsanto Company Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide
AU4237493A (en) 1993-05-06 1994-12-12 Dow Chemical Company, The Bicyclopolyazamacrocyclocarboxylic acid complexes, their conjugates, processes for their preparation, and use as radiopharmaceuticals
US5358704A (en) * 1993-09-30 1994-10-25 Bristol-Myers Squibb Hepatobiliary tetraazamacrocyclic magnetic resonance contrast agents
US5747026A (en) * 1993-10-15 1998-05-05 University Of Alabama At Birmingham Research Foundation Antioxidants
BR9507477A (pt) * 1994-04-22 1997-09-16 Searle & Co Métodos de análise de imagem de diagnóstico usando complexos metálicos de ligantes macrocíclicos contendo nitrogênio
CA2196408A1 (en) * 1994-08-10 1996-02-22 Roderick T. Coward Method of using hyaluronic acid for the detection, location and diagnosis of tumors
US6525041B1 (en) 1995-06-06 2003-02-25 Pharmacia Corporation Manganese or iron complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide
JPH11507621A (ja) 1995-06-07 1999-07-06 モンサント カンパニー 置換ポリアザ大環状化合物の製造法
BR9610241A (pt) * 1995-08-17 1999-06-29 Monsanto Co Processos para análise de imagem de diagnóstico utilizando bioconjgados de complexos de metal de ligandos macrocíclicos contendo nitrogênio
JPH11514971A (ja) * 1995-08-17 1999-12-21 モンサント カンパニー 窒素含有大環状リガンドの金属錯体を使用する診断造影検査方法
US6214817B1 (en) * 1997-06-20 2001-04-10 Monsanto Company Substituted pyridino pentaazamacrocyle complexes having superoxide dismutase activity

Also Published As

Publication number Publication date
NO980647L (no) 1998-04-03
US20040131550A1 (en) 2004-07-08
WO1997006830A1 (en) 1997-02-27
JPH11511168A (ja) 1999-09-28
AU6896796A (en) 1997-03-12
US20090098047A1 (en) 2009-04-16
US7407645B2 (en) 2008-08-05
CA2229781A1 (en) 1997-02-27
NO980647D0 (no) 1998-02-16
US20040057904A1 (en) 2004-03-25
EP0846003A1 (en) 1998-06-10

Similar Documents

Publication Publication Date Title
BR9610240A (pt) Métodos de análise de imagem para diagnóstico utilizando complexos de metal de ligantes macrociclicos que contém nitrogênio
BR9610241A (pt) Processos para análise de imagem de diagnóstico utilizando bioconjgados de complexos de metal de ligandos macrocíclicos contendo nitrogênio
BR9507477A (pt) Métodos de análise de imagem de diagnóstico usando complexos metálicos de ligantes macrocíclicos contendo nitrogênio
DE69919142D1 (de) Bicyclo [2.2.1] heptane und verwandte verbindungen
NO996253D0 (no) Diagnostiske midler og legemidler for maligne tumorer
DE69615738D1 (de) Bilderzeugungsgerät und Verfahren dafür
IL101409A0 (en) Method for the early diagnosis of cancer
IL113590A (en) Blood sampling apparatus
IL103600A0 (en) Method and kit for cancer diagnosis
FI943869L (fi) Yhdisteitä, jotka ovat käyttökelpoisia varjoaineissa röntgenkuvauksiin
FI952117L (fi) Substituoidut bisykliset heteroaroyyliguanidiinit, menetelmä niiden valmistamiseksi, niiden käyttö lääkeaineena tai diagnostisena aineena sekä niitä sisältävä lääkeaine
NO982233L (no) Diagnostisk avbildningsmiddel
DE69535697D1 (de) Dihydrobenzofurane und verwandte verbindungen als entzündungshemmende mittel
IL119520A0 (en) Method for interferometer based spectral imaging of moving objects
FR2737920B1 (fr) Procede de diagnostic pour un detecteur de gaz d'echappement
EP0651251A3 (en) Device for detecting trace amounts of a substance or an organism to be analyzed.
KR950702196A (ko) 방사선 사진의 조영제에 유용한 6가 리간드(hexadentate ligands useful in radiogrphic imaging agents)
KR970014904U (ko) 합승객 요금징수 가능한 택시메타기
ZA967395B (en) Compounds and methods for diagnosis of tuberculosis
PL308731A1 (en) Apparatus for spondylometric examination
BR9604536A (pt) Detector de metais ferrosos
ZA978967B (en) Compounds and methods for diagnosis of tuberculosis.
KR970038892U (ko) 금속물이동용 자석흡착기장치
DE69519928D1 (de) Diagnostikum zur Bilderzeugung
KR970038647U (ko) 자동차이동 감지장치

Legal Events

Date Code Title Description
FA10 Dismissal: dismissal - article 33 of industrial property law