BR9608245A - Derivados de piperazino como antagonistas de neurocinina - Google Patents
Derivados de piperazino como antagonistas de neurocininaInfo
- Publication number
- BR9608245A BR9608245A BR9608245A BR9608245A BR9608245A BR 9608245 A BR9608245 A BR 9608245A BR 9608245 A BR9608245 A BR 9608245A BR 9608245 A BR9608245 A BR 9608245A BR 9608245 A BR9608245 A BR 9608245A
- Authority
- BR
- Brazil
- Prior art keywords
- piperazine derivatives
- neurokinin antagonists
- compounds
- neurokinin
- antagonists
- Prior art date
Links
- 239000005557 antagonist Substances 0.000 title abstract 2
- 150000004885 piperazines Chemical class 0.000 title 1
- 229940066771 systemic antihistamines piperazine derivative Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 208000006673 asthma Diseases 0.000 abstract 1
- 230000001684 chronic effect Effects 0.000 abstract 1
- 208000023504 respiratory system disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Ophthalmology & Optometry (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/432,739 US5719156A (en) | 1995-05-02 | 1995-05-02 | Piperazino derivatives as neurokinin antagonists |
| US308495P | 1995-08-31 | 1995-08-31 | |
| PCT/US1996/005660 WO1996034864A1 (en) | 1995-05-02 | 1996-05-01 | Piperazino derivatives as neurokinin antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9608245A true BR9608245A (pt) | 1999-05-04 |
Family
ID=26671291
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9608245A BR9608245A (pt) | 1995-05-02 | 1996-05-01 | Derivados de piperazino como antagonistas de neurocinina |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP0823906B1 (pt) |
| JP (1) | JP4173912B2 (pt) |
| KR (1) | KR19990008230A (pt) |
| CN (1) | CN1111528C (pt) |
| AT (1) | ATE244712T1 (pt) |
| AU (1) | AU705683B2 (pt) |
| BR (1) | BR9608245A (pt) |
| CA (1) | CA2218887C (pt) |
| CZ (1) | CZ342397A3 (pt) |
| DE (1) | DE69629023T2 (pt) |
| ES (1) | ES2197238T3 (pt) |
| HU (1) | HUP9801382A3 (pt) |
| MX (1) | MX9708416A (pt) |
| NO (1) | NO315852B1 (pt) |
| NZ (1) | NZ307716A (pt) |
| PL (1) | PL323235A1 (pt) |
| SK (1) | SK147297A3 (pt) |
| WO (1) | WO1996034864A1 (pt) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5892039A (en) * | 1995-08-31 | 1999-04-06 | Schering Corporation | Piperazino derivatives as neurokinin antagonists |
| US5968929A (en) * | 1996-10-30 | 1999-10-19 | Schering Corporation | Piperazino derivatives as neurokinin antagonists |
| TR199901570T2 (xx) * | 1996-10-30 | 1999-09-21 | Schering Corporation | N�rokinin antagonistleri olarak piperazin t�revleri |
| US5783579A (en) * | 1996-12-20 | 1998-07-21 | Schering Corporation | Spiro-substituted azacyclic-substituted piperazino derivatives as neurokinin antagonists |
| KR100420616B1 (ko) * | 1996-12-26 | 2004-05-17 | 동화약품공업주식회사 | 신규테레프탈산아미드유도체 |
| US6207665B1 (en) | 1997-06-12 | 2001-03-27 | Schering Aktiengesellschaft | Piperazine derivatives and their use as anti-inflammatory agents |
| AUPO735997A0 (en) * | 1997-06-17 | 1997-07-10 | Fujisawa Pharmaceutical Co., Ltd. | Piperazine derivatives |
| DE19737334A1 (de) * | 1997-08-27 | 1999-03-04 | Solvay Pharm Gmbh | 7-Phenyl-1,4-diazepan-Derivate, sowie Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
| TW591025B (en) | 2000-06-13 | 2004-06-11 | Fujisawa Pharmaceutical Co | Production of the piperazine derivative |
| AUPR237301A0 (en) * | 2001-01-02 | 2001-01-25 | Fujisawa Pharmaceutical Co., Ltd. | Benzhydryl derivatives |
| MXPA02002749A (es) | 2001-03-27 | 2002-10-28 | Warner Lambert Co | Derivados de ciclohexilamina como antagonistas del subtipo selectivo del n-metil-d-aspartato. |
| UA75425C2 (en) | 2001-07-09 | 2006-04-17 | Piperazine oxime derivatives with antagonistic activity to nk-1 receptor, use thereof, a pharmaceutical composition based thereon, a method for producing and a method for producing intermediary compounds | |
| AUPR970701A0 (en) * | 2001-12-21 | 2002-01-24 | Fujisawa Pharmaceutical Co., Ltd. | Benzhydryl derivatives |
| CN107602317A (zh) * | 2017-08-02 | 2018-01-19 | 凯莱英医药集团(天津)股份有限公司 | 手性2‑氨基‑2‑芳基乙酸衍生物的制备方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8908587D0 (en) * | 1989-04-15 | 1989-06-01 | Scras Societe De Conseils De R | New 2-substituted n,n'-ditrimethoxybenzoyl piperazines |
| US5292726A (en) * | 1991-05-22 | 1994-03-08 | Merck & Co., Inc. | N,N-diacylpiperazines |
| US5344830A (en) * | 1992-12-10 | 1994-09-06 | Merck & Co., Inc. | N,N-diacylpiperazine tachykinin antagonists |
| IL111730A (en) * | 1993-11-29 | 1998-12-06 | Fujisawa Pharmaceutical Co | Piperazine derivatives processes for the preparation thereof and pharmaceutical compositions containing the same |
| US5607936A (en) * | 1994-09-30 | 1997-03-04 | Merck & Co., Inc. | Substituted aryl piperazines as neurokinin antagonists |
-
1996
- 1996-05-01 BR BR9608245A patent/BR9608245A/pt not_active Application Discontinuation
- 1996-05-01 CN CN96195171A patent/CN1111528C/zh not_active Expired - Fee Related
- 1996-05-01 WO PCT/US1996/005660 patent/WO1996034864A1/en not_active Ceased
- 1996-05-01 AT AT96915342T patent/ATE244712T1/de not_active IP Right Cessation
- 1996-05-01 MX MX9708416A patent/MX9708416A/es not_active IP Right Cessation
- 1996-05-01 PL PL96323235A patent/PL323235A1/xx unknown
- 1996-05-01 CA CA002218887A patent/CA2218887C/en not_active Expired - Fee Related
- 1996-05-01 EP EP96915342A patent/EP0823906B1/en not_active Expired - Lifetime
- 1996-05-01 ES ES96915342T patent/ES2197238T3/es not_active Expired - Lifetime
- 1996-05-01 DE DE69629023T patent/DE69629023T2/de not_active Expired - Lifetime
- 1996-05-01 NZ NZ307716A patent/NZ307716A/en unknown
- 1996-05-01 JP JP53335596A patent/JP4173912B2/ja not_active Expired - Fee Related
- 1996-05-01 CZ CZ973423A patent/CZ342397A3/cs unknown
- 1996-05-01 SK SK1472-97A patent/SK147297A3/sk unknown
- 1996-05-01 AU AU57141/96A patent/AU705683B2/en not_active Ceased
- 1996-05-01 KR KR1019970707756A patent/KR19990008230A/ko not_active Abandoned
- 1996-05-01 HU HU9801382A patent/HUP9801382A3/hu unknown
-
1997
- 1997-10-31 NO NO19975028A patent/NO315852B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| SK147297A3 (en) | 1998-07-08 |
| EP0823906A1 (en) | 1998-02-18 |
| NO315852B1 (no) | 2003-11-03 |
| HUP9801382A3 (en) | 2000-09-28 |
| HUP9801382A2 (hu) | 1999-06-28 |
| CN1189829A (zh) | 1998-08-05 |
| ES2197238T3 (es) | 2004-01-01 |
| CZ342397A3 (cs) | 1998-03-18 |
| DE69629023D1 (de) | 2003-08-14 |
| MX9708416A (es) | 1998-02-28 |
| KR19990008230A (ko) | 1999-01-25 |
| DE69629023T2 (de) | 2004-04-22 |
| EP0823906B1 (en) | 2003-07-09 |
| NO975028D0 (no) | 1997-10-31 |
| ATE244712T1 (de) | 2003-07-15 |
| JP4173912B2 (ja) | 2008-10-29 |
| AU705683B2 (en) | 1999-05-27 |
| AU5714196A (en) | 1996-11-21 |
| CN1111528C (zh) | 2003-06-18 |
| PL323235A1 (en) | 1998-03-16 |
| JPH11504921A (ja) | 1999-05-11 |
| NO975028L (no) | 1997-12-30 |
| CA2218887A1 (en) | 1996-11-07 |
| WO1996034864A1 (en) | 1996-11-07 |
| CA2218887C (en) | 2008-04-29 |
| NZ307716A (en) | 1999-10-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR9610277A (pt) | Derivados de piperazino como antagonistas de neurowuinina | |
| MX9707879A (es) | Derivados de piperazina sustituidos novedosos que tienen actividad antagonista de receptor de taquinina. | |
| ATE320426T1 (de) | Harnstoffderivate und ihre verwendung | |
| ATE207897T1 (de) | Piperidinderivate als neurokininantagonisten | |
| PT863875E (pt) | Novos compostos 4-(oxialcoxifenil)-3-oxi-piperidina para o tratamento de insuficiencia cardiaca e renal | |
| ES2169127T3 (es) | Nuevos carbamatos y ureas como modificadores de la resistencia multi-farmaco. | |
| BR9608245A (pt) | Derivados de piperazino como antagonistas de neurocinina | |
| TR200101969T2 (tr) | Enflamasyon tedavisi için sübstitüe edilmiş benzopiran analogları. | |
| ATE251614T1 (de) | Piperazinderivate als neurokinin-antagonisten | |
| ES2087038A1 (es) | Nuevas piperidinas con actividad antagonista del paf. | |
| ATE271861T1 (de) | Verwendung von nmda-antagonisten und/oder natriumkanalantagonisten zur behandlung von entzündlichen erkrankungen | |
| AP2001002188A0 (en) | 5HT1 antagonists for antidepressant therapy. | |
| BR9712720A (pt) | Derivados de piperazina como antagÈnicos de neurocinina | |
| ATE402694T1 (de) | Verwendung von 1-phenyl-3-dimethylamino-propan- verbindungen zur therapie der harninkontinenz | |
| PE20030236A1 (es) | Derivados de bencimidazol 1-aril-2-n,s- u o-sustituidos, obtencion de medicamentos y preparados farmaceuticos que contienen estos derivados | |
| NZ335057A (en) | Pentaerythritol derivatives, their production and use and intermediates for their synthesis | |
| HU9603540D0 (en) | Substituted alkyldiamine derivatives and their use as tachykinin antagonists | |
| DE50308230D1 (de) | Pyrazoloisoquinolinenderivaten zur inhibierung von nfkappab-induzierende kinase | |
| ID27656A (id) | Turunan azabisikloheptana n-tersubstitusi, pembuatan dan penggunaannya | |
| ATE265418T1 (de) | Neue substituierte 3-phenoxy- und 3- phenylalkyloxy-2-phenyl-propylamine | |
| ATE423780T1 (de) | Makrozyclen zur behandlung von krebserkrankungen | |
| SE9901273D0 (sv) | Novel compounds | |
| ATE358488T1 (de) | Behandlung von dyskinesie mit 2,3-benzodiazepinen | |
| CO4970818A1 (es) | Derivados piperazino como antagonistas de neuroquinina | |
| ECSP972299A (es) | Piperazino derivados como antagonistas de neurokinina |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: INDEFIRO O PRESENTE PEDIDO DE PATENTE COMO INVENCAO DE ACORDO COM O ART. 8O DA LPI. |