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BR9607364A - Método para preparação de prostaglandinas e1, e2 e análogos destas usando reagentes de furil cobre - Google Patents

Método para preparação de prostaglandinas e1, e2 e análogos destas usando reagentes de furil cobre

Info

Publication number
BR9607364A
BR9607364A BR9607364A BR9607364A BR9607364A BR 9607364 A BR9607364 A BR 9607364A BR 9607364 A BR9607364 A BR 9607364A BR 9607364 A BR9607364 A BR 9607364A BR 9607364 A BR9607364 A BR 9607364A
Authority
BR
Brazil
Prior art keywords
furil
prostaglandins
analogues
preparation
copper reagents
Prior art date
Application number
BR9607364A
Other languages
English (en)
Inventor
Miroslav Trampota
Bohumil Zak
Original Assignee
Vivus Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vivus Inc filed Critical Vivus Inc
Publication of BR9607364A publication Critical patent/BR9607364A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
BR9607364A 1995-03-10 1996-03-07 Método para preparação de prostaglandinas e1, e2 e análogos destas usando reagentes de furil cobre BR9607364A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/403,251 US5618959A (en) 1995-03-10 1995-03-10 Process for preparing prostaglandin E1, E2 and analogs thereof using furylcopper reagents
PCT/US1996/003090 WO1996028419A1 (en) 1995-03-10 1996-03-07 Process for preparing prostaglandin e1, e2 and analogs thereof using furylcopper reagents

Publications (1)

Publication Number Publication Date
BR9607364A true BR9607364A (pt) 1997-12-30

Family

ID=23595087

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9607364A BR9607364A (pt) 1995-03-10 1996-03-07 Método para preparação de prostaglandinas e1, e2 e análogos destas usando reagentes de furil cobre

Country Status (15)

Country Link
US (1) US5618959A (pt)
EP (1) EP0815076A1 (pt)
JP (1) JP2840457B2 (pt)
KR (1) KR19980702884A (pt)
AU (1) AU696027B2 (pt)
BR (1) BR9607364A (pt)
CA (1) CA2215000A1 (pt)
CZ (1) CZ278597A3 (pt)
HU (1) HUP9801428A3 (pt)
NO (1) NO974061L (pt)
NZ (1) NZ305104A (pt)
PL (1) PL322160A1 (pt)
SK (1) SK121597A3 (pt)
TR (1) TR199700929T1 (pt)
WO (1) WO1996028419A1 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6030959A (en) * 1997-04-04 2000-02-29 Monsanto Company Gastro-specific prodrugs
US6413945B1 (en) * 1997-04-04 2002-07-02 Pharmacia Corporation Gastro-specific prodrugs
AR071312A1 (es) * 2008-04-09 2010-06-09 Scinopharm Taiwan Ltd Proceso para la preparacion de analogos de prostaglandina y sus intermediarios
CN102351767B (zh) * 2011-09-20 2013-03-06 海南美兰史克制药有限公司 一种前列地尔化合物及其制法
JP6488472B2 (ja) 2013-09-30 2019-03-27 パテオン エーピーアイ サービシーズ インコーポレイテッドＰａｔｈｅｏｎ Ａｐｉ Ｓｅｒｖｉｃｅｓ Ｉｎｃ． メタセシスを用いるプロスタグランジンおよびプロスタグランジン中間体の新規合成経路
HU231185B1 (hu) 2017-07-11 2021-07-28 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. Eljárás Misoprostol előállítására és tisztítására

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4031129A (en) * 1972-01-26 1977-06-21 Wisconsin Alumni Research Foundation 15-Deoxy-PGE1 and method for preparing same
US4535180A (en) * 1972-07-24 1985-08-13 American Cyanamid Company 11-Deoxy-11-substituted prostaglandins of the E and F series
US4410720A (en) * 1973-08-06 1983-10-18 Hoffmann-La Roche Inc. 16-Fluoro prostaglandins
US4087621A (en) * 1974-03-26 1978-05-02 G. D. Searle & Co. 7-{3-Hydroxy-2β-[4-hydroxy-4-(lower alkyl)-trans-1-octen-1-yl]-5-oxocyclopent-1α-yl}hept-5-cis-enoic acids and related compounds
AU3437478A (en) * 1977-03-30 1979-09-27 American Cyanamid Co Prostanoic acids and congeners
US4149007A (en) * 1977-06-23 1979-04-10 Miles Laboratories, Inc. C14 Phenyl-substituted derivatives of prostaglandin analogues
GB2006186A (en) * 1977-08-29 1979-05-02 American Cyanamid Co 15-Deoxy-16-substituted prostanoic acids
US4282372A (en) * 1978-11-01 1981-08-04 Sumitomo Chemical Company, Limited Process for producing cyclopentenolones
US4452994A (en) * 1981-03-02 1984-06-05 G. D. Searle & Co. Process for isolating organic compounds and lithium salt complexes useful in said process
US4474979A (en) * 1981-05-21 1984-10-02 American Cyanamid Company Synthesis of d1-(methyl)-16,16-(dimethyl-11-alpha, 15-alpha, beta-dihydroxy-9-oxo-2,13,-trans,trans-prostadienoates
US4983753A (en) * 1981-05-21 1991-01-08 Floyd Jr Middleton B Precursors and synthesis of di-(methyl)-16,16-(dimethyl)-11-alpha,15-alpha beta-dihydroxy-9-oxo-2,13-trans,trans-prostadienoates
US4360688A (en) * 1981-05-21 1982-11-23 American Cyanamid Company Precursors and synthesis of d1-(methyl)-16,16-(dimethyl)-11-alpha, 15-alpha, beta-dihydroxy-9-oxo-2,13,-trans, trans-prostadienoates
US4644079A (en) * 1981-05-21 1987-02-17 American Cyanamid Company Precursors and synthesis of d1-(methyl)-16,16-(dimethyl)-11-alpha, 15-alpha, beta-dihydroxy-9-oxo-2,13,-trans, trans-prostadienoates
US5166369A (en) * 1981-05-21 1992-11-24 American Cyanamid Company Precursors and synthesis of D1-(methyl)-16,16-(dimethyl)-11-alpha, 15-alpha, beta-dihydroxy-9-oxo-2,13,-trans, trans-prostadienoates
US4543421A (en) * 1983-05-11 1985-09-24 Miles Laboratories, Inc. Conjugate addition of organocuprates generated from copper (I) cyanide and vinyl stannanes useful in prostaglandin analog synthesis
JPH0669984B2 (ja) * 1986-09-19 1994-09-07 住友化学工業株式会社 シクロペンテノン誘導体の製造法
US4785124A (en) * 1987-06-08 1988-11-15 G. D. Searle & Co. Process for preparing higher order cuprate complexes
US4904820A (en) * 1987-06-09 1990-02-27 G. D. Searle & Co. Process for substituting a hydrocarbon group
US4952710A (en) * 1988-10-07 1990-08-28 G. D. Searle & Co. Cyclopenteneheptenoic acid derivatives and method of preparation thereof
US5191109A (en) * 1990-02-02 1993-03-02 Sumitomo Chemical Company, Limited Process for preparing optically active cyclopentenones
US5055604A (en) * 1990-04-17 1991-10-08 G. D. Searle & Co. Process for preparing prostaglandin analogs using organozirconium compounds

Also Published As

Publication number Publication date
TR199700929T1 (xx) 1998-02-21
AU696027B2 (en) 1998-08-27
KR19980702884A (ko) 1998-08-05
HUP9801428A2 (hu) 1998-10-28
HUP9801428A3 (en) 1999-08-30
CZ278597A3 (cs) 1998-01-14
MX9706883A (es) 1997-11-29
NO974061L (no) 1997-09-10
NO974061D0 (no) 1997-09-04
JP2840457B2 (ja) 1998-12-24
WO1996028419A1 (en) 1996-09-19
CA2215000A1 (en) 1996-09-19
PL322160A1 (en) 1998-01-19
JPH10504321A (ja) 1998-04-28
AU5303696A (en) 1996-10-02
NZ305104A (en) 1999-02-25
US5618959A (en) 1997-04-08
EP0815076A1 (en) 1998-01-07
SK121597A3 (en) 1998-01-14

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Legal Events

Date Code Title Description
FD5 Application fees: dismissal - article 86 of industrial property law