BR9509998A - Derivados imidazol como inibidores de proteína quinase em particular egf-r tirosina quinase - Google Patents
Derivados imidazol como inibidores de proteína quinase em particular egf-r tirosina quinaseInfo
- Publication number
- BR9509998A BR9509998A BR9509998A BR9509998A BR9509998A BR 9509998 A BR9509998 A BR 9509998A BR 9509998 A BR9509998 A BR 9509998A BR 9509998 A BR9509998 A BR 9509998A BR 9509998 A BR9509998 A BR 9509998A
- Authority
- BR
- Brazil
- Prior art keywords
- imidazole derivatives
- protein kinase
- tyrosine kinase
- particular egf
- kinase inhibitors
- Prior art date
Links
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 title 1
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 title 1
- 229940045988 antineoplastic drug protein kinase inhibitors Drugs 0.000 title 1
- 150000002460 imidazoles Chemical class 0.000 title 1
- 229940079865 intestinal antiinfectives imidazole derivative Drugs 0.000 title 1
- 239000003909 protein kinase inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH376894 | 1994-12-13 | ||
| PCT/EP1995/004741 WO1996018626A1 (en) | 1994-12-13 | 1995-12-01 | Imidazole derivatives as protein kinase inhibitors in particular egf-r tyrosine kinase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9509998A true BR9509998A (pt) | 1997-12-30 |
Family
ID=4263074
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9509998A BR9509998A (pt) | 1994-12-13 | 1995-12-01 | Derivados imidazol como inibidores de proteína quinase em particular egf-r tirosina quinase |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US5959113A (pt) |
| EP (1) | EP0797575B1 (pt) |
| JP (1) | JPH10510281A (pt) |
| CN (1) | CN1145623C (pt) |
| AR (1) | AR003406A1 (pt) |
| AT (1) | ATE252094T1 (pt) |
| AU (1) | AU4301096A (pt) |
| BR (1) | BR9509998A (pt) |
| CA (1) | CA2207404C (pt) |
| DE (1) | DE69531956T2 (pt) |
| DK (1) | DK0797575T3 (pt) |
| ES (1) | ES2208698T3 (pt) |
| FI (1) | FI972492A0 (pt) |
| PT (1) | PT797575E (pt) |
| TR (1) | TR199501561A2 (pt) |
| WO (1) | WO1996018626A1 (pt) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6083949A (en) * | 1995-10-06 | 2000-07-04 | Merck & Co., Inc. | Substituted imidazoles having anti-cancer and cytokine inhibitory activity |
| US5880139A (en) * | 1996-11-20 | 1999-03-09 | Merck & Co., Inc. | Triaryl substituted imidazoles as glucagon antagonists |
| CA2271893A1 (en) * | 1996-11-20 | 1998-05-28 | Linda L. Chang | Triaryl substituted imidazoles as glucagon antagonists |
| WO1998021957A1 (en) * | 1996-11-20 | 1998-05-28 | Merck & Co., Inc. | Triaryl substituted imidazoles, compositions containing such compounds and methods of use |
| US6022884A (en) | 1997-11-07 | 2000-02-08 | Amgen Inc. | Substituted pyridine compounds and methods of use |
| AU4506399A (en) * | 1998-06-05 | 1999-12-30 | Novartis Ag | Aryl pyridinyl thiazoles |
| WO2000001688A1 (en) * | 1998-07-02 | 2000-01-13 | Sankyo Company, Limited | Five-membered heteroaryl compounds |
| JP3850596B2 (ja) | 1999-02-25 | 2006-11-29 | 本州化学工業株式会社 | 新規な部分保護トリスフェノール類とその製造方法 |
| WO2003024447A1 (en) * | 2001-09-20 | 2003-03-27 | Smithkline Beecham Corporation | Inhibitors of glycogen synthase kinase-3 |
| AR039241A1 (es) | 2002-04-04 | 2005-02-16 | Biogen Inc | Heteroarilos trisustituidos y metodos para su produccion y uso de los mismos |
| US6790852B2 (en) * | 2002-04-18 | 2004-09-14 | Hoffmann-La Roche Inc. | 2-(2,6-dichlorophenyl)-diarylimidazoles |
| CN101870691A (zh) | 2002-08-19 | 2010-10-27 | 劳洛斯治疗公司 | 2,4,5-三取代的咪唑及其作为抗菌剂的用途 |
| US7144889B2 (en) | 2003-10-16 | 2006-12-05 | Hoffman-La Roche Inc. | Triarylimidazoles |
| CN100436450C (zh) * | 2003-10-16 | 2008-11-26 | 霍夫曼-拉罗奇有限公司 | 三芳基咪唑 |
| US7169781B2 (en) * | 2003-10-17 | 2007-01-30 | Hoffmann-La Roche Inc. | Imidazole derivatives and their use as pharmaceutical agents |
| JP5095216B2 (ja) | 2003-11-14 | 2012-12-12 | ローラス セラピューティクス インコーポレーテッド | アリールイミダゾールおよびその抗癌剤としての使用 |
| KR100905678B1 (ko) * | 2005-02-18 | 2009-07-03 | 도쿠리쓰교세이호징 가가쿠 기주쓰 신코 기코 | 광학 활성 에폭시 화합물의 제조 방법, 및 상기 방법에사용하기 위한 착체 및 그의 제조 방법 |
| ES2473597T3 (es) | 2005-05-25 | 2014-07-07 | Lorus Therapeutics Inc. | Derivados de 2-indolil imidazo[4,5-d]fenantrolina y su uso en el tratamiento del cáncer |
| JP5283872B2 (ja) * | 2006-09-27 | 2013-09-04 | シスメックス株式会社 | 腫瘍細胞に対する阻害剤の増殖抑制効果を評価する方法、及び腫瘍細胞の増殖を阻害する化合物をスクリーニングする方法 |
| JP2010504974A (ja) * | 2006-09-28 | 2010-02-18 | フォリカ，インコーポレーテッド | 新しい毛嚢を生成させ毛髪を成長させる方法、キット、及び組成物 |
| CA2903866A1 (en) | 2013-03-20 | 2014-09-25 | Aptose Biosciences Inc. | 2-substituted imidazo[4,5-d]phenanthroline derivatives and their use in the treatment of cancer |
| KR20160058960A (ko) | 2013-10-04 | 2016-05-25 | 압토스 바이오사이언시스 인코포레이티드 | 암을 치료하기 위한 조성물과 방법 |
| BR112016017993A2 (pt) | 2014-02-03 | 2017-08-08 | Quadriga Biosciences Inc | Gama-aminoácidos beta-substituídos e análogos como agentes quimioterapêuticos |
| DK3102195T3 (da) | 2014-02-03 | 2021-12-20 | Quadriga Biosciences Inc | Beta-substituerede beta-aminosyrer og analoger som kemoterapeutiske midler |
| ES2926931T3 (es) * | 2014-02-07 | 2022-10-31 | Agency Science Tech & Res | Inhibidores de caseína quinasa 1 basados en azoles 2,4,5-tri-sustituidos como inductores de la cardiomiogénesis |
| EP3331851A1 (en) | 2015-08-03 | 2018-06-13 | Quadriga Biosciences, Inc. | Beta-substituted beta-amino acids and analogs as chemotherapeutic agents and uses thereof |
| CN109212045A (zh) * | 2017-07-04 | 2019-01-15 | 万全万特制药（厦门）有限公司 | 草酸艾司西酞普兰残留溶剂和杂质的分离测定方法 |
| AU2018360477A1 (en) | 2017-10-30 | 2020-06-04 | Aptose Biosciences Inc. | Aryl imidazoles for the treatment of cancer |
| CN114262298B (zh) * | 2021-12-03 | 2023-09-26 | 郑州轻工业大学 | 2-溴-4-n,n-二甲氨基咪唑及其制备方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3707475A (en) * | 1970-11-16 | 1972-12-26 | Pfizer | Antiinflammatory imidazoles |
| US3940486A (en) * | 1971-05-10 | 1976-02-24 | Ciba-Geigy Corporation | Imidazole derivatives in the treatment of pain |
| CH561717A5 (pt) * | 1971-05-10 | 1975-05-15 | Ciba Geigy Ag | |
| MC2096A1 (fr) * | 1989-02-23 | 1991-02-15 | Hoffmann La Roche | Pyrroles substitues |
| DE69322254T2 (de) * | 1992-01-13 | 1999-04-29 | Smithkline Beecham Corp., Philadelphia, Pa. 19101 | Pyridyl-substituierte imidazole |
| MX9300141A (es) * | 1992-01-13 | 1994-07-29 | Smithkline Beecham Corp | Compuestos de imidazol novedosos, procedimiento para su preparacion y composiciones farmaceuticas que lo contienen. |
| EP0654024A1 (en) * | 1992-08-06 | 1995-05-24 | Warner-Lambert Company | 2-thioindoles (selenoindoles) and related disulfides (selenides) which inhibit protein tyrosine kinases and which have antitumor properties |
| ZA945363B (en) * | 1993-07-21 | 1995-03-14 | Smithkline Beecham Corp | Novel compounds |
| CN1048731C (zh) * | 1993-09-17 | 2000-01-26 | 史密丝克莱恩比彻姆公司 | 编码细胞因子抑制性抗炎药物结合蛋白质的多核苷酸 |
-
1995
- 1995-12-01 ES ES95941646T patent/ES2208698T3/es not_active Expired - Lifetime
- 1995-12-01 PT PT95941646T patent/PT797575E/pt unknown
- 1995-12-01 JP JP8518206A patent/JPH10510281A/ja not_active Ceased
- 1995-12-01 CA CA002207404A patent/CA2207404C/en not_active Expired - Fee Related
- 1995-12-01 BR BR9509998A patent/BR9509998A/pt not_active IP Right Cessation
- 1995-12-01 US US08/860,750 patent/US5959113A/en not_active Expired - Fee Related
- 1995-12-01 AU AU43010/96A patent/AU4301096A/en not_active Abandoned
- 1995-12-01 EP EP95941646A patent/EP0797575B1/en not_active Expired - Lifetime
- 1995-12-01 DK DK95941646T patent/DK0797575T3/da active
- 1995-12-01 AT AT95941646T patent/ATE252094T1/de not_active IP Right Cessation
- 1995-12-01 FI FI972492A patent/FI972492A0/fi not_active IP Right Cessation
- 1995-12-01 CN CNB951976281A patent/CN1145623C/zh not_active Expired - Fee Related
- 1995-12-01 DE DE69531956T patent/DE69531956T2/de not_active Expired - Fee Related
- 1995-12-01 WO PCT/EP1995/004741 patent/WO1996018626A1/en not_active Ceased
- 1995-12-11 AR ARP950100495A patent/AR003406A1/es unknown
- 1995-12-12 TR TR95/01561A patent/TR199501561A2/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0797575B1 (en) | 2003-10-15 |
| ES2208698T3 (es) | 2004-06-16 |
| EP0797575A1 (en) | 1997-10-01 |
| US5959113A (en) | 1999-09-28 |
| MX9704263A (es) | 1997-09-30 |
| WO1996018626A1 (en) | 1996-06-20 |
| ATE252094T1 (de) | 2003-11-15 |
| DE69531956T2 (de) | 2004-07-29 |
| CA2207404A1 (en) | 1996-06-20 |
| FI972492L (fi) | 1997-06-12 |
| FI972492A7 (fi) | 1997-06-12 |
| AR003406A1 (es) | 1998-08-05 |
| FI972492A0 (fi) | 1997-06-12 |
| TR199501561A2 (tr) | 1996-07-21 |
| CN1175252A (zh) | 1998-03-04 |
| AU4301096A (en) | 1996-07-03 |
| PT797575E (pt) | 2004-02-27 |
| JPH10510281A (ja) | 1998-10-06 |
| DE69531956D1 (de) | 2003-11-20 |
| CN1145623C (zh) | 2004-04-14 |
| CA2207404C (en) | 2004-06-29 |
| DK0797575T3 (da) | 2004-02-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] | ||
| B24C | Patent annual fee: request for for restoration |
Free format text: REFERENTE A 10A , 12A , 13A E 14A ANUIDADES. |
|
| B24G | Patent annual fee: republication |
Free format text: REFERENTE AO DESPACHO 24.3 NA RPI 2048 DE 06/04/2010. TEXTO CORRETO: 12A, 13A E 14A. E COMPROVAR RECOLHIMENTO DA 15A, 16A E 17A ANUIDADES. |
|
| B21F | Lapse acc. art. 78, item iv - on non-payment of the annual fees in time | ||
| B24J | Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12) |
Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2433 DE 22-08-2017 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |