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BR9508298A - Inibidores de indolizina de spla2 - Google Patents

Inibidores de indolizina de spla2

Info

Publication number
BR9508298A
BR9508298A BR9508298A BR9508298A BR9508298A BR 9508298 A BR9508298 A BR 9508298A BR 9508298 A BR9508298 A BR 9508298A BR 9508298 A BR9508298 A BR 9508298A BR 9508298 A BR9508298 A BR 9508298A
Authority
BR
Brazil
Prior art keywords
indolizine
compounds
spla2
inhibitors
acetamides
Prior art date
Application number
BR9508298A
Other languages
English (en)
Inventor
Mutsuaki Ohtani
Sanji Hagishita
Robert Delane Dillard
Original Assignee
Shionogi & Co
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi & Co, Lilly Co Eli filed Critical Shionogi & Co
Publication of BR9508298A publication Critical patent/BR9508298A/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D221/00Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04Ortho- or peri-condensed ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/16Otologicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
BR9508298A 1994-07-21 1995-07-20 Inibidores de indolizina de spla2 BR9508298A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27844594A 1994-07-21 1994-07-21
PCT/US1995/009381 WO1996003383A1 (en) 1994-07-21 1995-07-20 INDOLIZINE sPLA2 INHIBITORS

Publications (1)

Publication Number Publication Date
BR9508298A true BR9508298A (pt) 1998-11-03

Family

ID=23065002

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9508298A BR9508298A (pt) 1994-07-21 1995-07-20 Inibidores de indolizina de spla2

Country Status (14)

Country Link
US (1) US6645976B1 (pt)
EP (1) EP0772596B1 (pt)
JP (1) JPH10505584A (pt)
KR (1) KR970704695A (pt)
CN (1) CN1158121A (pt)
AT (1) ATE251158T1 (pt)
AU (1) AU3145995A (pt)
BR (1) BR9508298A (pt)
CA (1) CA2195570A1 (pt)
DE (1) DE69531864T2 (pt)
ES (1) ES2208685T3 (pt)
HU (1) HUT77867A (pt)
MX (1) MX9700511A (pt)
WO (1) WO1996003383A1 (pt)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6177440B1 (en) 1996-10-30 2001-01-23 Eli Lilly And Company Substituted tricyclics
US6713645B1 (en) * 1996-10-30 2004-03-30 Eli Lilly And Company Substituted tricyclics
WO1998047507A1 (en) 1997-04-24 1998-10-29 Shionogi & Co., Ltd. Method for the treatment of stroke using n-heterocyclic glyoxylamide compounds
US6610728B2 (en) * 1997-08-28 2003-08-26 Eli Lilly And Company Method for treatment of non-rheumatoid arthritis
WO1999024033A1 (en) * 1997-11-12 1999-05-20 Shionogi & Co., Ltd. Method for the treatment of disorders associated with apoptosis using n-heterocyclic glyoxylamide compounds
US6407104B1 (en) 1998-03-31 2002-06-18 Shionogi & Co., Ltd. Pyrrolo[1,2-a]pyrazine spla2 inhibitor
IL129484A0 (en) * 1998-04-17 2000-02-29 Lilly Co Eli Substituted tricyclics
CN1302300A (zh) * 1998-05-21 2001-07-04 盐野义制药株式会社 吡咯并[1,2-b]哒嗪sPLA2抑制剂
US7098237B1 (en) 1998-10-14 2006-08-29 Shionogi & Co., Ltd. Remedies for ischemia reperfusion injury
AU6015600A (en) 1999-07-19 2001-02-05 Shionogi & Co., Ltd. Tricyclic compounds having spla2-inhibitory activities
AU6023200A (en) 1999-08-02 2001-02-19 Shionogi & Co., Ltd. Tricyclic compounds having spla2-inhibitory activities
JP4623483B2 (ja) 1999-08-23 2011-02-02 塩野義製薬株式会社 sPLA2阻害作用を有するピロロトリアジン誘導体
AU7559600A (en) * 1999-10-15 2001-04-23 Shionogi & Co., Ltd. V type and/or x type spla2 inhibitors
AU1304801A (en) 1999-11-15 2001-05-30 Shionogi & Co., Ltd. Tricyclic azaindolizine derivatives having an SPLA2- inhibiting effect
US7026318B2 (en) 2000-06-29 2006-04-11 Shionogi & Co., Ltd. Compounds exhibiting X-type sPLA2 inhibiting effect
AU2001267825A1 (en) 2000-06-29 2002-01-08 Shionogi And Co., Ltd. Remedies for cirrhosis
TWI314457B (pt) 2001-03-19 2009-09-11 Shionogi & Co
US20040116462A1 (en) * 2002-12-12 2004-06-17 Mitsunori Ono Indolizine compounds
JP2006504692A (ja) * 2002-09-13 2006-02-09 シンタ ファーマシューティカルズ コーポレーション インドリジンの合成方法
US20070185106A1 (en) * 2004-02-20 2007-08-09 Astrazeneca Ab Pyrrole derivatives as gonadotropin releasing hormone (gnrh) antagonists
EP1888063B1 (en) * 2005-05-18 2009-01-14 F2G Ltd. Antifungal agents
GB0518783D0 (en) * 2005-09-14 2005-10-26 Argenta Discovery Ltd Indolizine compounds
GB0623209D0 (en) * 2006-11-21 2007-01-03 F2G Ltd Antifungal agents
DK2626361T3 (en) 2008-04-24 2015-01-19 F2G Ltd Pyrrol-Antimycotics
GB0809773D0 (en) * 2008-05-29 2008-07-09 F2G Ltd Antifungal combination therapy
US20150025105A1 (en) * 2012-02-09 2015-01-22 Praveen Rao Perampalli Nekkar Indolizine derivatives
EP3415511A1 (en) 2014-11-21 2018-12-19 F2G Limited Antifungal agents
GB201609222D0 (en) 2016-05-25 2016-07-06 F2G Ltd Pharmaceutical formulation
US11819503B2 (en) 2019-04-23 2023-11-21 F2G Ltd Method of treating coccidioides infection
CN111440165B (zh) * 2020-04-13 2023-06-16 深圳职业技术学院 取代吲嗪类衍生物及其制备方法
CN111393437B (zh) * 2020-04-13 2022-11-22 深圳职业技术学院 三取代吲嗪类化合物及其制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1174124A (en) 1967-06-30 1969-12-10 Beecham Group Ltd Pharmacologically Active Indolizine Compounds
US3717644A (en) 1970-06-01 1973-02-20 L Walter 1-(di-lower alkyl amino lower alkyl)-2-phenyl-5,6,7,8-tetrahydroindolizines

Also Published As

Publication number Publication date
KR970704695A (ko) 1997-09-06
AU3145995A (en) 1996-02-22
US6645976B1 (en) 2003-11-11
HUT77867A (hu) 1998-09-28
JPH10505584A (ja) 1998-06-02
MX9700511A (es) 1997-04-30
CN1158121A (zh) 1997-08-27
HU9700179D0 (en) 1997-03-28
WO1996003383A1 (en) 1996-02-08
DE69531864T2 (de) 2004-07-22
ATE251158T1 (de) 2003-10-15
DE69531864D1 (de) 2003-11-06
CA2195570A1 (en) 1996-02-08
EP0772596A1 (en) 1997-05-14
ES2208685T3 (es) 2004-06-16
EP0772596A4 (en) 1999-01-13
EP0772596B1 (en) 2003-10-01

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Legal Events

Date Code Title Description
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 13A, 14A, 15A, 16A E 17A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: NAO APRESENTADA A GUIA DE CUMPRIMENTO DE EXIGENCIA. REFERENTE AS 8A, 9A, 10A, 11A, 12A, 13A, 14A, 15A, 16A E 17A ANUIDADES.