BR9506035A - Sistemas microeletrônicos auto-endereçáveis e automontáveis e disposotivos para análise e diagnóstico moleculares - Google Patents

Sistemas microeletrônicos auto-endereçáveis e automontáveis e disposotivos para análise e diagnóstico moleculares

Info

Publication number: BR9506035A
Authority: BR; Brazil
Prior art keywords: nucleic acid; self; selector; cell; sample
Prior art date: 1994-07-07

Application number

BR9506035A

Other languages

English (en)

Inventor

Michael J Heller

Eugene Tu

Glen A Evans

Ronald G Sosnowski

Original Assignee

Nanogem Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-07-07

Filing date

1995-07-05

Publication date

1997-10-14

1995-07-05 Application filed by Nanogem Inc filed Critical Nanogem Inc

1997-10-14 Publication of BR9506035A publication Critical patent/BR9506035A/pt

Classifications

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BR9506035A 1994-07-07 1995-07-05 Sistemas microeletrônicos auto-endereçáveis e automontáveis e disposotivos para análise e diagnóstico moleculares BR9506035A (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/271,882 US6017696A (en)	1993-11-01	1994-07-07	Methods for electronic stringency control for molecular biological analysis and diagnostics
PCT/US1995/008570 WO1996001836A1 (en)	1994-07-07	1995-07-05	Self-addressable self-assembling microelectronic systems and devices for molecular biological analysis and diagnostics

Publications (1)

Publication Number	Publication Date
BR9506035A true BR9506035A (pt)	1997-10-14

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BR9506035A BR9506035A (pt)	1994-07-07	1995-07-05	Sistemas microeletrônicos auto-endereçáveis e automontáveis e disposotivos para análise e diagnóstico moleculares

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US (3)	US6017696A (pt)
EP (1)	EP0717749B1 (pt)
JP (2)	JPH09503307A (pt)
CN (2)	CN1550556A (pt)
AT (1)	ATE232604T1 (pt)
AU (1)	AU708677B2 (pt)
BR (1)	BR9506035A (pt)
CA (1)	CA2169852C (pt)
DE (1)	DE69529601D1 (pt)
FI (1)	FI961034A7 (pt)
NZ (1)	NZ289731A (pt)
WO (1)	WO1996001836A1 (pt)

Families Citing this family (356)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6270961B1 (en)	1987-04-01	2001-08-07	Hyseq, Inc.	Methods and apparatus for DNA sequencing and DNA identification
US6197508B1 (en)	1990-09-12	2001-03-06	Affymetrix, Inc.	Electrochemical denaturation and annealing of nucleic acid
US5849486A (en)	1993-11-01	1998-12-15	Nanogen, Inc.	Methods for hybridization analysis utilizing electrically controlled hybridization
US6048690A (en) *	1991-11-07	2000-04-11	Nanogen, Inc.	Methods for electronic fluorescent perturbation for analysis and electronic perturbation catalysis for synthesis
US6051380A (en) *	1993-11-01	2000-04-18	Nanogen, Inc.	Methods and procedures for molecular biological analysis and diagnostics
US6569382B1 (en)	1991-11-07	2003-05-27	Nanogen, Inc.	Methods apparatus for the electronic, homogeneous assembly and fabrication of devices
US6652808B1 (en)	1991-11-07	2003-11-25	Nanotronics, Inc.	Methods for the electronic assembly and fabrication of devices
US6017696A (en)	1993-11-01	2000-01-25	Nanogen, Inc.	Methods for electronic stringency control for molecular biological analysis and diagnostics
US5605662A (en) *	1993-11-01	1997-02-25	Nanogen, Inc.	Active programmable electronic devices for molecular biological analysis and diagnostics
US6401267B1 (en) *	1993-09-27	2002-06-11	Radoje Drmanac	Methods and compositions for efficient nucleic acid sequencing
US6468742B2 (en) *	1993-11-01	2002-10-22	Nanogen, Inc.	Methods for determination of single nucleic acid polymorphisms using bioelectronic microchip
US5965452A (en) *	1996-07-09	1999-10-12	Nanogen, Inc.	Multiplexed active biologic array
US6306348B1 (en) *	1993-11-01	2001-10-23	Nanogen, Inc.	Inorganic permeation layer for micro-electric device
US7172864B1 (en)	1993-11-01	2007-02-06	Nanogen	Methods for electronically-controlled enzymatic reactions
US6331274B1 (en)	1993-11-01	2001-12-18	Nanogen, Inc.	Advanced active circuits and devices for molecular biological analysis and diagnostics
US6207373B1 (en) *	1998-02-25	2001-03-27	Nanogen, Inc.	Methods for determining nature of repeat units in DNA
US7582421B2 (en) *	1993-11-01	2009-09-01	Nanogen, Inc.	Methods for determination of single nucleic acid polymorphisms using a bioelectronic microchip
US20040077074A1 (en) *	1993-11-01	2004-04-22	Nanogen, Inc.	Multi-chambered analysis device
US7101661B1 (en)	1993-11-01	2006-09-05	Nanogen, Inc.	Apparatus for active programmable matrix devices
US6726880B1 (en)	1993-11-01	2004-04-27	Nanogen, Inc.	Electronic device for performing active biological operations and method of using same
US6225059B1 (en)	1993-11-01	2001-05-01	Nanogen, Inc.	Advanced active electronic devices including collection electrodes for molecular biological analysis and diagnostics
US6254827B1 (en)	1993-11-01	2001-07-03	Nanogen, Inc.	Methods for fabricating multi-component devices for molecular biological analysis and diagnostics
US6068818A (en) *	1993-11-01	2000-05-30	Nanogen, Inc.	Multicomponent devices for molecular biological analysis and diagnostics
US6129828A (en)	1996-09-06	2000-10-10	Nanogen, Inc.	Apparatus and methods for active biological sample preparation
US6315953B1 (en)	1993-11-01	2001-11-13	Nanogen, Inc.	Devices for molecular biological analysis and diagnostics including waveguides
US6309602B1 (en)	1993-11-01	2001-10-30	Nanogen, Inc.	Stacked, reconfigurable system for electrophoretic transport of charged materials
US7314708B1 (en) *	1998-08-04	2008-01-01	Nanogen, Inc.	Method and apparatus for electronic synthesis of molecular structures
US6071394A (en) *	1996-09-06	2000-06-06	Nanogen, Inc.	Channel-less separation of bioparticles on a bioelectronic chip by dielectrophoresis
US7857957B2 (en) *	1994-07-07	2010-12-28	Gamida For Life B.V.	Integrated portable biological detection system
US6403367B1 (en) *	1994-07-07	2002-06-11	Nanogen, Inc.	Integrated portable biological detection system
US6379897B1 (en)	2000-11-09	2002-04-30	Nanogen, Inc.	Methods for gene expression monitoring on electronic microarrays
US5544268A (en)	1994-09-09	1996-08-06	Deacon Research	Display panel with electrically-controlled waveguide-routing
US20040086917A1 (en) *	1995-09-27	2004-05-06	Nanogen, Inc.	Methods for electronic fluorescent perturbation for analysis and electronic perturbation catalysis for synthesis
US6387707B1 (en)	1996-04-25	2002-05-14	Bioarray Solutions	Array Cytometry
EP2290364A1 (en)	1996-04-25	2011-03-02	BioArray Solutions Ltd.	Light-controlled electrokinetic assembly of particles near surfaces
US6048691A (en) *	1996-05-13	2000-04-11	Motorola, Inc.	Method and system for performing a binding assay
US6355436B1 (en) *	1996-05-17	2002-03-12	L'ecole Centrale De Lyon	Method for analyzing biological substances in a conductive liquid medium
AU719533B2 (en) *	1996-07-12	2000-05-11	Wolf Bertling	A process and an apparatus for purifying and concentrating molecules
US7169556B2 (en) *	1996-07-29	2007-01-30	Nanosphere, Inc.	Nanoparticles having oligonucleotides attached thereto and uses therefor
CN1180248C (zh) *	1996-09-06	2004-12-15	内诺金有限公司	优化电子杂交反应的方法
US7045285B1 (en)	1996-11-05	2006-05-16	Clinical Micro Sensors, Inc.	Electronic transfer moieties attached to peptide nucleic acids
US7014992B1 (en)	1996-11-05	2006-03-21	Clinical Micro Sensors, Inc.	Conductive oligomers attached to electrodes and nucleoside analogs
US6133436A (en)	1996-11-06	2000-10-17	Sequenom, Inc.	Beads bound to a solid support and to nucleic acids
DE19646505A1 (de) *	1996-11-12	1998-05-14	Itt Ind Gmbh Deutsche	Vorrichtung zur Durchführung von Untersuchungen an Zellproben und dergleichen
EP0938674B1 (de) *	1996-11-16	2005-06-01	NMI Naturwissenschaftliches und Medizinisches Institut an der Universität Tübingen in Reutlingen Stiftung Bürgerlichen Rechts	Mikroelementenanordnung, verfahren zum kontaktieren von in einer flüssigen umgebung befindlichen zellen und verfahren zum herstellen einer mikroelementenanordnung
GB2319771B (en) *	1996-11-29	2001-09-26	Imperial College	Process
US6706473B1 (en)	1996-12-06	2004-03-16	Nanogen, Inc.	Systems and devices for photoelectrophoretic transport and hybridization of oligonucleotides
US6013459A (en)	1997-06-12	2000-01-11	Clinical Micro Sensors, Inc.	Detection of analytes using reorganization energy
NZ502246A (en) *	1997-06-20	2002-10-25	Univ New York	Electrospraying solutions of biologically active substances (proteins) on a substrate for mass fabrication of chips and libraries
DE19741715A1 (de) *	1997-09-22	1999-03-25	Hoechst Ag	Pentopyranosyl-Nucleosid, seine Herstellung und Verwendung
DE19753847A1 (de)	1997-12-04	1999-06-10	Roche Diagnostics Gmbh	Analytisches Testelement mit Kapillarkanal
DE19753850A1 (de) *	1997-12-04	1999-06-10	Roche Diagnostics Gmbh	Probennahmevorrichtung
DE19819735A1 (de) *	1998-05-02	1999-11-04	Novartis Ag	Vorrichtung und Verfahren zur Herstellung einer Anordnung von Kettenmolekülen auf einem Trägermaterial
US20030153023A1 (en) *	1999-05-13	2003-08-14	Starzl Timothy W.	Enumeration method of analyte detection
US6387632B2 (en) *	1998-06-11	2002-05-14	Hitachi, Ltd.	Polynucleotide separation method and apparatus therefor
US6761816B1 (en) *	1998-06-23	2004-07-13	Clinical Micro Systems, Inc.	Printed circuit boards with monolayers and capture ligands
US6281006B1 (en)	1998-08-24	2001-08-28	Therasense, Inc.	Electrochemical affinity assay
US6638716B2 (en)	1998-08-24	2003-10-28	Therasense, Inc.	Rapid amperometric verification of PCR amplification of DNA
KR100369694B1 (ko) *	1998-09-17	2003-01-29	인터내셔널 비지네스 머신즈 코포레이션	화학적 태그의 합성 방법
US7135283B1 (en)	1998-11-17	2006-11-14	Nanogen, Inc.	Topoisomerase type II gene polymorphisms and their use in identifying drug resistance and pathogenic strains of microorganisms
DE19854946C2 (de)	1998-11-27	2002-01-03	Guenter Von Kiedrowski	Klonieren und Kopieren an Oberflächen
US20030032029A1 (en) *	1998-12-21	2003-02-13	Nanogen, Inc.	Three dimensional apparatus and method for integrating sample preparation and multiplex assays
US6514768B1 (en) *	1999-01-29	2003-02-04	Surmodics, Inc.	Replicable probe array
US6294063B1 (en) *	1999-02-12	2001-09-25	Board Of Regents, The University Of Texas System	Method and apparatus for programmable fluidic processing
JP2002537781A (ja) *	1999-02-26	2002-11-12	モザイクテクノロジーズ	固定化捕捉プローブを有する生化学的精製装置およびその使用
US6410231B1 (en) *	1999-02-26	2002-06-25	Incyte Genomics, Inc.	SNP detection
EP1039291A1 (en) *	1999-03-26	2000-09-27	Sony International (Europe) GmbH	Optochemical sensor and method for its construction
US6238868B1 (en) *	1999-04-12	2001-05-29	Nanogen/Becton Dickinson Partnership	Multiplex amplification and separation of nucleic acid sequences using ligation-dependant strand displacement amplification and bioelectronic chip technology
US6326173B1 (en) *	1999-04-12	2001-12-04	Nanogen/Becton Dickinson Partnership	Electronically mediated nucleic acid amplification in NASBA
US6531302B1 (en) *	1999-04-12	2003-03-11	Nanogen/Becton Dickinson Partnership	Anchored strand displacement amplification on an electronically addressable microchip
US6309833B1 (en)	1999-04-12	2001-10-30	Nanogen/Becton Dickinson Partnership	Multiplex amplification and separation of nucleic acid sequences on a bioelectronic microchip using asymmetric structures
MXPA01010381A (es) *	1999-04-12	2003-07-21	Nanogen Inc	Metodos para determinar polimorfismos de acidos nucleicos sencillos utilizando un microchip bioelectronico.
WO2000062036A1 (en) *	1999-04-12	2000-10-19	Nanogen/Becton Dickinson Partnership	Amplification and separation of nucleic acid sequences using strand displacement amplification and bioelectronic microchip technology
CA2304260C (en) *	1999-04-20	2009-03-24	Japan Bioindustry Association	Method for determining a concentration of target nucleic acid molecules, nucleic acid probes for the method and method for analyzing data obtained by the method
US7312087B2 (en) *	2000-01-11	2007-12-25	Clinical Micro Sensors, Inc.	Devices and methods for biochip multiplexing
US6423536B1 (en) *	1999-08-02	2002-07-23	Molecular Dynamics, Inc.	Low volume chemical and biochemical reaction system
KR20020048425A (ko) *	1999-09-30	2002-06-22	해리 제이. 레온 하르트	마이크로전자 어레이 상의 생체분자 부착 부위
CA2386791A1 (en) *	1999-10-08	2001-04-19	Protogene Laboratories, Inc.	Method and apparatus for performing large numbers of reactions using array assembly
US6824664B1 (en)	1999-11-04	2004-11-30	Princeton University	Electrode-less dielectrophorises for polarizable particles
ATE269977T1 (de) *	1999-11-12	2004-07-15	Clinical Micro Sensors Inc	Bindungsbeschleunigungsverfahren zum nachweis von analyten
US6451191B1 (en) *	1999-11-18	2002-09-17	3M Innovative Properties Company	Film based addressable programmable electronic matrix articles and methods of manufacturing and using the same
EP2278637B2 (en) *	1999-12-01	2021-06-09	The Trustees of Princeton University	Complexes of form L2MX
DE19960076C2 (de) *	1999-12-13	2002-12-05	November Ag Molekulare Medizin	Verfahren und Vorrichtung zum Nachweis und zur Quantifizierung von Biomolekülen
US6303082B1 (en) *	1999-12-15	2001-10-16	Nanogen, Inc.	Permeation layer attachment chemistry and method
US6824669B1 (en) *	2000-02-17	2004-11-30	Motorola, Inc.	Protein and peptide sensors using electrical detection methods
JP3757412B2 (ja) *	2000-02-22	2006-03-22	横河電機株式会社	バイオチップ
US6569383B1 (en) *	2000-03-11	2003-05-27	Intrinsic Bioprobes, Inc.	Bioactive chip mass spectrometry
EP1134294A3 (en) *	2000-03-16	2004-06-30	Kabushiki Kaisha Toshiba	Method for producing immobilized nucleic acid strand
DE10013990C2 (de) *	2000-03-22	2003-12-04	Invitek Biotechnik & Biodesign	Polyfunktionelles Trägermaterial für die komplexe Nukleinsäureanalytik
AU2000267888A1 (en) *	2000-03-28	2001-10-08	Nanogen, Inc.	Methods for determination of single nucleic acid polymorphisms using a bioelectronic microchip
DE10015818A1 (de)	2000-03-30	2001-10-18	Infineon Technologies Ag	Biosensor und Verfahren zum Ermitteln makromolekularer Biopolymere mit einem Biosensor
DE10015547C2 (de) *	2000-03-30	2002-02-14	Aventis Res & Tech Gmbh & Co	Verfahren zur Detektion von Molekülen mittels Impedanzspektroskopie und Vorrichtung zur Durchführung dieser Verfahren
CA2302827A1 (en) *	2000-04-12	2001-10-12	Michelle Furtado	Oligonucleotide and dna de-hybridization on surfaces
US8232582B2 (en)	2000-04-24	2012-07-31	Life Technologies Corporation	Ultra-fast nucleic acid sequencing device and a method for making and using the same
US7001792B2 (en) *	2000-04-24	2006-02-21	Eagle Research & Development, Llc	Ultra-fast nucleic acid sequencing device and a method for making and using the same
US6413792B1 (en)	2000-04-24	2002-07-02	Eagle Research Development, Llc	Ultra-fast nucleic acid sequencing device and a method for making and using the same
CA2407973C (en) *	2000-05-03	2011-06-07	Jen-Jr Gau	Biological identification system with integrated sensor chip
CA2413634A1 (en) *	2000-06-14	2001-12-20	Peter R. C. Gascoyne	Method and apparatus for combined magnetophoretic and dielectrophoretic manipulation of analyte mixtures
EP1289661B1 (en) *	2000-06-14	2006-05-10	Board of Regents, The University of Texas System	Apparatus and method for fluid injection
ATE304174T1 (de) *	2000-06-14	2005-09-15	Univ Texas	Systeme und verfahren zur zellteilbevölkerungsanalyse
US6602400B1 (en)	2000-06-15	2003-08-05	Motorola, Inc.	Method for enhanced bio-conjugation events
US9709559B2 (en)	2000-06-21	2017-07-18	Bioarray Solutions, Ltd.	Multianalyte molecular analysis using application-specific random particle arrays
CA2635452A1 (en) *	2000-06-21	2001-12-27	Bioarray Solutions, Ltd.	Looped probe design to control hybridization stringency
CN1137999C (zh) *	2000-07-04	2004-02-11	清华大学	集成式微阵列装置
EP1930447A3 (en) *	2000-07-11	2008-06-25	Kirk Hogan	Methods and compositions for perioperative genomic profiling
EP1349956A2 (en) *	2000-08-02	2003-10-08	SurModics, Inc.	Replicable probe array
DE10038237A1 (de) *	2000-08-04	2002-02-14	Aventis Res & Tech Gmbh & Co	Verfahren zum Nachweis von Mutationen in Nucleotidsequenzen
WO2002019407A2 (en) *	2000-08-30	2002-03-07	National Research Council Of Canada	A method for spatial distribution of chemical groups on a semiconductor surface
US6780584B1 (en)	2000-09-27	2004-08-24	Nanogen, Inc.	Electronic systems and component devices for macroscopic and microscopic molecular biological reactions, analyses and diagnostics
US7060442B2 (en) *	2000-10-30	2006-06-13	Regents Of The University Of Michigan	Modulators on Nod2 signaling
EP2202520A1 (en)	2000-11-27	2010-06-30	Intelligent Medical Devices LLC	Clinically intelligent diagnostic devices and methods
CA2428568A1 (en) *	2000-11-28	2002-06-06	Nanogen, Inc.	Microtiter plate format device and methods for separating differently charged molecules using an electric field
AU2002241810A1 (en) *	2001-01-04	2002-07-16	Eagle Research And Development, Llc	Method of patterning a mask on the surface of a substrate and product manufactured thereby
US20050037348A1 (en) *	2001-02-19	2005-02-17	Akira Tsukada	Charged component detector, its using method and detection panel
DE10109777A1 (de) *	2001-03-01	2002-09-19	Infineon Technologies Ag	Verfahren zum Erfassen von makromolekularen Biopolymeren mittels mindestens einer Einheit zum Immobilisieren von makromolekularen Biopolymeren
DE10109779A1 (de) *	2001-03-01	2002-09-19	Infineon Technologies Ag	Vorrichtung und Verfahren zum Erfassen von makromolekularen Biopolymeren mittels mindestens einer Einheit zum Immobilisieren von makromolekularen Biopolymeren
DE10296423T8 (de) *	2001-03-02	2004-07-08	William Marsh Rice University, Houston	Mittles elektrischem Potential unterstützter Aufbau von molekularen Vorrichtungen
DE10112778A1 (de) *	2001-03-16	2002-10-02	Infineon Technologies Ag	Biosensor, Vorrichtung und Verfahren zum Erfassen von Nukleinsäuren mittels mindestens zwei Einheiten zum Immobilisieren von Nukleinsäuren
DE10113550A1 (de) *	2001-03-20	2002-10-02	Infineon Technologies Ag	Verfahren zum Erfassen von makromolekularen Biopolymeren mittels einer Elektrodenanordnung
WO2002087761A1 (en) *	2001-04-26	2002-11-07	Vrije Universiteit Brussel	Method for accelaration and intensification of target-receptor binding and devices therefor
US7214300B2 (en) *	2001-06-04	2007-05-08	Epocal Inc.	Integrated electrokinetic devices and methods of manufacture
US7262063B2 (en)	2001-06-21	2007-08-28	Bio Array Solutions, Ltd.	Directed assembly of functional heterostructures
US7166202B2 (en) *	2001-07-16	2007-01-23	Protein Forest, Inc.	Matrixes, arrays, systems and methods
US6893822B2 (en)	2001-07-19	2005-05-17	Nanogen Recognomics Gmbh	Enzymatic modification of a nucleic acid-synthetic binding unit conjugate
JP4098715B2 (ja) *	2001-07-25	2008-06-11	ポスコ	核酸ハイブリッド化検出方法
DE10137342A1 (de) *	2001-07-31	2003-03-06	Infineon Technologies Ag	Biosensor und Verfahren zum Erfassen von makromolekularen Biopolymeren mittels mindestens einer Einheit zum Immobilisieren von makromolekularen Biopolymeren
US20030148314A1 (en) *	2001-08-01	2003-08-07	Millennium Pharmaceuticals, Inc.	Compositions, kits, and methods for identification, assessment, prevention, and therapy of colon cancer
US20030119028A1 (en) *	2001-08-08	2003-06-26	Graves David J.	Device and methods for enhanced microarray hybridization reactions
US20030040000A1 (en) *	2001-08-08	2003-02-27	Connolly Dennis M.	Methods for attaching nucleic acid molecules to electrically conductive surfaces
US7666661B2 (en)	2001-08-27	2010-02-23	Platypus Technologies, Llc	Substrates, devices, and methods for quantitative liquid crystal assays
US10539561B1 (en)	2001-08-30	2020-01-21	Customarray, Inc.	Enzyme-amplified redox microarray detection process
US7198754B2 (en)	2001-08-31	2007-04-03	Kabushiki Kaisha Toshiba	Biological material detection element, biological material detection method and apparatus, charged material moving apparatus
JP3848226B2 (ja) *	2001-08-31	2006-11-22	株式会社東芝	生体物質検出装置及び生体物質検出素子
US6974671B1 (en)	2001-09-12	2005-12-13	Salk Institute For Biological Studies	Methods for indentifying compounds that modulate gluconeogenesis through the binding of CREB to the PGC-1 promoter
KR100449069B1 (ko) *	2001-09-12	2004-09-18	한국전자통신연구원	미소전극, 미소전극 어레이 및 미소전극 제조 방법
US7108975B2 (en) *	2001-09-21	2006-09-19	Regents Of The University Of Michigan	Atlastin
US7582425B2 (en) *	2001-09-21	2009-09-01	The Regents Of The University Of Michigan	Atlastin
WO2003034029A2 (en)	2001-10-15	2003-04-24	Bioarray Solutions, Ltd.	Multiplexed analysis of polymorphic loci by concurrent interrogation and enzyme-mediated detection
US7074519B2 (en) *	2001-10-26	2006-07-11	The Regents Of The University Of California	Molehole embedded 3-D crossbar architecture used in electrochemical molecular memory device
AU2002353997A1 (en) *	2001-11-01	2003-05-12	Rensselaer Polytechnic Institute	In vitro metabolic engineering on microscale devices
US20030175947A1 (en) *	2001-11-05	2003-09-18	Liu Robin Hui	Enhanced mixing in microfluidic devices
DE10155892A1 (de) *	2001-11-14	2003-05-28	Infineon Technologies Ag	Verfahren zum Erfassen von makromolekularen Biopolymeren mittels mindestens einer Einheit zum Immobilisieren von makromolekularen Biopolymeren und Biosensor zum Erfassen von makromolekularen Biopolymeren
US7413859B2 (en) *	2001-11-14	2008-08-19	Siemens Aktiengesellschaft	Method and biosensors for detecting macromolecular biopolymers
US6703819B2 (en)	2001-12-03	2004-03-09	Board Of Regents, The University Of Texas System	Particle impedance sensor
US6960298B2 (en)	2001-12-10	2005-11-01	Nanogen, Inc.	Mesoporous permeation layers for use on active electronic matrix devices
US6866762B2 (en) *	2001-12-20	2005-03-15	Board Of Regents, University Of Texas System	Dielectric gate and methods for fluid injection and control
US20030119057A1 (en) *	2001-12-20	2003-06-26	Board Of Regents	Forming and modifying dielectrically-engineered microparticles
US7255986B2 (en) *	2002-01-31	2007-08-14	The Board Of Trustees Operating Michigan State University	Compositions for the diagnosis and treatment of epizootic catarrhal enteritis in ferrets
EP1333281A3 (en) *	2002-01-31	2004-01-14	Fuji Photo Film Co., Ltd.	Method and reactor for conducting receptor-ligand association reactions
JP3888947B2 (ja) *	2002-02-01	2007-03-07	日清紡績株式会社	生体分子の担体への固定法
US6887362B2 (en) *	2002-02-06	2005-05-03	Nanogen, Inc.	Dielectrophoretic separation and immunoassay methods on active electronic matrix devices
WO2003066906A2 (en) *	2002-02-07	2003-08-14	Eastern Virginia Medical School Of The Medical College Of Hampton Roads	Diagnostic microarray and method of use thereof
GB0205455D0 (en)	2002-03-07	2002-04-24	Molecular Sensing Plc	Nucleic acid probes, their synthesis and use
JP3856214B2 (ja) *	2002-03-11	2006-12-13	横河電機株式会社	蛍光強度増強ビーズ
DE10214719A1 (de) *	2002-04-03	2003-11-20	Infineon Technologies Ag	Sensor zur qualitativen und quantitativen Bestimmung von (bio)organischen Oligomeren und Polymeren, Analyseverfahren hierzu sowie Verfahren zur Herstellung des Sensors
US20040038260A1 (en) *	2002-04-18	2004-02-26	Imedd, Inc.	Nanopump device for analyzing DNA sequences
US20030211478A1 (en) *	2002-05-08	2003-11-13	Gentel Corporation	Transcription factor profiling on a solid surface
US20040009516A1 (en) *	2002-05-08	2004-01-15	Nelson Bryce P.	Arrayed SPR prism
US6878523B2 (en) *	2002-05-08	2005-04-12	Gentel Bio Surfaces, Inc.	Molecular interaction assays on a solid surface
US6841379B2 (en) *	2002-05-15	2005-01-11	Beckman Coulter, Inc.	Conductive microplate
CA2486812A1 (en) *	2002-05-22	2004-05-21	Platypus Technologies, Llc	Substrates, devices, and methods for cellular assays
DE10224150B4 (de) *	2002-05-27	2004-04-01	Siemens Ag	Reaktor zur Behandlung eines Probenmediums
US20030222905A1 (en) *	2002-06-04	2003-12-04	Argonaut Technologies, Inc.	Recipe recorder for automated chemistry
DE10229210A1 (de) *	2002-06-28	2004-01-29	november Aktiengesellschaft Gesellschaft für Molekulare Medizin	Vorrichtung zur Detektion eines Analyten
US7470533B2 (en)	2002-12-20	2008-12-30	Acea Biosciences	Impedance based devices and methods for use in assays
US8263375B2 (en)	2002-12-20	2012-09-11	Acea Biosciences	Dynamic monitoring of activation of G-protein coupled receptor (GPCR) and receptor tyrosine kinase (RTK) in living cells using real-time microelectronic cell sensing technology
US8206903B2 (en)	2002-12-20	2012-06-26	Acea Biosciences	Device and method for electroporation-based delivery of molecules into cells and dynamic monitoring of cell responses
US7560269B2 (en)	2002-12-20	2009-07-14	Acea Biosciences, Inc.	Real time electronic cell sensing system and applications for cytotoxicity profiling and compound assays
JP2005537498A (ja)	2002-07-20	2005-12-08	アセアバイオサイエンシーズ，インク．	インピーダンスによる測定装置および方法
US7468255B2 (en)	2002-12-20	2008-12-23	Acea Biosciences	Method for assaying for natural killer, cytotoxic T-lymphocyte and neutrophil-mediated killing of target cells using real-time microelectronic cell sensing technology
US7732127B2 (en)	2002-12-20	2010-06-08	Acea Biosciences, Inc.	Dynamic monitoring of cell adhesion and spreading using the RT-CES system
US20040011650A1 (en) *	2002-07-22	2004-01-22	Frederic Zenhausern	Method and apparatus for manipulating polarizable analytes via dielectrophoresis
JP3917640B2 (ja) *	2002-07-26	2007-05-23	株式会社東芝	核酸プローブ固定化基体を用いた標的核酸の存在を検出する方法
US7601493B2 (en) *	2002-07-26	2009-10-13	Nanogen, Inc.	Methods and apparatus for screening and detecting multiple genetic mutations
AU2003254298A1 (en)	2002-08-02	2004-02-23	Stratatech Corporation	Species specific dna detection
US7153687B2 (en)	2002-08-13	2006-12-26	Hong Kong Dna Chips Limited	Apparatus and methods for detecting DNA in biological samples
US7267751B2 (en) *	2002-08-20	2007-09-11	Nanogen, Inc.	Programmable multiplexed active biologic array
US7563600B2 (en)	2002-09-12	2009-07-21	Combimatrix Corporation	Microarray synthesis and assembly of gene-length polynucleotides
US6911132B2 (en) *	2002-09-24	2005-06-28	Duke University	Apparatus for manipulating droplets by electrowetting-based techniques
US7329545B2 (en) *	2002-09-24	2008-02-12	Duke University	Methods for sampling a liquid flow
US6863731B2 (en) *	2002-10-18	2005-03-08	Controls Corporation Of America	System for deposition of inert barrier coating to increase corrosion resistance
US20040086872A1 (en) *	2002-10-31	2004-05-06	Childers Winthrop D.	Microfluidic system for analysis of nucleic acids
US7217542B2 (en) *	2002-10-31	2007-05-15	Hewlett-Packard Development Company, L.P.	Microfluidic system for analyzing nucleic acids
US7932098B2 (en) *	2002-10-31	2011-04-26	Hewlett-Packard Development Company, L.P.	Microfluidic system utilizing thin-film layers to route fluid
US7526114B2 (en)	2002-11-15	2009-04-28	Bioarray Solutions Ltd.	Analysis, secure access to, and transmission of array images
JP3956389B2 (ja) *	2002-12-11	2007-08-08	横河電機株式会社	ハイブリダイゼーション法およびハイブリダイゼーション用装置
US8206904B2 (en) *	2002-12-18	2012-06-26	Third Wave Technologies, Inc.	Detection of nucleic acids
EP2361991A1 (en)	2002-12-18	2011-08-31	Third Wave Technologies, Inc.	Detection of small nucleic acids
US9612234B2 (en)	2008-05-05	2017-04-04	Acea Biosciences, Inc.	Data analysis of impedance-based cardiomyocyte-beating signals as detected on real-time cell analysis (RTCA) cardio instruments
US10215748B2 (en)	2002-12-20	2019-02-26	Acea Biosciences, Inc.	Using impedance-based cell response profiling to identify putative inhibitors for oncogene addicted targets or pathways
US10539523B2 (en)	2002-12-20	2020-01-21	Acea Biosciences, Inc.	System and method for monitoring cardiomyocyte beating, viability, morphology, and electrophysiological properties
US11346797B2 (en)	2002-12-20	2022-05-31	Agilent Technologies, Inc.	System and method for monitoring cardiomyocyte beating, viability, morphology and electrophysiological properties
US10551371B2 (en)	2003-11-10	2020-02-04	Acea Biosciences, Inc.	System and method for monitoring cardiomyocyte beating, viability and morphology and for screening for pharmacological agents which may induce cardiotoxicity or modulate cardiomyocyte function
US7297780B2 (en)	2003-01-06	2007-11-20	Third Wave Technologies, Inc.	Reactive functional groups for preparation of modified nucleic acid
GB0302058D0 (en) *	2003-01-29	2003-02-26	Univ Cranfield	Replication of nucleic acid arrays
US20050014134A1 (en) *	2003-03-06	2005-01-20	West Jason Andrew Appleton	Viral identification by generation and detection of protein signatures
WO2004104177A2 (en) *	2003-05-15	2004-12-02	Integrated Nano-Technologies, Llc	Methods for localizing target molecules in a flowing fluid sample
US7384792B1 (en) *	2003-05-27	2008-06-10	Opto Trace Technologies, Inc.	Method of fabricating nano-structured surface and configuration of surface enhanced light scattering probe
ES2661168T3 (es) *	2003-07-12	2018-03-27	Accelerate Diagnostics, Inc.	Biodetección sensible y rápida
US20120077206A1 (en)	2003-07-12	2012-03-29	Accelr8 Technology Corporation	Rapid Microbial Detection and Antimicrobial Susceptibility Testing
US7341841B2 (en) *	2003-07-12	2008-03-11	Accelr8 Technology Corporation	Rapid microbial detection and antimicrobial susceptibility testing
CA2533659A1 (en)	2003-07-25	2005-03-10	Platypus Technologies, Llc	Liquid crystal based analyte detection
GB0318808D0 (en) *	2003-08-11	2003-09-10	Toshiba Res Europ Ltd	An encoded carrier
WO2005029705A2 (en) *	2003-09-18	2005-03-31	Bioarray Solutions, Ltd.	Number coding for identification of subtypes of coded types of solid phase carriers
PT1664722E (pt) *	2003-09-22	2011-12-28	Bioarray Solutions Ltd	Polielectrólito imobilizado à superfície com grupos funcionais múltiplos capazes de se ligarem covalentemente às biomoléculas
JP4328168B2 (ja) *	2003-10-02	2009-09-09	ソニー株式会社	毛細管現象を利用する物質間の相互作用検出部と該検出部を用いる方法及びバイオアッセイ用基板
US7390622B2 (en) *	2003-10-16	2008-06-24	Hai Kang Life Corporation Limited	Apparatus and methods for detecting nucleic acid in biological samples
AU2004286252A1 (en)	2003-10-28	2005-05-12	Bioarray Solutions Ltd.	Optimization of gene expression analysis using immobilized capture probes
WO2005045059A2 (en) *	2003-10-28	2005-05-19	Bioarray Solutions Ltd.	Allele assignment and probe selection in multiplexed assays of polymorphic targets
PT1694859E (pt)	2003-10-29	2015-04-13	Bioarray Solutions Ltd	Análise de ácidos nucleicos multiplexada através de fragmentação de adn de cadeia dupla
US20070207055A1 (en) *	2003-10-31	2007-09-06	Commissariat A L'energie Atomique	Operating Device Comprising A Localized Zone For The Capture Of A Drop A Liquid Of Interest
FR2861608B1 (fr) *	2003-10-31	2005-12-23	Commissariat Energie Atomique	Dispositif de travail comportant des zones de travail bordees, laboratoire sur puce et microsysteme
CA2545482A1 (en) *	2003-11-10	2005-05-26	Platypus Technologies, Llc	Substrates, devices, and methods for cellular assays
EP1692258A4 (en)	2003-11-12	2007-03-21	Xiao Xu	REAL-TIME ELECTRONIC CELL DETECTION SYSTEMS FOR CELL-BASED TESTS
EP1733265A4 (en) *	2004-01-22	2009-06-24	Incom Inc	INTERROGATED FIBER OPTIC MICROFLUIDIC EQUIPMENT
US7358113B2 (en) *	2004-01-28	2008-04-15	Zettacore, Inc.	Processing systems and methods for molecular memory
US7432057B2 (en) *	2004-01-30	2008-10-07	Michigan State University	Genetic test for PSE-susceptible turkeys
US7384779B2 (en) *	2004-04-12	2008-06-10	Corning Incorporated	Porous substrate plates and the use thereof
US7462451B2 (en) *	2004-04-26	2008-12-09	Third Wave Technologies, Inc.	Compositions for modifying nucleic acids
KR101506727B1 (ko) *	2004-05-13	2015-04-03	나노바이오심 인크.	나노-ｐｃｒ: 핵산 증폭 및 검출을 위한 방법 및 장치
US8974652B2 (en)	2004-05-28	2015-03-10	Board Of Regents, The University Of Texas System	Programmable fluidic processors
JP3952042B2 (ja) *	2004-06-07	2007-08-01	ソニー株式会社	凹状部位を有する電極を備えるハイブリダイゼーション検出部と該検出部を備えるｄｎａチップ
FR2872809B1 (fr) *	2004-07-09	2006-09-15	Commissariat Energie Atomique	Methode d'adressage d'electrodes
US7363170B2 (en) *	2004-07-09	2008-04-22	Bio Array Solutions Ltd.	Transfusion registry network providing real-time interaction between users and providers of genetically characterized blood products
US7848889B2 (en)	2004-08-02	2010-12-07	Bioarray Solutions, Ltd.	Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification
CA2513340A1 (en) *	2004-08-25	2006-02-25	F. Hoffmann-La Roche Ag	Reusable substrate for dna microarray production
US7828954B2 (en) *	2004-09-21	2010-11-09	Gamida For Life B.V.	Electrode based patterning of thin film self-assembled nanoparticles
US7524672B2 (en) *	2004-09-22	2009-04-28	Sandia Corporation	Microfluidic microarray systems and methods thereof
US7314542B2 (en) *	2004-09-23	2008-01-01	Nanogen, Inc.	Methods and materials for optimization of electronic transportation and hybridization reactions
US7592139B2 (en)	2004-09-24	2009-09-22	Sandia National Laboratories	High temperature flow-through device for rapid solubilization and analysis
US20060102471A1 (en)	2004-11-18	2006-05-18	Karl Maurer	Electrode array device having an adsorbed porous reaction layer
WO2006081558A2 (en)	2005-01-28	2006-08-03	Duke University	Apparatuses and methods for manipulating droplets on a printed circuit board
US7875426B2 (en) *	2005-02-04	2011-01-25	University Of South Florida	DNA biochip and methods of use
US20090203547A1 (en) *	2005-02-18	2009-08-13	Albert Banes	Gene and Cognate Protein Profiles and Methods to Determine Connective Tissue Markers in Normal and Pathologic Conditions
US20070034513A1 (en)	2005-03-25	2007-02-15	Combimatrix Corporation	Electrochemical deblocking solution for electrochemical oligomer synthesis on an electrode array
US9394167B2 (en)	2005-04-15	2016-07-19	Customarray, Inc.	Neutralization and containment of redox species produced by circumferential electrodes
US7439055B1 (en)	2005-05-03	2008-10-21	Sandia Corporation	Biomolecular detection device
US7939257B2 (en) *	2005-05-12	2011-05-10	Third Wave Technologies, Inc.	Polymorphic GHSR nucleic acids and uses thereof
US7655081B2 (en) *	2005-05-13	2010-02-02	Siluria Technologies, Inc.	Plating bath and surface treatment compositions for thin film deposition
US8486629B2 (en)	2005-06-01	2013-07-16	Bioarray Solutions, Ltd.	Creation of functionalized microparticle libraries by oligonucleotide ligation or elongation
US7410762B1 (en)	2005-06-27	2008-08-12	Sandia Corporation	Method for detecting biomolecules
EP1749917B1 (de) *	2005-07-25	2013-09-25	BERNINA International AG	Vorrichtung zum Sichern der Oberfadenschlaufe nach dem Einfädeln
US7662572B2 (en)	2005-08-25	2010-02-16	Platypus Technologies, Llc.	Compositions and liquid crystals
US20070065877A1 (en)	2005-09-19	2007-03-22	Combimatrix Corporation	Microarray having a base cleavable succinate linker
US20070207455A1 (en) *	2005-11-17	2007-09-06	Third Wave Technologies, Inc.	Compositions and methods for detecting an HCV-1 subtype
CN101495869B (zh)	2005-11-30	2013-06-19	麻省理工学院	病原体检测方法
US20070231805A1 (en) *	2006-03-31	2007-10-04	Baynes Brian M	Nucleic acid assembly optimization using clamped mismatch binding proteins
WO2007124105A2 (en)	2006-04-21	2007-11-01	Nanobiosym, Inc.	Single-molecule platform for drug discovery: methods and apparatuses for drug discovery, including discovery of anticancer and antiviral agents
US7674924B2 (en) *	2006-05-22	2010-03-09	Third Wave Technologies, Inc.	Compositions, probes, and conjugates and uses thereof
CN103146825B (zh)	2006-06-01	2017-08-25	第三次浪潮技术公司	核酸的检测
US7759062B2 (en) *	2006-06-09	2010-07-20	Third Wave Technologies, Inc.	T-structure invasive cleavage assays, consistent nucleic acid dispensing, and low level target nucleic acid detection
WO2008021071A2 (en)	2006-08-07	2008-02-21	Platypus Technologies, Llc	Substrates, devices, and methods for cellular assays
US7842499B2 (en) *	2006-08-07	2010-11-30	Platypus Technologies, Llc	Substrates, devices, and methods for cellular assays
US20100056388A1 (en) *	2006-08-21	2010-03-04	Cnvgenes, Inc.	Nucleic acid array having fixed nucleic acid anti-probes and complementary free nucleic acid probes
US7687103B2 (en) *	2006-08-31	2010-03-30	Gamida For Life B.V.	Compositions and methods for preserving permeation layers for use on active electronic matrix devices
WO2008027558A2 (en)	2006-08-31	2008-03-06	Codon Devices, Inc.	Iterative nucleic acid assembly using activation of vector-encoded traits
US20080057586A1 (en) *	2006-09-05	2008-03-06	Light James P	Fluorescent Cartridge for Calibration of a Microarray Reader
US8041515B2 (en)	2006-09-20	2011-10-18	Acea Biosciences, Inc.	Use of impedance-based cytological profiling to classify cellular response profiles upon exposure to biologically active agents
CN101848757B (zh) *	2007-07-13	2013-12-04	里兰斯坦福初级大学理事会	用于改进的生物测定法的使用电场的方法和设备
US8268246B2 (en) *	2007-08-09	2012-09-18	Advanced Liquid Logic Inc	PCB droplet actuator fabrication
US9968935B2 (en) *	2007-08-20	2018-05-15	Platypus Technologies, Llc	Devices for cell assays
US20100256017A1 (en) *	2007-09-17	2010-10-07	Harry Benjamin Larman	Supramolecular nanostamping printing device
KR20100085911A (ko) *	2007-10-09	2010-07-29	유니버시티 오브 노트르 담 디락	다중 타겟 검출을 위한 미소유체 플랫폼
JP5651022B2 (ja) *	2008-03-15	2015-01-07	ホロジック，インコーポレーテッド	増幅反応中の核酸分子を分析するための組成物及び方法
WO2009132667A1 (de) *	2008-04-30	2009-11-05	Micronas Gmbh	Verfahren zum nachweisen und/oder bestimmen der konzentration eines liganden
WO2009137440A1 (en)	2008-05-05	2009-11-12	Acea Biosciences, Inc.	Label-free monitoring of excitation-contraction coupling and excitable cells using impedance based systems with millisecond time resolution
US8472683B2 (en) *	2008-05-09	2013-06-25	General Electric Company	Motion correction in tomographic images
JP4997181B2 (ja) *	2008-06-13	2012-08-08	株式会社日立ハイテクノロジーズ	核酸分析デバイス及び核酸分析装置
US8178355B2 (en) *	2008-09-15	2012-05-15	Platypus Technologies, Llc.	Detection of vapor phase compounds by changes in physical properties of a liquid crystal
US8945912B2 (en) *	2008-09-29	2015-02-03	The Board Of Trustees Of The University Of Illinois	DNA sequencing and amplification systems using nanoscale field effect sensor arrays
GB2467338A (en) *	2009-01-30	2010-08-04	Sharp Kk	Electrical analyte sensor with optical output
EP2401388A4 (en) *	2009-02-23	2012-12-05	Univ Georgetown	SPECIFIC SEQUENCE SEQUENCE DETECTION OF NUCLEOTIDE SEQUENCES
US20110091931A1 (en) *	2009-04-24	2011-04-21	Colby Pharmaceutical Company	Methods and Kits for Determining Oxygen Free Radical (OFR) Levels in Animal and Human Tissues as a Prognostic Marker for Cancer and Other Pathophysiologies
WO2011056872A2 (en)	2009-11-03	2011-05-12	Gen9, Inc.	Methods and microfluidic devices for the manipulation of droplets in high fidelity polynucleotide assembly
WO2011066185A1 (en)	2009-11-25	2011-06-03	Gen9, Inc.	Microfluidic devices and methods for gene synthesis
CN102103112B (zh) *	2009-12-16	2013-05-01	中国科学院电子学研究所	一种识别残留农药的光寻址分子印迹阵列传感器
US9217144B2 (en)	2010-01-07	2015-12-22	Gen9, Inc.	Assembly of high fidelity polynucleotides
WO2011090793A2 (en)	2010-01-20	2011-07-28	Customarray, Inc.	Multiplex microarray of serially deposited biomolecules on a microarray
US8974651B2 (en)	2010-04-17	2015-03-10	C.C. Imex	Illuminator for visualization of fluorophores
EP4039363A1 (en)	2010-11-12	2022-08-10	Gen9, Inc.	Protein arrays and methods of using and making the same
US9295965B2 (en)	2010-11-12	2016-03-29	Gen9, Inc.	Methods and devices for nucleic acid synthesis
US10254204B2 (en)	2011-03-07	2019-04-09	Accelerate Diagnostics, Inc.	Membrane-assisted purification
US9434937B2 (en)	2011-03-07	2016-09-06	Accelerate Diagnostics, Inc.	Rapid cell purification systems
CN103797108B (zh)	2011-08-05	2015-12-09	株式会社东芝	多核酸扩增反应用具
EP2562536B1 (en)	2011-08-22	2018-08-01	Nxp B.V.	Analyte detection method and analyte detection apparatus
IL302248A (en)	2011-08-26	2023-06-01	Gen9 Inc	Compositions and methods for high fidelity assembly of nucleic acids
US10150993B2 (en) *	2011-12-22	2018-12-11	Ibis Biosciences, Inc.	Macromolecule positioning by electrical potential
EP2812344A4 (en)	2012-02-07	2015-10-28	Vibrant Holdings Llc	SUBSTRATES, PEPTIDE NETWORKS AND METHODS
US9150853B2 (en)	2012-03-21	2015-10-06	Gen9, Inc.	Methods for screening proteins using DNA encoded chemical libraries as templates for enzyme catalysis
EP2836482B1 (en)	2012-04-10	2019-12-25	The Regents of The University of California	Compositions and methods for treating cancer
LT2841601T (lt)	2012-04-24	2019-07-10	Gen9, Inc.	Nukleorūgščių rūšiavimo būdai ir multipleksinis preparatyvinis in vitro klonavimas
AU2013205064B2 (en)	2012-06-04	2015-07-30	Gen-Probe Incorporated	Compositions and Methods for Amplifying and Characterizing HCV Nucleic Acid
IL236303B (en)	2012-06-25	2022-07-01	Gen9 Inc	Methods for high-throughput nucleic acid assembly and sequencing
US10006909B2 (en)	2012-09-28	2018-06-26	Vibrant Holdings, Llc	Methods, systems, and arrays for biomolecular analysis
US10286376B2 (en)	2012-11-14	2019-05-14	Vibrant Holdings, Llc	Substrates, systems, and methods for array synthesis and biomolecular analysis
EP3702782B1 (en)	2013-02-15	2022-04-06	Vibrant Holdings, LLC	Methods and compositions for amplified electrochemiluminescence detection
US10933417B2 (en)	2013-03-15	2021-03-02	Nanobiosym, Inc.	Systems and methods for mobile device analysis of nucleic acids and proteins
US9677109B2 (en)	2013-03-15	2017-06-13	Accelerate Diagnostics, Inc.	Rapid determination of microbial growth and antimicrobial susceptibility
UY35464A (es)	2013-03-15	2014-10-31	Araxes Pharma Llc	Inhibidores covalentes de kras g12c.
JO3805B1 (ar)	2013-10-10	2021-01-31	Araxes Pharma Llc	مثبطات كراس جي12سي
CA2928598C (en) *	2013-12-19	2022-11-29	M. Shane Bowen	Substrates comprising nano-patterning surfaces and methods of preparing thereof
WO2015103225A1 (en)	2013-12-31	2015-07-09	Illumina, Inc.	Addressable flow cell using patterned electrodes
US9835587B2 (en)	2014-04-01	2017-12-05	C.C. Imex	Electrophoresis running tank assembly
JO3556B1 (ar)	2014-09-18	2020-07-05	Araxes Pharma Llc	علاجات مدمجة لمعالجة السرطان
US10011600B2 (en)	2014-09-25	2018-07-03	Araxes Pharma Llc	Methods and compositions for inhibition of Ras
US9862701B2 (en)	2014-09-25	2018-01-09	Araxes Pharma Llc	Inhibitors of KRAS G12C mutant proteins
US10253355B2 (en)	2015-03-30	2019-04-09	Accelerate Diagnostics, Inc.	Instrument and system for rapid microorganism identification and antimicrobial agent susceptibility testing
KR20170132856A (ko)	2015-03-30	2017-12-04	액셀러레이트 다이어그노스틱스, 아이엔씨.	신속한 미생물 동정 및 항균제 감수성 시험을 위한 기기 및 시스템
MX382355B (es)	2015-04-10	2025-03-13	Araxes Pharma Llc	Compuestos de quinazolina sustituidos y métodos de uso de los mismos.
MX2017013275A (es)	2015-04-15	2018-01-26	Araxes Pharma Llc	Inhibidores triciclicos fusionados de kras y metodos de uso de los mismos.
EP3112841A1 (en) *	2015-06-30	2017-01-04	Gnothis Holding SA	Single molecule analysis in an electrical field
US10144724B2 (en)	2015-07-22	2018-12-04	Araxes Pharma Llc	Substituted quinazoline compounds and methods of use thereof
WO2017058902A1 (en)	2015-09-28	2017-04-06	Araxes Pharma Llc	Inhibitors of kras g12c mutant proteins
US10730867B2 (en)	2015-09-28	2020-08-04	Araxes Pharma Llc	Inhibitors of KRAS G12C mutant proteins
WO2017058728A1 (en)	2015-09-28	2017-04-06	Araxes Pharma Llc	Inhibitors of kras g12c mutant proteins
WO2017058792A1 (en)	2015-09-28	2017-04-06	Araxes Pharma Llc	Inhibitors of kras g12c mutant proteins
WO2017058915A1 (en)	2015-09-28	2017-04-06	Araxes Pharma Llc	Inhibitors of kras g12c mutant proteins
US10647703B2 (en)	2015-09-28	2020-05-12	Araxes Pharma Llc	Inhibitors of KRAS G12C mutant proteins
WO2017058807A1 (en)	2015-09-28	2017-04-06	Araxes Pharma Llc	Inhibitors of kras g12c mutant proteins
WO2017070256A2 (en)	2015-10-19	2017-04-27	Araxes Pharma Llc	Method for screening inhibitors of ras
KR20180081596A (ko)	2015-11-16	2018-07-16	아락세스 파마 엘엘씨	치환된 헤테로사이클릭 그룹을 포함하는 2-치환된 퀴나졸린 화합물 및 이의 사용 방법
US12066428B2 (en)	2015-11-20	2024-08-20	Agilent Technologies, Inc.	Cell-substrate impedance monitoring of cancer cells
WO2017100546A1 (en)	2015-12-09	2017-06-15	Araxes Pharma Llc	Methods for preparation of quinazoline derivatives
US10822312B2 (en)	2016-03-30	2020-11-03	Araxes Pharma Llc	Substituted quinazoline compounds and methods of use
DK3472351T3 (da)	2016-06-15	2020-11-09	Univ Muenchen Ludwig Maximilians	Enkeltmolekylepåvisning eller -kvantificering ved hjælp af DNA-nanoteknologi
US10646488B2 (en)	2016-07-13	2020-05-12	Araxes Pharma Llc	Conjugates of cereblon binding compounds and G12C mutant KRAS, HRAS or NRAS protein modulating compounds and methods of use thereof
JP2019529484A (ja)	2016-09-29	2019-10-17	アラクセスファーマエルエルシー	Ｋｒａｓｇ１２ｃ変異体タンパク質の阻害剤
US10377743B2 (en)	2016-10-07	2019-08-13	Araxes Pharma Llc	Inhibitors of RAS and methods of use thereof
EP3555077B1 (en)	2016-12-15	2023-04-19	The Regents of The University of California	Compositions and methods for treating cancer
JP2020515817A (ja)	2016-12-29	2020-05-28	アドールダイアグノスティクスエス．アール．エル．	電気泳動用途のための電気泳動チップ
EP3573964A1 (en)	2017-01-26	2019-12-04	Araxes Pharma LLC	Benzothiophene and benzothiazole compounds and methods of use thereof
WO2018140514A1 (en)	2017-01-26	2018-08-02	Araxes Pharma Llc	1-(6-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)azetidin-1-yl)prop-2-en-1-one derivatives and similar compounds as kras g12c inhibitors for the treatment of cancer
EP3573954A1 (en)	2017-01-26	2019-12-04	Araxes Pharma LLC	Fused bicyclic benzoheteroaromatic compounds and methods of use thereof
WO2018140600A1 (en)	2017-01-26	2018-08-02	Araxes Pharma Llc	Fused hetero-hetero bicyclic compounds and methods of use thereof
US11279689B2 (en)	2017-01-26	2022-03-22	Araxes Pharma Llc	1-(3-(6-(3-hydroxynaphthalen-1-yl)benzofuran-2-yl)azetidin-1 yl)prop-2-en-1-one derivatives and similar compounds as KRAS G12C modulators for treating cancer
EP3589299B1 (en)	2017-03-03	2025-04-09	Agilent Technologies, Inc.	METHODS AND SYSTEMS FOR FUNCTIONAL MATURATION OF iPSC AND ESC DERIVED CARDIOMYOCYTES
CN110869357A (zh)	2017-05-25	2020-03-06	亚瑞克西斯制药公司	化合物及其用于治疗癌症的使用方法
KR20200010306A (ko)	2017-05-25	2020-01-30	아락세스 파마 엘엘씨	Kras의 공유적 억제제
US11639346B2 (en)	2017-05-25	2023-05-02	Araxes Pharma Llc	Quinazoline derivatives as modulators of mutant KRAS, HRAS or NRAS
US10538808B2 (en)	2017-05-26	2020-01-21	Vibrant Holdings, Llc	Photoactive compounds and methods for biomolecule detection and sequencing
AU2019266303B2 (en)	2018-05-09	2025-12-18	Vibrant Holdings, Llc	Methods of synthesizing a polynucleotide array using photactivated agents
US12134620B2 (en)	2018-08-01	2024-11-05	Araxes Pharma Llc	Heterocyclic spiro compounds and methods of use thereof for the treatment of cancer
US12415171B2 (en)	2018-12-21	2025-09-16	Microsoft Technology Licensing, Llc	Regulation of DNA synthesis by nucleotides linked to protecting groups
US11584956B2 (en) *	2018-12-21	2023-02-21	Microsoft Technology Licensing, Llc	Selectively controllable cleavable linkers
US10520437B1 (en)	2019-05-24	2019-12-31	Raytheon Company	High sensitivity sensor utilizing ultra-fast laser pulse excitation and time delayed detector
US12226746B2 (en)	2019-06-07	2025-02-18	Microsoft Technology Licensing, Llc	Reversing bias in polymer synthesis electrode array
US11773422B2 (en)	2019-08-16	2023-10-03	Microsoft Technology Licensing, Llc	Regulation of polymerase using cofactor oxidation states
US12390810B2 (en)	2019-08-23	2025-08-19	The Regents Of The University Of California	Electrokinetic microelectrode devices and methods for biomarker analysis
US11896945B2 (en)	2019-10-09	2024-02-13	Microsoft Technology Licensing, Llc	High surface area coatings for solid-phase synthesis
US12006535B2 (en)	2019-11-19	2024-06-11	Sarmal, Inc.	Methods and devices for detecting SARS-COV-2
US11873484B2 (en) *	2019-11-27	2024-01-16	Microsoft Technology Licensing, Llc	Oligonucleotide assembly using electrically controlled hybridization
US20210301245A1 (en)	2020-03-29	2021-09-30	Agilent Technologies, Inc.	Systems and methods for electronically and optically monitoring biological samples
CN112625890B (zh) *	2020-12-23	2021-08-31	广州和实生物技术有限公司	一种核酸poct检测装置及其检测方法
WO2022183121A1 (en)	2021-02-26	2022-09-01	Avery Digital Data, Inc.	Semiconductor chip devices and methods for polynucleotide synthesis
US12234502B2 (en)	2021-06-03	2025-02-25	Microsoft Technology Licensing, Llc	Oligonucleotide assembly using pH based electrode controlled hybridization
US20230257789A1 (en) *	2022-02-11	2023-08-17	Microsoft Technology Licensing, Llc	Enzymatic oligonucleotide assembly using hairpins and enzymatic cleavage

Family Cites Families (89)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5036087A (pt) *	1973-07-13	1975-04-04
US3995190A (en) *	1974-09-19	1976-11-30	Butler, Binion, Rice, Cook & Knapp	Mobile ion film memory
US4283773A (en)	1977-08-30	1981-08-11	Xerox Corporation	Programmable master controller communicating with plural controllers
US4225410A (en)	1978-12-04	1980-09-30	Technicon Instruments Corporation	Integrated array of electrochemical sensors
FI63596C (fi) *	1981-10-16	1983-07-11	Orion Yhtymae Oy	Mikrobdiagnostiskt foerfarande som grundar sig pao skiktshybridisering av nukleinsyror och vid foerfarandet anvaenda kombinationer av reagenser
US4537861A (en)	1983-02-03	1985-08-27	Elings Virgil B	Apparatus and method for homogeneous immunoassay
US4580895A (en) *	1983-10-28	1986-04-08	Dynatech Laboratories, Incorporated	Sample-scanning photometer
DK557884A (da)	1983-11-25	1985-05-26	Mars Inc	Automatisk testudstyr
US4661451A (en)	1984-02-06	1987-04-28	Ortho Diagnostic Systems, Inc.	Methods for immobilizing and translocating biological cells
FI71768C (fi) *	1984-02-17	1987-02-09	Orion Yhtymae Oy	Foerbaettrade nykleinsyrareagenser och foerfarande foer deras framstaellning.
US5118605A (en)	1984-10-16	1992-06-02	Chiron Corporation	Polynucleotide determination with selectable cleavage sites
US4828979A (en)	1984-11-08	1989-05-09	Life Technologies, Inc.	Nucleotide analogs for nucleic acid labeling and detection
US4584075A (en) *	1984-11-26	1986-04-22	Ionics Incorporated	Process and apparatus for electrically desorbing components selectively sorbed on an electrolytically conducting barrier
GB8432118D0 (en) *	1984-12-19	1985-01-30	Malcolm A D B	Sandwich hybridisation technique
US4594135A (en) *	1985-02-20	1986-06-10	Ionics Incorporated	Process and apparatus for electrically desorbing components selectively sorbed on granules
US5096807A (en) *	1985-03-06	1992-03-17	Murex Corporation	Imaging immunoassay detection system with background compensation and its use
US4751177A (en) *	1985-06-13	1988-06-14	Amgen	Methods and kits for performing nucleic acid hybridization assays
US4816418A (en) *	1985-07-22	1989-03-28	Sequoia-Turner Corporation	Method and apparatus for performing automated, multi-sequential immunoassays
EP0213825A3 (en) *	1985-08-22	1989-04-26	Molecular Devices Corporation	Multiple chemically modulated capacitance
US4822566A (en) *	1985-11-19	1989-04-18	The Johns Hopkins University	Optimized capacitive sensor for chemical analysis and measurement
EP0228075B1 (en) *	1986-01-03	1991-04-03	Molecular Diagnostics, Inc.	Eucaryotic genomic dna dot-blot hybridization method
US5242797A (en)	1986-03-21	1993-09-07	Myron J. Block	Nucleic acid assay method
US5125748A (en) *	1986-03-26	1992-06-30	Beckman Instruments, Inc.	Optical detection module for use in an automated laboratory work station
EP0273115B1 (en)	1986-10-22	1994-09-07	Abbott Laboratories	Chemiluminescent acridinium and phenanthridinium salts
US5202231A (en) *	1987-04-01	1993-04-13	Drmanac Radoje T	Method of sequencing of genomes by hybridization of oligonucleotide probes
YU57087A (en) *	1987-04-01	1990-08-31	Centar Za Genticko Inzenjerstv	Process for obtaining genome by hebridization and oligonucleotidic tests
US5114674A (en) *	1987-05-01	1992-05-19	Biotronic Systems Corporation	Added array of molecular chains for interfering with electrical fields
US4787963A (en) *	1987-05-04	1988-11-29	Syntro Corporation	Method and means for annealing complementary nucleic acid molecules at an accelerated rate
US5074977A (en)	1987-05-05	1991-12-24	The Washington Technology Center	Digital biosensors and method of using same
US4936963A (en)	1987-05-27	1990-06-26	Abbott Laboratories	Polycationic buffers and method for gel electrophoresis of nucleic acids
US5766960A (en)	1987-07-27	1998-06-16	Australian Membrane And Biotechnology Research Institute	Receptor membranes
WO1989001159A1 (en) *	1987-07-27	1989-02-09	Commonwealth Scientific And Industrial Research Or	Receptor membranes
GB8810400D0 (en) *	1988-05-03	1988-06-08	Southern E	Analysing polynucleotide sequences
US6054270A (en)	1988-05-03	2000-04-25	Oxford Gene Technology Limited	Analying polynucleotide sequences
US4908112A (en) *	1988-06-16	1990-03-13	E. I. Du Pont De Nemours & Co.	Silicon semiconductor wafer for analyzing micronic biological samples
US5188963A (en)	1989-11-17	1993-02-23	Gene Tec Corporation	Device for processing biological specimens for analysis of nucleic acids
US5075077A (en) *	1988-08-02	1991-12-24	Abbott Laboratories	Test card for performing assays
WO1990001564A1 (en) *	1988-08-09	1990-02-22	Microprobe Corporation	Methods for multiple target analyses through nucleic acid hybridization
AU633839B2 (en) *	1988-08-18	1993-02-11	Ambri Limited	Improvements in sensitivity and selectivity of ion channel membrane biosensors
EP0432188B1 (en) *	1988-08-18	1996-03-27	AUSTRALIAN MEMBRANE AND BIOTECHNOLOGY RESEARCH INSTITUTE LTD. Commonwealth Scientific and Industrial Research Organization	Improvements in sensitivity and selectivity of ion channel membrane biosensors
US5096669A (en)	1988-09-15	1992-03-17	I-Stat Corporation	Disposable sensing device for real time fluid analysis
US5063081A (en) *	1988-11-14	1991-11-05	I-Stat Corporation	Method of manufacturing a plurality of uniform microfabricated sensing devices having an immobilized ligand receptor
US5200051A (en) *	1988-11-14	1993-04-06	I-Stat Corporation	Wholly microfabricated biosensors and process for the manufacture and use thereof
US5219726A (en) *	1989-06-02	1993-06-15	The Salk Institute For Biological Studies	Physical mapping of complex genomes
US5143854A (en) *	1989-06-07	1992-09-01	Affymax Technologies N.V.	Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5744101A (en)	1989-06-07	1998-04-28	Affymax Technologies N.V.	Photolabile nucleoside protecting groups
US6984487B1 (en)	1989-08-22	2006-01-10	Hsc Research Development Corporation	Cystic fibrosis gene
US5750015A (en) *	1990-02-28	1998-05-12	Soane Biosciences	Method and device for moving molecules by the application of a plurality of electrical fields
US5126022A (en) *	1990-02-28	1992-06-30	Soane Tecnologies, Inc.	Method and device for moving molecules by the application of a plurality of electrical fields
DE69115690T2 (de)	1990-04-11	1996-05-30	Ludwig Inst Cancer Res	Verfahren und gerät zum folgerichtigen chemischen reaktionsablauf
US5166063A (en) *	1990-06-29	1992-11-24	Eli Lilly And Company	Immobolization of biomolecules by enhanced electrophoretic precipitation
US5064519A (en)	1990-06-29	1991-11-12	E. I. Du Pont De Nemours And Company	Neutral and positively charged dyes for electrophoresis sample loading solutions
US5527670A (en)	1990-09-12	1996-06-18	Scientific Generics Limited	Electrochemical denaturation of double-stranded nucleic acid
GB2247889A (en)	1990-09-12	1992-03-18	Scient Generics Ltd	DNA denaturation by an electric potential
AU8517391A (en) *	1990-09-12	1992-03-30	Scientific Generics Limited	Electrochemical denaturation of double-stranded nucleic acid
US5227265A (en) *	1990-11-30	1993-07-13	Eastman Kodak Company	Migration imaging system
US5110434A (en)	1990-12-20	1992-05-05	Bio-Rad Laboratories, Inc.	Use of zwitterions to mobilize isoelectrically focused ampholyte zones
WO1992019960A1 (en)	1991-05-09	1992-11-12	Nanophore, Inc.	Methods for the electrophoretic separation of nucleic acids and other linear macromolecules in gel media with restrictive pore diameters
CA2112130C (en) *	1991-06-27	1996-08-06	Cynthia A. Edwards	Screening assay for the detection of dna-binding molecules
US5726014A (en) *	1991-06-27	1998-03-10	Genelabs Technologies, Inc.	Screening assay for the detection of DNA-binding molecules
US5632957A (en)	1993-11-01	1997-05-27	Nanogen	Molecular biological diagnostic systems including electrodes
DE69231853T2 (de)	1991-11-07	2001-09-13	Nanotronics, Inc.	Hybridisierung von mit chromophoren und fluorophoren konjugierten polynukleotiden zur erzeugung eines donor-zu-donor energietransfersystems
US5849486A (en)	1993-11-01	1998-12-15	Nanogen, Inc.	Methods for hybridization analysis utilizing electrically controlled hybridization
US6051380A (en)	1993-11-01	2000-04-18	Nanogen, Inc.	Methods and procedures for molecular biological analysis and diagnostics
US6017696A (en)	1993-11-01	2000-01-25	Nanogen, Inc.	Methods for electronic stringency control for molecular biological analysis and diagnostics
US6048690A (en)	1991-11-07	2000-04-11	Nanogen, Inc.	Methods for electronic fluorescent perturbation for analysis and electronic perturbation catalysis for synthesis
US5605662A (en)	1993-11-01	1997-02-25	Nanogen, Inc.	Active programmable electronic devices for molecular biological analysis and diagnostics
US5846708A (en) *	1991-11-19	1998-12-08	Massachusetts Institiute Of Technology	Optical and electrical methods and apparatus for molecule detection
IL103674A0 (en) *	1991-11-19	1993-04-04	Houston Advanced Res Center	Method and apparatus for molecule detection
US5324633A (en)	1991-11-22	1994-06-28	Affymax Technologies N.V.	Method and apparatus for measuring binding affinity
JPH05236997A (ja) *	1992-02-28	1993-09-17	Hitachi Ltd	ポリヌクレオチド捕捉用チップ
US5667667A (en)	1992-04-24	1997-09-16	Isis Innovation Limited	Electrochemical treatment of surfaces
US5750335A (en) *	1992-04-24	1998-05-12	Massachusetts Institute Of Technology	Screening for genetic variation
GB9208921D0 (en) *	1992-04-24	1992-06-10	Isis Innovation	Electrochemical treatment of surfaces
US5304487A (en) *	1992-05-01	1994-04-19	Trustees Of The University Of Pennsylvania	Fluid handling in mesoscale analytical devices
US5726026A (en)	1992-05-01	1998-03-10	Trustees Of The University Of Pennsylvania	Mesoscale sample preparation device and systems for determination and processing of analytes
US5312527A (en) *	1992-10-06	1994-05-17	Concordia University	Voltammetric sequence-selective sensor for target polynucleotide sequences
US5747265A (en) *	1992-10-30	1998-05-05	T Cell Diagnostics, Inc.	Method for measuring the amount of a cell-associated molecule
FR2703359B1 (fr)	1993-03-31	1995-06-23	Cis Bio Int	Copolymère nucléotide(s)/polymère conducteur électronique ; son procédé de préparation et son utilisation .
US5433819A (en)	1993-05-26	1995-07-18	Pressac, Inc.	Method of making circuit boards
WO1995007363A1 (en) *	1993-09-10	1995-03-16	Genevue, Inc.	Optical detection of position of oligonucleotides on large dna molecules
US5965452A (en)	1996-07-09	1999-10-12	Nanogen, Inc.	Multiplexed active biologic array
US7101661B1 (en)	1993-11-01	2006-09-05	Nanogen, Inc.	Apparatus for active programmable matrix devices
US5445525A (en)	1994-05-12	1995-08-29	Intel Corporation	Interconnection scheme for integrated circuit card with auxiliary contacts
US5585069A (en)	1994-11-10	1996-12-17	David Sarnoff Research Center, Inc.	Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis
US5464517A (en)	1995-01-30	1995-11-07	Bio-Rad Laboratories	Electrophoresis in low conductivity buffers
US5660701A (en)	1996-02-29	1997-08-26	Bio-Rad Laboratories, Inc.	Protein separations by capillary electrophoresis using amino acid-containing buffers
ZA975891B (en)	1996-07-05	1998-07-23	Combimatrix Corp	Electrochemical solid phase synthesis of polymers
US6780584B1 (en)	2000-09-27	2004-08-24	Nanogen, Inc.	Electronic systems and component devices for macroscopic and microscopic molecular biological reactions, analyses and diagnostics

1994
- 1994-07-07 US US08/271,882 patent/US6017696A/en not_active Expired - Lifetime
1995
- 1995-07-05 WO PCT/US1995/008570 patent/WO1996001836A1/en not_active Ceased
- 1995-07-05 AT AT95925571T patent/ATE232604T1/de not_active IP Right Cessation
- 1995-07-05 JP JP8504426A patent/JPH09503307A/ja active Pending
- 1995-07-05 AU AU29661/95A patent/AU708677B2/en not_active Ceased
- 1995-07-05 NZ NZ289731A patent/NZ289731A/en unknown
- 1995-07-05 BR BR9506035A patent/BR9506035A/pt not_active Application Discontinuation
- 1995-07-05 CN CNA2004100324755A patent/CN1550556A/zh active Pending
- 1995-07-05 EP EP95925571A patent/EP0717749B1/en not_active Expired - Lifetime
- 1995-07-05 CA CA002169852A patent/CA2169852C/en not_active Expired - Fee Related
- 1995-07-05 CN CNB95190860XA patent/CN1151374C/zh not_active Expired - Fee Related
- 1995-07-05 DE DE69529601T patent/DE69529601D1/de not_active Expired - Lifetime
1996
- 1996-03-06 FI FI961034A patent/FI961034A7/fi not_active Application Discontinuation
- 1996-10-04 US US08/726,278 patent/US6238624B1/en not_active Expired - Lifetime
2006
- 2006-07-04 JP JP2006184471A patent/JP2007020568A/ja active Pending
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- 2007-02-05 US US11/702,353 patent/US7947486B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP0717749B1 (en)	2003-02-12
HK1011080A1 (en)	1999-07-02
CN1151374C (zh)	2004-05-26
WO1996001836A1 (en)	1996-01-25
AU708677B2 (en)	1999-08-12
ATE232604T1 (de)	2003-02-15
FI961034A0 (fi)	1996-03-06
CN1135220A (zh)	1996-11-06
US20100173792A1 (en)	2010-07-08
JPH09503307A (ja)	1997-03-31
CA2169852C (en)	2008-09-23
JP2007020568A (ja)	2007-02-01
FI961034A7 (fi)	1996-05-02
DE69529601D1 (de)	2003-03-20
AU2966195A (en)	1996-02-09
EP0717749A4 (en)	1998-07-01
US6017696A (en)	2000-01-25
US7947486B2 (en)	2011-05-24
CN1550556A (zh)	2004-12-01
NZ289731A (en)	1998-09-24
EP0717749A1 (en)	1996-06-26
CA2169852A1 (en)	1996-01-25
US6238624B1 (en)	2001-05-29

Publication	Publication Date	Title
BR9506035A (pt)	1997-10-14	Sistemas microeletrônicos auto-endereçáveis e automontáveis e disposotivos para análise e diagnóstico moleculares
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WO1998058083A3 (en)	1999-03-11	Method for quantitative measurement of gene expression using multiplex competitive reverse transcriptase-polymerase chain reaction
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ATE269160T1 (de)	2004-07-15	Miniaturisierte probenvorbereitungsvorrichtungen sowie systeme zur feststellung und behandlung von analyten
SE9601318D0 (sv)	1996-04-04	Method for nucleic acid analysis
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CA2258489A1 (en)	1998-01-08	High-throughput screening assay systems in microscale fluidic devices
ATE409236T1 (de)	2008-10-15	Derivatisierte nukleinsäuren und deren verwendung
IL136862A0 (en)	2001-06-14	High throughput assay system
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PT918991E (pt)	2005-03-31	Metodo de ensaio
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