BR9304910A - Composto, processo para a sua preparação, medicamento, processo para a sua preparação e aplicação do dito composto - Google Patents

Composto, processo para a sua preparação, medicamento, processo para a sua preparação e aplicação do dito composto

Info

Publication number: BR9304910A
Authority: BR; Brazil
Prior art keywords: compound; preparation; medicine; application; image
Prior art date: 1992-12-02

Application number

BR9304910A

Other languages

English (en)

Inventor

Christoph Dr Naumann

Hans Jochen Dr Lang

Juergen Dr Sandow

Anne-Marie Moura

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-12-02

Filing date

1993-12-01

Publication date

1994-08-16

1993-05-13 Priority claimed from DE19934316019 external-priority patent/DE4316019A1/de

1993-12-01 Application filed by Hoechst Ag filed Critical Hoechst Ag

1994-08-16 Publication of BR9304910A publication Critical patent/BR9304910A/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4025—Esters of poly(thio)phosphonic acids
- C07F9/405—Esters of poly(thio)phosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/5532—Seven-(or more) membered rings
- C07F9/5535—Seven-(or more) membered rings condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
- C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/60—Quinoline or hydrogenated quinoline ring systems

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Physical Education & Sports Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Hematology (AREA)
Obesity (AREA)
Vascular Medicine (AREA)
Diabetes (AREA)
Urology & Nephrology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

BR9304910A 1992-12-02 1993-12-01 Composto, processo para a sua preparação, medicamento, processo para a sua preparação e aplicação do dito composto BR9304910A (pt)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DE4240422		1992-12-02
DE19934316019 DE4316019A1 (de)	1993-05-13	1993-05-13	Benzoylguanidinalkyl-1,1-bisphosphonsäuren, Verfahren zu ihrer Herstellung und ihre Verwendung
DE4332362		1993-09-23

Publications (1)

Publication Number	Publication Date
BR9304910A true BR9304910A (pt)	1994-08-16

Family

ID=27204511

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BR9304910A BR9304910A (pt)	1992-12-02	1993-12-01	Composto, processo para a sua preparação, medicamento, processo para a sua preparação e aplicação do dito composto

Country Status (15)

Country	Link
US (3)	US5395826A (pt)
EP (1)	EP0600371B1 (pt)
JP (1)	JP3499905B2 (pt)
KR (1)	KR100347423B1 (pt)
AT (1)	ATE176476T1 (pt)
AU (1)	AU663983B2 (pt)
BR (1)	BR9304910A (pt)
CA (1)	CA2110443C (pt)
DE (1)	DE59309360D1 (pt)
DK (1)	DK0600371T3 (pt)
ES (1)	ES2129485T3 (pt)
FI (1)	FI108034B (pt)
GR (1)	GR3030020T3 (pt)
NZ (1)	NZ250322A (pt)
RU (1)	RU2114855C1 (pt)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4223940A1 (de) *	1992-07-21	1994-01-27	Boehringer Mannheim Gmbh	Neue acyclische Amidingruppen-haltige Diphosphonsäurederivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
ES2129485T3 (es) *	1992-12-02	1999-06-16	Hoechst Ag	Derivados de acidos guanidinoalquil-1,1-bisfosfonicos, procedimiento para su preparacion y su utilizacion.
US6169107B1 (en)	1993-04-28	2001-01-02	Sumitomo Pharmaceutical Co., Ltd.	Indoloylguanidine derivatives
DE4404183A1 (de) *	1994-02-10	1995-08-17	Merck Patent Gmbh	4-Amino-1-piperidylbenzoylguanidine
DE4421495A1 (de) *	1994-06-20	1995-12-21	Merck Patent Gmbh	Heterocyclyloxy-benzoylguanidine
CA2160600A1 (en) *	1994-10-18	1996-04-19	Masahumi Kitano	Indoloylguanidine derivatives
DE19540995A1 (de) *	1995-11-03	1997-05-07	Hoechst Ag	Substituierte Sulfonimidamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19542306A1 (de) *	1995-11-14	1997-05-15	Hoechst Ag	Sulfonylamino-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
PL316439A1 (en) *	1995-11-20	1997-05-26	Hoechst Ag	Novel substituted derivatives of benzoyloguanidine, method of obtaining them, their application in production of pharmaceutic and diagnostic agents and pharmaceutic agent as such
DE19601303A1 (de) *	1996-01-16	1997-07-17	Boehringer Ingelheim Kg	Neuartige Benzoylguanidin-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung bei der Herstellung von Arzneimitteln
AU6691498A (en)	1997-03-07	1998-09-22	Metabasis Therapeutics, Inc.	Novel benzimidazole inhibitors of fructose-1,6-bisphosphatase
WO1998039342A1 (en)	1997-03-07	1998-09-11	Metabasis Therapeutics, Inc.	Novel indole and azaindole inhibitors of fructose-1,6-bisphosphatase
US6284748B1 (en)	1997-03-07	2001-09-04	Metabasis Therapeutics, Inc.	Purine inhibitors of fructose 1,6-bisphosphatase
US6558784B1 (en)	1999-03-02	2003-05-06	Adc Composites, Llc	Composite footwear upper and method of manufacturing a composite footwear upper
JP2003519183A (ja) *	2000-01-04	2003-06-17	ザリージェンツオブザユニバーシティオブカリフォルニア	心臓および動脈の石灰化を抑制する低用量ビスホスホネートの使用
ES2268086T3 (es) *	2001-05-02	2007-03-16	Novartis Ag	Metodo de administracion de bisfosfonatos por inhalacion en el tratamiento o prevencion de la resorcion osea y la osteoporosis.
KR100620672B1 (ko) *	2002-12-14	2006-09-13	주식회사 하이닉스반도체	포토레지스트 조성물
WO2005090370A1 (en) *	2004-02-05	2005-09-29	The Regents Of The University Of California	Pharmacologically active agents containing esterified phosphonates and methods for use thereof
EP1865967A4 (en) *	2005-04-08	2011-02-09	Chimerix Inc	COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATING VIRAL INFECTIONS AND OTHER DISEASES
JP2008535862A (ja)	2005-04-08	2008-09-04	キメリクス，インコーポレイテッド	ポックスウイルス感染の治療のための化合物、組成物および方法
EP2086330A4 (en) *	2006-11-21	2010-10-20	Teikoku Pharma Usa Inc	BIPHOSPHONATE FORMULATIONS FOR INHALING AND METHOD FOR THEIR USE
WO2009094191A2 (en) *	2008-01-25	2009-07-30	Chimerix, Inc.	Methods of treating viral infections
US20100034752A1 (en) *	2008-08-11	2010-02-11	Toru Hibi	Inhalant formulations comprising a bisphosphonate and a pyrazolone derivative and methods for using the same
US8614200B2 (en)	2009-07-21	2013-12-24	Chimerix, Inc.	Compounds, compositions and methods for treating ocular conditions
CA2770282A1 (en)	2009-08-03	2011-02-10	Chimerix, Inc.	Composition and methods of treating viral infections and viral induced tumors
PT2534150T (pt)	2010-02-12	2017-05-02	Chimerix Inc	Métodos para tratar uma infecção viral
AU2011248620B2 (en)	2010-04-26	2015-11-26	Chimerix, Inc.	Methods of treating retroviral infections and related dosage regimes

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2838437A1 (de) *	1978-09-02	1980-03-20	Benckiser Gmbh Joh A	N,n'-dialkyl-ureidomethan-diphosphonsaeure, deren herstellung und verwendung
IL77243A (en) *	1984-12-21	1996-11-14	Procter & Gamble	Pharmaceutical compositions containing geminal diphosphonic acid compounds and certain such novel compounds
DE3623397A1 (de) *	1986-07-11	1988-01-14	Boehringer Mannheim Gmbh	Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
EP0282309A3 (en) *	1987-03-11	1990-03-14	Yamanouchi Pharmaceutical Co. Ltd.	Azole-aminomethylene bisphosphonic acid derivatives
IL86951A (en) *	1987-07-06	1996-07-23	Procter & Gamble Pharma	Methylene phosphonoalkylphosphinates and pharmaceutical preparations containing them
JPH0248587A (ja) *	1988-08-10	1990-02-19	Yamanouchi Pharmaceut Co Ltd	複素環置換ビスフォスフォン酸誘導体及びその医薬
US4990503A (en) *	1988-08-12	1991-02-05	Yamanouchi Pharmaceutical Co., Ltd.	Heterocyclic bisphosphonic acid derivatives
DE3929582A1 (de) *	1989-09-06	1991-03-07	Hoechst Ag	Benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltendes medikament
TW222637B (pt) *	1991-12-12	1994-04-21	Hoechst Ag
ES2129485T3 (es) *	1992-12-02	1999-06-16	Hoechst Ag	Derivados de acidos guanidinoalquil-1,1-bisfosfonicos, procedimiento para su preparacion y su utilizacion.

1993
- 1993-11-25 ES ES93118992T patent/ES2129485T3/es not_active Expired - Lifetime
- 1993-11-25 EP EP93118992A patent/EP0600371B1/de not_active Expired - Lifetime
- 1993-11-25 DK DK93118992T patent/DK0600371T3/da active
- 1993-11-25 AT AT93118992T patent/ATE176476T1/de not_active IP Right Cessation
- 1993-11-25 DE DE59309360T patent/DE59309360D1/de not_active Expired - Fee Related
- 1993-11-30 NZ NZ250322A patent/NZ250322A/en unknown
- 1993-11-30 US US08/159,119 patent/US5395826A/en not_active Expired - Fee Related
- 1993-11-30 AU AU52040/93A patent/AU663983B2/en not_active Ceased
- 1993-11-30 FI FI935360A patent/FI108034B/fi not_active IP Right Cessation
- 1993-12-01 BR BR9304910A patent/BR9304910A/pt not_active Application Discontinuation
- 1993-12-01 RU RU93054537A patent/RU2114855C1/ru not_active IP Right Cessation
- 1993-12-01 JP JP30142893A patent/JP3499905B2/ja not_active Expired - Fee Related
- 1993-12-01 CA CA002110443A patent/CA2110443C/en not_active Expired - Fee Related
- 1993-12-02 KR KR1019930026202A patent/KR100347423B1/ko not_active Expired - Fee Related
1994
- 1994-11-23 US US08/346,239 patent/US5498617A/en not_active Expired - Fee Related
1996
- 1996-03-01 US US08/609,473 patent/US5661174A/en not_active Expired - Fee Related
1999
- 1999-04-21 GR GR990401101T patent/GR3030020T3/el unknown

Also Published As

Publication number	Publication date
CA2110443A1 (en)	1994-06-03
ATE176476T1 (de)	1999-02-15
RU2114855C1 (ru)	1998-07-10
DE59309360D1 (de)	1999-03-18
JP3499905B2 (ja)	2004-02-23
FI935360L (fi)	1994-06-03
ES2129485T3 (es)	1999-06-16
KR100347423B1 (ko)	2002-10-30
GR3030020T3 (en)	1999-07-30
JPH06279470A (ja)	1994-10-04
DK0600371T3 (da)	1999-09-20
NZ250322A (en)	1995-12-21
CA2110443C (en)	2006-02-21
KR940014421A (ko)	1994-07-18
FI935360A0 (fi)	1993-11-30
US5498617A (en)	1996-03-12
AU5204093A (en)	1994-06-16
US5661174A (en)	1997-08-26
EP0600371B1 (de)	1999-02-03
EP0600371A1 (de)	1994-06-08
FI108034B (fi)	2001-11-15
AU663983B2 (en)	1995-10-26
US5395826A (en)	1995-03-07

Publication	Publication Date	Title
BR9304910A (pt)	1994-08-16	Composto, processo para a sua preparação, medicamento, processo para a sua preparação e aplicação do dito composto
RU93054537A (ru)	1996-12-27	Производные гуанидиналкил-1,1-бисфосфоновой кислоты, способ их получения и их применение
BR9808953A (pt)	2000-08-01	Composto, processo para tratar um distúrbio mediado pela ciclooxigenase-2 em um paciente, e, composição farmacêutica
BR9914696A (pt)	2002-02-05	Composto, processo para tratamento de distúrbio mediado por ciclo-oxigenase-2 em um indivìduo, e, composição farmacêutica
DK0534859T3 (da)	1995-05-08	3-Benzazepin-2-oner, som er substituerede med en benzocyklobutyl- eller indanylalkylaminoalkylgruppe, og som er anvendelige til behandling af cardiovaskulære sygdomme
BR9509683A (pt)	1997-09-16	Compostos e processos para tratar uma condição clínica em um mamífero para tratar uma condição hiperlipidêmica em um manífero e para a preparação de um composto
BR1100717A (pt)	2000-03-14	Compostos, seu processo de preparação e medicamentos contendo estes compostos.
NO931056L (no)	1993-09-27	Sulfonamido- og sulfonamidokarbonyl-pyridin-2-karboksylsyreamider samt deres pyridin-n-oksider, fremgangsmaater for fremstilling derav og anvendelse av forbindelsene som legemidler
DK0587088T3 (da)	1996-09-23	Substituerede cyclohexan-derivater, fremgangsmåde til deres fremstilling og anvendelsen af forbindelserne til behandling af sygdomme
FI102964B1 (fi)	1999-03-31	Terapeuttisia yhdisteitä
ATE30583T1 (de)	1987-11-15	Vitamin-d3-derivate.
FI923664A0 (fi)	1992-08-14	Piperidinderivat.
NO891703D0 (no)	1989-04-25	Farmasoeytiske sammensetninger for behandling av psoriasis.
BR9407862A (pt)	1997-05-20	Composto de flavina flavina derivado de flavina ou uma mistura que compreende duas ou mais destas composiçao farmacêutica e processo para o tratamento por profilaxia ou terapia de doença causada por infecçao virótica
SE8701375D0 (sv)	1987-04-02	Novel pyridyl- and pyrimidyl derivatives
IL79910A (en)	1990-02-09	5,7-dihydro-6-(thi)oxopyrrolo(2,3-f)benzimidazole,-benzothiazole and-benzoxazoles,6-imines thereof,their preparation and pharmaceutical compositions containing them
DE69419954D1 (de)	1999-09-16	Arzneimittel zur Behandlung von Hauterkrankungen
FI923662A0 (fi)	1992-08-14	Terapeutiska medel.
PT82407B (pt)	1988-08-17	Processo para a preparacao de novos derivados do triazole
DK47988A (da)	1988-07-31	Substituerede 3-phenyl-7h-thiazolooe3,2-baaoe1,2,4aatriazin-7-oner, deres fremstilling og anvendelse som laegemiddel, samt ved fremstillingen anvendelige mellemprodukter
PT88074A (pt)	1989-06-30	Processo para a preparacao de antagonistas de leucotrieno e de composicoes farmaceuticas que os contem
PT92668A (pt)	1990-06-29	Processo para a preparacao de derivados de azabiciclo-heptano
DK0622372T3 (da)	1999-02-15	Hidtil ukendt forbindelse, Leustroducsin H, dens fremstilling og dens terapeutiske anvendelse
BR9201771A (pt)	1992-12-29	Compostos,derivado de amino acidos,processo para sua fabricacao,medicamento,aplicacao do mencionado derivado e processo para tratar ou prevenir infeccoes viais

Legal Events

Date	Code	Title	Description
1999-07-13	EG	Technical examination (opinion): publication of technical examination (opinion)
2000-02-15	FC	Decision: refusal