BR9200786A - Utilizacao de agentes de penetracao hidrofilos e composicao dermatologica para o tratamento de onicomicoses - Google Patents
Utilizacao de agentes de penetracao hidrofilos e composicao dermatologica para o tratamento de onicomicosesInfo
- Publication number
- BR9200786A BR9200786A BR929200786A BR9200786A BR9200786A BR 9200786 A BR9200786 A BR 9200786A BR 929200786 A BR929200786 A BR 929200786A BR 9200786 A BR9200786 A BR 9200786A BR 9200786 A BR9200786 A BR 9200786A
- Authority
- BR
- Brazil
- Prior art keywords
- dermatological composition
- agents
- penetration
- onicomycosis
- hydrophyl
- Prior art date
Links
- 230000035515 penetration Effects 0.000 title abstract 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 abstract 4
- 229940121375 antifungal agent Drugs 0.000 abstract 3
- 239000003429 antifungal agent Substances 0.000 abstract 3
- 239000003795 chemical substances by application Substances 0.000 abstract 3
- 230000000149 penetrating effect Effects 0.000 abstract 3
- JBKVHLHDHHXQEQ-UHFFFAOYSA-N epsilon-caprolactam Chemical compound O=C1CCCCCN1 JBKVHLHDHHXQEQ-UHFFFAOYSA-N 0.000 abstract 2
- LZCLXQDLBQLTDK-UHFFFAOYSA-N ethyl 2-hydroxypropanoate Chemical compound CCOC(=O)C(C)O LZCLXQDLBQLTDK-UHFFFAOYSA-N 0.000 abstract 2
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 abstract 2
- MEJYDZQQVZJMPP-ULAWRXDQSA-N (3s,3ar,6r,6ar)-3,6-dimethoxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan Chemical compound CO[C@H]1CO[C@@H]2[C@H](OC)CO[C@@H]21 MEJYDZQQVZJMPP-ULAWRXDQSA-N 0.000 abstract 1
- CYSGHNMQYZDMIA-UHFFFAOYSA-N 1,3-Dimethyl-2-imidazolidinon Chemical compound CN1CCN(C)C1=O CYSGHNMQYZDMIA-UHFFFAOYSA-N 0.000 abstract 1
- VTDOEFXTVHCAAM-UHFFFAOYSA-N 4-methylpent-3-ene-1,2,3-triol Chemical compound CC(C)=C(O)C(O)CO VTDOEFXTVHCAAM-UHFFFAOYSA-N 0.000 abstract 1
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 abstract 1
- FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 abstract 1
- 239000002202 Polyethylene glycol Substances 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 230000001476 alcoholic effect Effects 0.000 abstract 1
- 229960001760 dimethyl sulfoxide Drugs 0.000 abstract 1
- 229940116333 ethyl lactate Drugs 0.000 abstract 1
- 125000005456 glyceride group Chemical group 0.000 abstract 1
- 229940074046 glyceryl laurate Drugs 0.000 abstract 1
- 150000002334 glycols Chemical class 0.000 abstract 1
- OZGNYLLQHRPOBR-DHZHZOJOSA-N naftifine Chemical compound C=1C=CC2=CC=CC=C2C=1CN(C)C\C=C\C1=CC=CC=C1 OZGNYLLQHRPOBR-DHZHZOJOSA-N 0.000 abstract 1
- 229960004313 naftifine Drugs 0.000 abstract 1
- 229920001223 polyethylene glycol Polymers 0.000 abstract 1
- ARIWANIATODDMH-UHFFFAOYSA-N rac-1-monolauroylglycerol Chemical compound CCCCCCCCCCCC(=O)OCC(O)CO ARIWANIATODDMH-UHFFFAOYSA-N 0.000 abstract 1
- 229960002722 terbinafine Drugs 0.000 abstract 1
- DOMXUEMWDBAQBQ-WEVVVXLNSA-N terbinafine Chemical compound C1=CC=C2C(CN(C\C=C\C#CC(C)(C)C)C)=CC=CC2=C1 DOMXUEMWDBAQBQ-WEVVVXLNSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q3/00—Manicure or pedicure preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Emergency Medicine (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9102838A FR2673537B1 (fr) | 1991-03-08 | 1991-03-08 | Utilisation d'agents de penetration hydrophiles dans les compositions dermatologiques pour le traitement des onychomycoses, et compositions correspondantes. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9200786A true BR9200786A (pt) | 1992-11-17 |
Family
ID=9410536
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR929200786A BR9200786A (pt) | 1991-03-08 | 1992-03-09 | Utilizacao de agentes de penetracao hidrofilos e composicao dermatologica para o tratamento de onicomicoses |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US5814305A (pt) |
| EP (1) | EP0503988B1 (pt) |
| JP (1) | JP3559973B2 (pt) |
| AT (1) | ATE190485T1 (pt) |
| AU (1) | AU1147092A (pt) |
| BR (1) | BR9200786A (pt) |
| CA (1) | CA2062341C (pt) |
| CY (1) | CY2233B1 (pt) |
| DE (1) | DE69230772T2 (pt) |
| DK (1) | DK0503988T3 (pt) |
| ES (1) | ES2144409T3 (pt) |
| FR (1) | FR2673537B1 (pt) |
| GR (1) | GR3033297T3 (pt) |
| MX (1) | MX9200965A (pt) |
| PT (1) | PT503988E (pt) |
| SG (1) | SG46660A1 (pt) |
| ZA (1) | ZA921706B (pt) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8697753B1 (en) | 2013-02-07 | 2014-04-15 | Polichem Sa | Method of treating onychomycosis |
Families Citing this family (85)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2673537B1 (fr) | 1991-03-08 | 1993-06-11 | Oreal | Utilisation d'agents de penetration hydrophiles dans les compositions dermatologiques pour le traitement des onychomycoses, et compositions correspondantes. |
| US6005001A (en) * | 1991-05-20 | 1999-12-21 | Novartis Ag (Formerly Sandoz Ag) | Pharmaceutical composition |
| HU223343B1 (hu) * | 1991-05-20 | 2004-06-28 | Novartis Ag. | Allil-amin-származékot tartalmazó gyógyászati készítmények és eljárás azok előállítására |
| HU219480B (hu) * | 1991-05-23 | 2001-04-28 | Novartis Ag. | Eljárás gombás körömmegbetegségek ellen helyileg alkalmazható, allil-amin-származékot tartalmazó gyógyászati készítmények előállítására |
| US5652256A (en) * | 1995-06-06 | 1997-07-29 | Knowles; W. Roy | Topical composition for fungal treatment |
| WO1998016251A1 (de) * | 1996-10-16 | 1998-04-23 | Ipr-Institute For Pharmaceutical Research Ag | Neue carrier-systeme |
| WO1999039680A1 (en) * | 1998-02-09 | 1999-08-12 | Macrochem Corporation | Antifungal nail lacquer and method using same |
| US6231875B1 (en) * | 1998-03-31 | 2001-05-15 | Johnson & Johnson Consumer Companies, Inc. | Acidified composition for topical treatment of nail and skin conditions |
| CA2343284C (en) | 1998-09-10 | 2008-11-18 | Ipr-Institute For Pharmaceutical Research Ag | Topical application products |
| US6159977A (en) * | 1998-11-16 | 2000-12-12 | Astan, Inc. | Therapeutic anti-fungal nail preparation |
| US6517863B1 (en) | 1999-01-20 | 2003-02-11 | Usbiomaterials Corporation | Compositions and methods for treating nails and adjacent tissues |
| DE10011081A1 (de) * | 2000-03-09 | 2001-09-13 | Aventis Pharma Gmbh | Antiinfektive Wirkstoffkombinationen und ihre Verwendung zur topischen Behandlung von Pilzerkrankungen der Fuß- und Fingernägel |
| US8257688B2 (en) * | 2000-03-27 | 2012-09-04 | Taro Pharmaceuticals Industries | Controlled delivery system of antifungal and keratolytic agents for local treatment of fungal infections of the nail and surrounding tissues |
| US7074392B1 (en) * | 2000-03-27 | 2006-07-11 | Taro Pharmaceutical Industries Limited | Controllled delivery system of antifungal and keratolytic agents for local treatment of fungal infections |
| GB0014448D0 (en) * | 2000-06-13 | 2000-08-09 | Novartis Ag | Organic compounds |
| GB0019283D0 (en) * | 2000-08-04 | 2000-09-27 | Novartis Ag | Organic compounds |
| WO2006057616A1 (en) * | 2004-11-29 | 2006-06-01 | Ambria Dermatology Ab | A composition comprising at least 3 different diols |
| US6664292B2 (en) | 2001-06-04 | 2003-12-16 | Mark H. Bogart | Methods for the treatment of nail fungus and other microbial and mycotic conditions and compositions useful therefor |
| US7244703B2 (en) | 2001-06-22 | 2007-07-17 | Bentley Pharmaceuticals, Inc. | Pharmaceutical compositions and methods for peptide treatment |
| US6821508B2 (en) | 2001-06-27 | 2004-11-23 | Rutgers, The State University | Composition and method for topical nail treatment |
| US20030049307A1 (en) * | 2002-08-15 | 2003-03-13 | Gyurik Robert J. | Pharmaceutical composition |
| CA2495923A1 (en) * | 2002-08-20 | 2004-03-04 | Doren M. Pinnell | Methods for treating fungal infections |
| AU2003270273B2 (en) * | 2002-09-05 | 2009-03-19 | Galderma S.A. | Solution for ungual application |
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| US20040126343A1 (en) * | 2002-12-26 | 2004-07-01 | Garshowitz Solomon David | Nail drug delivery |
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| JP6516759B2 (ja) | 2013-10-03 | 2019-05-22 | ダウ ファーマシューティカル サイエンシーズ，インコーポレイティド | 安定化エフィナコナゾール組成物 |
| KR102612453B1 (ko) | 2013-11-22 | 2023-12-08 | 다우 파마슈티컬 사이언시즈, 인코포레이티드 | 항감염 방법，조성물，및 장치 |
| WO2016015094A1 (en) * | 2014-07-31 | 2016-02-04 | Acrux Dds Pty Ltd | Topical composition |
| WO2017031075A1 (en) * | 2015-08-17 | 2017-02-23 | Arno Therapeutics, Inc. | Methods and compositions for enhanced transungual delivery of ar-12 |
| JP6895429B2 (ja) * | 2015-10-07 | 2021-06-30 | エクソドス ライフ サイエンシーズ リミテッド パートナーシップ | 局所抗真菌組成物 |
| US10993890B2 (en) | 2018-03-15 | 2021-05-04 | Pelli Skin Co., Llc | Antifungal solution and foot wipe |
| CN108653195A (zh) * | 2018-08-08 | 2018-10-16 | 江苏知原药业有限公司 | 透皮或透粘膜给药制剂 |
| JP2022518357A (ja) * | 2018-12-19 | 2022-03-15 | マーリンズ・ファーマ・エルエルシー | 局所組成物 |
| WO2020231800A1 (en) * | 2019-05-10 | 2020-11-19 | Encube Ethicals Private Limited | Topical antifungal formulation |
| EP4129292A1 (en) | 2021-08-04 | 2023-02-08 | OnychoPharm GmbH | Formulation for substituted 2-aminothiazoles in the treatment of fungal and fungal-bacterial infections of the nail |
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| EP0024587B1 (en) * | 1979-08-22 | 1984-11-14 | Sandoz Ag | Propenylamines, processes for their production, pharmaceutical compositions containing them and their use as pharmaceuticals |
| FR2572933B1 (fr) * | 1981-04-06 | 1988-03-18 | Sandoz Sa | Compositions pharmaceutiques topiques a base de tizanidine |
| FR2502951B1 (fr) * | 1981-04-06 | 1985-12-06 | Sandoz Sa | Compositions pharmaceutiques topiques sous forme d'une micro-emulsion |
| JPS60224638A (ja) * | 1984-04-23 | 1985-11-09 | Kao Corp | 経皮吸収促進剤およびこれを含有する外用剤 |
| JPS6169721A (ja) * | 1984-09-13 | 1986-04-10 | Kao Corp | 抗真菌組成物 |
| AU599064B2 (en) * | 1985-11-04 | 1990-07-12 | Dermatological Products Of Texas | Film-forming, pharmaceutical vehicles for application of medicaments to nails, pharmaceutical compositions based on those vehicles, and methods of using same |
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| US5215520A (en) * | 1991-09-17 | 1993-06-01 | Centre Internationale De Recherches Dermatologiques Galderma (C.I.R.D. Galderma) | Method for delivering an active substance topically or percutaneously |
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-
1991
- 1991-03-08 FR FR9102838A patent/FR2673537B1/fr not_active Expired - Lifetime
-
1992
- 1992-02-13 DK DK92400384T patent/DK0503988T3/da active
- 1992-02-13 ES ES92400384T patent/ES2144409T3/es not_active Expired - Lifetime
- 1992-02-13 DE DE69230772T patent/DE69230772T2/de not_active Expired - Lifetime
- 1992-02-13 AT AT92400384T patent/ATE190485T1/de active
- 1992-02-13 SG SG1996007522A patent/SG46660A1/en unknown
- 1992-02-13 PT PT92400384T patent/PT503988E/pt unknown
- 1992-02-13 EP EP92400384A patent/EP0503988B1/fr not_active Expired - Lifetime
- 1992-03-05 CA CA002062341A patent/CA2062341C/fr not_active Expired - Lifetime
- 1992-03-05 MX MX9200965A patent/MX9200965A/es unknown
- 1992-03-06 JP JP08292492A patent/JP3559973B2/ja not_active Expired - Lifetime
- 1992-03-06 ZA ZA921706A patent/ZA921706B/xx unknown
- 1992-03-06 AU AU11470/92A patent/AU1147092A/en not_active Abandoned
- 1992-03-09 BR BR929200786A patent/BR9200786A/pt not_active Application Discontinuation
-
1995
- 1995-01-30 US US08/381,583 patent/US5814305A/en not_active Expired - Lifetime
-
1998
- 1998-09-28 US US09/162,020 patent/US6143793A/en not_active Expired - Lifetime
-
2000
- 2000-04-21 GR GR20000400979T patent/GR3033297T3/el unknown
- 2000-10-04 US US09/678,772 patent/US6455592B1/en not_active Expired - Lifetime
-
2001
- 2001-09-07 CY CY0100024A patent/CY2233B1/xx unknown
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8697753B1 (en) | 2013-02-07 | 2014-04-15 | Polichem Sa | Method of treating onychomycosis |
| US9107877B2 (en) | 2013-02-07 | 2015-08-18 | Polichem Sa | Method of treating onychomycosis |
| US10172811B2 (en) | 2013-02-07 | 2019-01-08 | Polichem Sa | Topical antifungal composition for treating onychomycosis |
Also Published As
| Publication number | Publication date |
|---|---|
| EP0503988A1 (fr) | 1992-09-16 |
| GR3033297T3 (en) | 2000-09-29 |
| CA2062341C (fr) | 2004-05-11 |
| CY2233B1 (en) | 2003-04-18 |
| US6143793A (en) | 2000-11-07 |
| DE69230772D1 (de) | 2000-04-20 |
| DK0503988T3 (da) | 2000-07-24 |
| DE69230772T2 (de) | 2000-07-27 |
| ES2144409T3 (es) | 2000-06-16 |
| PT503988E (pt) | 2000-06-30 |
| SG46660A1 (en) | 1998-02-20 |
| ZA921706B (en) | 1992-11-25 |
| MX9200965A (es) | 1992-09-01 |
| US6455592B1 (en) | 2002-09-24 |
| FR2673537A1 (fr) | 1992-09-11 |
| JP3559973B2 (ja) | 2004-09-02 |
| AU1147092A (en) | 1992-09-10 |
| FR2673537B1 (fr) | 1993-06-11 |
| ATE190485T1 (de) | 2000-04-15 |
| EP0503988B1 (fr) | 2000-03-15 |
| US5814305A (en) | 1998-09-29 |
| CA2062341A1 (fr) | 1992-09-09 |
| JPH0585929A (ja) | 1993-04-06 |
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Legal Events
| Date | Code | Title | Description |
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| FA1 | Application withdrawn (art. 18(2)) |