BR9106118A - Antraquinona substituida,composicao famaceutica e processo para inibir quinase c de proteina e,uso de um composto - Google Patents
Antraquinona substituida,composicao famaceutica e processo para inibir quinase c de proteina e,uso de um compostoInfo
- Publication number
- BR9106118A BR9106118A BR919106118A BR9106118A BR9106118A BR 9106118 A BR9106118 A BR 9106118A BR 919106118 A BR919106118 A BR 919106118A BR 9106118 A BR9106118 A BR 9106118A BR 9106118 A BR9106118 A BR 9106118A
- Authority
- BR
- Brazil
- Prior art keywords
- famaceutic
- anthraquinone
- replaced
- compound
- composition
- Prior art date
Links
- 102000003923 Protein Kinase C Human genes 0.000 title 1
- 108090000315 Protein Kinase C Proteins 0.000 title 1
- PYKYMHQGRFAEBM-UHFFFAOYSA-N anthraquinone Natural products CCC(=O)c1c(O)c2C(=O)C3C(C=CC=C3O)C(=O)c2cc1CC(=O)OC PYKYMHQGRFAEBM-UHFFFAOYSA-N 0.000 title 1
- 150000004056 anthraquinones Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/36—Compounds containing oxirane rings with hydrocarbon radicals, substituted by nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
- C07C225/24—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones the carbon skeleton containing carbon atoms of quinone rings
- C07C225/26—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones the carbon skeleton containing carbon atoms of quinone rings having amino groups bound to carbon atoms of quinone rings or of condensed ring systems containing quinone rings
- C07C225/32—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones the carbon skeleton containing carbon atoms of quinone rings having amino groups bound to carbon atoms of quinone rings or of condensed ring systems containing quinone rings of condensed quinone ring systems formed by at least three rings
- C07C225/34—Amino anthraquinones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
- C07C225/24—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones the carbon skeleton containing carbon atoms of quinone rings
- C07C225/26—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones the carbon skeleton containing carbon atoms of quinone rings having amino groups bound to carbon atoms of quinone rings or of condensed ring systems containing quinone rings
- C07C225/32—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones the carbon skeleton containing carbon atoms of quinone rings having amino groups bound to carbon atoms of quinone rings or of condensed ring systems containing quinone rings of condensed quinone ring systems formed by at least three rings
- C07C225/34—Amino anthraquinones
- C07C225/36—Amino anthraquinones the carbon skeleton being further substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/52—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
- C07C229/68—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings being part of the same condensed ring system
- C07C229/72—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings being part of the same condensed ring system the carbon skeleton being further substituted by doubly-bound oxygen atoms
- C07C229/74—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings being part of the same condensed ring system the carbon skeleton being further substituted by doubly-bound oxygen atoms the condensed ring system being formed by at least three rings, e.g. amino anthraquinone carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/12—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/30—Isothioureas
- C07C335/32—Isothioureas having sulfur atoms of isothiourea groups bound to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/22—Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
- C07C2603/24—Anthracenes; Hydrogenated anthracenes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Epoxy Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60917990A | 1990-11-02 | 1990-11-02 | |
| US07/609,252 US5204370A (en) | 1990-11-05 | 1990-11-05 | Bis-(hydroxyalkylamino)-anthraquinone inhibitors of protein kinase C |
| PCT/US1991/008026 WO1992007557A1 (en) | 1990-11-02 | 1991-10-30 | Bis-(hydroxyalkylamino)-anthraquinone inhibitors of protein kinase c |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9106118A true BR9106118A (pt) | 1993-03-02 |
Family
ID=27085973
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR919106118A BR9106118A (pt) | 1990-11-02 | 1991-10-30 | Antraquinona substituida,composicao famaceutica e processo para inibir quinase c de proteina e,uso de um composto |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5344841A (pt) |
| EP (1) | EP0507938A4 (pt) |
| JP (1) | JPH05503721A (pt) |
| KR (1) | KR920703513A (pt) |
| AU (1) | AU637014B2 (pt) |
| BR (1) | BR9106118A (pt) |
| CA (1) | CA2072889A1 (pt) |
| HU (1) | HUT64295A (pt) |
| WO (1) | WO1992007557A1 (pt) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5141957A (en) * | 1990-11-02 | 1992-08-25 | Sphinx Pharmaceuticals Corporation | 1,4-bis-(amino-hydroxyalkylamino)-anthraquinones for inhibiting protein kinase c |
| GB9205859D0 (en) * | 1992-03-18 | 1992-04-29 | Imp Cancer Res Tech | Compounds |
| US5519035A (en) * | 1993-07-02 | 1996-05-21 | Cornell Research Foundation, Inc. | Treatment of stroke or in anticipation of the occurrence of brain ischemia |
| GB9320191D0 (en) * | 1993-09-30 | 1993-11-17 | Univ Napier | Compounds |
| US5436243A (en) * | 1993-11-17 | 1995-07-25 | Research Triangle Institute Duke University | Aminoanthraquinone derivatives to combat multidrug resistance |
| US6232299B1 (en) * | 1996-05-01 | 2001-05-15 | Eli Lilly And Company | Use of protein kinase C inhibitors to enhance the clinical efficacy of oncolytic agents and radiation therapy |
| US6376467B1 (en) * | 1998-10-09 | 2002-04-23 | The Regents Of The University Of California | Use of inhibitors of protein kinase C epsilon to treat pain |
| US6717030B2 (en) * | 1998-07-06 | 2004-04-06 | The Regents Of The University Of California | Protein kinase C epsilon as modulator of anxiety, alcohol consumption and self-administration of drugs of abuse |
| GB2403474B (en) * | 2002-04-18 | 2006-10-11 | Inst Med Molecular Design Inc | Amide derivatives |
| DE10244453A1 (de) * | 2002-09-24 | 2004-04-01 | Phenomiques Gmbh | Hemmung der Proteinkinase C-alpha zur Behandlung von Krankheiten |
| CN102266272B (zh) * | 2002-11-27 | 2012-12-26 | Dmi生物科学公司 | 一种个人护理组合物及其产品 |
| EP1670497A4 (en) | 2003-09-16 | 2009-07-15 | Garvan Inst Med Res | METHOD FOR IDENTIFYING MODULATORS OF PROTEIN KINASE C EPSILON (PKC Ε) AND METHOD FOR TREATING THEREOF CONVERTING DERIVED GLUCOSE METABOLISM |
| US8158586B2 (en) * | 2005-04-11 | 2012-04-17 | Pharmagap Inc. | Inhibitors of protein kinases and uses thereof |
| EP2124987A4 (en) | 2007-01-19 | 2012-05-02 | Kai Pharmaceuticals Inc | METHOD OF USE OF EPSILON HEMMER COMPOUNDS FOR PAIN LIFTING |
| DE102007063056A1 (de) * | 2007-12-28 | 2009-07-02 | Universität Leipzig | Verwendung von 4-Amino-1,3,8-trihydroxyanthracen-9,10-dionderivaten zur Inhibierung von Proteinkinasen |
| EP2942060A1 (en) | 2009-09-29 | 2015-11-11 | Joslin Diabetes Center, Inc. | Use of Protein Kinase C Delta (PKCD) Inhibitors to Treat Diabetes, Obesity and, Hepatic Steatosis |
| EP2744775B1 (en) | 2011-08-19 | 2018-03-07 | Emory University | Bax agonist, compositions, and methods related thereto |
| AU2015256266B2 (en) * | 2014-05-05 | 2019-01-17 | Emory University | BH4 antagonists and methods related thereto |
| CN104491889B (zh) * | 2014-12-05 | 2017-05-24 | 江苏省中医药研究院 | 放射性同位素标记的单蒽核蒽醌类化合物在制备用于检测心肌活性的药物中的应用 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1540733A (en) * | 1923-10-25 | 1925-06-02 | British Dyestuffs Corp Ltd | Dyestuffs of the anthraquinone series |
| US2411148A (en) * | 1943-10-23 | 1946-11-19 | Eastman Kodak Co | Anthraquinone dyestuffs |
| US3960751A (en) * | 1973-09-19 | 1976-06-01 | Matsushita Electric Industrial Co., Ltd. | Electro-optical display element |
| US4197249A (en) * | 1977-08-15 | 1980-04-08 | American Cyanamid Company | 1,4-Bis(substituted-amino)-5,8-dihydroxyanthraquinones and leuco bases thereof |
| US4310666A (en) * | 1978-04-10 | 1982-01-12 | United States Of America | Anti-neoplastic 1,4-bis-(substituted aminoalkyl amino)-anthraquinones |
| US4526989A (en) * | 1978-07-11 | 1985-07-02 | American Cyanamid Company | 1,4-Bis (substituted-amino)-5,8-dihydroxy-anthraquinones and leuco bases thereof |
| US4598155A (en) * | 1981-11-18 | 1986-07-01 | Ciba-Geigy Corporation | 3(5-tetrazolyl)1,4-diaminoanthraquinones |
| US4540788A (en) * | 1983-07-14 | 1985-09-10 | American Cyanamid Company | Schiff bases of [(aminoalkyl or substituted aminoalkyl)amino]-9,10-anthracenediones |
| DE3331296A1 (de) * | 1983-08-31 | 1985-03-14 | Hoechst Ag, 6230 Frankfurt | Mono- und bisfunktionelle anthrachinon-(oxy-2,3-oxidopropane), verfahren zu ihrer herstellung und ihre verwendung |
| US4894451A (en) * | 1985-04-01 | 1990-01-16 | The University Of Vermont | Unsymmetrical 1,4-bis(aminoalkylamino)-anthracene-9, 10-diones and derivatives |
| JPS6315853A (ja) * | 1986-07-07 | 1988-01-22 | Dainippon Printing Co Ltd | 熱転写シ−ト用染料 |
| US4816450A (en) * | 1986-09-15 | 1989-03-28 | Duke University | Inhibition of protein kinase C by long-chain bases |
| JPH0219819A (ja) * | 1988-07-08 | 1990-01-23 | Nikon Corp | 角度制御装置 |
| DE3827974A1 (de) * | 1988-08-18 | 1990-02-22 | Boehringer Mannheim Gmbh | Kombinationspraeparate von proteinkinase-c-inhibitoren mit lipiden, lipid-analoga, cytostatica oder inhibitoren von phospholipasen |
-
1991
- 1991-10-30 BR BR919106118A patent/BR9106118A/pt unknown
- 1991-10-30 KR KR1019920701572A patent/KR920703513A/ko not_active Ceased
- 1991-10-30 EP EP19920900251 patent/EP0507938A4/en not_active Withdrawn
- 1991-10-30 JP JP4500870A patent/JPH05503721A/ja active Pending
- 1991-10-30 AU AU90398/91A patent/AU637014B2/en not_active Ceased
- 1991-10-30 US US07/859,514 patent/US5344841A/en not_active Expired - Fee Related
- 1991-10-30 HU HU9202206A patent/HUT64295A/hu unknown
- 1991-10-30 CA CA002072889A patent/CA2072889A1/en not_active Abandoned
- 1991-10-30 WO PCT/US1991/008026 patent/WO1992007557A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| AU637014B2 (en) | 1993-05-13 |
| AU9039891A (en) | 1992-05-26 |
| KR920703513A (ko) | 1992-12-18 |
| EP0507938A4 (en) | 1993-03-10 |
| JPH05503721A (ja) | 1993-06-17 |
| EP0507938A1 (en) | 1992-10-14 |
| CA2072889A1 (en) | 1992-05-03 |
| US5344841A (en) | 1994-09-06 |
| HUT64295A (en) | 1993-12-28 |
| WO1992007557A1 (en) | 1992-05-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR9106118A (pt) | Antraquinona substituida,composicao famaceutica e processo para inibir quinase c de proteina e,uso de um composto | |
| BR8503490A (pt) | Composto,processo para preparar o composto,composicao,processo para exterminar ervas daninhas e uso de um composto | |
| BR1100323A (pt) | Composto, uso de um composto, composição farmacêutica e processo para preparar um composto | |
| BR9107219A (pt) | Composicao de revestimento e processo para preparar a mesma | |
| BR9602705A (pt) | Composto composição farmacéutica processo para a preparação de um composto e uso | |
| BR9103195A (pt) | Composto e processo para sua preparacao | |
| BR9004852A (pt) | Composto,processo para sua preparacao,sua aplicacao e composicao farmaceutica | |
| BR9505107A (pt) | Composto composiçao farmacêutica processo para a preparaçao de um composto e seu uso | |
| BR8905837A (pt) | Composto,processo para sua preparacao e composicao fotocuravel | |
| BR1100979A (pt) | Derivado de carboidrato, processo para preparar um derivado de carboidrato, composição farmacêutica de carboidrato e uso de derivado de carboidrato | |
| BR9102489A (pt) | Aminobenzo diazepinas,benzodiaze pinotionas,processo para preparar um composto,medicamento,uso e composto | |
| BR9106117A (pt) | Antraquinona substituida,composicao farmaceutica para inibir quinase c de proteina,processo para tal inibicao e uso de um composto | |
| BR8500565A (pt) | Corantes,processo para sua preparacao,utilizacao,compostos,processo para sua preparacao | |
| BR8806217A (pt) | Derivados de 2,2-difluorciclopropiletano,processo para sua preparacao,composicoes praguicidas e aplicacao | |
| BR8702278A (pt) | Processo para a preparacao de um composto e composicao | |
| BR9005793A (pt) | Composicao de fluoreto estanoso aquoso estabilizada e processo para preparacao da mesma | |
| BR9202446A (pt) | Composicao de dentifricio,dentifricio e processo para a preparacao de um dentifricio | |
| BR9602025A (pt) | Composto composição farmacêutica uso e processo para a preparação de um composto | |
| BR8904212A (pt) | Processo para preparar 1,3,5-trinitro-2,4,6-tripicrilbenzeno e composto | |
| BR8702907A (pt) | Processo para preparacao de composto herbicida e composicao herbicida | |
| BR9005094A (pt) | Composto,processo para preparar o mesmo,composicao herbicida,processo para exterminar ervas daninhas e uso de tal composto | |
| BR9106781A (pt) | Xilanase,processo para produzir xilanese e uso da mesma | |
| BR8702908A (pt) | Processo para preparacao de composto herbicida e composicao herbicida | |
| BR8702902A (pt) | Processo para preparacao de composto,e composicao herbicida | |
| BR8803768A (pt) | Composicao odorante,processo para producao de compostos e uso dos ditos compostos |