BR8803345A - Processo aperfeicoado para producao em larga escala de cristais de insulina humana purificada - Google Patents

Processo aperfeicoado para producao em larga escala de cristais de insulina humana purificada

Info

Publication number: BR8803345A
Authority: BR; Brazil
Prior art keywords: wide; human insulin; scale production; purified human; insulin crystals
Prior art date: 1988-06-30

Application number

BR8803345A

Other languages

English (en)

Inventor

Mariza Suzana Santos Pe Xavier

Heloisa Ribeiro Tunes De Souza

Luciano Vilela

Marcelo Junior Zuculin

Simone Baeta Lage De Oliveira

Marcos Luiz Dos Mares Guia

Original Assignee

Biobras Bioquimica Do Brasil S

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-06-30

Filing date

1988-06-30

Publication date

1990-02-13

1988-06-30 Application filed by Biobras Bioquimica Do Brasil S filed Critical Biobras Bioquimica Do Brasil S

1988-06-30 Priority to BR8803345A priority Critical patent/BR8803345A/pt

1989-03-02 Priority to PCT/BR1989/000003 priority patent/WO1990000176A1/en

1990-02-13 Publication of BR8803345A publication Critical patent/BR8803345A/pt

Links

101000976075 Homo sapiens Insulin Proteins 0.000 title 1
239000013078 crystal Substances 0.000 title 1
PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- C07K14/625—Extraction from natural sources

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Toxicology (AREA)
Endocrinology (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Diabetes (AREA)
Peptides Or Proteins (AREA)

BR8803345A 1988-06-30 1988-06-30 Processo aperfeicoado para producao em larga escala de cristais de insulina humana purificada BR8803345A (pt)

Priority Applications (2)

Application Number	Priority Date	Filing Date	Title
BR8803345A BR8803345A (pt)	1988-06-30	1988-06-30	Processo aperfeicoado para producao em larga escala de cristais de insulina humana purificada
PCT/BR1989/000003 WO1990000176A1 (en)	1988-06-30	1989-03-02	Improved process for purifying insulin

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
BR8803345A BR8803345A (pt)	1988-06-30	1988-06-30	Processo aperfeicoado para producao em larga escala de cristais de insulina humana purificada

Publications (1)

Publication Number	Publication Date
BR8803345A true BR8803345A (pt)	1990-02-13

Family

ID=4045111

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BR8803345A BR8803345A (pt)	1988-06-30	1988-06-30	Processo aperfeicoado para producao em larga escala de cristais de insulina humana purificada

Country Status (2)

Country	Link
BR (1)	BR8803345A (pt)
WO (1)	WO1990000176A1 (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HUP0102577A3 (en) *	1998-06-30	2002-02-28	Novo Nordisk As	Seeding crystals for the preparation of peptides or proteins, process for their preparation and their use
RU2205188C2 (ru) *	1998-06-30	2003-05-27	Ново Нордиск А/С	Затравочные кристаллы для получения пептидов или протеинов
US6444788B1 (en)	1999-03-15	2002-09-03	Novo Nordisk A/S	Ion exchange chromatography of GLP-1, analogs and derivatives thereof
US6451987B1 (en)	1999-03-15	2002-09-17	Novo Nordisk A/S	Ion exchange chromatography of proteins and peptides
KR20060106812A (ko)	2003-08-21	2006-10-12	노보 노르디스크 에이/에스	라세미화 아미노산을 포함하는 폴리펩티드의 분리

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3907676A (en) *	1970-07-28	1975-09-23	Novo Terapeutisk Labor As	Process for purifying insulin
DK119785D0 (da) *	1985-03-15	1985-03-15	Nordisk Gentofte	Insulinpraeparat
DE3511269A1 (de) *	1985-04-12	1986-10-09	Veb Berlin-Chemie, Ddr 1199 Berlin	Verfahren zur reinigung von insulin

1988
- 1988-06-30 BR BR8803345A patent/BR8803345A/pt unknown
1989
- 1989-03-02 WO PCT/BR1989/000003 patent/WO1990000176A1/en not_active Ceased

Also Published As

Publication number	Publication date
WO1990000176A1 (en)	1990-01-11

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Legal Events

Date	Code	Title	Description
2018-03-27	B15K	Others concerning applications: alteration of classification	Ipc: C07K 14/625 (2006.01)