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BR8302318A - HUMAN TISSUE PLASMINOGEN ACTIVATOR, DNA FOLLOWING, REPLICABLE EXPRESSION VECTOR, PLASMIDE, MICROORGANISM OR CELLULOR CULTURE, COMPOSITION, USE OF THAT ACTIVATOR, EXPRESSION PROCESS, AND PROCESS TO PRODUCE HUMAN T PA - Google Patents

HUMAN TISSUE PLASMINOGEN ACTIVATOR, DNA FOLLOWING, REPLICABLE EXPRESSION VECTOR, PLASMIDE, MICROORGANISM OR CELLULOR CULTURE, COMPOSITION, USE OF THAT ACTIVATOR, EXPRESSION PROCESS, AND PROCESS TO PRODUCE HUMAN T PA

Info

Publication number
BR8302318A
BR8302318A BR8302318A BR8302318A BR8302318A BR 8302318 A BR8302318 A BR 8302318A BR 8302318 A BR8302318 A BR 8302318A BR 8302318 A BR8302318 A BR 8302318A BR 8302318 A BR8302318 A BR 8302318A
Authority
BR
Brazil
Prior art keywords
activator
cellulor
plasmide
microorganism
culture
Prior art date
Application number
BR8302318A
Other languages
Portuguese (pt)
Inventor
David V Goeddel
William J Kohr
Diane Pennica
Gordon A Vehar
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27409206&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR8302318(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US06/483,052 external-priority patent/US4766075A/en
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of BR8302318A publication Critical patent/BR8302318A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0026—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on CH-NH groups of donors (1.5)
    • C12N9/0028—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on CH-NH groups of donors (1.5) with NAD or NADP as acceptor (1.5.1)
    • C12N9/003—Dihydrofolate reductase [DHFR] (1.5.1.3)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C12N15/71—Expression systems using regulatory sequences derived from the trp-operon
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Plant Pathology (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
BR8302318A 1982-05-05 1983-05-04 HUMAN TISSUE PLASMINOGEN ACTIVATOR, DNA FOLLOWING, REPLICABLE EXPRESSION VECTOR, PLASMIDE, MICROORGANISM OR CELLULOR CULTURE, COMPOSITION, USE OF THAT ACTIVATOR, EXPRESSION PROCESS, AND PROCESS TO PRODUCE HUMAN T PA BR8302318A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US37486082A 1982-05-05 1982-05-05
US39800382A 1982-07-14 1982-07-14
US06/483,052 US4766075A (en) 1982-07-14 1983-04-07 Human tissue plasminogen activator

Publications (1)

Publication Number Publication Date
BR8302318A true BR8302318A (en) 1984-01-10

Family

ID=27409206

Family Applications (1)

Application Number Title Priority Date Filing Date
BR8302318A BR8302318A (en) 1982-05-05 1983-05-04 HUMAN TISSUE PLASMINOGEN ACTIVATOR, DNA FOLLOWING, REPLICABLE EXPRESSION VECTOR, PLASMIDE, MICROORGANISM OR CELLULOR CULTURE, COMPOSITION, USE OF THAT ACTIVATOR, EXPRESSION PROCESS, AND PROCESS TO PRODUCE HUMAN T PA

Country Status (26)

Country Link
EP (1) EP0093619B2 (en)
JP (2) JPH0216981A (en)
AR (1) AR241654A1 (en)
BG (1) BG60253B1 (en)
BR (1) BR8302318A (en)
CA (1) CA1293211C (en)
CS (1) CS248705B2 (en)
CY (1) CY1341A (en)
DD (1) DD210303A5 (en)
DE (3) DE93619T1 (en)
DK (1) DK174236B1 (en)
ES (1) ES8501629A1 (en)
FR (1) FR2526443B1 (en)
GB (1) GB2119804B (en)
GR (1) GR79202B (en)
HK (1) HK88586A (en)
IE (1) IE54975B1 (en)
IL (1) IL68561A (en)
KE (1) KE3647A (en)
MY (1) MY8700119A (en)
NO (2) NO831575L (en)
OA (1) OA07419A (en)
PL (1) PL152438B1 (en)
PT (1) PT76636B (en)
RO (1) RO90639B (en)
ZW (1) ZW10483A1 (en)

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US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
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US5639639A (en) * 1983-11-02 1997-06-17 Genzyme Corporation Recombinant heterodimeric human fertility hormones, and methods, cells, vectors and DNA for the production thereof
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US4703008A (en) * 1983-12-13 1987-10-27 Kiren-Amgen, Inc. DNA sequences encoding erythropoietin
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Also Published As

Publication number Publication date
EP0093619B2 (en) 1996-09-18
FR2526443A1 (en) 1983-11-10
AR241654A1 (en) 1992-10-30
IE831024L (en) 1983-11-05
AU1414283A (en) 1983-11-10
PL152438B1 (en) 1990-12-31
DK174236B1 (en) 2002-10-07
EP0093619A1 (en) 1983-11-09
BG60253B2 (en) 1994-03-24
JPH0216981A (en) 1990-01-19
DK198883D0 (en) 1983-05-04
BG60253B1 (en) 1994-03-24
IE54975B1 (en) 1990-04-11
ES522085A0 (en) 1984-12-16
GB2119804A (en) 1983-11-23
IL68561A (en) 1991-01-31
DE93619T1 (en) 1987-08-13
RO90639B (en) 1987-01-31
EP0093619B1 (en) 1989-09-13
GB2119804B (en) 1986-02-26
PT76636B (en) 1986-01-10
OA07419A (en) 1984-11-30
RO90639A (en) 1987-01-30
DK198883A (en) 1983-12-20
DD210303A5 (en) 1984-06-06
GR79202B (en) 1984-10-22
IL68561A0 (en) 1983-09-30
FR2526443B1 (en) 1985-12-06
PL241805A1 (en) 1984-07-30
JPH0448440B2 (en) 1992-08-06
AU563031B2 (en) 1987-06-25
CY1341A (en) 1987-01-16
KE3647A (en) 1986-07-25
DE3316297A1 (en) 1983-11-17
DE3316297C2 (en) 1989-09-21
MY8700119A (en) 1987-12-31
JPH05137583A (en) 1993-06-01
JP2564444B2 (en) 1996-12-18
ES8501629A1 (en) 1984-12-16
CA1293211C (en) 1991-12-17
NO831575L (en) 1983-11-07
HK88586A (en) 1986-11-28
NO852065L (en) 1983-11-07
DE3380567D1 (en) 1989-10-19
PT76636A (en) 1983-06-01
CS248705B2 (en) 1987-02-12
GB8312221D0 (en) 1983-06-08
ZW10483A1 (en) 1983-09-21

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Ipc: C12N 9/06 (2006.01), C12N 9/72 (2006.0