[go: up one dir, main page]

BR0318561A - processo seletivo para a preparação de erbumino perindopril cristalino - Google Patents

processo seletivo para a preparação de erbumino perindopril cristalino

Info

Publication number
BR0318561A
BR0318561A BRPI0318561-3A BR0318561A BR0318561A BR 0318561 A BR0318561 A BR 0318561A BR 0318561 A BR0318561 A BR 0318561A BR 0318561 A BR0318561 A BR 0318561A
Authority
BR
Brazil
Prior art keywords
preparation
perindopril
erbumin
erbumino
crystalline perindopril
Prior art date
Application number
BRPI0318561-3A
Other languages
English (en)
Inventor
Girij Pal Singh
Himanshu Madhav Godbole
Sagar Purushottam Nehate
Original Assignee
Lupin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lupin Ltd filed Critical Lupin Ltd
Publication of BR0318561A publication Critical patent/BR0318561A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

"PROCESSO SELETIVO PARA A PREPARAçãO DE ERBUMINO PERINDOPRIL CRISTALINO". Um processo para a preparação de erbumino perindopril cristalino tendo a fórmula (II) o qual exibe um padrão de difração (pó) de raios-X como aquele mostrado na Figura 2. O processo compreende a reação de uma solução de perindopril da fórmula (I), em um solvente selecionado a partir de N,N-dimetilaformamido ou de acetais de dimetila de aldeídos alifáticos inferiores e acetonas com butilamino terciário e a cristalização do sal de erbumino assim obtido pelo aquecimento da mistura de reação até o refluxo, filtração a calor, resfriamento gradual até 20 <198>C a 30 <198>C, e o resfriamento em adição até 0 <198>C a 15 <198>C por 30 minutos até 1 hora e finalmente a filtração pata fora e a secagem dos cristais.
BRPI0318561-3A 2003-10-21 2003-10-21 processo seletivo para a preparação de erbumino perindopril cristalino BR0318561A (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IN2003/000340 WO2005037788A1 (en) 2003-10-21 2003-10-21 Novel method for preparation of crystalline perindopril erbumine

Publications (1)

Publication Number Publication Date
BR0318561A true BR0318561A (pt) 2006-10-10

Family

ID=34452214

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0318561-3A BR0318561A (pt) 2003-10-21 2003-10-21 processo seletivo para a preparação de erbumino perindopril cristalino

Country Status (15)

Country Link
US (1) US7456296B2 (pt)
EP (1) EP1675827B1 (pt)
JP (1) JP4677611B2 (pt)
AT (1) ATE452124T1 (pt)
AU (1) AU2003300689B2 (pt)
BR (1) BR0318561A (pt)
CY (1) CY1110608T1 (pt)
DE (1) DE60330603D1 (pt)
DK (1) DK1675827T3 (pt)
ES (1) ES2336554T3 (pt)
IL (1) IL174860A (pt)
PT (1) PT1675827E (pt)
SI (1) SI1675827T1 (pt)
WO (1) WO2005037788A1 (pt)
ZA (1) ZA200604068B (pt)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005108365A1 (en) * 2004-05-07 2005-11-17 Glenmark Pharmaceuticals Limited Processes for the preparation of alpha polymorph of perindopril erbumine
SG125976A1 (en) * 2005-03-11 2006-10-30 Servier Lab New gama crystalline form of perindopril tert-butylamine salt, a process for its preparation and pharmaceutical compositions containing it
SG125975A1 (en) * 2005-03-11 2006-10-30 Servier Lab New alpha crystalline form of perindopril tert-butylamine salt, a process for its preparation and pharmaceutical compositions containing it
WO2007017894A2 (en) * 2005-05-05 2007-02-15 Arch Pharmalabs Limited PREPARATION OF NOVEL CRYSTALLINE η(ETA) FORM OF PERINDOPRIL ERBUMINE
US20090099370A1 (en) * 2005-08-12 2009-04-16 Sandoz Ag Crystalline Form of Perindopril Erbumine
BRPI0615607A2 (pt) * 2005-08-30 2011-05-24 Lek Pharmaceuticals composição farmacêutica compreendendo perindopril ou seus sais
EA200600630A1 (ru) * 2006-04-20 2007-02-27 ИСМАГИЛОВ, Искандар Халиуллович ζ-ЗЕТА ФОРМА ПЕРИНДОПРИЛ ЭРБУМИНА
WO2008050185A2 (en) * 2006-10-26 2008-05-02 Glenmark Pharmaceuticals Limited Novel polymorphs of perindopril erbumine
EP1964836A3 (en) * 2006-11-06 2008-11-19 IPCA Laboratories Limited A process for the preparation of perindopril erbumine in alpha crystalline form
GB0624090D0 (en) * 2006-12-01 2007-01-10 Selamine Ltd Ramipril amine salts
WO2008114270A1 (en) * 2007-03-22 2008-09-25 Aarti Healthcare Limited Process for the preparation of perindopril erbumine salt and novel polymorph (s) thereof
AU2013201812B2 (en) * 2007-06-27 2015-04-02 Les Laboratoires Servier Salts of perindopril
SI22543A (sl) * 2007-06-27 2008-12-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Nove soli perindoprila
PT105315B (pt) 2010-09-29 2013-01-16 Inst Superior Tecnico Uma nova forma cristalina hidratada de erbumina de perindopril, métodos para a sua preparação e sua utilização em preparações farmacêuticas
JP5776888B2 (ja) * 2011-05-25 2015-09-09 日産自動車株式会社 電気デバイス用負極活物質
WO2016178591A2 (en) 2015-05-05 2016-11-10 Gene Predit, Sa Genetic markers and treatment of male obesity
CN107098949B (zh) * 2017-04-20 2021-03-16 上药东英（江苏）药业有限公司 一种制备培哚普利叔丁胺盐的绿色合成新工艺
CN116500156A (zh) * 2023-04-20 2023-07-28 上海市食品药品检验研究院 一种培哚普利叔丁胺立体异构体杂质分离检测方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2620709B1 (fr) * 1987-09-17 1990-09-07 Adir Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese
FR2807431B1 (fr) * 2000-04-06 2002-07-19 Adir Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables
FR2811319B1 (fr) 2000-07-06 2002-08-23 Adir Nouvelle forme cristalline beta du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent
FR2811320B1 (fr) 2000-07-06 2002-08-23 Adir Nouvelle forme cristalline alpha du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent
FR2811318B1 (fr) 2000-07-06 2002-08-23 Adir Nouvelle forme cristalline gamma du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent
AR036187A1 (es) * 2001-07-24 2004-08-18 Adir Un proceso para la preparacion de perindopril, compuestos analogos y sus sales, compuesto intermediario 2,5-dioxo-oxazolidina y proceso para preparar un intermediario
DK1333026T3 (da) * 2002-01-30 2007-10-22 Servier Lab Fremgangsmåde til fremstilling af perindopril med höj renhed og nyttige mellemforbindelser til syntesen
ES2250853T3 (es) * 2003-08-29 2006-04-16 Les Laboratoires Servier Procedimiento para la sintesis de perindopril y de sus sales farmaceuticamente aceptables.

Also Published As

Publication number Publication date
EP1675827B1 (en) 2009-12-16
US7456296B2 (en) 2008-11-25
IL174860A (en) 2011-09-27
IL174860A0 (en) 2006-08-20
US20070149604A1 (en) 2007-06-28
CY1110608T1 (el) 2015-04-29
ZA200604068B (en) 2008-01-08
PT1675827E (pt) 2010-02-15
JP2007518668A (ja) 2007-07-12
WO2005037788A1 (en) 2005-04-28
DE60330603D1 (de) 2010-01-28
SI1675827T1 (sl) 2010-04-30
AU2003300689B2 (en) 2009-01-29
DK1675827T3 (da) 2010-04-19
ES2336554T3 (es) 2010-04-14
JP4677611B2 (ja) 2011-04-27
AU2003300689A1 (en) 2005-05-05
EP1675827A1 (en) 2006-07-05
ATE452124T1 (de) 2010-01-15

Similar Documents

Publication Publication Date Title
BR0318561A (pt) processo seletivo para a preparação de erbumino perindopril cristalino
FR2820342B1 (fr) Procede de preparation de membranes zeolithiques supportees par cristallisation controlee en temperature
BR9906539A (pt) Polimorfo de ácido 2-(3-ciano-4-isobutil-óxi-fenil)-4-metil-5-tiazol-carboxì lico, composto amorfo, processos para produção de um composto amorfo, para produção de cristal, a, b, c, d, g de ácido. 2-(3-ciano-4-isobutil-óxi-fenil)-4-metil-5-tiazol-carboxì lico, e, polimorfo
BRPI0107921B8 (pt) processo para produzir seletivamente monohidrato e hemipentahidrato de ácido 3-piridil-1-hidroxietilideno-1,1-bisfosfônico de sódio
ES2039009T3 (es) Procedimiento para la preparacion de poliglicerinas.
Kakaei et al. Expeditious synthesis of 1-substituted taurines with diverse functionalized side-chains
DK182583A (da) N-alkyl-norscopiner og fremgangsmaade til fremstilling heraf
AR034124A1 (es) Forma cristalina alfa de la sal de terbutilamina de perindopril, procedimiento para su preparacion y composiciones farmaceuticas que la contienen
PT92378A (pt) Processo para a preparacao de derivados de cromano, activos sobre o sistema nervoso central
PT1403266E (pt) Novo processo de síntese industrial do ranelato de estrôncio e dos seus hidratos
BR0013311A (pt) Derivados substituìdos de 1,5-dihidropirrol-2-ona eficazes como antagonistas de receptores nmda para o tratamento de estados de dor
KR900001215B1 (ko) (3-아미노-1h-피라졸-4-일)(아릴) 메탄온의 제조방법
PT758651E (pt) Cristal de derivado de pirrolidiltiocarbapenem formulacao liofilizada contendo o citado cristal e processo para a producao do mesmo
NO20006441D0 (no) Katalysator for dampkrakkingsreaksjoner, fremgangsmåte for fremstilling derav, og fremgangsmåte for fremstilling av lette olefiner
KR840003625A (ko) (＋)-카테킨 1 수화물 및 무수형의 결정 변형체의 제조방법
AR070008A1 (es) Proceso e intermediarios para la sintesis de compuestos de 3,4- dioxo-1- ciclobuteno 1,2- sustituidos
BR0113259A (pt) Processo para a preparação de um composto, composto e processo para a preparação de compostos
DK0717042T3 (da) Fremgangsmåde til fremstilling af 1-(4,5-dihydro-2-thiazolyl)-3-azetidin-thiol-derivater
ES2616406T3 (es) Procedimiento para producir formiato de potasio
DE60104639D1 (de) Neue Thioether-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung
BRPI0408031A (pt) processo para estabilizar soluções de formaldeìdo de alta concentração, solução de alta concentração de formaldeìdo, e, uso da mesma
BR0010488B1 (pt) tienocicloalqu(en)ilamino-1,3,5-triazinas substituÍdas como herbicidas, processo para sua preparaÇço, mÉtodo para controle de vegetaÇço indesejÁvel, bem como uso e composiÇço herbicida.
WO1980000345A1 (fr) Esters de l&#39;acide pyridine 2,6-dimethyle-1,4-dihydro-3,5-dicarboxylique et leur methode de production
Liu et al. 4-Amino-3-methyl-1, 2, 4-triazole-5-thione derivative of p-nitrophenylaldehyde
RU2266286C1 (ru) Гетероциклические о-дикарбонитрилы

Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: LES LABORATOIRES SERVIER (FR)

Free format text: TRANSFERIDO DE: LUPIN LIMITED

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B11D Dismissal acc. art. 38, par 2 of ipl - failure to pay fee after grant in time