BR0318360A - aporfina e oxoaporfina e o uso médico das mesmas - Google Patents
aporfina e oxoaporfina e o uso médico das mesmasInfo
- Publication number
- BR0318360A BR0318360A BRPI0318360-2A BR0318360A BR0318360A BR 0318360 A BR0318360 A BR 0318360A BR 0318360 A BR0318360 A BR 0318360A BR 0318360 A BR0318360 A BR 0318360A
- Authority
- BR
- Brazil
- Prior art keywords
- ischemic
- disease
- medical use
- compounds
- oxoaporfin
- Prior art date
Links
- BZKUYNBAFQJRDM-UHFFFAOYSA-N aporphine Chemical compound C12=CC=CC=C2CC2N(C)CCC3=CC=CC1=C32 BZKUYNBAFQJRDM-UHFFFAOYSA-N 0.000 title 2
- QCMQEZNBBPGFKQ-UHFFFAOYSA-N Thalisopynine Natural products CN1CCC2=C(OC)C(OC)=C(OC)C3=C2C1CC1=C3C=C(OC)C(O)=C1 QCMQEZNBBPGFKQ-UHFFFAOYSA-N 0.000 title 1
- FVRABHGHBLRNNR-UHFFFAOYSA-N liriodenine Natural products O=C1C=CC=c2c1cc3nccc4cc5OCOc5c2c34 FVRABHGHBLRNNR-UHFFFAOYSA-N 0.000 title 1
- 230000000302 ischemic effect Effects 0.000 abstract 3
- 102000008052 Nitric Oxide Synthase Type III Human genes 0.000 abstract 2
- 108010075520 Nitric Oxide Synthase Type III Proteins 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000023589 ischemic disease Diseases 0.000 abstract 2
- 206010008088 Cerebral artery embolism Diseases 0.000 abstract 1
- 206010008132 Cerebral thrombosis Diseases 0.000 abstract 1
- 206010070511 Hypoxic-ischaemic encephalopathy Diseases 0.000 abstract 1
- 201000001429 Intracranial Thrombosis Diseases 0.000 abstract 1
- 208000032382 Ischaemic stroke Diseases 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 208000037212 Neonatal hypoxic and ischemic brain injury Diseases 0.000 abstract 1
- 208000027418 Wounds and injury Diseases 0.000 abstract 1
- 208000009973 brain hypoxia - ischemia Diseases 0.000 abstract 1
- 230000006378 damage Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 208000014674 injury Diseases 0.000 abstract 1
- 201000010849 intracranial embolism Diseases 0.000 abstract 1
- 208000031225 myocardial ischemia Diseases 0.000 abstract 1
- XHCICOLGLYLOAA-UHFFFAOYSA-N oxoaporphine Natural products COC1=C(OC)C=C2C(C(C(OC)=C3)=O)=C4C3=CC=NC4=CC2=C1 XHCICOLGLYLOAA-UHFFFAOYSA-N 0.000 abstract 1
- 208000033300 perinatal asphyxia Diseases 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/18—Ring systems of four or more rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/06—Peri-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
"APORFINA E OXOAPORFINA E O USO MéDICO DAS MESMAS". A invenção proporciona certas aporfinas e oxoaporfinas para preparação de remédio que podem ser usadas para prevenção e tratamento de doença isquêmica. O mecanismo farmacológico de referidos compostos é manter ou aumentar a síntase de óxido nítrico endotelial (eNOS), desse modo, os compostos podem ser usados para produzir remédios para impedir ou tratar doença isquêmica de mamíferos ou seres humanos, incluindo apoplexia isquêmica, trombose cerebral isquêmica, embolismo cerebral isquêmico, encefalopatia isquêmica hipóxica, doença cardíaca isquêmica ou lesão intestinal isquêmica.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2003/000477 WO2004110449A1 (en) | 2003-06-19 | 2003-06-19 | Aporphine and oxoaporphine and the medical use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0318360A true BR0318360A (pt) | 2006-07-25 |
Family
ID=33546168
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0318360-2A BR0318360A (pt) | 2003-06-19 | 2003-06-19 | aporfina e oxoaporfina e o uso médico das mesmas |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US7057044B2 (pt) |
| EP (1) | EP1634596A4 (pt) |
| JP (1) | JP2006527699A (pt) |
| AU (1) | AU2003242227A1 (pt) |
| BR (1) | BR0318360A (pt) |
| CA (1) | CA2531406A1 (pt) |
| WO (1) | WO2004110449A1 (pt) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1737458A4 (en) * | 2004-04-13 | 2010-08-04 | Mclean Hospital Corp | R (-) - 11-HYDROXYPORPHINE DERIVATIVES AND THEIR USE |
| WO2009009083A1 (en) * | 2007-07-12 | 2009-01-15 | The Mclean Hospital Corporation | R(-)-2-methoxy-11-hydroxyaporphine and derivatives thereof |
| TWI386396B (zh) * | 2008-06-20 | 2013-02-21 | Standard Chem & Pharm Co Ltd | 阿朴芬化合物與含羧基藥劑之醫藥可接受鹽類及其製備方法 |
| WO2010026487A1 (en) * | 2008-09-08 | 2010-03-11 | University Of Concepcion | Therapeutic methods and compositions |
| SG190914A1 (en) * | 2010-11-24 | 2013-07-31 | Dong A St Co Ltd | Quinoline derivative compound, method for preparing same, and pharmaceutical composition containing same |
| KR101079927B1 (ko) | 2010-11-24 | 2011-11-04 | 동아제약주식회사 | 퀴놀린 유도체 화합물, 이의 제조방법 및 이를 포함하는 약학 조성물 |
| TWI531369B (zh) * | 2014-05-30 | 2016-05-01 | 資元堂生物科技股份有限公司 | 阿朴啡生物鹼衍生物用於製備促進ａｍｐｋ活性的藥物之用途 |
| CN105315208A (zh) * | 2014-07-17 | 2016-02-10 | 中国科学院兰州化学物理研究所 | 阿朴菲类生物碱及其制备方法 |
| KR20230063451A (ko) | 2021-11-02 | 2023-05-09 | 연세대학교 산학협력단 | 세포예정괴사 관련 질병 치료제로서의 아포모르핀의 용도 |
| CN114751860B (zh) * | 2022-03-22 | 2024-03-15 | 华侨大学 | 一种荷叶碱或其衍生物的合成方法以及荷叶碱衍生物及其应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3810987A (en) * | 1972-06-12 | 1974-05-14 | Merck & Co Inc | Blood pressure lowering method using an aporphine |
| US4188392A (en) * | 1975-07-16 | 1980-02-12 | The University Of Mississippi | Antimicrobial compositions |
| DE2757335C3 (de) * | 1977-12-22 | 1982-03-25 | Gödecke AG, 1000 Berlin | Verfahren zur O-Methylierung von Hydroxyaporphinen |
| DE3118521A1 (de) * | 1981-05-09 | 1982-12-02 | Gödecke AG, 1000 Berlin | Dibenzo(de,g)chinolin-derivate, verfahren zu deren herstellung und deren verwendung bei der bekaempfung von erkaeltungskrankheiten und allergien |
| US4543256A (en) * | 1982-03-17 | 1985-09-24 | Northeastern University | (-)-10,1L Methylenedioxy-N-N-propylnoraporphine and methods employing it for inhibiting the effects of epileptic seizures and for prevention and treatment of duodenal ulcers |
| WO1990012574A1 (en) * | 1989-04-25 | 1990-11-01 | Northeastern University | Dopamine agonist compounds |
| US5156847A (en) * | 1990-09-20 | 1992-10-20 | Walter H. Lewis | Wound-healing composition |
| TWI225397B (en) * | 2000-05-04 | 2004-12-21 | Nat Science Council | Uses of thaliporphine or its derivatives in treatment of cardiac diseases and preparation of the same |
| SE0002934D0 (sv) * | 2000-08-17 | 2000-08-17 | Axon Biochemicals Bv | New aporphine esters and in their use in therapy |
| CN1176909C (zh) * | 2000-08-23 | 2004-11-24 | 美时化学制药股份有限公司 | 沙立朴吩或其衍生物在治疗心脏疾病中的应用及其制备方法 |
-
2003
- 2003-06-19 CA CA002531406A patent/CA2531406A1/en not_active Abandoned
- 2003-06-19 AU AU2003242227A patent/AU2003242227A1/en not_active Abandoned
- 2003-06-19 EP EP03732200A patent/EP1634596A4/en not_active Withdrawn
- 2003-06-19 WO PCT/CN2003/000477 patent/WO2004110449A1/zh not_active Ceased
- 2003-06-19 JP JP2005500673A patent/JP2006527699A/ja active Pending
- 2003-06-19 BR BRPI0318360-2A patent/BR0318360A/pt not_active IP Right Cessation
-
2004
- 2004-04-02 US US10/817,641 patent/US7057044B2/en not_active Expired - Fee Related
-
2006
- 2006-05-23 US US11/439,076 patent/US7294715B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1634596A1 (en) | 2006-03-15 |
| US20040198759A1 (en) | 2004-10-07 |
| JP2006527699A (ja) | 2006-12-07 |
| US7294715B2 (en) | 2007-11-13 |
| CA2531406A1 (en) | 2004-12-23 |
| AU2003242227A1 (en) | 2005-01-04 |
| US7057044B2 (en) | 2006-06-06 |
| EP1634596A4 (en) | 2006-06-21 |
| WO2004110449A1 (en) | 2004-12-23 |
| US20060211723A1 (en) | 2006-09-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application fees: application dismissed [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 4A,5A,6A E 7A ANUIDADES |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2073 DE 28/09/2010. |