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BR0317752A - Conjugados poliméricos de citocinas, quimiocinas, fatores do crescimento, hormÈnios polipeptìdicos e seus antagonistas com atividade de ligação a receptores conservada - Google Patents

Conjugados poliméricos de citocinas, quimiocinas, fatores do crescimento, hormÈnios polipeptìdicos e seus antagonistas com atividade de ligação a receptores conservada

Info

Publication number
BR0317752A
BR0317752A BR0317752-1A BR0317752A BR0317752A BR 0317752 A BR0317752 A BR 0317752A BR 0317752 A BR0317752 A BR 0317752A BR 0317752 A BR0317752 A BR 0317752A
Authority
BR
Brazil
Prior art keywords
conjugates
receptor
polypeptide hormones
receptor binding
chemokines
Prior art date
Application number
BR0317752-1A
Other languages
English (en)
Inventor
Shyam S Bhaskaran
Merry R Sherman
Mark G P Saifer
L David Williams
Original Assignee
Mountain View Pharmaceuticals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mountain View Pharmaceuticals filed Critical Mountain View Pharmaceuticals
Publication of BR0317752A publication Critical patent/BR0317752A/pt

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2013—IL-2
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
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    • A61K38/19—Cytokines; Lymphokines; Interferons
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
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    • C08G63/46—Polyesters chemically modified by esterification
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Abstract

"CONJUGADOS POLIMéRICOS DE CITOCINAS, QUIMIOCINAS, FATORES DO CRESCIMENTO, HORMÈNIOS POLIPEPTìDICOS E SEUS ANTAGONISTAS COM ATIVIDADE DE LIGAçãO A RECEPTORES CONSERVADA". São proporcionados métodos para a síntese de conjugados poliméricos de citocinas, quimiocinas, fatores do crescimento, hormónios polipeptídicos e antagonistas de ligação a receptores dos mesmos, conjugados estes que conservam uma atividade de ligação ao receptor anormalmente alta. A preparação dos conjugados poliméricos de acordo com os métodos da presente invenção diminui ou evita a inibição estérica das interações entre receptores-ligantes que comumente resulta da ligação dos polímeros às regiões de ligação a receptores das citocinas, das quimiocinas, dos fatores do crescimento e dos hormónios polipeptídicos, assim como aos seus análogos agonísticos e antagonísticos. A invenção também proporciona conjugados e composições produzidos por tais métodos. Os conjugados da presente invenção conservam um nível maior de atividade de ligação ao receptor do que aqueles produzidos por métodos tradicionais de acoplamento de polímeros que não são visados para evitar os domínios de ligação a receptores das citocinas, das quimiocinas, dos fatores do crescimento e dos hormónios polipeptídicos. Os conjugados da presente invenção também exibem uma meia-vida prolongada in vivo e in vitro comparados às citocinas, quimiocinas, fatores do crescimento e hormónios polipeptídicos não conjugados. A presente invenção também proporciona kits compreendendo tais conjugados e/ou composições, e métodos de uso de tais conjugados e composições em uma variedade de aplicações diagnósticas, profiláticas, terapêuticas e de bio-processamento.
BR0317752-1A 2002-12-26 2003-12-23 Conjugados poliméricos de citocinas, quimiocinas, fatores do crescimento, hormÈnios polipeptìdicos e seus antagonistas com atividade de ligação a receptores conservada BR0317752A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US43602002P 2002-12-26 2002-12-26
US47991403P 2003-06-20 2003-06-20
PCT/US2003/041162 WO2004060300A2 (en) 2002-12-26 2003-12-23 Polymer conjugates of cytokines, chemokines, growth factors, polypeptide hormones and antagonists thereof with preserved receptor-binding activity

Publications (1)

Publication Number Publication Date
BR0317752A true BR0317752A (pt) 2005-11-22

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
BR0317752-1A BR0317752A (pt) 2002-12-26 2003-12-23 Conjugados poliméricos de citocinas, quimiocinas, fatores do crescimento, hormÈnios polipeptìdicos e seus antagonistas com atividade de ligação a receptores conservada

Country Status (19)

Country Link
US (2) US20040136952A1 (pt)
EP (1) EP1628618A4 (pt)
JP (2) JP2006519170A (pt)
KR (1) KR101162908B1 (pt)
AU (1) AU2003303636B2 (pt)
BR (1) BR0317752A (pt)
CA (1) CA2511815A1 (pt)
CR (1) CR7895A (pt)
EA (1) EA013535B1 (pt)
EC (1) ECSP055931A (pt)
GE (1) GEP20084487B (pt)
IS (1) IS7931A (pt)
MX (1) MXPA05006945A (pt)
NO (1) NO20053555L (pt)
NZ (1) NZ541122A (pt)
PL (2) PL396711A1 (pt)
RS (1) RS20050501A (pt)
TW (1) TWI364295B (pt)
WO (1) WO2004060300A2 (pt)

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