BR0315958A - Composto, composição farmacêutica, processo para a preparação de um composto, novos intermediários e uso do composto - Google Patents
Composto, composição farmacêutica, processo para a preparação de um composto, novos intermediários e uso do compostoInfo
- Publication number
- BR0315958A BR0315958A BR0315958-2A BR0315958A BR0315958A BR 0315958 A BR0315958 A BR 0315958A BR 0315958 A BR0315958 A BR 0315958A BR 0315958 A BR0315958 A BR 0315958A
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- pharmaceutically acceptable
- compounds
- general formula
- pharmaceutical composition
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 9
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 239000000543 intermediate Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 abstract 3
- 239000002207 metabolite Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000012453 solvate Substances 0.000 abstract 2
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 230000000975 bioactive effect Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 239000002552 dosage form Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/36—Oxygen atoms in position 3, e.g. adrenochrome
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Physical Education & Sports Medicine (AREA)
- Addiction (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Ophthalmology & Optometry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Obesity (AREA)
- Anesthesiology (AREA)
- Otolaryngology (AREA)
- Child & Adolescent Psychology (AREA)
- Vascular Medicine (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
Abstract
"COMPOSTO, COMPOSIçãO FARMACêUTICA, PROCESSO PARA A PREPARAçãO DE UM COMPOSTO, NOVOS INTERMEDIáRIOS E USO DO COMPOSTO". A presente invenção refere-se os compostos de 3aminoalcóxindolos substituídos da fórmula geral (I), seus estereoisómeros, seus rádio isótopos, suas formas geométricas, seus N-óxidos, seus polimorfos, seus sais farmaceuticamente aceitáveis, seus solvatos farmaceuticamente aceitáveis, seus metabólitos bio-ativos úteis e qualquer combinação dos acima mencionados. A invenção também revela os processos para a preparação de tais compostos da fórmula geral (I), os seus estereoisómeros, os seus rádio isótopos, as suas formas geométricas, os seus óxidos de N, os seus polimorfos, os seus sais farmaceuticamente aceitáveis, os seus solvatos farmaceuticamente aceitáveis, os seus metabólitos bio ativos úteis e também inclui qualquer combinação dos acima mencionados. Também são descritos em adição os vários métodos para a ministração destes compostos da fórmula geral (I), por exemplo as formas de dosagem farmaceuticamente aceitáveis, as suas composições e os seus usos tanto em uma terapia ou em um diagnóstico.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN883/MAS/2002 | 2002-11-28 | ||
| IN883MA2002 | 2002-11-28 | ||
| PCT/IN2003/000370 WO2004048328A2 (en) | 2002-11-28 | 2003-11-25 | N-arylsulfonyl-3-aminoalkoxyindoles |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BR0315958A true BR0315958A (pt) | 2005-09-13 |
| BRPI0315958B1 BRPI0315958B1 (pt) | 2018-06-26 |
| BRPI0315958B8 BRPI0315958B8 (pt) | 2021-05-25 |
Family
ID=34362365
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0315958A BRPI0315958B8 (pt) | 2002-11-28 | 2003-11-25 | composto, composição farmacêutica, processo para a preparação de um composto, novos intermediários e uso do composto |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US7507835B2 (pt) |
| EP (1) | EP1567492B1 (pt) |
| JP (2) | JP4782425B2 (pt) |
| KR (1) | KR100776118B1 (pt) |
| CN (2) | CN102249981A (pt) |
| AU (1) | AU2003285759B2 (pt) |
| BR (1) | BRPI0315958B8 (pt) |
| CA (1) | CA2507505C (pt) |
| CY (1) | CY1114241T1 (pt) |
| EA (1) | EA009193B1 (pt) |
| ES (1) | ES2425143T3 (pt) |
| MX (1) | MXPA05005700A (pt) |
| NO (1) | NO331805B1 (pt) |
| NZ (1) | NZ540842A (pt) |
| PT (1) | PT1567492E (pt) |
| SI (1) | SI1567492T1 (pt) |
| WO (1) | WO2004048328A2 (pt) |
| ZA (1) | ZA200504044B (pt) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1567492E (pt) * | 2002-11-28 | 2013-07-22 | Suven Life Sciences Ltd | N-arilsulfonil-3-aminoalcoxi-indóis |
| NZ540841A (en) * | 2002-12-18 | 2008-08-29 | Suven Life Sciences Ltd | Tetracyclic 3-substituted indoles having serotonin receptor affinity |
| KR101049868B1 (ko) | 2004-01-02 | 2011-07-19 | 수벤 라이프 사이언시스 리미티드 | 신규한 인데노[2,1ａ]인덴 및 이소인돌[2,1-ａ]인돌 |
| CA2618636C (en) | 2005-08-12 | 2011-01-18 | Suven Life Sciences Limited | Aminoaryl sulphonamide derivatives as functional 5-ht6 ligands |
| US7923566B2 (en) | 2005-08-16 | 2011-04-12 | Suven Life Sciences Limited | Alternative process for the preparation of losartan |
| KR100724095B1 (ko) * | 2005-10-21 | 2007-06-04 | 한국표준과학연구원 | 정밀 전류, 전압 및 전력 측정장치 |
| DK2114878T3 (da) | 2007-01-08 | 2011-03-14 | Suven Life Sciences Ltd | 5-(Heterocyclyl)alkyl-N-(arylsulfonyl)indolforbindelser og deres anvendelse som 5-HT6-ligander |
| EP1947085A1 (en) * | 2007-01-19 | 2008-07-23 | Laboratorios del Dr. Esteve S.A. | Substituted indole sulfonamide compounds, their preparation and use as medicaments |
| WO2008136017A1 (en) | 2007-05-03 | 2008-11-13 | Suven Life Sciences Limited | Aminoalkoxy aryl sulfonamide compounds and their use as 5-ht6 ligands |
| ES2370680T3 (es) * | 2007-10-26 | 2011-12-21 | Suven Life Sciences Limited | Compuestos de aminoarilsulfonamida y su empleo como ligandos de 5-ht6. |
| AR072297A1 (es) * | 2008-06-27 | 2010-08-18 | Novartis Ag | Derivados de indol-2-il-piridin-3-ilo, composicion farmaceutica que los comprende y su uso en medicamentos para el tratamiento de enfermedades mediadas por la sintasa aldosterona. |
| EP2149573A1 (en) * | 2008-08-01 | 2010-02-03 | Laboratorios Del. Dr. Esteve, S.A. | Substituted indole sulfonamide compounds their preparation and use as medicaments |
| EP2346847B1 (en) | 2008-09-17 | 2013-05-15 | Suven Life Sciences Limited | Aryl sulfonamide amine compounds and their use as 5-ht6 ligands |
| US8318725B2 (en) | 2008-09-17 | 2012-11-27 | Suven Life Sciences Limited | Aryl indolyl sulfonamide compounds and their use as 5-HT6 ligands |
| SG181992A1 (en) | 2010-01-05 | 2012-08-30 | Suven Life Sciences Ltd | Sulfone compounds as 5-ht6 receptor ligands |
| EP2932922B1 (en) * | 2012-12-13 | 2018-09-05 | Olympus Corporation | Treatment device |
| DE102013013602A1 (de) * | 2013-08-19 | 2015-02-19 | Trützschler GmbH + Co KG Textilmaschinenfabrik | Vorrichtung an einer Karde oder Krempel für Baumwolle, Chemiefasern u. dgl. mit einer drehbaren Abstreifwalze |
| WO2015090233A1 (en) | 2013-12-20 | 2015-06-25 | Sunshine Lake Pharma Co., Ltd. | Aromatic heterocyclic compounds and their application in pharmaceuticals |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE111890C (pt) | ||||
| US723550A (en) * | 1902-09-15 | 1903-03-24 | Eagle Lock Co | Padlock. |
| CH481104A (de) | 1967-01-25 | 1969-11-15 | Geigy Ag J R | Verfahren zur Herstellung von neuen Indolderivaten |
| GB1306230A (pt) * | 1969-05-27 | 1973-02-07 | ||
| US3860609A (en) | 1969-05-27 | 1975-01-14 | Novo Terapeutisk Labor As | 3-aminoalkyloxyindoles |
| US3860608A (en) | 1969-05-27 | 1975-01-14 | Novo Terapeutisk Labor As | 3-aminoalkyloxyindoles |
| ZA795239B (en) | 1978-10-12 | 1980-11-26 | Glaxo Group Ltd | Heterocyclic compounds |
| BE889931A (fr) | 1980-08-12 | 1982-02-11 | Glaxo Group Ltd | Derives indoliques, leur preparation et leurs applications en tant que medicaments |
| JPS57200362A (en) | 1981-06-05 | 1982-12-08 | Mitsui Toatsu Chem Inc | Preparation of indoxyl |
| GB8600397D0 (en) | 1986-01-08 | 1986-02-12 | Glaxo Group Ltd | Chemical compounds |
| GB8719167D0 (en) | 1987-08-13 | 1987-09-23 | Glaxo Group Ltd | Chemical compounds |
| JPH01139564A (ja) * | 1987-08-31 | 1989-06-01 | Terumo Corp | Ｎ−置換インドールエステル化合物、その製造法ならびに該化合物を用いた試験組成物および試験具 |
| GB8724912D0 (en) | 1987-10-23 | 1987-11-25 | Wellcome Found | Indole derivatives |
| GB8819024D0 (en) | 1988-08-10 | 1988-09-14 | Glaxo Group Ltd | Chemical compounds |
| IL96891A0 (en) | 1990-01-17 | 1992-03-29 | Merck Sharp & Dohme | Indole-substituted five-membered heteroaromatic compounds,their preparation and pharmaceutical compositions containing them |
| CA2042295A1 (fr) | 1990-05-15 | 1991-11-16 | Jacques Chauveau | Derives de mediateurs endogenes, leurs sels, procede de preparation, applications, et compositions les renfermant |
| PT97888B (pt) | 1990-06-07 | 1998-12-31 | Zeneca Ltd | Processo para a preparacao de compostos heterociclicos derivados de indol e de composicoes farmaceuticas que os contem |
| SK278998B6 (sk) | 1991-02-01 | 1998-05-06 | Merck Sharp & Dohme Limited | Deriváty imidazolu, triazolu a tetrazolu, spôsob i |
| GB9113802D0 (en) | 1991-06-26 | 1991-08-14 | Smithkline Beecham Plc | Medicaments |
| GB9210400D0 (en) | 1992-05-15 | 1992-07-01 | Merck Sharp & Dohme | Therapeutic agents |
| KR940007001A (ko) | 1992-09-16 | 1994-04-26 | 최승주 | 새로운 n-신나모일-2-메틸-5-메톡시-3-인돌 아세트산 에스테르, 그 제조방법 및 이를 함유하는 약학적 제제 |
| IL130169A (en) | 1999-05-27 | 2006-08-20 | Neurim Pharma 1991 | Indole derivatives, and pharmaceutical preparations, skin protection preparations, and cosmetics containing them |
| FR2799757B1 (fr) | 1999-10-15 | 2001-12-14 | Adir | Nouveaux derives polycycliques azaindoliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR2821843B1 (fr) | 2001-03-12 | 2003-05-09 | Servier Lab | Nouveaux derives d'isoindoloindolones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| CA2490254C (en) * | 2002-06-21 | 2011-11-01 | Suven Life Sciences Limited | Novel tetracyclic arylsulfonyl indoles having serotonin receptor affinity useful as therapeutic agents, process for their preparation and pharmaceutical compositions containing them |
| AR040659A1 (es) * | 2002-07-22 | 2005-04-13 | Basf Ag | Mezclas de accion herbicida sinergetica |
| PT1567492E (pt) * | 2002-11-28 | 2013-07-22 | Suven Life Sciences Ltd | N-arilsulfonil-3-aminoalcoxi-indóis |
-
2003
- 2003-11-25 PT PT37787397T patent/PT1567492E/pt unknown
- 2003-11-25 US US10/536,592 patent/US7507835B2/en not_active Expired - Fee Related
- 2003-11-25 MX MXPA05005700A patent/MXPA05005700A/es active IP Right Grant
- 2003-11-25 EP EP03778739.7A patent/EP1567492B1/en not_active Expired - Lifetime
- 2003-11-25 JP JP2004554902A patent/JP4782425B2/ja not_active Expired - Fee Related
- 2003-11-25 WO PCT/IN2003/000370 patent/WO2004048328A2/en not_active Ceased
- 2003-11-25 KR KR1020057009253A patent/KR100776118B1/ko not_active Expired - Fee Related
- 2003-11-25 NZ NZ540842A patent/NZ540842A/en not_active IP Right Cessation
- 2003-11-25 CN CN2011101270926A patent/CN102249981A/zh active Pending
- 2003-11-25 SI SI200332271T patent/SI1567492T1/sl unknown
- 2003-11-25 BR BRPI0315958A patent/BRPI0315958B8/pt not_active IP Right Cessation
- 2003-11-25 EA EA200500882A patent/EA009193B1/ru not_active IP Right Cessation
- 2003-11-25 AU AU2003285759A patent/AU2003285759B2/en not_active Ceased
- 2003-11-25 CN CNA2003801046430A patent/CN1720227A/zh active Pending
- 2003-11-25 CA CA2507505A patent/CA2507505C/en not_active Expired - Fee Related
- 2003-11-25 ES ES03778739T patent/ES2425143T3/es not_active Expired - Lifetime
-
2005
- 2005-06-10 NO NO20052825A patent/NO331805B1/no not_active IP Right Cessation
-
2006
- 2006-05-19 ZA ZA200504044A patent/ZA200504044B/en unknown
-
2009
- 2009-01-06 US US12/349,043 patent/US7718690B2/en not_active Expired - Fee Related
-
2011
- 2011-02-28 JP JP2011043072A patent/JP2011116769A/ja active Pending
-
2013
- 2013-08-14 CY CY20131100698T patent/CY1114241T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CY1114241T1 (el) | 2016-08-31 |
| BRPI0315958B1 (pt) | 2018-06-26 |
| US7718690B2 (en) | 2010-05-18 |
| AU2003285759A1 (en) | 2004-06-18 |
| KR20050083963A (ko) | 2005-08-26 |
| WO2004048328A3 (en) | 2004-10-28 |
| NO331805B1 (no) | 2012-04-10 |
| KR100776118B1 (ko) | 2007-11-15 |
| ZA200504044B (en) | 2006-07-26 |
| NO20052825L (no) | 2005-08-25 |
| EA009193B1 (ru) | 2007-12-28 |
| NZ540842A (en) | 2008-05-30 |
| US20090131507A1 (en) | 2009-05-21 |
| US20060173193A1 (en) | 2006-08-03 |
| BRPI0315958B8 (pt) | 2021-05-25 |
| AU2003285759B2 (en) | 2010-01-28 |
| SI1567492T1 (sl) | 2013-07-31 |
| MXPA05005700A (es) | 2005-08-16 |
| US7507835B2 (en) | 2009-03-24 |
| EA200500882A1 (ru) | 2005-12-29 |
| EP1567492B1 (en) | 2013-05-22 |
| CA2507505C (en) | 2011-10-04 |
| NO20052825D0 (no) | 2005-06-10 |
| ES2425143T3 (es) | 2013-10-11 |
| CA2507505A1 (en) | 2004-06-10 |
| CN102249981A (zh) | 2011-11-23 |
| JP2011116769A (ja) | 2011-06-16 |
| JP2006511506A (ja) | 2006-04-06 |
| WO2004048328A2 (en) | 2004-06-10 |
| CN1720227A (zh) | 2006-01-11 |
| JP4782425B2 (ja) | 2011-09-28 |
| EP1567492A2 (en) | 2005-08-31 |
| PT1567492E (pt) | 2013-07-22 |
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