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BR0309551A - Derivados substituìdos de pirazina - Google Patents

Derivados substituìdos de pirazina

Info

Publication number
BR0309551A
BR0309551A BR0309551-7A BR0309551A BR0309551A BR 0309551 A BR0309551 A BR 0309551A BR 0309551 A BR0309551 A BR 0309551A BR 0309551 A BR0309551 A BR 0309551A
Authority
BR
Brazil
Prior art keywords
crf
pyrazine derivatives
substituted pyrazine
disorders
derivatives
Prior art date
Application number
BR0309551-7A
Other languages
English (en)
Inventor
Jeffrey W Corbett
Michael D Ennis
Kristine E Frank
Jian-Min Fu
Robert L Hoffman
Patrick R Verhoest
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of BR0309551A publication Critical patent/BR0309551A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
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    • A61P11/06—Antiasthmatics
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    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
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    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
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    • A61P17/10—Anti-acne agents
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P3/00—Drugs for disorders of the metabolism
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    • A61P5/00—Drugs for disorders of the endocrine system
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    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/20—Nitrogen atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S206/00—Special receptacle or package
    • Y10S206/828—Medicinal content

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Addiction (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Virology (AREA)
  • Obesity (AREA)
  • Reproductive Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • AIDS & HIV (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)

Abstract

"DERIVADOS SUBSTITUìDOS DE PIRAZINA". A presente invenção proporciona derivados de pirazina substituída de Fórmula I, que são antagonistas do receptor CRF~ 1~, incluindo receptores CRF~ 1~ humanos. Esta invenção relaciona-se também com a utilização de compostos da invenção para tratar uma doença ou estado, cujo tratamento pode ser efectuado ou facilitado pela antagonização de um receptor de CRF, tais como doenças do SNC, em particular perturbações relacionadas com a ansiedade e perturbações do humor.
BR0309551-7A 2002-04-26 2003-04-17 Derivados substituìdos de pirazina BR0309551A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37603102P 2002-04-26 2002-04-26
PCT/US2003/010474 WO2003091225A1 (en) 2002-04-26 2003-04-17 Substituted pyrazine derivatives

Publications (1)

Publication Number Publication Date
BR0309551A true BR0309551A (pt) 2005-02-09

Family

ID=29270752

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0309551-7A BR0309551A (pt) 2002-04-26 2003-04-17 Derivados substituìdos de pirazina

Country Status (10)

Country Link
US (1) US6964965B2 (pt)
EP (1) EP1499599A1 (pt)
JP (1) JP2005533014A (pt)
AR (1) AR039445A1 (pt)
AU (1) AU2003223475A1 (pt)
BR (1) BR0309551A (pt)
CA (1) CA2480497A1 (pt)
MX (1) MXPA04008384A (pt)
TW (1) TW200307672A (pt)
WO (1) WO2003091225A1 (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006514628A (ja) * 2002-11-21 2006-05-11 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー Ｃｒｆ変調剤としてのピラジン化合物
WO2004099201A1 (en) * 2003-05-09 2004-11-18 Pharmacia & Upjohn Company Llc Compounds as crf1 receptor antagonists
US20060211710A1 (en) * 2005-03-17 2006-09-21 Pfizer Inc Substituted aryl 1,4-pyrazine derivatives
US7414142B2 (en) 2005-09-19 2008-08-19 Wyeth 5-aryl-indan-1-one oximes and analogs useful as progesterone receptor modulators
US7319152B2 (en) 2005-09-19 2008-01-15 Wyeth 5-Aryl-indan-1-one and analogs useful as progesterone receptor modulators
KR101118932B1 (ko) * 2006-04-14 2012-02-27 아보트 러보러터리즈 바닐로이드 서브타입 1(ｖｒ1) 수용체를 억제하는 인다졸릴우레아의 제조방법
WO2009006245A2 (en) * 2007-07-02 2009-01-08 Smithkline Beecham Corporation Calcilytic compounds
TWI806832B (zh) * 2016-07-12 2023-07-01 美商銳新醫藥公司 作為異位shp2抑制劑之2,5-雙取代型3-甲基吡嗪及2,5,6-三取代型3-甲基吡嗪

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6495343B1 (en) * 1993-06-18 2002-12-17 The Salk Institute For Biological Studies Cloning and recombinant production of CRF receptor(s)
US5675033A (en) 1995-06-06 1997-10-07 Allergan 2,4-pentadienoic acid derivatives having retinoid-like biological activity
US5795905A (en) * 1995-06-06 1998-08-18 Neurocrine Biosciences, Inc. CRF receptor antagonists and methods relating thereto
US5872136A (en) 1996-04-03 1999-02-16 Merck & Co., Inc. Arylheteroaryl inhibitors of farnesyl-protein transferase
US5883105A (en) 1996-04-03 1999-03-16 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
EP0891357A1 (en) 1996-04-03 1999-01-20 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US5880140A (en) 1996-04-03 1999-03-09 Merck & Co., Inc. Biheteroaryl inhibitors of farnesyl-protein transferase
CA2249645A1 (en) 1996-04-03 1997-10-09 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
DE19652246A1 (de) 1996-12-16 1998-06-18 Hoechst Ag 5,7-Difluor-3,4-dihydro-2H-naphthalin-1-on-Derivate und ihre Verwendung in flüssigkristallinen Mischungen
DE19652250A1 (de) 1996-12-16 1998-06-18 Hoechst Ag 1,1,5,7-Tetrafluor-1,2,3,4-tetrahydronaphthalin-Derivate und ihre Verwendung in flüssigkristallinen Mischungen
DE19652247A1 (de) 1996-12-16 1998-06-18 Hoechst Ag 5,7-Difluor-1,2,3,4-tetrahydronaphthalin-Derivate und ihre Verwendung in flüssigkristallinen Mischungen
EP0951285A1 (en) 1996-12-30 1999-10-27 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
MA26473A1 (fr) * 1997-03-01 2004-12-20 Glaxo Group Ltd Composes pharmacologiquement actifs.
PA8467401A1 (es) 1998-02-17 2000-09-29 Pfizer Prod Inc Procedimiento para tratar la insuficiencia cardiaca
AU4327600A (en) 1999-04-02 2000-10-23 Du Pont Pharmaceuticals Company Aryl sulfonyls as factor xa inhibitors
IL139197A0 (en) 1999-10-29 2001-11-25 Pfizer Prod Inc Use of corticotropin releasing factor antagonists and related compositions
CA2397493A1 (en) 2000-01-27 2001-08-02 Cytovia, Inc. Substituted nicotinamides and analogs as activators of caspases and inducers of apoptosis and the use thereof
AU783915B2 (en) 2000-02-16 2005-12-22 Neurogen Corporation Substituted arylpyrazines
WO2002019975A1 (fr) 2000-09-05 2002-03-14 Taisho Pharmaceutical Co., Ltd. Stimulants de la croissance des cheveux
AP2003002924A0 (en) 2001-06-12 2003-12-31 Neurogen Corp 2,5-diarylpyrazines, 2,5 - diarylpyridines and 2,5 - diarylpyrimidines as CRF1 receptor modulators

Also Published As

Publication number Publication date
AU2003223475A1 (en) 2003-11-10
CA2480497A1 (en) 2003-11-06
TW200307672A (en) 2003-12-16
MXPA04008384A (es) 2004-11-26
US6964965B2 (en) 2005-11-15
JP2005533014A (ja) 2005-11-04
AR039445A1 (es) 2005-02-16
EP1499599A1 (en) 2005-01-26
US20040053941A1 (en) 2004-03-18
WO2003091225A1 (en) 2003-11-06

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