BR0308355A - Composto ou um sal farmaceuticamente aceitável ou um seu enanciÈmero, métodos para modular uma função mediada pelo receptor de androgênio em um mamìfero em necessidade de tal modulação, para ativar a função do receptor de androgênio em um mamìfero em necessidade de tal ativação, para tratar uma condição em um mamìfero, e para tratar osteoporose em um mamìfero em sua necessidade, composição farmacêutica, métodos para aumentar a densidade mineral óssea em um mamìfero em necessidade disto, para reduzir o risco de fraturas vertebrais ou não vertebrais em um mamìfero em necessidade disto, e para produzir um marcador de modificação óssea em um mamìfero em necessidade disto, processo para produzir uma composição farmacêutica, e, método para tratar ou prevenir uma condição artrìtica em um mamìfero em necessidade disto - Google Patents
Composto ou um sal farmaceuticamente aceitável ou um seu enanciÈmero, métodos para modular uma função mediada pelo receptor de androgênio em um mamìfero em necessidade de tal modulação, para ativar a função do receptor de androgênio em um mamìfero em necessidade de tal ativação, para tratar uma condição em um mamìfero, e para tratar osteoporose em um mamìfero em sua necessidade, composição farmacêutica, métodos para aumentar a densidade mineral óssea em um mamìfero em necessidade disto, para reduzir o risco de fraturas vertebrais ou não vertebrais em um mamìfero em necessidade disto, e para produzir um marcador de modificação óssea em um mamìfero em necessidade disto, processo para produzir uma composição farmacêutica, e, método para tratar ou prevenir uma condição artrìtica em um mamìfero em necessidade distoInfo
- Publication number
- BR0308355A BR0308355A BR0308355-1A BR0308355A BR0308355A BR 0308355 A BR0308355 A BR 0308355A BR 0308355 A BR0308355 A BR 0308355A BR 0308355 A BR0308355 A BR 0308355A
- Authority
- BR
- Brazil
- Prior art keywords
- mammal
- need
- pharmaceutical composition
- methods
- androgen receptor
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 8
- 210000000988 bone and bone Anatomy 0.000 title abstract 6
- 102000001307 androgen receptors Human genes 0.000 title abstract 4
- 108010080146 androgen receptors Proteins 0.000 title abstract 4
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 4
- 208000001132 Osteoporosis Diseases 0.000 title abstract 3
- 230000003213 activating effect Effects 0.000 title abstract 2
- 230000002917 arthritic effect Effects 0.000 title abstract 2
- 229910052500 inorganic mineral Inorganic materials 0.000 title abstract 2
- 239000003550 marker Substances 0.000 title abstract 2
- 230000001404 mediated effect Effects 0.000 title abstract 2
- 239000011707 mineral Substances 0.000 title abstract 2
- 230000004048 modification Effects 0.000 title abstract 2
- 238000012986 modification Methods 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 title abstract 2
- 241000124008 Mammalia Species 0.000 title 8
- 230000004913 activation Effects 0.000 title 1
- 239000003098 androgen Substances 0.000 abstract 3
- 206010006895 Cachexia Diseases 0.000 abstract 2
- 206010002261 Androgen deficiency Diseases 0.000 abstract 1
- 208000032467 Aplastic anaemia Diseases 0.000 abstract 1
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 208000010392 Bone Fractures Diseases 0.000 abstract 1
- 206010065687 Bone loss Diseases 0.000 abstract 1
- 208000035150 Hypercholesterolemia Diseases 0.000 abstract 1
- 208000031226 Hyperlipidaemia Diseases 0.000 abstract 1
- 206010027304 Menopausal symptoms Diseases 0.000 abstract 1
- 208000029725 Metabolic bone disease Diseases 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 206010049088 Osteopenia Diseases 0.000 abstract 1
- 208000002500 Primary Ovarian Insufficiency Diseases 0.000 abstract 1
- 206010060862 Prostate cancer Diseases 0.000 abstract 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 230000001668 ameliorated effect Effects 0.000 abstract 1
- 230000003042 antagnostic effect Effects 0.000 abstract 1
- 206010003246 arthritis Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 208000026500 emaciation Diseases 0.000 abstract 1
- 201000003585 eunuchism Diseases 0.000 abstract 1
- 201000003617 glucocorticoid-induced osteoporosis Diseases 0.000 abstract 1
- 230000003394 haemopoietic effect Effects 0.000 abstract 1
- 230000002757 inflammatory effect Effects 0.000 abstract 1
- 208000037106 male hypogonadism Diseases 0.000 abstract 1
- 210000003205 muscle Anatomy 0.000 abstract 1
- 201000006938 muscular dystrophy Diseases 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 208000028169 periodontal disease Diseases 0.000 abstract 1
- 206010036601 premature menopause Diseases 0.000 abstract 1
- 208000017942 premature ovarian failure 1 Diseases 0.000 abstract 1
- 210000002307 prostate Anatomy 0.000 abstract 1
- 238000002278 reconstructive surgery Methods 0.000 abstract 1
- 208000001076 sarcopenia Diseases 0.000 abstract 1
- 230000009759 skin aging Effects 0.000 abstract 1
- 210000001519 tissue Anatomy 0.000 abstract 1
- 210000004291 uterus Anatomy 0.000 abstract 1
- ACWBQPMHZXGDFX-QFIPXVFZSA-N valsartan Chemical compound C1=CC(CN(C(=O)CCCC)[C@@H](C(C)C)C(O)=O)=CC=C1C1=CC=CC=C1C1=NN=NN1 ACWBQPMHZXGDFX-QFIPXVFZSA-N 0.000 abstract 1
Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
- C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
- C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Reproductive Health (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Transplantation (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Nutrition Science (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Oncology (AREA)
- AIDS & HIV (AREA)
- Vascular Medicine (AREA)
- Gynecology & Obstetrics (AREA)
- Child & Adolescent Psychology (AREA)
- Pain & Pain Management (AREA)
Abstract
"COMPOSTO OU UM SAL FARMACEUTICAMENTE ACEITáVEL OU UM SEU ENANCIÈMERO, MéTODOS PARA MODULAR UMA FUNçãO MEDIADA PELO RECEPTOR DE ANDROGêNIO EM UM MAMìFERO EM NECESSIDADE DE TAL MODULAçãO, PARA ATIVAR A FUNçãO DO RECEPTOR DE ANDROGêNIO EM UM MAMìFERO EM NECESSIDADE DE TAL ATIVAçãO, PARA TRATAR UMA CONDIçãO EM UM MAMìFERO, E PARA TRATAR OSTEOPOROSE EM UM MAMìFERO EM SUA NECESSIDADE, COMPOSIçãO FARMACêUTICA, MéTODOS PARA AUMENTAR A DENSIDADE MINERAL óSSEA EM UM MAMìFERO EM NECESSIDADE DISTO, PARA REDUZIR O RISCO DE FRATURAS VERTEBRAIS OU NãO VERTEBRAIS EM UM MAMìFERO EM NECESSIDADE DISTO, E PARA PRODUZIR UM MARCADOR DE MODIFICAçãO óSSEA EM UM MAMìFERO EM NECESSIDADE DISTO, PROCESSO PARA PRODUZIR UMA COMPOSIçãO FARMACêUTICA, E, MéTODO PARA TRATAR OU PREVENIR UMA CONDIçãO ARTRìTICA EM UM MAMìFERO EM NECESSIDADE DISTO". Os compostos da fórmula estrutural I são moduladores do receptor de androgênio (AR) de uma maneira seletiva de tecido. Eles são úteis como agonistas do receptor de androgênio no tecido ósseo e/ou muscular, enquanto antagonizam o AR na próstata de um paciente masculino ou no útero de um paciente feminino. Estes compostos são, portanto, úteis no tratamento de condições causadas pela deficiência de androgênio ou que possam ser melhoradas pela administração de androgênio, incluindo a osteoporose, a osteopenia, a osteoporose induzida pela glicocorticóide, a doença periodontal, a fratura óssea, a perda óssea em seguida à cirurgia reconstrutiva óssea, a sarcopenia, a debilidade, o envelhecimento da pele, o hipogonadismo masculino, os sintomas pós-menopáusicos em mulheres, a aterosclerose, a hipercolesterolemia, a hiperlipidemia, a obesidade, a anemia aplástica e outros distúrbios hematopoiéticos, a artrite inflamatória e a reparação das articulações, a emaciação do HIV, o câncer prostático, a cachexia cancerosa, as distrofias musculares, a insuficiência ovariana prematura, e a doença autoimune, sozinhos ou em combinação com outros agentes ativos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36382202P | 2002-03-13 | 2002-03-13 | |
| PCT/US2003/008277 WO2003077919A1 (en) | 2002-03-13 | 2003-03-07 | Fluorinated 4-azasteroid derivatives as androgen receptor modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0308355A true BR0308355A (pt) | 2005-01-25 |
Family
ID=28041817
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0308355-1A BR0308355A (pt) | 2002-03-13 | 2003-03-07 | Composto ou um sal farmaceuticamente aceitável ou um seu enanciÈmero, métodos para modular uma função mediada pelo receptor de androgênio em um mamìfero em necessidade de tal modulação, para ativar a função do receptor de androgênio em um mamìfero em necessidade de tal ativação, para tratar uma condição em um mamìfero, e para tratar osteoporose em um mamìfero em sua necessidade, composição farmacêutica, métodos para aumentar a densidade mineral óssea em um mamìfero em necessidade disto, para reduzir o risco de fraturas vertebrais ou não vertebrais em um mamìfero em necessidade disto, e para produzir um marcador de modificação óssea em um mamìfero em necessidade disto, processo para produzir uma composição farmacêutica, e, método para tratar ou prevenir uma condição artrìtica em um mamìfero em necessidade disto |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US7186838B2 (pt) |
| EP (1) | EP1485095A4 (pt) |
| JP (2) | JP4516316B2 (pt) |
| KR (1) | KR100938136B1 (pt) |
| CN (1) | CN1652786A (pt) |
| AU (1) | AU2003218235B2 (pt) |
| BR (1) | BR0308355A (pt) |
| CA (1) | CA2478186C (pt) |
| EC (1) | ECSP045287A (pt) |
| HR (1) | HRP20040822A2 (pt) |
| IL (2) | IL163825A0 (pt) |
| IS (1) | IS7425A (pt) |
| MA (1) | MA27112A1 (pt) |
| MX (1) | MXPA04008800A (pt) |
| NO (1) | NO20044312L (pt) |
| NZ (1) | NZ534946A (pt) |
| PL (1) | PL372920A1 (pt) |
| RU (1) | RU2320670C2 (pt) |
| UA (1) | UA78029C2 (pt) |
| WO (1) | WO2003077919A1 (pt) |
| ZA (1) | ZA200406843B (pt) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7622503B2 (en) | 2000-08-24 | 2009-11-24 | University Of Tennessee Research Foundation | Selective androgen receptor modulators and methods of use thereof |
| US8853266B2 (en) | 2001-12-06 | 2014-10-07 | University Of Tennessee Research Foundation | Selective androgen receptor modulators for treating diabetes |
| US7772433B2 (en) | 2002-02-28 | 2010-08-10 | University Of Tennessee Research Foundation | SARMS and method of use thereof |
| PL372920A1 (en) * | 2002-03-13 | 2005-08-08 | Merck & Co,Inc. | Fluorinated 4-azasteroid derivatives as androgen receptor modulators |
| DE60317061T2 (de) * | 2002-05-10 | 2008-07-24 | F. Hoffmann-La Roche Ag | Ibandronsäure zur behandlung und vorbeugung von osteoporose |
| US8309603B2 (en) | 2004-06-07 | 2012-11-13 | University Of Tennessee Research Foundation | SARMs and method of use thereof |
| US20070088042A1 (en) * | 2004-09-09 | 2007-04-19 | Meissner Robert S | Fluorinated 4-azasteroid derivatives as androgen receptor modulators |
| JP2007505120A (ja) * | 2003-09-10 | 2007-03-08 | メルク エンド カムパニー インコーポレーテッド | アンドロゲン受容体調節因子としての１７−複素環式−４−アザステロイド誘導体。 |
| CA2535953C (en) * | 2003-10-14 | 2012-07-03 | Gtx, Inc. | Treating bone-related disorders with selective androgen receptor modulators |
| JP2007509962A (ja) * | 2003-10-31 | 2007-04-19 | メルク エンド カムパニー インコーポレーテッド | アンドロゲン受容体調節剤としての２１−複素環−４−アザステロイド誘導体 |
| KR20130124576A (ko) * | 2004-01-07 | 2013-11-14 | 앙도르쉐르슈 인코포레이티드 | 헬릭스 12 배향형 스테로이드계 약학 제품 |
| EP1734963A4 (en) * | 2004-04-02 | 2008-06-18 | Merck & Co Inc | METHOD FOR TREATING PEOPLE WITH METABOLIC AND ANTHROPOMETRIC DISORDER |
| CN1950086A (zh) * | 2004-04-28 | 2007-04-18 | 默克公司 | 作为雄激素受体调节剂的氟化的4－氮杂甾族化合物 |
| US9884038B2 (en) | 2004-06-07 | 2018-02-06 | University Of Tennessee Research Foundation | Selective androgen receptor modulator and methods of use thereof |
| US9889110B2 (en) | 2004-06-07 | 2018-02-13 | University Of Tennessee Research Foundation | Selective androgen receptor modulator for treating hormone-related conditions |
| AU2005280334A1 (en) * | 2004-08-25 | 2006-03-09 | Merck Sharp & Dohme Corp. | Androgen receptor modulators |
| EP2371367A1 (en) * | 2005-03-25 | 2011-10-05 | Merck Sharp & Dohme (I.A.) Corp. | Method of treating men with testosterone supplement and 5alpha reductase inhibitor |
| US7301026B2 (en) * | 2005-05-05 | 2007-11-27 | Merck & Co., Inc | Process for making fluorinated 4-azasteroid derivatives |
| TW200730505A (en) * | 2005-12-07 | 2007-08-16 | Merck & Co Inc | Polymorphs of an androgen receptor modulator |
| US9844528B2 (en) | 2006-08-24 | 2017-12-19 | University Of Tennessee Research Foundation | SARMs and method of use thereof |
| US10010521B2 (en) | 2006-08-24 | 2018-07-03 | University Of Tennessee Research Foundation | SARMs and method of use thereof |
| US9730908B2 (en) | 2006-08-24 | 2017-08-15 | University Of Tennessee Research Foundation | SARMs and method of use thereof |
| CA2669763C (en) | 2006-11-16 | 2015-02-17 | Bayer Schering Pharma Aktiengesellschaft | Ep2 and ep4 agonists as agents for the treatment of influenza a viral infection |
| US7968603B2 (en) | 2007-09-11 | 2011-06-28 | University Of Tennessee Research Foundation | Solid forms of selective androgen receptor modulators |
| ES2413504T3 (es) | 2007-12-21 | 2013-07-16 | Ligand Pharmaceuticals Inc. | Moduladores selectivos del receptor de andrógeno (SARM) y usos de los mismos |
| JP2011511085A (ja) * | 2008-02-07 | 2011-04-07 | ブリストル−マイヤーズ スクイブ カンパニー | グルココルチコイド受容体、ＡＰ−１、および／またはＮＦ−κＢ活性の縮合ヘテロアリール修飾因子並びにその使用 |
| EP2149551A1 (de) | 2008-07-30 | 2010-02-03 | Bayer Schering Pharma AG | N-(Indol-3-ylalkyl)-(hetero)arylamidderivate als Modulatoren des EP2-Rezeptors |
| EP2149552A1 (de) | 2008-07-30 | 2010-02-03 | Bayer Schering Pharma AG | 5,6 substituierte Benzamid-Derivate als Modulatoren des EP2-Rezeptors |
| EP2149554A1 (de) | 2008-07-30 | 2010-02-03 | Bayer Schering Pharma Aktiengesellschaft | Indolylamide als Modulatoren des EP2-Rezeptors |
| MX2012014431A (es) | 2010-06-10 | 2013-02-26 | Aragon Pharmaceuticals Inc | Modulares del receptor de estrogenos y usos de los mismos. |
| DE102010027016A1 (de) | 2010-07-09 | 2012-01-12 | Universitätsklinikum Jena | Steroid-Styrylfarbstoff-Konjugate zur Simulation und direkten lichtoptischen Detektion des Verhaltens von Steroiden im lebenden biologischen Gewebe und in Gegenwart von steroidbindenden Proteinen |
| JP2015500346A (ja) | 2011-12-14 | 2015-01-05 | セラゴン ファーマシューティカルズ，インク． | エストロゲン受容体モジュレーターおよびその使用 |
| US10314807B2 (en) | 2012-07-13 | 2019-06-11 | Gtx, Inc. | Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS) |
| US10987334B2 (en) | 2012-07-13 | 2021-04-27 | University Of Tennessee Research Foundation | Method of treating ER mutant expressing breast cancers with selective androgen receptor modulators (SARMs) |
| US9622992B2 (en) | 2012-07-13 | 2017-04-18 | Gtx, Inc. | Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs) |
| US9744149B2 (en) | 2012-07-13 | 2017-08-29 | Gtx, Inc. | Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs) |
| US9969683B2 (en) | 2012-07-13 | 2018-05-15 | Gtx, Inc. | Method of treating estrogen receptor (ER)-positive breast cancers with selective androgen receptor modulator (SARMS) |
| KR102122941B1 (ko) | 2012-07-13 | 2020-06-15 | 지티엑스, 인코포레이티드 | 선택적 안드로겐 수용체 조절자(sarms)를 이용한 안드로겐 수용체(ar) 양성 유방암의 치료 방법 |
| US10258596B2 (en) | 2012-07-13 | 2019-04-16 | Gtx, Inc. | Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS) |
| US9566310B2 (en) | 2012-09-10 | 2017-02-14 | Board Of Regents Of The Nevada System Of Higher Education On Behalf Of The University Of Nevada, Reno | Methods of treating muscular dystrophy |
| US9707210B2 (en) | 2013-03-15 | 2017-07-18 | Board Of Regents Of The Nevada System Of Higher Education On Behalf Of The University Of Nevada, Reno | Methods of treating muscular dystrophy |
| EP3613418A1 (en) | 2014-01-17 | 2020-02-26 | Ligand Pharmaceuticals, Inc. | Methods and compositions for modulating hormone levels |
| KR101586345B1 (ko) * | 2014-08-06 | 2016-01-18 | 한국생명공학연구원 | 에스트라디올 벤조에이트(Estradiol benzoate) 또는 이의 약학적으로 허용 가능한 염을 포함하는 근력약화 관련 질환의 예방 또는 치료용 약학적 조성물 |
| US10342786B2 (en) | 2017-10-05 | 2019-07-09 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD |
| KR20200067170A (ko) | 2017-10-05 | 2020-06-11 | 풀크럼 쎄러퓨틱스, 인코포레이티드 | FSHD의 치료를 위하여 DUX4 및 하류 유전자 발현을 저감시키는 p38 키나제 저해제 |
| WO2019154257A1 (zh) | 2018-02-11 | 2019-08-15 | 江苏豪森药业集团有限公司 | 一种甾族类衍生物调节剂及其制备方法和应用 |
| JP2022529341A (ja) | 2019-04-19 | 2022-06-21 | リガンド・ファーマシューティカルズ・インコーポレイテッド | 化合物の結晶形、および化合物の結晶形を生成する方法 |
| CN118027131A (zh) | 2019-08-07 | 2024-05-14 | 上海翰森生物医药科技有限公司 | 一种甾族类衍生物调节剂的盐及其晶型 |
| US11904006B2 (en) | 2019-12-11 | 2024-02-20 | University Of Iowa Research Foundation | Poly(diaminosulfide) particle-based vaccine |
| CN112851745B (zh) * | 2021-01-25 | 2021-11-16 | 广西民族大学 | 氮杂甾体吡啶类化合物及其合成与应用 |
| WO2022271951A1 (en) | 2021-06-23 | 2022-12-29 | University Of Iowa Research Foundation | Sustained release formulations comprising a selective androgen receptor modulator |
| CN120289552A (zh) * | 2021-07-02 | 2025-07-11 | 石家庄迪斯凯威医药科技有限公司 | 一种甾体磷酸酯化合物及其应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5187278A (en) | 1990-08-27 | 1993-02-16 | Merck & Co., Inc. | Trialkylsilyl trifluoromethanesulfonate mediated α-methylenic carbon functionalization of 4-aza-5α-androstan-3-one steroids |
| IE76452B1 (en) * | 1990-10-29 | 1997-10-22 | Sankyo Co | Azasteroid compounds for the treatment of prostatic hypertrophy their preparation and use |
| GB9216284D0 (en) * | 1992-07-31 | 1992-09-16 | Erba Carlo Spa | Fluorinated 17beta-substituted 4-aza-5alpha-androstane-3-one derivatives |
| TW408127B (en) * | 1993-09-17 | 2000-10-11 | Glaxo Inc | Androstenones |
| EP0859761A4 (en) * | 1995-09-15 | 2000-01-26 | Merck & Co Inc | 4-AZASTEROIDS FOR TREATING HYPERANDROGEN STATES |
| AU5594398A (en) * | 1996-12-09 | 1998-07-03 | Merck & Co., Inc. | Methods and compositions for preventing and treating bone loss |
| PL372920A1 (en) * | 2002-03-13 | 2005-08-08 | Merck & Co,Inc. | Fluorinated 4-azasteroid derivatives as androgen receptor modulators |
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| ZA200406843B (en) | 2007-06-27 |
| MXPA04008800A (es) | 2004-11-26 |
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| EP1485095A4 (en) | 2009-11-18 |
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| WO2003077919A1 (en) | 2003-09-25 |
| AU2003218235B2 (en) | 2008-05-15 |
| JP2005526082A (ja) | 2005-09-02 |
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| KR20040097167A (ko) | 2004-11-17 |
| NZ534946A (en) | 2007-05-31 |
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| JP2010168391A (ja) | 2010-08-05 |
| EP1485095A1 (en) | 2004-12-15 |
| IL163825A0 (en) | 2005-12-18 |
| CN1652786A (zh) | 2005-08-10 |
| AU2003218235A1 (en) | 2003-09-29 |
| US7186838B2 (en) | 2007-03-06 |
| JP5268975B2 (ja) | 2013-08-21 |
| CA2478186C (en) | 2011-08-23 |
| ECSP045287A (es) | 2004-10-26 |
| NO20044312L (no) | 2004-10-12 |
| US20050165039A1 (en) | 2005-07-28 |
| MA27112A1 (fr) | 2004-12-20 |
| RU2320670C2 (ru) | 2008-03-27 |
| PL372920A1 (en) | 2005-08-08 |
| UA78029C2 (en) | 2007-02-15 |
| IL163825A (en) | 2010-12-30 |
| RU2004130452A (ru) | 2005-04-10 |
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